Population genetics of spinoсerebellar ataxias caused by polyglutamine expansions by A. N. Shuvaev, O. S. Belozor, M. V. Smolnikova, D. A. Yakovleva, Andr. N. Shuvaev, O. M. Kazantseva, E. A. Pozhilenkova, O. I. Mozhei, S. Kasparov

“…Development of new methods of detection of polyglutamine SCAs will allow the scientists to better understand how they lead to the brain disease, the means of their spread in the population and to develop better methods for therapy and prevention of these diseases.…”
Get full text

The link between sleep bruxism and oxidative stress based on a polysomnographic study by Michal Fulek, Weronika Frosztega, Mieszko Wieckiewicz, Anna Szymanska-Chabowska, Pawel Gac, Rafal Poreba, Grzegorz Mazur, Milena Sciskalska, Marta Kepinska, Adrian Martuszewski, Helena Martynowicz

“…Using successive receiver operating characteristic (ROC) curves, optimal cut-off values were identified, enabling the detection of correlations with moderate (BEI > 2) and severe (BEI > 4) sleep bruxism. …”
Get full text

Metabolic Alteration in Hepatocellular Carcinoma: Mechanism of Lipid Accumulation in Well-Differentiated Hepatocellular Carcinoma by Hideo Suzuki, Motoyuki Kohjima, Masatake Tanaka, Takeshi Goya, Shinji Itoh, Tomoharu Yoshizumi, Masaki Mori, Mariko Tsuda, Motoi Takahashi, Miho Kurokawa, Koji Imoto, Shigeki Tashiro, Akifumi Kuwano, Masaki Kato, Seiji Okada, Makoto Nakamuta, Yoshihiro Ogawa

“…Similar alterations of metabolic genes were detected in NASH-HCC mice, which were consistent with the results of metabolomics. …”
Get full text

Comparison of clinical metagenomics with 16S rDNA Sanger sequencing for the bacteriological diagnosis of culture-negative samples by Camille d’Humières, Skerdi Haviari, Marie Petitjean, Laurène Deconinck, Signara Gueye, Nathan Peiffer-Smadja, Lynda Chalal, Naima Beldjoudi, Geoffrey Rossi, Yann Nguyen, Charles Burdet, Ségolène Perrineau, Diane Le Pluart, Roza Rahli, Michael Thy, Piotr Szychowiak, Xavier Lescure, Véronique Leflon-Guibout, Victoire de Lastours, Etienne Ruppé

“…Clinical metagenomics (CMg), i.e. the sequencing of a sample’s entire nucleic acids, may allow for the identification of bacteria not detected by conventional methods. Here, we tested the performance of CMg compared to 16S rDNA sequencing (Sanger) in 50 patients with suspected bacterial infection but negative cultures. …”
Get full text

Identification of MYC and STAT3 for early diagnosis based on the long noncoding RNA-mRNA network and bioinformatics in colorectal cancer by Kunhou Yao, Hao Fan, Tiancheng Yang, Can Yang, Guibin Wang, Xingwang Li, Xin-Ying Ji, Qun Wang, Shaojiang Lv, Shihao Guo

“…Most CRC cases are diagnosed at intermediate to advanced stages, and reliable biomarkers for early detection are lacking. Long non-coding RNAs (lncRNAs) have been implicated in various cancers, including CRC, playing key roles in tumor development, progression, and prognosis.MethodsA comprehensive search of the PubMed database was conducted to identify relevant studies on the early diagnosis of CRC. …”
Get full text

Morphology of 137 Fast Radio Bursts Down to Microsecond Timescales from the First CHIME/FRB Baseband Catalog by Ketan R. Sand, Alice P. Curtin, Daniele Michilli, Victoria M. Kaspi, Emmanuel Fonseca, Kenzie Nimmo, Ziggy Pleunis, Kaitlyn Shin, Mohit Bhardwaj, Charanjot Brar, Matt Dobbs, Gwendolyn M. Eadie, B.M. Gaensler, Ronniy C. Joseph, Calvin Leung, Robert Main, Kiyoshi W. Masui, Ryan Mckinven, Ayush Pandhi, Aaron B. Pearlman, Masoud Rafiei-Ravandi, Mawson W. Sammons, Kendrick Smith, Ingrid H. Stairs

