The bergen 4-day treatment for panic disorder: a longer-term follow-up by Thorstein Olsen Eide, Bjarne Hansen, Kay Morten Hjelle, Stian Solem, Michael G. Wheaton, Thröstur Björgvinsson, Gerd Kvale, Kristen Hagen

“…Confirming these preliminary results in rigorous study designs is needed. Trial registration The study was approved by the Regional Committee for Medical and Health Research Ethics of Northern Norway (REK Nord-2021/209619).…”
Get full text

Keeping Active with Texting after Stroke (KATS): a single-arm feasibility and acceptability study of a behavioural intervention to promote community-based physical activity after s... by Gozde Ozakinci, Stephan U Dombrowski, Andrew Murphy, Albert Farre, Jenna Breckenridge, Jacqui H Morris, Linda A Irvine, Keith Jenkinson

“…Objectives To test the feasibility and acceptability of a text-message-delivered behavioural intervention to promote and maintain physical activity and recovery after stroke rehabilitation.Design A single-arm acceptability and feasibility study.Setting Community rehabilitation services in two Health Board areas in Scotland.Participants People with stroke who could participate in physical activities and use a mobile phone were recruited during rehabilitation and community rehabilitation.Intervention Keeping Active with Texting after Stroke (KATS) is an automated text message-delivered intervention informed by behaviour change theory. …”
Get full text

Impact of dexmedetomidine-ropivacaine versus sufentanil-ropivacaine combination for epidural labour analgesia on neonatal outcomes: a pilot randomised clinical trial by Dong-Xin Wang, Chun-Mei Deng, Ke-Xin Jin, Ting Ding, Yuan Qu

“…Objective To investigate the impact of dexmedetomidine-ropivacaine combination versus sufentanil-ropivacaine combination for epidural labour analgesia on neonatal and maternal outcomes and test the feasibility of a future large, randomised trial.Design A randomised, double-blind, pilot clinical trial from 16 March 2023 to 15 June 2023.Setting A tertiary-care hospital in Beijing, China.Participants 200 women aged≥18 years who had full-term single pregnancy and were scheduled for vaginal delivery with epidural analgesia.Interventions Eligible participants were randomly assigned in a 1:1 ratio to receive self-controlled epidural labour analgesia using ropivacaine supplemented with either dexmedetomidine (0.45 µg/mL for induction and 0.36 µg/mL for maintenance) or sufentanil (0.45 µg/mL for induction and 0.36 µg/mL for maintenance).Main outcomes and measures The primary endpoint was a composite of neonatal morbidity, including 1- or 5 min Apgar score<7, umbilical artery PH<7.1, requirement for immediate assisted ventilation and admission to neonatal ward or intensive care unit within 24 hours. …”
Get full text

Longitudinal DNA methylation profiles in saliva of offspring from mothers with gestational diabetes: associations with early childhood growth patterns by Teresa M. Linares-Pineda, Alfonso Lendínez-Jurado, Alberto Piserra-López, María Suárez-Arana, María Pozo, María Molina-Vega, María José Picón-César, Sonsoles Morcillo

“…Conclusions This study’s longitudinal design reveals stable DNA methylation patterns in saliva samples that differentiate GDM-exposed children from controls across the first year of life, highlighting the feasibility of saliva as a minimally invasive biomarker source. …”
Get full text

An analysis of controlled human infection studies registered on ClinicalTrials.gov by James Wilkinson, Joshua Osowicki, Euzebiusz Jamrozik, Ian J Saldanha, Meta Roestenberg, Danny Toomey, Jupiter Adams-Phipps, John Pietro, Jake Littman, Steffen Kamenicek, Daniel Kaufman

“…The objectives of the current analysis were to (1) evaluate the use of ClinicalTrials.gov for CHIS data reporting and (2) compare CHIS clinical trial participant flow and AE reporting in ClinicalTrials.gov with the same data in corresponding published articles.Design ClinicalTrials.gov records that described a CHIS were included and data were accessed using the Aggregated Analysis of ClinicalTrials.gov application programming interface. …”
Get full text

Hubungan Personal Hygiene Dengan Kejadian Skabies Di Pondok Pendidikan Islam Darul Ulum, Palarik Air Pacah, Kecamatan Koto Tangah Padang Tahun 2013 by Suci Chairiya Akmal, Rima Semiarty, Gayatri Gayatri

