A Novel Point-of-Care Prediction Model for Steatotic Liver Disease: Expected Role of Mass Screening in the Global Obesity Crisis by Jeayeon Park, Goh Eun Chung, Yoosoo Chang, So Eun Kim, Won Sohn, Seungho Ryu, Yunmi Ko, Youngsu Park, Moon Haeng Hur, Yun Bin Lee, Eun Ju Cho, Jeong-Hoon Lee, Su Jong Yu, Jung-Hwan Yoon, Yoon Jun Kim

“…We developed a machine learning-based point-of-care prediction model for SLD that is readily available to the broader population with the aim of facilitating early detection and timely intervention and ultimately reducing the burden of SLD. …”
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Periodontitis promotes tumor growth and immune evasion via PD-1/PD-L1 by Suli Wang, Fujiao Nie, Qiuyue Yin, Haoyang Tian, Pizhang Gong, Jinhong Ju, Jiayi Liu, Pishan Yang, Chengzhe Yang

“…Tumor volume and weight were recorded and the levels of relevant immune-suppressive cells and T cells were detected by flow cytometry or immunofluorescence. THP-1 cells were stimulated using conditioned media of LPS-stimulated Cal-27 cells and PD-L1 expression was measured by quantitative real-time PCR, western blotting and immunofluorescence. …”
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Therapeutic target genes and regulatory networks of gallic acid in cervical cancer by Zhixi You, Ye Lei, Yongkang Yang, Zhihui Zhou, Xu Chao, Keyi Ju, Songyi Wang, Yuanyuan Li, Yuanyuan Li

“…The upstream 13 miRNAs, 4 lncRNA, and 42 circRNAs were detected and used to construct a lncRNA/circRNA-miRNA-mRNA-pathway regulatory network.ConclusionThis study identified candidate genes and the regulatory networks underlying the therapeutic effects of GA on CC using GA data mining methods, thus establishing a theoretical basis for targeted therapy of CC.…”
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Lung ultrasound for assessing disease progression in UIP and NSIP: a comparative study with HRCT and PFT/DLCO by Nasrollahzadeh Milad, Idani Esmaeil, Abedini Atefeh, Malekshoaar Mehran, Sadeghi Mohsen, Kasravi Maryam, Tofighi Rozhin, Roostaei Ghazal, Kiani Arda

“…Abstract Background This study aims to compare Lung Ultrasound (LUS) findings with High-Resolution Computerized Tomography (HRCT) and Pulmonary Function Tests (PFTs) to detect the severity of lung involvement in patients with Usual Interstitial Pneumonia (UIP) and Non-Specific Interstitial Pneumonia (NSIP). …”
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Optimization of the "Loose Tea Blooming" Process for Guizhou Green Tea and Analysis of Characteristic Volatile Compounds by Linyao SONG, Hui XU, Siyao WU, Fengwei MA, Qiang FEI, Junyi DENG, Dajuan SHI, Yuze LIU, Yichen ZHAO, Xuan DONG, Su XU

“…Concurrently, volatile compounds in both the raw material and the final product were detected using headspace solid phase microextraction-gas chromatography-mass spectrometry (HS-SPME-GC-MS), followed by an analysis of the characteristic volatile compounds. …”
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Anopheles mosquitoes in Mondulkiri forest, Cambodia: abundance, distribution, seasonal patterns and Plasmodium prevalence by Sebastien Boyer, Bros Doeurk, Antsa Rakotonirina, Sophy Chy, Chantrea Vong, Eakpor Piv, Baura Tat, Malen Ea, Chansophea Chhin, Sreyvouch Phen, Nimol Kloeung, Sopheakvatey Ke, Jean Popovici, Patrice Piola, Benoit Witkowski, Pierre-Olivier Maquart, Amélie Vantaux

“…-infected samples were detected, mainly in forest sites (94%), and in specimens collected at night. …”
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New Evidence for <i>Cotinus coggygria</i> Scop. Extracts Application in Gastrointestinal Ailments by Dejan Stojković, Nina Dragičević, Marija Ivanov, Nevena Gajović, Milena Jurišević, Ivan Jovanović, Marina Tomović, Jelena Živković

