Overview of systematic reviews on strategies to improve treatment initiation, adherence to antiretroviral therapy and retention in care for people living with HIV: part 1 by Lehana Thabane, Shari Margolese, Lawrence Mbuagbaw, Beth Rachlis, Winston Husbands, Carmen Logie, Marek Smieja, Elizabeth Alvarez, Daeria O Lawson, Anisa Hajizadeh, Annie Wang, Dominik Mertz, Anita C Benoit, Lisa Puchalski Ritchie, Babalwa Zani

“…Knowledge gaps were the types of participants included in primary studies (vulnerable populations not included), poor research quality of primary studies and poorly tailored interventions (not designed for vulnerable populations). Digital, mixed and peer/community-based interventions were reported to be effective across the continuum of care.Conclusions Interventions along the care cascade are mostly focused on adherence and do not sufficiently address all vulnerable populations.…”
Get full text

Automatic vessel segmentation and reformation of non-contrast coronary magnetic resonance angiography using transfer learning-based three-dimensional U-net with attention mechanism by Lu Lin, Yijia Zheng, Yanyu Li, Difei Jiang, Jian Cao, Jian Wang, Yueting Xiao, Xinsheng Mao, Chao Zheng, Yining Wang

“…ABSTRACT: Background: Coronary magnetic resonance angiography (CMRA) presents distinct advantages, but its reliance on manual image post-processing is labor-intensive and requires specialized knowledge. This study aims to design and test an efficient artificial intelligence (AI) model capable of automating coronary artery segmentation and reformation from CMRA images for coronary artery disease (CAD) diagnosis. …”
Get full text

Impact of a phone call with a medical student/general practitioner team on morbidity of chronic patients during the first French COVID-19 lockdown (COVIQuest): a cluster randomised... by Bruno Giraudeau, Estelle Boivin, Vincent Camus, Agnes Caille, Olivier Saint-Lary, Jean-Pierre Lebeau, Stéphanie Sidorkiewicz, Denis Pouchain, Maeva Jego, Sophie Sun, Denis Angoulvant, Wissam El-Hage, Sébastien Bruel, Clarisse Dibao-Dina, Julie Léger, Isabelle Ettori-Ajasse, Juliette Chambe, Karim Abou-Mrad-Fricquegnon, Baptiste Motte, Benoit Chiron, Cam-Anh Khau, Tiphanie Bouchez, Maria Ghali, Leslie Guillon-Grammatico, Emeline Laurent, Rémy Boussageon

“…The objective of COVIQuest was to evaluate whether a general practitioner (GP)-initiated phone call to patients with CVD and MHD during the COVID-19 lockdown could reduce the number of hospitalisation(s) over a 1-month period.Design This is a cluster randomised controlled trial. …”
Get full text

Evaluation of a transdiagnostic mental health intervention in German primary care: study protocol for a parallel-group, two-arm, cluster randomised controlled pilot study by Christopher Ebert, Marie Vogel, Jochen Gensichen, Hanna Reif, Lena Grögor, Lukas Junker, Thomas Ehring, Alkomiet Hasan, Stefan Leucht, Kirsten Lochbühler, for the POKAL-Group

“…Findings may inform the design of a main trial by identifying barriers to the transdiagnostic intervention’s feasibility and acceptability, whilst advancing treatment delivery protocols to support effectiveness. …”
Get full text

Laminated Veneers with Stratified Feldspathic Ceramics by Henrique Tuzzolo Neto, Wagner Ferreira do Nascimento, Larissa Erly, Rodrigo Alves Ribeiro, Jorge de Sá Barbosa, Jessica Mina Zambrana, Lariça Barbosa Raimundo, Cristiane da Silva Mendes, Ivan Pereira da Silva, Alfredo Mikail Melo Mesquita, Daniela Miranda Richarte de Andrade Salgado, Claudio Costa

“…This clinical case report was used to design the digital smile, which guided the production of the diagnostic waxing of the superior model. …”
Get full text

