Elevation of ganglioside degradation pathway drives GM2 and GM3 within amyloid plaques in a transgenic mouse model of Alzheimer's disease by Wenxuan Wang, Sarah J. Myers, Nikita Ollen-Bittle, Shawn N. Whitehead

“…This study utilized a dual-resolution approach in combination with whole-brain imaging for comprehensive detection of ganglioside expression across neuroanatomical regions via high-resolution imaging of the cerebral cortex and hippocampus to investigate plaque-associated ganglioside alterations. …”
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Explorating the Involvement of Plasma Sestrin2 in Obstructive Sleep Apnea by Rong Jiang, Qiru Wang, Huifen Zhai, Xiaohua Du, Shibo Sun, Haoyan Wang

“…A multivariate stepwise regression model was used to detect the relationship between Sestrin2 and other variable factors. …”
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Advancing a machine learning-based decision support tool for pre-hospital assessment of dyspnoea by emergency medical service clinicians: a retrospective observational study by Wivica Kauppi, Henrik Imberg, Johan Herlitz, Oskar Molin, Christer Axelsson, Carl Magnusson

“…The gradient boosting algorithm had the overall best performance, with excellent calibration of the predictions, and consistently showed higher sensitivity to detect SAE than the other methods. The ROC AUC on test data increased from 0.73 (95% CI 0.70–0.76) with RETTS-A to 0.81 (95% CI 0.78–0.84) using gradient boosting. …”
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On the Biosynthesis of Bioactive Tryptamines in Black Cohosh (<i>Actaea racemosa</i> L.) by Martin J. Spiering, James F. Parsons, Edward Eisenstein

“…<i>TDC</i> expression was detected in several black cohosh tissues, and phytochemical analysis using LC-MS revealed several new tryptamines, including tryptamine and serotonin, along with <i>N</i>-methylserotonin and, interestingly, <i>N</i>-<i>N</i>-dimethyl-5-hydroxytryptamine (bufotenine), which may contribute to hepatotoxicity. …”
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Lactoferrin Induces Osteoblast Growth through IGF-1R by Jian-Ming Hou, En-Yu Chen, Fan Lin, Qing-Ming Lin, Ying Xue, Xu-Hua Lan, Man Wu

“…Osteoblast received 5 d lactoferrin intervention at a concentration of 0.1, 1, 10, 100, and 1000 μg/mL, and the IGF-1 and IGF-1R were detected using RT-PCR and western blot. The osteoblast into the control, 100 μg/mL lactoferrin, Neo-scramble (NS, empty vector), NS + 100 μg/mL lactoferrin, shIGF-1R and shIGF-1R + 100 μg/mL lactoferrin group. …”
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Ontologies in modelling and analysing of big genetic data by N. L. Podkolodnyy, O. A. Podkolodnaya, V. A. Ivanisenko, M. A. Marchenko

“…Experiments on cancer diagnostic datasets show that Deep GONet is easily interpretable and has high performance in distinguishing cancerous and non-cancerous samples. (2) ONN4MST, which uses biome ontologies to trace microbial sources of samples whose niches were previously poorly studied or unknown, detecting microbial contaminants. ONN4MST can distinguish samples from ontologically similar biomes, thus offering a quantitative way to characterize the evolution of the human gut microbial community. …”
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Severe pregnancy-associated atypical hemolytic uremia syndrome in the context of the COVID-19 pandemic: a novel survival case report by Yan Yang, Xiao-jin Li, Hua-Yan Yuan, Jing-Jing Xiong, Peng-Fei Li, Zhen Wang

“…Case presentation A 26-year-old patient with a history of four pregnancies and one delivery (P4G1) presented at 30 weeks and 2 days of gestation with vaginal fluid leakage and fetal growth restriction detected by ultrasound at a different hospital. During labor induction, the patient developed a high fever and coagulopathy, followed by heart failure, acute kidney injury, anemia, and severe thrombocytopenia. …”
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Nurses’ Perspectives and Experiences of Using a Bed-Exit Information System in an Acute Hospital Setting: Mixed Methods Study by Stefan Walzer, Isabel Schön, Johanna Pfeil, Sam Klemm, Sven Ziegler, Claudia Schmoor, Christophe Kunze

“… BackgroundTechnology that detects early when a patient at risk of falling leaves the bed can support nurses in acute care hospitals. …”
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Xiaohua Funing decoction ameliorates non-alcoholic fatty liver disease by modulating the gut microbiota and bile acids by Jindong Zhao, Jindong Zhao, Yan Li

“…A total of 17, 24, and 24 differentially abundant BAs were detected in the feces, liver, and serum samples from the Mod and Con groups, respectively (p &lt; 0.05 or p &lt; 0.01). …”
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Sistem Pendeteksi Sleep-Disordered Breathing Berdasarkan High dan Low Frequency Menggunakan Metode Naïve Bayes by Achmad Ghifari, Edita Rosana Widasari