“…Results: The presence of numerous flavonoid and phenolic compounds such as sulfuretin, gallic acid, rutin, hyperoside, and isoquercitrine was detected. <i>Micrococcus luteus</i>, <i>Streptococcus parasanguinis</i>, and <i>Candida tropicalis</i> were the most sensitive microbiological species, with MICs of 0.12 mg/mL for the most effective extracts. …”
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PretoxTM: a text mining system for extracting treatment-related findings from preclinical toxicology reports by Javier Corvi, Nicolás Díaz-Roussel, José M. Fernández, Francesco Ronzano, Emilio Centeno, Pablo Accuosto, Celine Ibrahim, Shoji Asakura, Frank Bringezu, Mirjam Fröhlicher, Annika Kreuchwig, Yoko Nogami, Jeong Rih, Raul Rodriguez-Esteban, Nicolas Sajot, Joerg Wichard, Heng-Yi Michael Wu, Philip Drew, Thomas Steger-Hartmann, Alfonso Valencia, Laura I. Furlong, Salvador Capella-Gutierrez

“…In the context of the eTRANSAFE project, we present PretoxTM (Preclinical Toxicology Text Mining), the first system specifically designed to detect, extract, organise and visualise treatment-related findings from toxicology reports. …”
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Obesity-associated memory impairment and neuroinflammation precede widespread peripheral perturbations in aged rats by Michael J. Butler, Stephanie M. Muscat, Maria Elisa Caetano-Silva, Akriti Shrestha, Brigitte M. González Olmo, Sabrina E. Mackey-Alfonso, Nashali Massa, Bryan D. Alvarez, Jade A. Blackwell, Menaz N. Bettes, James W. DeMarsh, Robert H. McCusker, Jacob M. Allen, Ruth M. Barrientos

“…Thus, our study investigated the impact of HFD after two distinct consumption durations: 3 months (to model diet-induced obesity) or 3 days (to detect the rapid changes occurring with HFD) on memory function, anxiety-like behavior, central and peripheral inflammation, and gut microbiome profile in young and aged rats. …”
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A suite of wildlife crossing structures facilitates mammal movement across tropical forest fragments in a city by Li Si Tay, Ruisheng Choo, Max D. Y. Khoo, Eunice Kong, Yi Xiang Chan, Wivian H. Y. Neo, Sebastian Ow, Yuet Hsin Toh, Han Ling, Malcolm C. K. Soh, Benjamin P. Y.‐H. Lee, Adrian H. B. Loo, Kenneth B. H. Er

“…Fourteen mammal species were detected across all crossing types, with wild boar (Sus scrofa) being the most prevalent species (68.2%). …”
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Survival of Generic Escherichia coli on In-Field Mature and Immature Gala and Golden Delicious Apples With or Without Overhead Evaporative Cooling Treatment by Claire M Murphy, Kyu Ho Jeong, Lauren Walter, Manoella Mendoza, Tonia Green, Andy Liao, Karen Killinger, Ines Hanrahan, Mei-Jun Zhu

“…For most treatments, inoculated E. coli decreased by almost or over 6 log CFU/apple over the study duration; however, E. coli remained detectable at low levels on apples at 154 h postinoculation. …”
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Study on exhaled volatile organic compounds identifying cognitive fatigue induced by N-back task in healthy young adults by Xiaoyu Zhang, Xiaoyan Dong, Qiang Huang, Zhe Liu, Qin Wang

“…Exhaled VOCs were collected and detected using a Bio-VOC sampler and Thermal Desorption Gas Chromatography-Mass Spectroscopy method. …”
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Retinal thickness and vascular density changes in Keratoconus: A systematic review and meta-analysis by Hadi Vahedi, Mirsaeed Abdollahi, Reza Moshfeghinia, Shima Emami, Navid Sobhi, Rana Sorkhabi, Ali Jafarizadeh

“…Understanding these changes may be essential for future research focused on early detection, potential prognosis markers, and further exploration of the retina-corneal connection in KC.…”
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Pathology of Red Blood Cells in Patients with SARS-CoV-2 by Sona Hakobyan, Lina Hakobyan, Liana Abroyan, Aida Avetisyan, Hranush Avagyan, Nane Bayramyan, Lyudmila Niazyan, Mher Davidyants, Knarik Sargsyan, Tehmine Ghalechyan, Anna Semerjyan, Elena Karalova, Zaven Karalyan

“…<b>Results:</b> Erythroblasts were detected in approximately 30% of SARS-CoV-2 patients, predominantly in the severe group. …”
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Salivary proteomics profiling reveals potential biomarkers for chronic kidney disease: a pilot study by Bianca Uliana Picolo, Nathália Rabello Silva, Mário Machado Martins, Hebréia Oliveira Almeida-Souza, Letícia Cristina Machado de Sousa, Richard Costa Polveiro, Luiz Ricardo Goulart Filho, Robinson Sabino-Silva, Vivian Alonso-Goulart, Luciana Saraiva da Silva