Oral human papillomavirus (HPV) prevalence and genotyping among healthy adult populations in the United States and Europe: results from the PROGRESS (PRevalence of Oral hpv infecti... by Laia Alemany, Marisa Felsher, Anna R. Giuliano, Tim Waterboer, Haitham Mirghani, Hisham Mehanna, Craig Roberts, Ya-Ting Chen, Núria Lara, Mark Lynam, Mayara Torres, Montse Pedrós, Emilio Sanchez, Jacque Spitzer, Bradley Sirak, Beatriz Quirós, Gema Carretero, Sonia Paytubi, Edith Morais, Miquel Angel Pavón

“…Summary: Background: HPV-related oropharyngeal squamous cell carcinoma (OPSCC) is increasing in incidence, yet there are few well-designed oral HPV epidemiology studies in general populations. …”
Get full text

A blended learning approach for capacity strengthening to improve the quality of integrated HIV, TB, and malaria services during antenatal and postnatal care in LMICs: a feasibilit... by Alice Norah Ladur, Uzochukwu Egere, Marion Ravit, Florence Mgawadere, Christopher Murray, Sarah Ann White, Mohammed Hauwa, Rael Mutai, Lucy Nyaga, Shikuku Duncan, Issak Bashir, Olubunmi Olufunmilola Ayinde, Rukia Bakar, Leonard Katalambula, Carlo Federici, Aleksandra Torbica, Nicholas Furtado, Elizabeth Adjoa Kumah, Charles Ameh

“…Methods A mixed methods design was used. A total of 89 healthcare professionals, were purposively selected. …”
Get full text

Comparison of Gensini score and SYNTAX score for predicting in-stent restenosis in patients with coronary artery disease and drug-eluting stent implantation by Min-Tao Gai, Shi-Qi Yan, Ming-yuan Wang, Amanguli Ruze, Ling Zhao, Qiu-Lin Li, Bang-Hao Zhao, An-Xia Deng, Su Hu, Xiao-Ming Gao

“…A retrospective case-control study and a validating retrospective cohort study were designed. All subjects’ information was collected from the First Affiliated Hospital of Xinjiang Medical University. …”
Get full text

Exploring the relationship between mental health issues and academic performance of undergraduate students in a Ghanaian tertiary institution: a cross-sectional study by Andrew Nketsia Arthur, Joanne Fraikue, Bijoux Adu-Amankwah, Richard Ofori, Dorcas Sekyi, Abena Afrakomah Boateng, Elsie Asamoah, Seth Christopher Yaw Appiah

“…Methods The study adopted a quantitative study with an analytical cross-sectional design. Through the multistage sampling technique, structured questionnaires were administered to 384 undergraduate students at Kwame Nkrumah University of Science and Technology (KNUST). …”
Get full text

Citizen science platforms can effectively support early detection of invasive alien species according to species traits by Pablo González‐Moreno, Ana A. Anđelković, Tim Adriaens, Christophe Botella, Jakovos Demetriou, Rita Bastos, Sandro Bertolino, Celia López‐Cañizares, Franz Essl, Živa Fišer, Milka Glavendekić, Marc Herremans, Philip E. Hulme, Viola Jani, Dimitra Katsada, Periklis Kleitou, Nicola La Porta, Katharina Lapin, Marta López‐Darias, Vanessa Lozano, Angeliki F. Martinou, Damiano Oldoni, Esra Per, Stephanie Rorke, Helen E. Roy, Karl‐Manfred Schweinzer, Kristijn Swinnen, Elena Tricarico, Joana R. Vicente, Maarten de Groot, Michael J. O. Pocock

“…Multi‐species citizen science platforms for reporting nature sightings are a valuable source of information on early detection of IAS even though they are not specifically designed for this purpose. We recommend that IAS surveillance programmes should be better connected with citizen science platforms, including greater acknowledgement of the role of citizen scientists and better data flow from smaller citizen science initiatives into global databases, to support efficient early detection. …”
Get full text

