Characterising SRD5A2 Gene Variants in 37 Indonesian Patients with 5-Alpha-Reductase Type 2 Deficiency by Nanis S. Marzuki, Firman P. Idris, Hannie D. Kartapradja, Alida R. Harahap, Jose R. L. Batubara

“…In addition, the respective sensitivities for detecting severe 5ARD2 cases using T/DHT (cutoff: 10) and urinary Et/An ratios (cutoff: 0.95) were 85% and 90%, whereas mild cases were only identified with 64.7% and 47.1% sensitivity, respectively. …”
Get full text

Candidate vaccine construction against tick-born encephalitis based on hybrid recombinant flagG-protE-protein by P. A. Belavin, D. A. Kunyk, E. V. Protopopova, V. B. Loktev, E. V. Deineko

“…MCA 4F6, 7F10, and 6B9 did not recognize the corresponding epitope in the recombinant flagG­protE protein, while in the recombinant protein protE, these epitopes were detected successfully. Our data indicate that the antigenic structure of recombinant protE­protein can be changed under the influence of the flagellin domain, which in turn can lead to the unavailability of some antigenic determinants. …”
Get full text

Association between systemic inflammatory response index and glaucoma incidence from 2005 to 2008 by Xiang Li, Yi Qing Sun, Xiao Dan Zhong, Zhi Jie Zhang, Jia Feng Tang, Zhan Yang Luo

“…SIRI may serve as a useful biomarker for identifying individuals at risk of glaucoma, facilitating early detection and targeted intervention strategies. Further research is needed to validate these findings and explore their clinical applications.…”
Get full text

Resistance to causal agents of late blight and golden potato nematode of the modern cultivars of seed potatoes and their phytosanitary status in various agroclimatic zones of the E... by A. V. Khiutti, D. A. Rybakov, T. A. Gavrilenko, O. S. Afanasenko

“…Resistant to G. rostochiensis were 38 cultivars. 57R marker of the H1 gene conferring resistance to the Ro1 pathotype of G. rostochiensis was detected in 96.6 % of the nematode resistant cultivars studied; susceptible varieties did not possess this marker. …”
Get full text

Maximizing Identification Precision of Hymenoptera and Brachycera (Diptera) With a Non‐Destructive DNA Metabarcoding Approach by Isabel C. Kilian, Ameli Kirse, Ralph S. Peters, Sarah J. Bourlat, Vera G. Fonseca, Wolfgang J. Wägele, Andrée Hamm, Ximo Mengual

“…Depending on the selected approach, DNA metabarcoding results strongly varied in terms of detected molecular units blasted to brachyceran and hymenopteran species. …”
Get full text

Comparison of Extracellular Metabolites and Antioxidant Activity of Different Strains of Wolfiporia hoelen (Fr.) Y.C. Dai &V. Papp by TAN Yun, SHEN Airong, SHEN Baoming, YU Jinxiu, LIU Lina, LI Sainan, TAN Zhuming

“…Totally 55 flavonoids and 33 phenolic compounds were qualitatively detected using ultra-high performance liquid chromatography-mass spectrometry (UPLC-MS). …”
Get full text

Evaluating handgrip strength and functional tests as indicators of gait speed in older females by Valentina Muollo, Samuel D’Emanuele, Laura Ghiotto, Doriana Rudi, Federico Schena, Cantor Tarperi

“…Receiver operating characteristic (ROC) curves were employed to evaluate the effectiveness of various tests in detecting slow GS (<1.0 m/s), by means of the area under the curve (AUC), sensitivity, and specificity.ResultsHGS showed positive significant (p < 0.001) associations with 30 s-AC (r = 0.499), SPPB (r = 0.447), and 30 s-CS (r = 0.329). …”
Get full text

Development of a Dual-Targeted Oral Delivery System for Mesalazine and Acetaminophen by Fatemeh Soltani, Reihaneh Arghand, Ghazaleh Mehdipour, Hossein Shahdadi Sardou, Ali Mohammadi, Abbas Akhgari

“…Physicochemical tests indicated that the pellets had a smooth surface, uniform coating, and appropriate hardness, with no detectable interactions between the drugs and excipients. …”
Get full text

A multi-stage weakly supervised design for spheroid segmentation to explore mesenchymal stem cell differentiation dynamics by Arash Shahbazpoor Shahbazi, Farzin Irandoost, Reza Mahdavian, Seyedehsamaneh Shojaeilangari, Abdollah Allahvardi, Hossein Naderi-Manesh

“…Additionally, we developed a robust learning scheme for spheroid detection, providing a reliable foundation to study MSC differentiation dynamics. …”
Get full text

Evaluación técnica, financiera y ambiental de la higienización alcalina del lodo de aguas residuales ordinarias para su transformación en biosólido by Erick Centeno Mora, Ronald Calderón Mejía

