Severe pneumonia due to concurrent Legionella pneumophila and Acinetobacter baumannii infections: a case report by Xiaoming Yang, Zhongda Liu, Xiaojing Liu, Quan Li, Hui Huang, Yibo Wei, Tao Sun

“…Close clinical monitoring, early pathogen detection and antibiotic susceptability tests, and appropriate antibiotic regimen adjustments should be applied to these patients who failed initial antibiotic treatments.…”
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Unraveling the genetic mysteries of spinal muscular atrophy in Chinese families by Shanshan Gao, Duo Chen, Qianqian Li, Xuechao Zhao, Chen Chen, Lina Liu, Miao Jiang, Zhenhua Zhao, Yanhua Wang, Xiangdong Kong

“…Conclusions This study comprehensively analyzed the genetics of suspected familial SMA cases in the Chinese population, providing insights into the molecular genetic mechanisms of SMA and the utility of various detection techniques. The findings revealed important implications for genetic counseling, prenatal diagnosis, and targeted therapies in clinical practice.…”
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Validation of the Zarit Burden Interview in Informal Caregivers of Patients with Severe Visual Impairment and Blindness by Raul E. Ruiz-Lozano, Monica I. Herrera-Rodriguez, Jazmin A. Mendoza-Pallares, Natalia Reyes-Godinez, Veronica E. Tamez-Tamez, Eugenia M. Ramos-Dávila, Luis G. Villagomez-Valdez, Lucas A. Garza-Garza, Manuel E. Quiroga-Garza, Ali Khodor, Jose J. Gongora-Cortes, Alejandro Rodriguez-Garcia

“…Conclusions The ZBI is a valid instrument to detect burden in Mexican caregivers of patients with visual impairment. …”
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Nasal microbial diversity is associated with survival in piglets infected by a highly virulent PRRSV-1 strain by Pau Obregon-Gutierrez, Martí Cortey, Gerard E. Martín-Valls, Hepzibar Clilverd, Florencia Correa-Fiz, Virginia Aragón, Enric Mateu

“…Since the dysbiosis detected as an initial response to infection may be not specific for this virus, further investigations should explore this phenomenon in the context of other viral infections.…”
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The Modulation of Reward and Habit Systems by Acupuncture in Adolescents with Internet Addiction by Yang Wang, Yun Qin, Hui Li, Dezhong Yao, Bo Sun, Zhiliang Li, Xin Li, Yu Dai, Chao Wen, Lingrui Zhang, Chenchen Zhang, Tianmin Zhu, Cheng Luo

“…Seed-to-voxel and ROI-to-ROI analyses were applied to detect the rsFC alterations of the VS and related network in IA subjects and to investigate the modulation effect of acupuncture on the rsFC. …”
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Nutritional Properties, Antioxidant and Antihaemolytic Activities of the Dry Fruiting Bodies of Wild Edible Mushrooms Consumed by Ethnic Communities of Northeast India by Merilin Kakoti, Dibya Jyoti Hazarika, Assma Parveen, Samim Dullah, Alokesh Ghosh, Dipankar Saha, Madhumita Barooah, Robin Chandra Boro

“…Other compounds viz. citric acid, caffeic acid, riboflavin, vanillic acid, pyruvic acid, and p -coumaric acid were detected with variations. This study established the nutritional and health-promoting benefits of wild edible mushrooms of Northeast India region for consumption as functional foods in the human diet.…”
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Newly identified single-nucleotide polymorphism associated with the transition from nonalcoholic fatty liver disease to liver fibrosis: results from a nested case-control study in... by Yitong Ling, Yu Xuan Yang, Yan Chun Chen, Jing Hao Wang, Dong Ge Feng, Shi Jian Xiang, Xiaoyu Zhang, Jun Lyu, Sha Sha Li

“…To quantify gene expression, we used real-time PCR with fluorescence detection.Results The study analyzed data from 5467 participants (1094 cases and 4373 controls). …”
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Potential Research Tool of Stem Cells from Human Exfoliated Deciduous Teeth: Lentiviral Bmi-1 Immortalization with EGFP Marker by Siqi Yao, Lingping Tan, Huan Chen, Xiaojun Huang, Wei Zhao, Yan Wang