Evaluating the impact of a multicountry interprofessional training programme to improve HIV knowledge and clinical confidence among healthcare workers in sub-Saharan Africa: a coho... by Jehan Z Budak, Ian Couper, Michael Reid, Deborah von Zinkernagel, Elsie Kiguli-Malwadde, Maeve Forster, Shayanne Martin, Evelyn Chilemba, Keneilwe Motlhatlhedi, Jessica Celentano, Clara Haruzivishe, David Sears, Judy N. Khanyola, Mmoloki Molwantwa, Fred Semitala, Marietjie de Villiers, Abigail Kazembe

“…Objective To assess the impact of an interprofessional case-based training programme to enhance clinical knowledge and confidence among clinicians working in high HIV-burden settings in sub-Saharan Africa (SSA).Setting Health professions training institutions and their affiliated clinical training sites in 12 high HIV-burden countries in SSA.Participants Cohort comprising preservice and in-service learners, from diverse health professions, engaged in HIV service delivery.Intervention A standardised, interprofessional, case-based curriculum designed to enhance HIV clinical competency, implemented between October 2019 and April 2020.Main outcome measures The primary outcomes measured were knowledge and clinical confidence related to topics addressed in the curriculum. …”
Get full text

Developing an automatic treatment record review system for quality assurance of patient treatment delivery in radiation therapy by Peng Huang, Yingjie Xu, Fukui Huan, Yanxin Zhang, Min Ma, Kuo Men, Jianrong Dai

“…Eight review categories (parameter consistency, treatment completeness, treatment progression, image guidance, override, treatment couch, documentation, and treatment mode) are created. Tailored rules are designed for various review items to automate the review process. …”
Get full text

Is grip strength linked to body composition and cardiovascular risk markers in primary schoolchildren? Cross-sectional data from three African countries by Juerg Utzinger, Nicole Probst-Hensch, Honorati Masanja, Uwe Pühse, Bassirou Bonfoh, Ivan Müller, Cheryl Walter, Rosa Du Randt, Stefanie Gall, Siphesihle Nqweniso, Peter Steinmann, Markus Gerber, Fredros O Okumu, Serge Ayekoé, Jean T Coulibaly, Dao Daouda, Bomey Clément Gba, Benal Kouassi, Sylvain G Traoré, Marceline F Finda, Elihaika G Minja, Getrud J Mollel, Johanna Beckmann, Christin Lang, Kurt Z Long

“…Therefore, this study examines whether HGS is associated with body composition and markers of cardiovascular risk in children from three sub-Saharan African countries.Design Cross-sectional study.Setting Public primary schools (grade 1–4) in Taabo (Côte d’Ivoire), Gqeberha (South Africa) and Ifakara (Tanzania).Participants Data from 467 children from Côte d’Ivoire (210 boys, 257 girls), 864 children from South Africa (429 boys, 435 girls) and 695 children from Tanzania (334 boys, 361 girls) were analysed.Primary and secondary outcome measures Body composition (assessed via bioelectrical impedance analysis) was the primary outcome. …”
Get full text

Cohort profile: the ChicagO Multiethnic Prevention and Surveillance Study (COMPASS) by Habibul Ahsan, Farzana Jasmine, Muhammad G Kibriya, Briseis Aschebrook-Kilfoy, Liz Stepniak, Rajan Gopalakrishnan, Andrew Craver, Paul Zakin, Saira Tasmin, Karen E Kim, Kathleen H Goss, Marcy List, Michelle LeBeau

“…We will supplement self-reported data with electronic medical records, expand the collection of biometrics and biosamples to facilitate increasing digital epidemiological study designs and link to state and/or national level databases to ascertain outcomes. …”
Get full text

Alterations in DNA Damage Repair Genes Before and After Neoadjuvant Cisplatin-based Chemotherapy in Muscle-invasive Bladder Cancer by Ursula Lemberger, Büsra Ernhofer, Sigurd Krieger, Andreas Bruchbacher, André Oszwald, Ekaterina Laukhtina, Andrea Haitl, Melanie R. Hassler, Bernhard Englinger, Eva Compérat, Shahrokh F. Shariat

“…Methods: Matched tissue from 46 patients with MIBC was investigated via Ion Torrent–based next-generation sequencing using a self-designed panel of 30 DDR genes. Phosphorylation of γ-histone 2A.X (H2AX) was analyzed via immunohistochemistry to evaluate DNA damage. …”
Get full text