“…Most multicomponent bursts in our sample exhibit subburst separations of ≤1 ms, with no bursts showing separations < 41 μ s, even at a time resolution of 2.56 μ s, but both scattering and low signal-to-noise ratio can hinder the detection of additional components. Lastly, given the morphological diversity of our sample, we suggest that one-off and repeating FRBs can come from different classes but have overlapping property distributions.…”
Get full text

Enhancing Infection Control in ICUS Through AI: A Literature Review by Aditya Amit Godbole, Paras, Maanya Mehra, Sumitaksha Banerjee, Poulami Roy, Novonil Deb, Sarang Jagtap

“…Real‐time patient monitoring and alert systems powered by AI are shown to enhance infection detection and patient outcomes. The paper also addresses AI's role in automating sterilization and disinfection, with studies affirming its effectiveness in reducing infections. …”
Get full text

Lactiplantibacillus plantarum ameliorated the negative effects of a low-protein diet on growth performance, antioxidant capacity, immune status, and gut microbiota of laying chicks by Lele Hou, Huiling Qiu, Jihong Dong, Huawei Liu, Shansong Gao, Fu Chen

“…The growth performance, antioxidant capacity, immune status, and gut microbiota of laying chickens were detected. We found that L. plantarum supplementation increased the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), total antioxidant capacity (T-AOC), and levels of immunoglobulin (Ig) A, IgG, and interleukin-10 (IL-10) in serum of 17% protein +1.0 × 109 CFU/kg L. plantarum (LPL) compared to the 19% protein group (control). …”
Get full text

Residential Indoor and Outdoor PM Measured Using Low-cost Monitors during the Heating Season in Monroe County, NY by Andrea R. Ferro, Naděžda Zíková, Mauro Masiol, Gursumeeran P. Satsangi, Thomas Twomey, David C. Chalupa, David Q. Rich, Philip K. Hopke

“…While the accuracy of LCMs is inconsistent and source dependent, the LCMs provided reasonable precision for estimating indoor/outdoor (I/O) ratios based on laboratory and field testing, understanding the relationship between indoor sources and concentration, and comparing PM concentrations across residences for the detected size range (0.5–3 µm). The indoor PM2.5 concentration pattern showed clear morning and evening peaks as well as higher indoor concentrations during the weekends when people are typically at home. …”
Get full text

Prevalence of Dental Caries in Schoolchildren from the Galapagos Islands: ESSO-Gal Cohort Report by Ana Armas-Vega, Juan Marcos Parise-Vasco, María Cristina Díaz-Segovia, David Alejandro Arroyo-Bonilla, María José Cabrera-Dávila, María Christel Zambrano-Bonilla, Ingrid Ordonez-Romero, Andrea Caiza-Rennella, Andrea Zambrano-Mendoza, Celia Ponce-Faula, Andrés Viteri-García

“…The prevalence of dental caries was assessed using the International Caries Detection and Assessment System (ICDAS II) criteria, while the presence of dental biofilm was assessed using the Silness–Löe index. …”
Get full text

Advancing privacy-aware machine learning on sensitive data via edge-based continual µ-training for personalized large models by Zhaojing Huang, Leping Yu, Luis Fernando Herbozo Contreras, Kamran Eshraghian, Nhan Duy Truong, Armin Nikpour, Omid Kavehei

“…This paper introduces an innovative method for fine-tuning a large multi-label model for abnormality detection, utilizing a smaller trainer and advanced knowledge distillation techniques. …”
Get full text

Fermented soil amendments made from stabilized biosolids and fly ash improve maize (Zea mays L.) nutrition and growth by Karla E. Cortés-Tello, Pablo F Jaramillo-López

“…Cadmium and lead concentrations were below the detection limits both in the soil amendments and in the tissue of maize plants.…”
Get full text

