Retargeting Clostridium difficile Toxin B to Neuronal Cells as a Potential Vehicle for Cytosolic Delivery of Therapeutic Biomolecules to Treat Botulism by Greice Krautz-Peterson, Yongrong Zhang, Kevin Chen, George A. Oyler, Hanping Feng, Charles B. Shoemaker

“…Development of botulism antidotes will require neuronal delivery of agents that inhibit or destroy the BoNT protease. Here, we investigated the potential of engineering Clostridium difficile toxin B (TcdB) as a neuronal delivery vehicle by testing two recombinant TcdB chimeras. …”
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Experimental and Numerical Study on Fracture Characteristics of Interface between In Situ Engineered Cementitious Composites and Steel Deck by Weiwei Han, Shuyin Wu, Xue Gao, Xinyao Zong, Jingsong Shan

“…The fracture effect produced by the hydrodynamic pressure of the interfacial water-bearing crack was far less than the fracture toughness of the interface, which indicated that the hydrodynamic pressure could hardly destroy the interface at one time but might cause the erosion fatigue damage of the interface.…”
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Recent advances in nanotechnology for Parkinson’s disease: diagnosis, treatment, and future perspectives by Virendra Kumar Yadav, Seshathiri Dhanasekaran, Nisha Choudhary, Deepak Nathiya, Vishal Thakur, Rachna Gupta, Sheersha Pramanik, Pankaj Kumar, Nishant Gupta, Ashish Patel

“…Parkinson’s disease is a progressive neurodegenerative disease that destroys substantia nigra dopaminergic neurons, causing tremors, bradykinesia, rigidity, and postural instability. …”
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Improving ferroptosis-mediated immunotherapy for colorectal cancer through lysosome-targeted photodynamic therapy by Zhian Chen, Yutong Wang, Zhenhao Li, Meijuan Chen, Yingshi Li, Chuyue Lu, Zhenyu Lin, Hua Zheng, Lujia Chen, Qianbing Zhang

“…Upon internalized by cancer cells, TLA was specifically accumulated in lysosome, and which would destroy the integrity of lysosomal membranes and inhibit protective autophagy upon exposure to light irradiation. …”
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Diagenesis and Fluid Flow Variability of Structural Heterogeneity Units in Tight Sandstone Carrier Beds of Dibei, Eastern Kuqa Depression by H. Shi, X. R. Luo, G. L. Lei, L. Q. Zhang, L. K. Zhang, Y. H. Lei

“…Ductile grains or eogenetic calcite cements destroy the reservoir quality of tight compacted or tight carbonate-cemented sandstones. …”
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Cyclooxygenase-2/prostaglandin E2 inhibition remodulated photodynamic therapy-associated immunosuppression for enhanced cancer immunotherapy by Tao Xu, Kehan Liu, Shuqi Mi, Yao Yao, Mengyao Zhang, Shujuan Xue, Feng Zhi, Sally-Ann Cryan, Dawei Ding

“…Photodynamic therapy (PDT) directly destroys cancer cells by producing reactive oxygen species (ROS), and enhances the immunogenicity of ''cold'' tumors by inducing immunogenic cell death (ICD), thereby promoting T cell development against tumors. …”
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A two-patch prey-predator model with predator dispersal driven by the predation strength by Yun Kang, Sourav Kumar Sasmal, Komi Messan

“…Our analytical results combined with bifurcation diagrams suggest that: (1) dispersal may stabilize or destabilize the coupled system; (2) dispersal may generate multiple interior equilibria that lead to rich bistable dynamics or may destroy interior equilibria that lead to the extinction of predator in one patch or both patches; (3) Under certain conditions, the large dispersal can promote the permanence of the system. …”
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Characterization of the Prediabetic State in a Novel Rat Model of Type 2 Diabetes, the ZFDM Rat by Ghupurjan Gheni, Norihide Yokoi, Masayuki Beppu, Takuro Yamaguchi, Shihomi Hidaka, Ayako Kawabata, Yoshikazu Hoshino, Masayuki Hoshino, Susumu Seino

“…As islet architecture was destroyed with age in ZFDM rats, a combination of severe insulin resistance, diminished insulin secretory response to incretin, and intrinsic fragility of the islets may cause the development of T2D in this strain.…”
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Preparation of NiCr/YSZ two-layered burn-resistant coating on γ-TiAl alloys based on plasma surface metallurgy and ion plating methods by Wei D.-B., Li M.-F., Zhou X., Li F.-K., Li S.-Q., Zhang P.-Z.