Comparing physician associates and foundation year two doctors-in-training undertaking emergency medicine consultations in England: a mixed-methods study of processes and outcomes by Simon de Lusignan, Mary Halter, Carly Wheeler, Laura Nice, Sally Brearley, James Ennis, Jonathan Gabe, Heather Gage, Phil Begg, Chao Wang, Jim Parle, Vari Drennan

“…Objectives To compare the contribution of physician associates to the processes and outcomes of emergency medicine consultations with that of foundation year two doctors-in-training.Design Mixed-methods study: retrospective chart review using 4 months’ anonymised clinical record data of all patients seen by physician associates or foundation year two doctors-in-training in 2016; review of a subsample of 40 records for clinical adequacy; semi-structured interviews with staff and patients; observations of physician associates.Setting Three emergency departments in England.Participants The records of 8816 patients attended by 6 physician associates and 40 foundation year two doctors-in-training; of these n=3197 had the primary outcome recorded (n=1129 physician associates, n=2068 doctor); 14 clinicians and managers and 6 patients or relatives for interview; 5 physician associates for observation.Primary and secondary outcome measures The primary outcome was unplanned re-attendance at the same emergency department within 7 days. …”
Get full text

Association between active tobacco use during pregnancy and infant respiratory health: a systematic review and meta-analysis by Billie Bonevski, Gillian Sandra Gould, Joerg Mattes, Vanessa E Murphy, Ediane de Queiroz Andrade, Carla Rebeca Da Silva Sena, Adam Collison

“…Objective To evaluate what is known about active tobacco use during pregnancy and the association with infant respiratory health.Design Systematic review and meta-analysis using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.Data sources MEDLINE, EMBASE, Cochrane, CINAHL, and Maternity and Infant Care were searched thoroughly until June 2020.Eligibility criteria for selecting studies We included case–control and cohort studies estimating the association between active tobacco use during pregnancy and infant respiratory health (wheezing and apnoea) and lung function parameters in the first 12 months of life.Data extraction and synthesis Extraction and risk of bias assessment were conducted by two independent reviewers. …”
Get full text

Efficacy and safety of super selective bronchial artery coil embolisation for haemoptysis: a single-centre retrospective observational study by Daijiro Kabata, Ayumi Shintani, Masanori Akira, Masahiko Hara, Hideo Ishikawa, Misaki Ryuge, Jun Takafuji, Mihoko Youmoto, Yukio Nagasaka, Kouji Yamamoto

“…The objective of the present study was to evaluate the safety and the 3-year postprocedure haemoptysis-free survival rate of de novo elective ssBAE using platinum coils rather than particles for the treatment of haemoptysis.Design A single-centre retrospective observational study.Setting Hemoptysis and Pulmonary Circulation Center in Japan.Participants A total of 489 consecutive patients with massive and non-massive haemoptysis who underwent de novo elective ssBAE without malignancy or haemodialysis.Interventions ssBAE using platinum coils. …”
Get full text

Development and evaluation of a CRISPR/Cas12a-based diagnostic test for rapid detection and genotyping of HR-HPV in clinical specimens by Lijuan Yin, Ziqian Zhao, Chunhua Wang, Caihong Zhou, Xiuzhen Wu, Baoxue Gao, Liangyuan Wang, Shuli Man, Xinkuan Cheng, Qiankun Wu, Siqi Hu, Hongxia Fan, Long Ma, Hui Xing, Liang Shen

“…This platform not only enables the rapid, highly sensitive, and specific detection and genotyping of 14 types of HR-HPV but also achieves single-tube multiplex detection of 14 HR-HPV types through ingenious design. The outcomes of the detection can be interpreted either through a fluorescence reader or visually. …”
Get full text