Experimental study of the effects of siestas on the nocturnal sleep quality and thermal comfort levels under thermoneutral environment in summer by Huili Yu, Xue Zhao, Liping Chen, Xiaohui Tian, Shimin Liang, Songtao Hu

“…Higher DA concentration was also detected in the siesta group after the nocturnal sleep. …”
Get full text

Alpha-1 Antitrypsin Deficiency and Pulmonary Morbidity in Patients with Primary Immunodeficiency Disease: A Single-Center Experience by Georg Evers, Arik Bernard Schulze, Michael Thrull, Jan-Philipp Hering, Christoph Schülke, Rainer Wiewrodt, Helmut Wittkowski, Lars Henning Schmidt, Michael Mohr

“…Among the investigated patients, reduced serum AAT levels were detected in 7 patients. With regard to the genotype, PI∗ZZ was found in 2 patients, whereas PI∗MZ was observed in 5 patients. …”
Get full text

Long-term Breast Shape Analysis After Short-scar Reduction Mammaplasty: A Critical View by Daniel Hilewitz, MD, Oren Ganor, MD, Neta Adler, MD, Asaf Olshinka, MD, Dafna Shilo Yaacobi, MD, Lior Har-Shai, MD, Tamir Shay, MD, Michael Icekson, MD, Dean Ad-El, MD, Sagit Meshulam-Derazon, MD

“…The nipple-to-inframammary fold distance, which was intraoperatively shortened by an average of 63%, elongated back to 88% of its preoperative measurements. No correlation was detected between the long-term changes across all 3 measurements, the amount of tissue removed or the satisfaction reported by patients. …”
Get full text

RETRACTED: LncRNA CCAT2 promotes the proliferation and metastasis of colorectal cancer through activation of the ERK and Wnt signaling pathways by regulating GNB2 expression by Jinhai Tian, Xu Cao, Zongying Jiang, Jia Wang, Wan Fan, Shaoting Zhang, Sien Zhao, Jianmin Sun

“…Methods High‐throughput sequencing and RT‐qPCR were used to detect CCAT2 expression in CRC. Functional analyses including CCK8, colony formation, wound healing migration, transwell chamber, and Muse® Cell Analyzer assays were performed to study the effects of CCAT2 gene deletion on CRC cells. …”
Get full text

Podocyte-related biomarkers' role in evaluating renal toxic effects of silver nanoparticles with the possible ameliorative role of resveratrol in adult male albino rats by Eman El-Sayed Khayal, Mona G. Elhadidy, Sulaiman Mohammed Alnasser, Manal Mohammad Morsy, Azza I. Farag, Samah A. El-Nagdy

“…A significant increase in the optical density of transforming growth factor-beta 1 and claudin-1 immunostaining was detected in the Ag NPs group when compared to other groups. …”
Get full text

The Effect of IL-4 Gene Polymorphisms on Cytokine Production in Patients with Chronic Periodontitis and in Healthy Controls by Jirina Bartova, Petra Borilova Linhartova, Stepan Podzimek, Tatjana Janatova, Kazi Svobodova, Antonin Fassmann, Jana Duskova, Jaromir Belacek, Lydie Izakovicova Holla

“…Sixty-two subjects (47 CP patients and 15 healthy controls) with detected two polymorphisms in the IL-4 gene (-590C/T and intron 3 VNTR) were examined. …”
Get full text

Clinicopathological risk factors of oral second primary tumours by Jelena Karan, Miriam P. Rosin, Lewei Zhang, Denise M. Laronde

“…Incorporating these risk predictors into clinical follow-up can enhance early cancer detection and improve patient outcomes.…”
Get full text

Parameters of labile organic carbon as the indicators of the stability of soil organic matter under different land use by Erika Balontayová, Juraj Hreško, Viera Petlušová, Peter Petluš, Bożena Dębska, Tomáš Lošák

“…The aim of this study was to determine the reliable and relatively simple indicators for detecting the chemical and physical stabilizations of OC, which would respond sensitively to land use. …”
Get full text