“…This study aimed to determine the relationship of personal hygiene with the incidence of scabies in students at boarding Darul Ulum Islamic Education, Palarik, Air Pacah, Padang. Design research is an analytic cross sectional observational study using questionnaires and interviews. …”
Get full text

Maximizing the performance of heat stressed broilers by optimizing starch-to-lipid ratios, digestible amino acid, and metabolizable energy during the finisher phase by Dilshaan Duhra, Denise Beaulieu, Tory Shynkaruk, Juliano C. de Paula Dorigam, Rose Whelan, Karen Schwean-Lardner

“…A {3,3} simplex lattice design was used to assess relative effects and generate predictive models. …”
Get full text

The Association between ER, PR, HER2, and ER−/PR+ Expression and Lung Cancer Subsequent in Breast Cancer Patients: A Retrospective Cohort Study Based on SEER Database by Hong Yu Shao, Bao Tan Hao, Feng Xiao Gao

“…The present study employed a cohort design and utilized data from the Surveillance, Epidemiology, and End Results (SEER) program spanning from 2010 to 2015. …”
Get full text

Lifetime quality of life and cost consequences of delays in endovascular treatment for acute ischaemic stroke: a cost-effectiveness analysis from a Singapore healthcare perspective by Mayank Goyal, Weiyi Ni, Deidre Anne De Silva, Yu Li Ng, Kelvin Tan, Wolfgang G Kunz

“…This study determined the impact of EVT treatment delay on cost effectiveness of EVT in the Singapore healthcare setting.Design A short-term decision tree and long-term Markov health state transition model was constructed. …”
Get full text

Lipid Profile in Adolescent Girls with Type 1 Diabetes Mellitus and Hyperandrogenemia by Agnieszka Zachurzok, Grazyna Deja, Aneta Gawlik, Agnieszka Drosdzol-Cop, Katarzyna Klimek, Ewa Malecka-Tendera

“…The study aim was to evaluate whether hyperandrogenemia in adolescent girls with type 1 diabetes mellitus (T1DM) may adversely influence lipid profile. Design and Participants. Lipid levels in 16 diabetic girls with biochemical hyperandrogenemia (T1DM-H) aged 16.3 ± 1.2 years were compared to 38 diabetic girls with normal androgen levels (T1DM-N) aged 15.8 ± 1.2 years. 15 healthy girls served as controls (CG). …”
Get full text

A novel model-based meta-analysis to indirectly estimate the comparative efficacy of two medications: an example using DPP-4 inhibitors, sitagliptin and linagliptin, in treatment o... by Yan Gong, James Rogers, Christian Friedrich, Sanjay Patel, Alexander Staab, Jorge Luiz Gross, Daniel Polhamus, William Gillespie, Brigitta Ursula Monz, Silke Retlich

“…Comparison of two oral dipeptidyl peptidase (DPP)-4 inhibitors, sitagliptin and linagliptin, for type 2 diabetes mellitus (T2DM) treatment was used as an example.Design Systematic review with MBMA.Data sources MEDLINE, EMBASE, http://www.ClinicalTrials.gov, Cochrane review of DPP-4 inhibitors for T2DM, sitagliptin trials on Food and Drug Administration website to December 2011 and linagliptin data from the manufacturer.Eligibility criteria for selecting studies Double-blind, randomised controlled clinical trials, ≥12 weeks’ duration, that analysed sitagliptin or linagliptin efficacies as changes in glycated haemoglobin (HbA1c) levels, in adults with T2DM and HbA1c >7%, irrespective of background medication.Model development and application A Bayesian model was fitted (Markov Chain Monte Carlo method). …”
Get full text

Evaluating the Effectiveness of a Multimodal Psychotherapy Training Program for Medical Students in China: Protocol for a Randomized Controlled Trial by Tao Pei, Yinan Ding, Jinsong Tang, Yanhui Liao

“…ObjectiveThis study involves a randomized controlled trial of a 2-day multimodal intensive educational intervention designed to evaluate the effectiveness of a new psychotherapy teaching program for medical students and residents in China. …”
Get full text