Clinical management of community-acquired meningitis in adults in the UK and Ireland in 2017: a retrospective cohort study on behalf of the National Infection Trainees Collaborativ... by Amy Robinson, Kamaljit Khalsa, Arjun Chandna, John Bowen, Viva Levee, Jan Coebergh, Tom Solomon, Clive Graham, David Turner, Robert Tilley, Tim Jones, Susan Hopkins, Matthew Stevens, Daniel White, Celestine Eshiwe, Anna Goodman, Ramandeep Singh, Robert S Heyderman, Nicholas Davies, Joseph Thompson, Ed Moran, Martin Williams, Rhea O’Regan, Simon Tiberi, Jonathan Lambourne, Naomi Bulteel, Susan Larkin, Ruth McEwen, Hassan Paraiso, Aarti Shah, Martin Wiselka, Sylviane Defres, Ernest Mutengesa, Maria Krutikov, Ruth Owen, David Griffith, David Harvey, Trupti Patel, Brendan Davies, Emma Mclean, Joanna Allen, Ali Khan, Alastair Miller, Ashutosh Deshpande, Christopher Green, Lewis Jones, Mark Melzer, Fiona McGill, Amanda Fife, Nimal Wickramasinghe, Stephanie Harris, Ewan Hunter, Jayne Ellis, Benedict Rogers, Imogen Fordham, Elen Vink, Victoria Ward, Anna Smith, Andrew Rosser, Alison Muir, Ken Woodhouse, John Shone, Iain Crossingham, Ryan Jayesinghe, Eavan Muldoon, Avneet Shahi, Terry John Evans, Jeremy Wong, Eloisa MacLachlan, Amy Chue, Karishma Gokani, Katherine Ajdukiewicz, Lucinda Barrett, Frances Edwards, Adam Usher, Mairi McLeod, Su su Htwe, Grace Duane, Nicholas Wong, Jennifer Poyner, Jenni Crane, Ollie Lloyd, Emma Chisholm, Ildiko Kustos, Sam Sutton, M. Estee Torok, Isobel Ramsay, Monica Ivan, Joshua York, Jennifer Ansett, Maithili Varadarajan, Priya Sekhon, James Cruise, Shivani Kanabar, Mirella Ling, Charlotte Milne, Jayanta Sarma, Aline Wilson, Lynn Urquhart, Sahar Eldirdiri, Leila White, Jody Aberdein, Phillip Simpson, Hnin Hay Mar, Keying Tan, Eint Shwe Zin thein, Mahmoud Aziz, Anthony Cadwgan, Natasha Weston, Salman Zeb, Angela Houston, Louise Wootton, Iona Willingham, Aimee Johnson, Ashley Horsley, Eamonn Trainor, Olivier Gaillemin, Nicholas J Norton, Katie Cheung, Megan Duxbury, Emilie Bellhouse, Helena Brezovjakova, Kanitkar Tanmay, Alexsander Dawidziuk, Razan Saman, Hugh Adler, Elshadai Ejere, Yiwen Soo, Wendy Beadles, Heather Sturgeon, Brodie Cameron, David Chadwick Ben Tomlinson, Claire McGoldrick, Katie McDowell, Mpho Molosiwa, Katherine FlackAdrian Kennedy, Phoebe Cross, Fay Perry, Vithusha Inpadhas, Sarathy Selvam, Vhairi Bateman, Henry Wu, Monika Pasztor, Ajanthiha Karunakaran, Basma Soliman, Andrew Blanshard, Harish Reddy, Helen Chesterfield, Ben Schroeder, Tee Keat Teoh, Sathyavani Subbarao, Caryn RosmarinLucy Bell, Emma McGuire, Robert Serafino, Ishaan Bhide, Karanjeet Sagoo, Indran Balakrishnan, Kajal Patel, Barzo Faris, Graeme Calver, Ricky Singh, Hazel Sanghvi, Mohamed Eltayeb, Rathur Haris

“…Objectives To assess practice in the care of adults with suspected community-acquired bacterial meningitis in the UK and Ireland.Design Retrospective cohort study.Setting 64 UK and Irish hospitals.Participants 1471 adults with community-acquired meningitis of any aetiology in 2017.Results None of the audit standards, from the 2016 UK Joint Specialists Societies guideline on diagnosis and management of meningitis, were met in all cases. …”
Get full text