Evaluating a multicomponent intervention for managing kidney outcomes among patients with moderate or advanced chronic kidney disease (CKD): protocol for the Strategies for Kidney... by Tazeen Hasan Jafar, Ngiap Chuan Tan, Mihir Gandhi, Sungwon Yoon, Eric Finkelstein, Peter Moey Kirm Seng, Ruiheng Ong, Anandan Gerard Thiagarajah, Bing Long Lee, Ka Chi To, Aminath Shiwaza Moosa

“…Abstract Background Chronic kidney disease (CKD) poses a global health challenge with high morbidity and mortality rates. Early detection and prompt intervention are critical in preventing progression to end-stage kidney disease (ESKD) and cardiovascular complications. …”
Get full text

Three local plants adapt to ecological restoration of abandoned lead-zinc mines through assembly of rhizosphere bacterial communities by Wei Gao, Shuyi Chen, Xin Yu, Sumin Chen, Caijing Wan, Ying Wang, Peng Wu, Qiang Li

“…IntroductionThe plant restoration and ecological restoration of lead-zinc mines are very important.MethodsIn this study, we used three local plants to carry out ecological restoration of abandoned lead–zinc mining areas and detected the adaptive mechanisms of soil bacterial diversity and function during the ecological restoration of lead–zinc mines through 16S rRNA sequencing.ResultsThe results revealed that lead-zinc mining significantly reduced the soil bacterial diversity, including the Shannon, Simpson, and observed species indices, whereas the planting of the three ecological restoration plants restored the soil microbial diversity to a certain extent, leading to increases in the Shannon index and Observed species indices. …”
Get full text

Comparison of analytical sensitivity of automated microbiological blood culture systems by Lyamin A.V., Ismatullin D.D., Kozlov A.V., Alekseev D.V., Kayumov K.A., Bochkareva P.V., Antipov V.A.

“…At this value and values below, the analyzers did not detect the growth of microorganisms significantly more often. …”
Get full text

Proactive Maintenance and Data-Driven Optimization of Mineral Lubricating Oil in a Gas Engine Cogeneration System Extending Oil Change Intervals for Cost Savings and a Reduced Envi... by Krzysztof Pytel, Roman Filipek, Adam Kalwar, Małgorzata Piaskowska-Silarska, Wiktor Hudy, Jana Depešová, Franciszek Kurdziel

“…Regular oil analysis conducted every 1000 operating hours proved critical for early detection of oil degradation, supporting proactive maintenance strategies and ensuring optimal engine performance and longevity.…”
Get full text

Pathogenic and Genetic Characteristics of Helicobacter Pylori, and its Relationship with Drug-Resistance by Nilgün Uyduran Ünal, Adnan Barutçu, Toğrul Nagiyev, Mehmet Ağın, Tülay Kandemir, Oğuz Üsküdar, Figen Doran, Fatih Köksal, Gökhan Tümgör

“…Through histopathology, culture, and glmM-polymerase chain reaction (PCR) techniques, we detected H. pylori. The vacA, cagA, and cagE genes were determined in patients with positive PCR results were positive. …”
Get full text

CD34 evaluation of microvasculature in lung adenocarcinoma and its microvascular density predicts postoperative tumor recurrence by Zijian Qiu, Jiaji Wu, Guanchao Pang, Xia Xu, Jun Lin, Pingli Wang

“…BackgroundAngiogenesis is closely associated with tumor growth and metastasis, and microvascular density (MVD) is currently the clinical standard for evaluating tumor angiogenesis. Thus, the detection of intratumoral MVD is of great significance for understanding disease progression and predicting patient prognosis.MethodsTumor tissue sections of 238 patients with lung adenocarcinoma (LUAD) who underwent radical surgery were retrospectively analyzed. …”
Get full text

Intercropping of Saccharum spp. with Dictyophora indusiata: effects on microbial communities and metabolite profiles during bagasse degradation by Mingzheng Duan, Mingzheng Duan, Xiaojian Wu, Shengfeng Long, Hairong Huang, Xiang Li, Yijie Li, Changning Li, Bin Feng, Jiafu Chen, Defa Zhong, Zhendong Chen, Zeping Wang

“…In addition, unique metabolites such as L-alanine, serine, and oxaloacetate were detected in the DIBA treatment, suggesting more efficient bagasse degradation compared with natural processes.ConclusionThe use of macrofungi such as D. indusiata can play a pivotal role in circular agriculture by transforming agricultural waste into valuable soil amendments. …”
Get full text

Biochemical analysis of miR-217 and miR-532 in patients with fibromyalgia by Shymaa E. Ayoub, Azza M. Ahmed, Mostafa Y. Abdelwahed, Abeer A. Khalefa, Aeshah A. Awaji, Samer S. Zekry, Enas G. Ibrahim, Hana M. Eid, Shimaa M. Elasmer, Reham Fares

“…The miR-217 and miR-532 serum expressions were detected using quantitative real-time PCR (qRT-PCR). …”
Get full text

Investigation of newborn blood metabolomics in varying intrauterine growth conditions by Shengwen Wang, Xiaofei Lin, Yu Zhou, Xin Yang, Mingming Ou, Linxin Zhang, Yumei Wang, Jing Gao

“…Blood samples were obtained from all newborns between 3 and 5 days after birth and analyzed using tandem mass spectrometry to detect blood metabolites. Subsequently, we screened for different metabolites and metabolic pathways among the groups using the MetaboAnalystR package (Version 1.0.1) in R software (R-3.6.0). …”
Get full text

