The interplay between RNA m6A modification and radiation biology of cancerous and non-cancerous tissues: a narrative review by Yajia Cheng, Yue Shang, Shuqin Zhang, Saijun Fan

“…It begins with an overview of m6A modification and its detection methods, followed by a detailed examination of how m6A dynamically regulates the sensitivity of cancerous tissues to RT, the injury response in non-cancerous tissues, and the toxicological effects of UV exposure. …”
Get full text

A socioecological taxonomy of determinants to colorectal cancer screening in black men: Insights from a mixed-methods systematic review by P.J. Zaire, E. Miller, A.P. Ewing, J. Hefner, K. Wright, L.H. Smith

“…Although CRC is preventable and treatable with early detection, screening rates among Black men remain low. …”
Get full text

Ethanol Extracts of Solanum lyratum Thunb Regulate Ovarian Cancer Cell Proliferation, Apoptosis, and Epithelial-to-Mesenchymal Transition (EMT) via the ROS-Mediated p53 Pathway by Chen Zhang, Zheming Li, Jie Wang, Xuelu Jiang, Mengting Xia, Jianfen Wang, Shenyi Lu, Shouye Li, Hanmei Wang

“…Furthermore, A2780 and SKOV3 cells cocultured with M0 macrophages showed that SLT activated the polarization of M0 macrophages to M1 macrophages and inhibited the polarization to M2 macrophages, with the increased percentage of CD86+ cells and decreased percentage of CD206+ cells were detected. In summary, this study illustrated the anticancer effects of SLT on ovarian cancer cells, suggesting that SLT may have the potential to provide basic evidence for the discovery of antiovarian cancer agents.…”
Get full text

Muscle strength measurements reflecting the extent of complete subscapularis tears: reliability in patients with rotator cuff tears by Wataru Sahara, MD, PhD, Keishi Takagi, PT, Shuhei Tada, PT, Daichi Yamada, PT, Hiroki Kiya, PT, Hiroto Hanai, MD, PhD, Shoji Konda, PhD, Seiji Okada, MD, PhD

“…Intrarater reliability was assessed using the intraclass correlation coefficient (ICC) (1, 3), minimal detectable change (MDC), and MDC% based on three preoperative measurements on the operated side. …”
Get full text

A novel CUL4B gene variant activating Wnt4/β-catenin signal pathway to karyotype 46, XY female with disorders of sex development by Chunlin Wang, Hong Chen, Qingqing Chen, Yangbin Qu, Ke Yuan, Li Liang, Qingfeng Yan

“…A hemizygous variant c.838 T > A of the CUL4B gene was detected. The mRNA and protein levels of WNT4 and FOXL2 genes were higher than those in the wild-type group; however, CTNNB1, SOX9, and DMRT1 were lower in the wild-type group in NT2/D1 cells. …”
Get full text

Abdominal fat distribution and its relationship to brain changes: the differential effects of age on cerebellar structure and function: a cross-sectional, exploratory study by Yvonne Böttcher, Michael Stumvoll, Kees Straatman, Matthias Raschpichler, Matthias Leopold Schroeter, Katrin Arelin, Haiko Schlögl, Dominik Fritzsch, Meinhard Mende, André Pampel, Arno Villringer, Karsten Mueller

“…Investigating functional brain architecture showed again inverse VAT–cerebellum correlations, whereas now regions involved in cognitive and emotional processing were significant. Although we detected similar results for EC using BMI, significant age interaction for both brain structure and functional architecture was only found using VAT.Conclusions Visceral adiposity is associated with cerebellar changes of both structure and function, whereas the regions involved contribute to motor, cognitive and emotional processes. …”
Get full text

Exploring the effects of Tianma Gouteng granules on L-NAME-induced hypertensive rats based on 16S rDNA gene sequencing and metabolomics by Li Cheng, Zhenyang Huang, Jiawei He, Xinyi Zhang, Jiangxue Di, Hanmei Jiang, Yi Liu

“…After drug administration, 16S rDNA gene sequencing and non-targeted metabolomics were applied to detect and analyze the intestinal flora and fecal metabolites of the rats in each group. …”
Get full text

