Differentiating Pulmonary Nodule Malignancy Using Exhaled Volatile Organic Compounds: A Prospective Observational Study by Guangyu Lu, Zhixia Su, Xiaoping Yu, Yuhang He, Taining Sha, Kai Yan, Hong Guo, Yujian Tao, Liting Liao, Yanyan Zhang, Guotao Lu, Weijuan Gong

“…Methods Employing a prospective study design from June 2023 to January 2024 at the Affiliated Hospital of Yangzhou University, we assessed the malignancy of pulmonary nodules using the Mayo Clinic model and collected exhaled breath samples alongside lifestyle and health examination data. …”
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Use of cannabis during pregnancy and birth outcomes in an Aboriginal birth cohort: a cross-sectional, population-based study by Deirdre Gartland, Stephanie J Brown, Karen Glover, Fiona K Mensah, Cathy Leane, Jane Yelland, Jackie Ah Kit, Deanna Stuart-Butler, Donna Weetra, Jonathan Newbury

“…We aimed to assess the extent to which adverse birth outcomes are associated with maternal cannabis use and exposure to stressful events and social health issues during pregnancy.Design/setting Cross-sectional, population-based survey of women giving birth to Aboriginal babies in South Australia, July 2011–June 2013. …”
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Adaptive coping mechanisms use and associated factors among adult glaucoma patients attending the University of Gondar Comprehensive Specialized Hospital, Tertiary Eye Care and Tra... by Bisrat Misganaw Geremew, Biruk Fanta Alemayehu, Getenet Shumet Birhan, Biruk Lelisa Eticha, Mahtot Leykun Sisay, Woretaw Endalew Melese, Abebe Tilahun Mekonenne

“…This study aimed to assess the proportion of ACM and associated factors among adult glaucoma patients enrolled at the tertiary eye care and training centre in Northwest Ethiopia.Design An institution-based cross-sectional study.Setting This study was conducted at a tertiary eye care and training centre in Northwest Ethiopia from 15 May 2022 to 30 June 2022.Participants The study included a sample of 398 adult glaucoma patients selected using a systematic random sampling technique.Primary and secondary outcome measures The participants were diagnosed with glaucoma by ophthalmologists. …”
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Assessing the effectiveness of targeted educational interventions on enhancing self-efficacy and foot care practices among diabetic women in Jordan by Heba Hijazi, Heba Hijazi, Rabah Al Abdi, Rabah Al Abdi, Sawsan Abuhammad, Sawsan Abuhammad, Wegdan Bani Issa, Alham Al-Sharman, Alham Al-Sharman, Nesreen Saadeh, Alounoud AlMarzooqi, Fatma Refaat Ahmed, Fatma Refaat Ahmed, Ahmed Hossain, Hadia Radwan, Muhammad Arsyad Subu, Mohamad Alameddine

“…This study aimed to evaluate the effectiveness of targeted health education interventions on self-efficacy and foot care practices among diabetic women in Jordan.MethodsA pretest-posttest, quasi-experimental design was used to collect data from 76 diabetic women at a tertiary hospital in northern Jordan. …”
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Prediction model study focusing on eHealth in the management of urinary incontinence: the Personalised Advantage Index as a decision-making aid by Huibert Burger, Henk van der Worp, Marco H Blanker, Marjolein Y Berger, Anne Martina Maria Loohuis, Nienke Wessels, Janny Dekker, Alec GGA Malmberg

“…Objective To develop a prediction model and illustrate the practical potential of personalisation of treatment decisions between app-based treatment and care as usual for urinary incontinence (UI).Design A prediction model study using data from a pragmatic, randomised controlled, non-inferiority trial.Setting Dutch primary care from 2015, with social media included from 2017. …”
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Bayesian joint-regression analysis of unbalanced series of on-farm trials by Turbet Delof, Michel, Rivière, Pierre, Dawson, Julie C, Gauffreteau, Arnaud, Goldringer, Isabelle, van Frank, Gaëlle, David, Olivier

“…This challenge is not unique to PPB, as many breeding programs use sparse testing or incomplete block designs to evaluate more genotypes, however in PPB genotypes are not always assigned randomly to environments. …”
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Relationship between bacteria and nitrogen dynamics in wastewater treatment oxidation ponds by S. Saneha, T. Pattamapitoon, S. Bualert, O. Phewnil, W. Wararam, N. Semvimol, K. Chunkao, C. Tudsanaton, M. Srichomphu, U. Nachaiboon, O. Wongsrikaew, P. Wichittrakarn, C. Chanthasoon

“…Oxidation ponds act as a natural treatment system for wastewater and are designed to promote the growth and activity of certain bacterial species that remove contaminants from the water. …”
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Do sex differences in the prevalence of ECG abnormalities vary across ethnic groups living in the Netherlands? A cross-sectional analysis of the population-based HELIUS study by Ralf E Harskamp, Anton E Kunst, Hanno L Tan, Renee Bolijn, C Cato ter Haar, Jan A Kors, Pieter G Postema, Marieke B Snijder, Ron J G Peters, Irene G M van Valkengoed