“…The high-energy laser beam destroyed the surface of γ-TiAl alloy, forming protruding combustion products in ablation zone and splashing residues around ablation zone. …”
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Ultrasound-assisted extraction of polysaccharide from Allium chinense G. Don epidermal waste: Evaluation of extraction mechanism, physicochemical properties, and bioactivities by Jiangfei Li, Guanjun Ye, Zhilong Zhou, Jianlong Wang, Jiayu Wang, Ting Ju, Alejandro Cifuentes, Elena Ibañez, Denis Baranenko, Haitian Zhao, Weihong Lu

“…UAE can efficiently extract ACGDP by changing the composition of the cell wall, destroying the microstructure, and reducing the particle size. …”
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A deep learning ICDNET architecture for efficient classification of histopathological cancer cells using Gaussian noise images by Hui Zong, Wenlong An, Xin Chen, Zhanhui Yang, Heng Zhou, Xiangchao Liu, Jianchu Lin, Chuanyue Zong

“…To address this issue, this study introduces a new hybrid network model, termed ICDNET, designed to fuse global and local features without destroying the integrity of the feature data, thus enhancing the accuracy of medical image classification. …”
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Traumatic Brain Injury and Stem Cell: Pathophysiology and Update on Recent Treatment Modalities by Cesar Reis, Vadim Gospodarev, Haley Reis, Michael Wilkinson, Josileide Gaio, Camila Araujo, Sheng Chen, John H. Zhang

“…In the acute phase, brain tissue destroyed upon impact includes neurons, glia, and endothelial cells, the latter of which makes up the blood-brain barrier. …”
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Influence of Incremental Impact on the Damage of Coal-Rock under Unidirectional Constraint by Hongbao Zhao, Huan Zhang, Jinyu Li, Nansong Ju, Zhijie Wen

“…The cumulative damage degree of coal-rock decreases with the increase of axial pressure, and the number of impact needed to destroy coal-rock is increased. In addition, the damage model of coal-rock was proposed, and the criterion of coal-rock damage was obtained, which shows that the damage degree of coal-rock increases with the increase of impact load and decreases with the increase of static axial load.…”
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Respiratory Epithelium Lined Cyst of the Maxilla: Differential Diagnosis by C. P. Martinelli-Kläy, S. Chatelain, F. Salvado, T. Lombardi

“…It could also be an unusual radicular cyst in which the stratified squamous epithelium was destroyed by inflammation and replaced by a respiratory epithelium of the maxillary sinus.…”
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Ultrastructure of Placenta of Gravidas with Gestational Diabetes Mellitus by Qian Meng, Li Shao, Xiucui Luo, Yingping Mu, Wen Xu, Chao Gao, Li Gao, Jiayin Liu, Yugui Cui

“…On TEM, the distinct ultrastructural alterations indicating the degeneration of terminal villi were found in the GDM placentas as follows: thickening of the basal membrane (BM) of vasculosyncytial membrane (VSM) and the VSM itself, significantly fewer or even absent syncytiotrophoblastic microvilli, swollen or completely destroyed mitochondria and endoplasmic reticulum, and syncytiotrophoblasts with multiple vacuoles. …”
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VMLP neural network design using optimization algorithms to predict spider suspend (Case Study: Watershed Dam Kardeh) by masooume darmani, mohammad nohtani, haydeh ara, Ali golkarian, Salman Sharif Azari

“…One of the most important processes of erosion and sediment transport in streams is the river most complex engineering  issues.this process special effects on water quality indices, action suburbs floor and destroyed much damage to the river and also into the development plans  Lack of continuity sediment sampling and measurement of many existing stations. due to the low number of hydrometric stations in Iran and the lack of continuity of sediment sampling and measuring in many existing stations, on one hand the exact amount of sediment load in many rivers in the country is not available and because of differences in climatic, hydrological and topographical conditions in the country, on the other hand, the preparation and calibration of sediment Erosion Models different regions, is unavoidableCalibration models of erosion and sedimentation in different locations is difficult and requires financial capital andthe time . the But evolutionary optimization algorithm able to resolve this problems of mathematical and experimental methods in this paper, a new optimization algorithm spiders can be made to education And the evolutionary pattern for input (discharge and precipitation) and rain-gauge gauging stations and Watershed Kardeh designated evolutionary algorithms and artificial network performance for 24 year 24-year dam catchment Kardeh for the period studied. …”
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Enhancing Mechanical and Thermal Properties of Polyurethane Rubber Reinforced with Polyethylene Glycol-g-Graphene Oxide by Li Wang, Wen Fu, Wenlong Peng, Haotuo Xiao, Shenglin Li, Jianning Huang, Cuiwen Liu

“…The reason was that the hydrogen bond interactions between MGO and PUR were destroyed and the hidden length was released during the strain process. …”
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Pathological Diagnosis of Systemic Amyloidosis in a New Zealand White Rabbit by LIN Qingqing, DAI Jinlong, CHEN Zhisen, GUO Jianmin, YANG Wei

“…HE staining showed that the splenic tissue structure was destroyed, the white pulp of the spleen was surrounded by dense amyloid deposition in the form of nodular rings, along with pressure atrophy of the white pulp. …”
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Oriental Mysticism in the Works of Konstantin Balmont, the Poet of Symbolism and Poet Laureate of the Russian Language by Marzieh Yahyapour, Masoumeh Motamednia, Janolah Karimi Motahhar

“…The idea of divine religions, which means that only body of man is destroyed by the death and the man returns to God, is also the basis of Russian symbolism, which is frequently seen in Balmont's poetry. …”
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Laser Irradiation Alters the Expression Profile of Genes Involved in the Extracellular Matrix In Vitro by Sandra M. Ayuk, Nicolette N. Houreld, Heidi Abrahamse

“…Healing may be impaired if some of these components are destroyed. Photobiostimulation has demonstrated a stimulatory response in biological processes. …”
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