“…[Resultados]: Pudo corroborarse que la aplicación de dosis de cal de 40% permitió obtener un biosólido tipo A con concentraciones de microorganismos patógenos no detectables, que se mantuvo en esa condición por más de 30 días. …”
Get full text

Longitudinal associations between informal caring, social network, and psychological distress among adolescents and young adults: modelling within-person effects by Miharu Nakanishi, Satoshi Yamaguchi, Mai Sakai, Hatsumi Yoshii, Syudo Yamasaki, Atsushi Nishida, Takahiro Tabuchi

“…We employed a random intercept cross-lagged model to detect within-person prospective associations between informal caring, social network, and psychological distress. …”
Get full text

Study on the Changes of Liver and Kidney Function-Related Indicators and Clinical Significance in Patients with OSAHS by Rongyue Liu, Xiangdong Kong

“…In addition, 50 healthy people who underwent physical examination in our hospital at the same time were selected as the control group, and the liver and kidney function and polysomnography (PSG)-related indexes of the above subjects were detected, and the comparison between the groups was carried out. …”
Get full text

Transition zone-based prostate-specific antigen density for differentiating clinically significant prostate cancer in PI-RADS score 3 lesions by Yongming Jin, Fei Chen, Gang Xu, Chaogang Wei, Congsong Dong

“…Abstract We intended to investigate the potential of several transitional zone (TZ) volume-related variables for the detection of clinically significant prostate cancer (csPCa) among lesions scored as Prostate Imaging Reporting and Data System (PI-RADS) category 3. …”
Get full text

Impedance mapping with high-density microelectrode array chips reveals dynamic heterogeneity of in vitro epithelial barriers by Alessandra Venz, Bastien Duckert, Liesbet Lagae, Saeedeh Ebrahimi Takalloo, Dries Braeken

“…This method could thus, in principle, enable detection of tissue barrier disrupting and modifying agents with higher specificity. …”
Get full text

Mechanism and Pharmacodynamic Substance Basis of Raw and Wine-Processed Evodia rutaecarpa on Smooth Muscle Cells of Dysmenorrhea Mice by Yeqian Liu, Hong Li, Lei Chen, Hongxia Zhao, Jian Liu, Shan Gong, Danfeng Ma, Chunming Chen, Shuiqing Zeng, Hongping Long, Weiqiong Ren

“…The cell contraction and the expression of P2X3 and Ca2+ in vitro were determined using immunofluorescence staining and laser confocal; ELISA was used for detection of PGE2, ET-1, and NO content after 7-hydroxycoumarin, chlorogenic acid, and limonin administered for 24 h. …”
Get full text

circ-SIRT1 Promotes Colorectal Cancer Proliferation and EMT by Recruiting and Binding to eIF4A3 by Xiangjie Wang, Shuang Liu, Bin Xu, Yabin Liu, Peng Kong, Changlin Li, Binghui Li

“…The expression of circ-SIRT1 in CRC cells and tissue was detected by RT-qPCR. Colony formation and Cell Counting Kit-8 assays were used to evaluate the effect of circ-SIRT1 knockdown on the proliferative ability of CRC cells. …”
Get full text

Variational Approaches for Drug-Disease-Gene Links in Periodontal Inflammation by Pradeep Kumar Yadalam, Prabhu Manickam Natarajan, Musab Hamed Saeed, Carlos M. Ardila

“…The VQA model demonstrated a high accuracy rate of 97.5%, although it only detected 50% of anomalies. The VQC model achieved a precision of 78%, with Class 1 samples showing improved recall and a balanced F1 score. …”
Get full text

Hippocampal dendritic spines store-operated calcium entry and endoplasmic reticulum content is dynamic microtubule dependent by Anastasiya Rakovskaya, Ekaterina Volkova, Ilya Bezprozvanny, Ekaterina Pchitskaya

“…These effects are opposite of those detected during overexpression of the wild type STIM2. …”
Get full text

Randomized Controlled Trial of Polyethylene Glycol versus Oral Sodium Phosphate for Bowel Preparation in Unsedated Colonoscopy by Dong Yang, Ke Tao, Geng Chen, Luping Zhang, Qingying He, Hong Xu

“…There were no significant differences in the cecal intubation rate and the detection rate of polyps and ulcers/erosion between the two groups. …”
Get full text

Evaluating the impact of ESICM 2023 guidelines and the new global definition of ARDS on clinical outcomes: insights from MIMIC-IV cohort data by Duanhong Song, Qingquan Chen, Shangbin Huang, Shengxun Qiu, Zeshun Chen, Yuanhang Cai, Yifu Zeng, Xiaoyang Chen, Yixiang Zhang

“…Conclusions The new ARDS definition offers advantages in earlier detection, more accurate grading, and more precise diagnosis in resource-limited settings compared with the Berlin definition. …”
Get full text