“…The expression of Bmi-1 was detected with Western blot. Replicative lifespan determination and colony-forming efficiency assessment were using to assay proliferation capability. …”
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Evaluation of Juice Production Characteristics and Analysis of Characteristic Flavor Components of Phyllanthus emblica Fruit Varieties by Zifen ZHENG, Xiaowei CHEN, Bo ZOU, Yuanshan YU, Gengsheng XIAO, Lukai MA

“…A total of 68 volatile aroma components were detected, and 15 aroma components with ROAV>1 were selected. …”
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JAK/STAT3 signaling promotes pain and depression-like behaviors in rats with bone cancer pain by regulating Th17 cell differentiation by Shuyan Wu, Jundan Jiang, Danfeng Wang, Daoyi Lin, Mingxue Lin, Pinzhong Chen, Jianghu Chen, Honghong Zhang, Ying Wang, Xiaohui Chen, Xiaochun Zheng

“…Changes in inflammatory factors and related protein expression levels in the amygdala were detected using western blotting, immunofluorescence, and reverse transcription-quantitative polymerase chain reaction (RT-qPCR). …”
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Celastrol boosts fluconazole efficacy against vaginal candidiasis: in vitro and in vivo evidence by Fatma Al-zahraa A. Yehia, Hisham A Abbas, Tarek M. Ibrahim, Basem Mansour, Zuhier A. Awan, Mohammed W. Al-Rabia, Wesam H. Abdulaal, Mustafa Adnan Zeyadi, Solomon Z. Okbazghi, Tarek S. Ibrahim, Wael A. H. Hegazy, Salwa E. Gomaa

“…Upon celastrol treatment, a significant decline in ABC transporters transcript levels were detected. Moreover, molecular docking demonstrated that celastrol is a potential ABC efflux transporters blocker that successfully fits into target binding pockets. …”
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Prospective multicentre randomised trial comparing the efficacy and safety of single-anastomosis duodeno–ileal bypass with sleeve gastrectomy (SADI-S) versus Roux-en-Y gastric bypa... by Delphine Maucort-Boulch, Maud Robert, Tigran Poghosyan, Dominique Delaunay, Elise Pelascini, Sylvain Iceta, Adrien Sterkers, Charles Barsamian, Litavan Khamphommala, Sylvie Bin Dorel, Sebastien Czernichow, Emmanuel Disse

“…Patients randomised by minimisation in two arms, based on centre, surgery as a revisional procedure, presence of type 2 diabetes and BMI >50 kg/m2 will be included over 2 years.A sample size of 166 patients in each group will have a power of 90% to detect a probability of 0.603 that excess weight loss in the RYGB arm is less than excess weight loss in the SADI-S arm with a 5% two-sided significance level. …”
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Thermal Response and Degressive Reaction Study of Oxo-Biodegradable Plastic Products Exposed to Various Degradation Media by S. M. Al-Salem, A. Y. Al-Nasser, M. H. Behbehani, H. H. Sultan, H. J. Karam, M. H. Al-Wadi, A. T. Al-Dhafeeri, Z. Rasheed, M. Al-Foudaree

“…A shift in the degradation mechanism was also detected after studying the kinetic parameters which showed a range of Ea between 86.64 and 226.90 kJ mol-1 depending on the type of specimens and exposure media. …”
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Is The SARS-CoV2 Evolved in Human Being: A prospective Genetic Analysis by Salvatore Dimonte, Paywast Jamal Jalal, Hiwa Abdulrahman Ahmad, Safa Bakr Karim, Taib Ahmed Hama Soor, Salar Ibrahim Ali, Muhammed Babakir-Mina, Francesco Greco