Standardised protocol for a prospective cross-sectional multicentre clinical utility evaluation of two dual point-of-care tests in non-clinical settings for the screening of HIV an... by James Kiarie, Karel Blondeel, Igor Toskin, Jordi Casabona, Soe Soe Thwin, Massimo Mirandola, Rosanna Peeling, Ronald Ballard, Laura Fernàndez-López, Inga Upmace, Juliana Reyes-Urueña, Mara Vaselova, Mitja Ćosić, Simon Maljevac, William Mejías, Ander Pazos, Andrii Chernyshev

“…Introduction Point-of-care dual tests (POCTs) for simultaneously detecting antibodies to HIV and syphilis (dual HIV-syphilis POCTs) have been developed recently and show encouraging performance compared with the reference tests in laboratory-based studies. …”
Get full text

Evaluation of Tissue Tropism and Horizontal Transmission of a Duck Enteritis Virus Vectored Vaccine in One-Day-Old Chicken by Yassin Abdulrahim, Yingying You, Linggou Wang, Zhixiang Bi, Lihua Xie, Saisai Chen, Benedikt B. Kaufer, Armando Mario Damiani, Kehe Huang, Jichun Wang

“…Even though a recently developed DEV vector vaccine expressing the influenza hemagglutinin H5 of highly pathogenic avian influenza (DEV-H5) induces highly detectable anti-HA antibodies, safety issues hamper further vaccine development. …”
Get full text

Interaction effect between vitamin D and gestational diabetes mellitus in the second trimester by MA Ziwen, DING Xiaoying, CHU Liming, ZHANG Yan, ZHANG Aifeng, ZHU Yanjun, WANG Xun, XIE Zhenyu

“…The level of serum 25(OH)D at the time of OGTT were detected and other clinical indicators were followed up.ResultsThe age, systolic blood pressure in early pregnancy, pre-pregnancy BMI, FPG, OGTT 1-hour and 2-hour glucose, GHb, HOMA-IR, TG, AST, Cr, D-D, FDP and SF at 35 weeks’ gestation of the pregnant women were higher in the GDM group than that of the pregnant women in the normal group, while gestational weight gain and serum 25(OH)D level were significantly lower than that of the pregnant women in the normal group. …”
Get full text

Microsatellite analyses reveal genetic diversity and population structure of Cipangopaludina chinensis in Guangxi, China by Xiao-kai Wei, Kang-qi Zhou, Xin-xi Zou, Xue-ling Zhang, Yu-Sen Li, Hui Luo, Yin Huang, Xue-song Du, Jun-qi Qin, Zhong Chen, Yong Lin, Xian-hui Pan, Hua Ye

“…The results showed that a total of 176 alleles in the populations were detected by 12 microsatellite markers. The polymorphism information content (PIC) was 0.523–0.918, indicating that these markers were highly polymorphic (PIC > 0.5). …”
Get full text

Evaluating the Accessibility of Urban Public Open Spaces Based on an Improved 2SFCA Model: A Case Study Within Chengdu’s Second Ring Road by Ling Jian, Xiaojiang Xia, Yinbing Zhao, Yang Zhang, Yuanqiao Wang, Yi Tang, Jie Chang, Changliu Wang

“…The accessibility results are further analyzed using hotspot analysis, and blind zone detection. In terms of supply improvements, the model incorporates additional indicators beyond the spatial area of UPOS, including service quality and the diversity of surrounding environmental service functions, to better evaluate the overall attractiveness of UPOS to residents. …”
Get full text

Identification of Potential Biomarkers and Immune Features of Sepsis Using Bioinformatics Analysis by Fang-Chen Gong, Ran Ji, Yu-Ming Wang, Zhi-Tao Yang, Ying Chen, En-Qiang Mao, Er-Zhen Chen

“…Markers currently in use have shortcomings such as a lack of specificity and failures in the early detection of sepsis. In this study, we aimed to identify key genes involved in the molecular mechanisms of sepsis and search for potential new biomarkers and treatment targets for sepsis using bioinformatics analyses. …”
Get full text