“…Gene ontology (GO) analysis revealed data on molecular functions, biological processes, cellular components, and protein classes.ConclusionWe can conclude that the salivary API5, PI-PLC, and Sgsm2 can be potential biomarker candidates for CKD detection. These proteins may participate in pathways related to renal fibrosis and other associated diseases, such as mineral and bone disorders.…”
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Association of Corticosteroid Inhaler Type with Saliva Microbiome in Moderate-to-Severe Pediatric Asthma by Amir Hossein Alizadeh Bahmani, Mahmoud I. Abdel-Aziz, Simone Hashimoto, Corinna Bang, Susanne Brandstetter, Paula Corcuera-Elosegui, Andre Franke, Mario Gorenjak, Susanne Harner, Parastoo Kheiroddin, Leyre López-Fernández, Anne H. Neerincx, Maria Pino-Yanes, Uroš Potočnik, Olaia Sardón-Prado, Antoaneta A. Toncheva, Christine Wolff, Michael Kabesch, Aletta D. Kraneveld, Susanne J. H. Vijverberg, Anke H. Maitland-van der Zee, on behalf of the SysPharmPediA consortium

“…Significant differential abundance between groups, with higher relative abundance in the MDI group compared to the DPI group, was detected at the family level [Carnobacteriaceae (adjusted <i>p</i> = 0.033)] and at the genus level [<i>Granulicatella</i> (adjusted <i>p</i> = 0.021) and <i>Aggregatibacter</i> (adjusted <i>p</i> = 0.011)]. …”
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Diagnostic Management and Surgical Treatment of Isolated Tricuspid Regurgitation by Arthur Cicupira Rodrigues de Assis, Gustavo Andre Boeing Boros, Lea Maria Macruz Ferreira Demarchi, Thiago Luis Scudeler, Paulo Cury Rezende

“…No late gadolinium enhancement was detected. Because of persistent symptoms, even after optimization of medical therapy, the patient was submitted to tricuspid valve replacement surgery. …”
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Monitoring M-Protein, Therapeutic Antibodies, and Polyclonal Antibodies in a Multiparametric Mass Spectrometry Assay Provides Insight into Therapy Response Kinetics in Patients wit... by Charissa Wijnands, Peter G. A. Karel, Jolein Gloerich, Gad Armony, Anastasia Tzasta, Corrie M. de Kat Angelino, Luciano Di Stefano, Vincent Bonifay, Theo M. Luider, Martijn M. VanDuijn, Sandra J. Croockewit, Elizabeth A. de Kort, Daan A. R. Castelijn, Claudia A. M. Stege, Hans J. C. T. Wessels, Alain J. van Gool, Niels W. C. J. van de Donk, Joannes F. M. Jacobs

“…M-protein and t-Ab were also detectable in the CSF of one patient with MS-MRD. <b>Conclusions:</b> This proof-of-concept study shows that the multiplex monitoring of the M-protein, any t-Ab combination, and all Ig-isotypes within one mass spectrometry run is feasible and provides unique insight into therapy response kinetics.…”
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Analysis of Risk Factors of Gastric Low-Grade Intraepithelial Neoplasia in Asymptomatic Subjects Undergoing Physical Examination by Yingling Liu, Yuli Cai, Si Chen, Yawen Gou, Qiaomin Wang, Mingli Zhang, Yetao Wang, Haiou Hong, Kaiguang Zhang

“…Low-grade intraepithelial neoplasia (LGIN) is the last stage of precancerous lesion, and its timely diagnosis can greatly improve the detection rate of early gastric cancer. We performed a prospective study to analyze the risk factors of gastric LGIN in asymptomatic subjects undergoing physical examination. …”
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A novel virulent core genome multilocus sequence type CT 11424 of Listeria monocytogenes isolate causing stillbirth in Bangladesh by Muntasir Alam, Md Saiful Islam, M. Ishrat Jahan, Arpita Shyama Deb, Afruna Rahman, Zahidul Islam, Atique Iqbal Chowdhury, Kazi Munisul Islam, Mohammad Zahid Hossain, Dilruba Ahmed, Shams El Arifeen, Emily S. Gurley, Mustafizur Rahman

“…Key L. monocytogenes virulence genes facilitating the crossing of the placental barrier, including full-length inlA, LIPI-1, and LIPI-3, were detected. The isolate was closely related to clinical L. monocytogenes isolates, as determined by GrapeTree based on cgMLST. …”
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