“…The evolutionary changes observed in the inserted 23 amino acids in the RNA binding domain (RBD) of the coronvirus spike glycoprotein which cannot be detected in any other human coronavirus. Moreover, the 2019-nCoV is not closely related to other alpha, beta and gamma human Coronavirus, including MERS-CoV. …”
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Synthetic Data Generation and Evaluation Techniques for Classifiers in Data Starved Medical Applications by Wan D. Bae, Shayma Alkobaisi, Matthew Horak, Siddheshwari Bankar, Sartaj Bhuvaji, Sungroul Kim, Choon-Sik Park

“…This leads to a training dataset where healthy cases outnumber unhealthy ones, resulting in biased prediction models that struggle to detect the minority, unhealthy cases effectively. …”
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Integrative deep immune profiling of the elderly reveals systems-level signatures of aging, sex, smoking, and clinical traitsResearch in context by Lennart Riemann, Rodrigo Gutierrez, Ivan Odak, Joana Barros-Martins, Lennart M. Roesner, Ximena Leon Lara, Christine Falk, Thomas F. Schulz, Gesine Hansen, Thomas Werfel, Reinhold Förster, Berislav Bošnjak, Felix Jenniches, Norman Klopp, Till Robin Lesker, Martin Stangel

“…Our large sample size allowed detection of even subtle changes in cytokines and immune cell clusters. …”
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Nasopharyngeal carriage of Staphylococcus aureus in a rural population, Sierra Leone by Lisa Maria Kleine, Emmanuel Marx Kanu, Tobias Grebe, Desmond Mohamed Sesay, Henning Loismann, Maxwell Sesay, Tom Theiler, Viktoria Rudolf, Alexander Mellmann, Laura C. Kalkman, Martin P. Grobusch, Frieder Schaumburg

“…Resistance to penicillin was predominant (97.1 %, 169/174), followed by tetracycline (66.1 %, 115/174), co-trimoxazole (56.9 %, 99/174) and oxacillin (24.1 %, 42/174, all mecA-positive, mostly associated with ST8/PVL-negative). PVL gene was detected in 21.3 % of isolates (37/174) mainly associated with ST15 and ST152. …”
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Pacific sailfish (Istiophorus platypterus) in the Eastern Pacific Ocean, association with ocean currents and seasonal effects of upwelling using real-time Argos locations by Chelsea E. Clyde-Brockway, Chelsea E. Clyde-Brockway, Samir Harshad Patel, Gabriela Blanco, Samuel J. Friederichk, Stephen Morreale, Frank V. Paladino, Frank V. Paladino

“…The two location recording methods produced similar tracking intervals—deployment date until the final location date—(Argos: 33.0 ± 13.5 d; GPE: 32.0 ± 11.2 d), and detection days—number of days the transmitter recorded a location—(Argos: 7.8 ± 6.0 d; GPE: 12.3 ± 8.5 d). …”
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Expression of PD-1 on CD4+ Tumor-Infiltrating Lymphocytes in Tumor Microenvironment Associated with Pathological Characteristics of Breast Cancer by Yan-Jie Zhao, Jian Zhang, Feng Shi, Zhi-Ping Hu, Jiang-Ping Wu, Guang-Jiang Wu, Rui-Bin Wang, Quan Zhou, Hong Chang, Ying-Nan Li, Qing-Kun Song

“…The expression of CD4, programmed cell death protein 1 (PD-1), CK7, CK20, E-cadherin, or Ki-67 was detected by immunohistochemistry. The associations between CD4+/PD-1+ or CD4+/PD-1− tumor-infiltrating lymphocytes and pathological characteristics were evaluated. …”
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Time-resolved Hubble Space Telescope UV Observations of an X-Ray Quasiperiodic Eruption Source by T. Wevers, M. Guolo, S. Lockwood, A. Mummery, D. R. Pasham, R. Arcodia

“…Here, we report on time-resolved, coordinated Hubble Space Telescope far-ultraviolet (FUV) and XMM-Newton X-ray observations of the shortest period X-ray QPE source currently known, eRO-QPE2. We detect a bright UV point source ( L _FUV ≈ few × 10 ^41 erg s ^−1 ) that does not show statistically significant variability between the X-ray eruption and quiescent phases. …”
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