“…Therefore, in this research, a system was created to detect sleep disorders into Normal, OSA, or CSA classes using Electrocardiography (ECG) signals acquired by the 3-lead placement technique. …”
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Bacteraemia in a Nigerian hospital: Implementing antimicrobial resistance surveillance by Adewale A. Amupitan, Adeyemi T. Adeyemo, Adefunke O. Amupitan, Temitope O. Obadare, Aaron O. Aboderin

“…Bacterial identification, antibiotic susceptibility testing and detection of AMR genes followed standard protocols. …”
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Esophageal oxyhemoglobin saturation as a resuscitative metric in hemorrhagic shock by Julia Garcia Mancebo, Kristen Sack, Padraic Romfh, Yifeng Peng, John Kheir

“…Using time-matched ShbO2-SvO2 pairs, the performance of ShbO2 to detect severe tissue hypoxia (SvO2&lt;20%) was excellent (AUC 0.843 for eShbO2, 0.879 for tShbO2). …”
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Predictors of survival rates among breast cancer patients in Ethiopia: a systematic review and meta-analysis 2024 by Chalie Mulugeta, Tadele Emagneneh, Getinet Kumie, Assefa Sisay, Nigusie Abebaw, Mulat Ayele, Abebaw Alamrew

“…Health stakeholders and policymakers emphasizing public health education, managing comorbidities, and expanding access to early detection and treatment, especially in rural areas, are critical.…”
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PTEN suppresses renal cell carcinoma proliferation and migration via inhibition of the PI3K/AKT pathway by Xu Xu, Yuan-Yue Tang, Xiaohong Liang, Wen Luo, Dong-Mei Jiang, Jie Chen

“…PTEN and related protein levels were detected using RT-qPCR and Western blot. Statistical analyses were performed using the Mann-Whitney U test and Kruskal-Wallis H test. …”
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Solid Indeterminate Pulmonary Nodules Less Than or Equal to 250 mm3: Application of the Updated Fleischner Society Guidelines in Clinical Practice by Andrea Borghesi, Silvia Michelini, Giorgio Nocivelli, Mario Silva, Alessandra Scrimieri, Stefania Pezzotti, Roberto Maroldi, Davide Farina

“…A significant volumetric increase was detected in 5/27 (18.5%) SIPNs; all growing nodules were observed in high-risk patients. …”
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SHP2 promotes the epithelial-mesenchymal transition in triple negative breast cancer cells by regulating β-catenin by Shihan Qian, Jingjing Zhu, Qing Han, Huang Cheng, Huaibin Zhou

“…An in vivo experiment utilizing a mouse xenograft model was also performed to evaluate tumor metastasis. Moreover, we detected the expression levels of epithelial-mesenchymal transition (EMT) biomarkers and investigated the mechanism between SHP2 and β-catenin using Western blot and immunofluorescence experiments. …”
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Protective Effects of Baicalein on Lipopolysaccharide-Induced AR42J PACs through Attenuation of Both Inflammation and Pyroptosis via Downregulation of miR-224-5p/PARP1 by Ming-Wei Liu, Chun-Hai Zhang, Shou-Hong Ma, De-Qiong Zhang, Li-Qiong Jiang, Yang Tan

“…The RNA and protein expression of miR-224-5p, poly ADP-ribose polymerase-1 (PARP1), nuclear transcription factor-κB65 (NF-κB65), phospho-kappa B alpha(p-IκB-α), interleukin(IL)-18R, NOD-like receptor thermal protein domain-associated protein 3 (NLRP3), gasdermin D (GSDMD), apoptosis-associated speck-like protein containing a CARD (ASC), and caspase-1 was detected based on the WB and RT-PCR assays. IL-1β, IL-6, IL-18, and TNF-α expression levels in AR42J cells were measured via ELISA method. …”
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Differences in EEG complexity of cognitive activities among subtypes of schizophrenia by Hang Qi, Jilin Zou, Zhenzhen Yao, Gaofeng Zhao, Jing Zhang, Chunlei Liu, Min Chen

“…Cognitive abilities were evaluated using a change detection task. The NeuroScan EEG/ERP System, comprising 64 channels and utilising standard 10-20 electrode placements, was employed to record EEG signals. …”
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Respiratory pathogen spectrum and epidemiological trends in Hainan Province: a retrospective analysis from 2017 to 2023 by Lvying Wu, Jianan Zhang, Zhiming Wu, Hua Pei, You Zhang

“…Results During 2017–2023, the number of RTI patients and pathogen detection rate was gradually decrease from 33.30% (3,886/11,670; pre-COVID-19), to 30.81% (2,034/6,602; NPI) and 22.43% (620/2,764; COVID-19). …”
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Triglyceride glucose index–body mass index as a predictor of coronary artery disease severity in patients with H-type hypertension across different glucose metabolic states by Lian Wang, Zijin Li, Rui Qiu, Li Luo, Xisheng Yan

“…Receiver operating characteristic (ROC) curves were used to evaluate the predictive value of TyG-BMI in detecting the severity of CAD in different glucose metabolism states, including normal glucose regulation (NGR), pre-diabetes mellitus (Pre-DM), and diabetes mellitus (DM). …”
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