Induction of annexin-1 at transcriptional and post-transcriptional level in rat brain by methylprednisolone and the 21-aminosteroid U74389F by P. H. Voermans, K. G. Go, G. J. Ter Horst, M. H. J. Ruiters, E. Solito, L. Parente

“…In ependyma, choroid plexus, meninges, and vascular walls there was no Anx-1 mRNA transcription detectable. An opposite profile was shown by the Anx-1 immunoreactivity, the protein was present in control animals as well as the steroid-pretreated animals, suggesting that here the protein was either from systemic origin, or has diffused from adjacent structures. …”
Get full text

A novel cytoprotective organ perfusion platform for reconstructing homeostasis of DCD liver while alleviating IRI injury by Tingting Lan, Mingxing Yu, Tao Ming, Hong Wang, Juan Deng, Shuhan Cheng, Zhongyang Shen, Deling Kong

“…Besides, with isolated rat livers from donation after circulatory death (DCD) perfusion with ADSCs for 6 h by the BBGs, we detected fewer apoptotic cells and a reduced inflammatory response, evidenced by down‐regulated TNF‐α expression. …”
Get full text

Palm Tocotrienol Activates the Wnt3a/β-Catenin Signaling Pathway, Protecting MC3T3-E1 Osteoblasts from Cellular Damage Caused by Dexamethasone and Promoting Bone Formation by Norfarahin Abdullah Sani, Nur Aqilah Kamaruddin, Ima Nirwana Soelaiman, Kok-Lun Pang, Kok-Yong Chin, Elvy Suhana Mohd Ramli

“…Alizarin Red staining was performed to detect calcium deposits. Cellular alkaline phosphatase activity was measured to evaluate osteogenic activity. …”
Get full text

Non-stationarity analysis of flood extremes under climate change and human activities in the Yuan River Basin, China by Ting Wang, Dehua Mao, Meirong Deng, Chang Feng, Guangwei Hu, Jingya Zhang, Yang Zou

“…Temporal variations were detected and non-stationary models were developed by incorporating physically-based covariates under climate change and human activities using the Mann-Kendall test, Pettitt test, and the Generalized Additive Models for Location, Scale, and Shape (GAMLSS) framework. …”
Get full text

Extreme Solar Particle Ejection Event in the Last Few Million Years from Asteroid Itokawa Sample by Tomoya Obase, Ken-ichi Bajo, Yuta Otsuki, Hisayoshi Yurimoto

“…Extreme solar particle ejection events in the past 11,000 yr have been detected by sharp increases of cosmogenic isotopes in annual tree rings and ice cores. …”
Get full text

Phenotypic divergence across populations does not affect habitat selection in an Amazonian poison frog by Martin Mayer, Lia Schlippe Justicia, Bibiana Rojas

“…We found little variation in habitat selection among populations or between disturbed and pristine areas but detected strong general patterns across populations. …”
Get full text

Prospective evaluation of the impact of repeated whole prison testing for hepatitis C by Stuart McPherson, Naw April Phaw, Manoj Valappil, Carolyn Miller, Craig Thompson, Francesca McCullough, Caroline Allsop, Kate McQue, Ryan Jelley, Jenna Kerry, Jodi Aldridge, Tony Jefferson, Colin Lawton, Lee Christensen, Aung Min Thant

“…Universal reception HCV testing is recommended, but acceptance can be suboptimal. To detect and treat missed HCV infections, a high-intensity test and treat (HITT) programme was introduced to rapidly test entire prisons. …”
Get full text

Paediatric nephroblastoma at a South African tertiary hospital: A 21-year retrospective analysis by E Brits, E Gerber, I Iroka, L Mgidlana, J Willoughby, S Dhlamini, P Nxumalo, S Sefadi, A Mthembu, J B Sempa

“…Consequently, there is an urgent need for enhanced early detection strategies, addressing survival rate disparities and late-stage presentations to improve outcomes. …”
Get full text

Cross-sectional study exploring barriers to adverse drug reactions reporting in community pharmacy settings in Dhaka, Bangladesh by Tahir Mehmood Khan, Mohammad Nurul Amin, Syed Masudur Rahman Dewan, Mohammad Safiqul Islam, Mizanur Rahman Moghal, Long Chiau Ming

“…Moreover, a lack of knowledge about pharmacotherapy and the detection of ADRs was another major factor hindering their reporting (RII=0.731).Conclusions The Directorate of Drug Administration in Bangladesh needs to consider the results of this study to help it improve and simplify ADR reporting in Bangladeshi community pharmacy settings.…”
Get full text

Adverse health effects after breast cancer up to 14 years after diagnosis by Marianne J. Heins, Kelly M. de Ligt, Janneke Verloop, Sabine Siesling, Joke C. Korevaar, Annette Berendsen, Daan Brandenbarg, Anneriet Dassen, Agnes Jager, Jacqueline Hugtenburg, Gerda van der Weele

“…Insight in individual risks may assist healthcare professionals in managing patient expectations and improve monitoring, detection and treatment of adverse health effects.…”
Get full text

The Combinational Effect of Enhanced Infection Control Measures and Targeted Clinical Metagenomics Surveillance on the Burden of Endemic Carbapenem and Other β-Lactam Resistance Am... by Athina Giampani, Maria Simitsopoulou, Maria Sdougka, Christos Paschaloudis, Emmanuel Roilides, Elias Iosifidis

“…The direct implementation of a targeted and customized rapid molecular detection assay to clinical samples seems to be an effective clinical tool for the evaluation of EICM measures.…”
Get full text