Psychometric properties of the Iranian version of the polycystic ovary syndrome quality of life questionnaire for married and unmarried women with PCOS: PCOSQoL-47 and PCOSQoL-42 by Fatemeh Bazarganipour, Seyed Abdolvahab Taghavi, Ali Montazeri, Fazlollah Ahmadi, Zahra Derakhshideh, Zahra Asadikalameh

“…Methods This study employed a cross-sectional design. Following the linguistic validation of the Iranian adaptation of the PCOSQoL-47 and PCOSQoL-42, a panel of experts reviewed the items through an evaluation of the content validity index (CVI) and content validity ratio (CVR). …”
Get full text

KAJIAN DESAIN LANSKAP KORIDOR JALAN DAGO BERDASARKAN PERSEPSI MASYARAKAT DALAM MENDUKUNG CITY BRANDING KOTA BANDUNG by Kusriantari Fenny Aprillia, Estuti Rochimah, Estuti Rochimah

“…Therefore this research has the purpose to uncover the extent of the landscape corridor design of Dago after revitalization can support city branding of Bandung City, which is Paris Van Java. …”
Get full text

Exploring public perceptions and awareness of Parkinson's disease: A scoping review. by Sophie Crooks, Gillian Carter, Christine Brown Wilson, Lisa Wynne, Patrick Stark, Michail Doumas, Matthew Rodger, Emma O'Shea, Gary Mitchell

“…All 23 studies adopted some aspect of cross-sectional design. Three themes emerged from the studies, the first being public knowledge of symptoms, causes and treatment of PD and this highlighted a lack of understanding about the disease. …”
Get full text

The differentiated impacts of interprovincial trade on achieving nine environment-related SDGs in China by Xiaoyu Duan, Qingxu Huang, Ziwen Liu, Ling Zhang, Penghui Li, Chunyang He, Delin Fang, Zhenci Xu, Yihao Li

Get full text

Combinatorial functionomics identifies HDAC6-dependent molecular vulnerability of radioresistant head and neck cancer by Sharon Pei Yi Chan, Celestia Pei Xuan Yeo, Boon Hao Hong, Evelyn Mui Cheng Tan, Chaw Yee Beh, Eugenia Li Ling Yeo, Dennis Jun Jie Poon, Pek Lim Chu, Khee Chee Soo, Melvin Lee Kiang Chua, Edward Kai-Hua Chow

“…In this study, we utilized a combinatorial functionomics approach, the Quadratic Phenotypic Optimization Platform (QPOP), to rationally design drug pairings that exploit the molecular fingerprint and vulnerability of established in vitro isogenic radioresistant (RR)-HNC models. …”
Get full text

Clinical evidence of acupuncture for amnestic mild cognitive impairment: A systematic review and meta-analysis of randomized controlled trials by Guangyao Lin, Stella Lim Jin Yie, Shanshan Guo, Xuanling Li, Lianwei Xu

“…There is a need for larger-scale multicenter RCTs using standardised training protocols and more rigorous designs to confirm the conclusions further. Registration: This study was registered in the International Prospective Register of Systematic Reviews (PROSPERO). …”
Get full text

Evaluasi User Experience Aplikasi “J-KOPI (Jember Kota Pintar)” Menggunakan Metode Survei Dengan User Experience Questionnaire Dan User Interview by Pradiptya Kahvi Sugiharto, Satrio Hadi Wijoyo, Mochamad Chandra Saputra

“…Based on these problems, recommendations for improvement were designed, followed by retesting. The improvement results show that it has succeeded in improving the user experience for all aspects of the UEQ questionnaire and the increase in user experience on the UEQ benchmark for the Attractiveness and Stimulation scales reached the "very good" category. …”
Get full text

Tracking hydrothermal infiltration within light oil reservoirs using organic geochemical proxies in the Shunbei area of Tarim Basin in China by Jian Gao, Shaojie Li, Huan Li, Zicheng Cao, Huili Li, Feng Geng, Jun Han, Cheng Huang

“…To resolve this puzzle, this study was designed to unravel the potential thermal impact of hydrothermal infiltration on hydrocarbons according to molecular and stable carbon isotopic compositions of oils and associated natural gases, reflectance analysis of solid bitumen, and fluid inclusion thermometry. …”
Get full text