Method and Experimental Research of Transmission Line Tower Grounding Body Condition Assessment Based on Multi-Parameter Time-Domain Pulsed Eddy Current Characteristic Signal Extra... by Yun Zuo, Jie Wang, Xiaoju Huang, Yuan Liu, Zhiwu Zeng, Ruiqing Xu, Yawen Chen, Kui Liu, Hongkang You, Jingang Wang

“…To assess the operational status of a grounding body in a timely manner, this paper proposes a multi-parameter pulsed eddy current (PEC) time-domain characteristic signal corrosion classification method for the detection of the state of a pole tower grounding body. …”
Get full text

Clinical evaluation of corneal ulcer with a portable and smartphone-attachable slit lamp device: Smart Eye Camera by Sadegh Ghafarian, Ahmad Masoumi, Seyed Ali Tabatabaei, Mehdi Yaseri, Eisuke Shimizu, Shintaro Nakayama, Rohan Jeetendra Khemlani, Hiroki Nishimura, Hassan Asadigandomani

“…All corneal ulcers were detected by two ophthalmologists using SEC. Ulcer size evaluated in slit lamp and SEC horizontally (Intraclass Correlation Coefficient (ICC); 0.90, 95% CI; 0.84–0.94) and vertically (ICC; 0.90, 95% CI; 0.84–0.94) is correlated about 90%. …”
Get full text

Increased TLR4 Expression Aggravates Sepsis by Promoting IFN-γ Expression in CD38−/− Mice by Qi Li, Chenyi Wu, Zhenlong Liu, Huiqing Zhang, Yuna Du, Yuxiang Liu, Kuangyu Song, Qiaofa Shi, Rong Li

“…In addition, compared with CD38−/−TLR4mut mice, we found an increase of TLR4 expression and mRNA expression of these cytokines in the kidney of CD38−/− mice, although only increased IFN-γ level was detected in the serum. Taken together, these results demonstrated that an increased TLR4 expression in CD38−/− mice could contribute to the aggravation of AKI through boosting of the production of IFN-γ.…”
Get full text

Optimising fatigue, abdominal pain and faecal incontinence in people with inflammatory bowel disease (IBD-BOOST Optimise): feasibility study of a checklist and algorithm for initia... by Thomas Hamborg, John McLaughlin, Ailsa Hart, Christine Norton, Sonia Bouri, Laura Miller, Jean-Frédéric LeBlanc, Asma Fikree, Imogen Stagg, Fionn Cléirigh Büttner

“…Not all patients accepted algorithm-indicated interventions, but a yield of 43% with symptoms having potentially reversible causes detected is clinically useful. Nurses endorsed ease and utility of the implementation process. …”
Get full text

Soluble Receptor for Advanced Glycation End Products: A Protective Molecule against Intramyocardial Lipid Accumulation in Obese Zucker Rats? by Elena Dozio, Elena Vianello, Francesco Bandera, Erika Longhi, Stefano Brizzola, Manuela Nebuloni, Massimiliano M. Corsi Romanelli

“…Oil red staining was used to detect lipids on frozen heart sections. The lipid metabolism-related transcriptome (84 genes) was analyzed by a specific PCR array. …”
Get full text

Newborn screening for congenital hypothyroidism: worldwide coverage 50 years after its start by Marta Arrigoni, Nitash Zwaveling-Soonawala, Stephen H LaFranchi, A S Paul van Trotsenburg, Christiaan F Mooij

“…Background: Congenital hypothyroidism (CH) is a preventable cause of neurodevelopmental delay in children, detectable by newborn screening (NBS) programs for CH. …”
Get full text

<i>Syntrichia laevipila</i> Brid., a Bryophyta from Northwest Argentina as a Source of Antioxidants and Antimicrobials by Luis Ignacio Jiménez, Florencia Maria Correa Uriburu, José Javier Martínez Chamás, Guillermo Martin Suárez, Iris Catiana Zampini, Mario J. Simirgiotis, María Inés Isla

“…<i>laevipila,</i> were also detected in <i>J. mimosifolia</i>, a substrate of this moss. …”
Get full text