“…The objectives were to investigate (1) sex differences in the prevalence of major and, as a secondary outcome, minor ECG abnormalities, (2) whether patterns of sex differences varied across ethnic groups, by age and (3) to what extent conventional cardiovascular risk factors contributed to observed sex differences.Design Cross-sectional analysis of population-based study.Setting Multi-ethnic, population-based Healthy Life in an Urban Setting cohort, Amsterdam, the Netherlands.Participants 8089 men and 11 369 women of Dutch, South-Asian Surinamese, African Surinamese, Ghanaian, Turkish and Moroccan origin aged 18–70 years without CVD.Outcome measures Age-adjusted and multivariable logistic regression analyses were performed to study sex differences in prevalence of major and, as secondary outcome, minor ECG abnormalities in the overall population, across ethnic groups and by age-groups (18–35, 36–50 and >50 years).Results Major and minor ECG abnormalities were less prevalent in women than men (4.6% vs 6.6% and 23.8% vs 39.8%, respectively). …”
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Assessment of Hemoglobin Variants in Patients Receiving Health Care at the Ho Teaching Hospital: A Three-Year Retrospective Study by Daniel Kpodji Awaitey, Elliot Elikplim Akorsu, Emmanuel Allote Allotey, David Annor Kwasie, Precious Kwablah Kwadzokpui, Philip Apraku Tawiah, Stephen Adomako Amankwah, Albert Abaka-Yawson

“…A retrospective study design was used to extract information from the Hospital Administration and Management Systems (HAMS) on the hemoglobin electrophoresis results and corresponding full blood count results of the SCD and sickle cell anemia (SCA) patients as well as patients who were asked to do Hb electrophoresis irrespective of their sickling status. …”
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Can smoking duration alone replace pack-years to predict the risk of smoking-related oncogenic mutations in non-small cell lung cancer? A cross-sectional study in Japan by Masahiko Ando, Yoshihiko Taniguchi, Akihiro Tamiya, Akihide Matsumura, Koichi Ogawa, Yasuhiro Koh, Hiroyasu Kaneda, Motohiro Izumi, Yoshiya Matsumoto, Kenji Sawa, Mitsuru Fukui, Naoki Yoshimoto, Akihito Kubo, Shun-ichi Isa, Hideo Saka, Tomoya Kawaguchi

“…Objective To investigate whether smoking duration alone can replace pack-years to predict the risk of oncogenic mutations in non-small cell lung cancer (NSCLC).Design A cross-sectional study using the baseline dataset from the Japan Molecular Epidemiology for Lung Cancer Study.Setting Forty-three medical institutions nationwide in Japan.Participants From July 2012 to December 2013, 957 patients with newly diagnosed stage I–IIIB NSCLC who underwent surgery were enrolled, and molecular analyses were performed on 876 samples (from 441 ever-smokers and 435 never-smokers).Main outcomes measured We calculated the area under the receiver operating characteristic curve (AUC) values using logistic regression to compare between the predictive values of smoking duration and pack-years for mutational frequencies in the v-Ki-ras2 Kirsten rat sarcoma (KRAS), tumour suppressor p53 (TP53), and epidermal growth factor receptor (EGFR) genes and for cytosine-to-adenine base substitution (C>A).Results For predicting KRAS mutations, the AUC values for smoking duration and pack-years were 0.746 (95% CI 0.682 to 0.800) and 0.759 (95% CI 0.700 to 0.810), respectively (p=0.058). …”
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Evaluation and mitigation methods for virtual reality motion sickness(面向虚拟现实晕动症的评估与缓解方法) by 顾展滔(GU Zhantao), 丁玎(DING Ding), 陈亦婷(CHEN Yiting), 张文杰(ZHANG Wenjie)

“…Based on these, three mitigation schemes were designed. By collecting subjective and physiological data from 30 participants, the effectiveness of different mitigation solutions under various motion states was evaluated. …”
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Nested case-control study investigating factors affecting initial adoption of HIV self-testing among men who have sex with men in Guangzhou, China: amidst comprehensive service cov... by Yuzhou Gu, JiaLi Yang, Yefei Luo, Lishan Zhan, Fanghua Liu, Wenting Zeng, Huifang Xu, Huifang Xu, Yongheng Lu, Yanshan Cai, Zhigang Han

“…Among the study participants, 43 who initially adopted HIVST during the follow-up period were designated as the case group, while the rest comprised the control group. …”
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Experiences and opinions of adults with type 1 diabetes on the android-based open-source closed-loop system in China: a qualitative study by Chaofan Wang, Daizhi Yang, Jinhua Yan, Ping Ling, Mengyun Lei, Ying Ni, Xiaodi Guo, Qingying Huang

“…This study aimed to explore the experiences and opinions of adult patients with T1D on the AAPS.Design Semi-structured interviews and the Insulin Dosing Systems: Perceptions, Ideas, Reflections and Expectations questionnaires were conducted among patients. …”
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Does diabetes modify the triglyceride–glucose index associated with cardiovascular events and mortality? A meta-analysis of 50 cohorts involving 7,239,790 participants by Jun Zhang, Qiye Zhan, Zhihao Deng, Ling Lin, Zhaolan Feng, Huabin He, Deju Zhang, Huilei Zhao, Xiang Gu, Xiaoping Yin, Peng Yu, Xiao Liu

“…This study aimed to evaluate the association between the TyG index and CVD risk, stratified by diabetes status, as well as the potential modifying effect of diabetic status. Methods/design The PubMed, Cochrane Library, and Embase databases were searched for studies on the associations between the TyG index and cardiovascular events and mortality in patients with and without diabetes from inception to December 2, 2024. …”
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Sex-specific differences in children attending the emergency department: prospective observational study by Joany M Zachariasse, Henriette A Moll, Ian K Maconochie, Ewout W Steyerberg, Daan Nieboer, Dorine M Borensztajn, Claudio F Alves, Frank J Smit, Susanne Greber-Platzer, Claudia M G Keyzer-Dekker

“…Objective To assess the role of sex in the presentation and management of children attending the emergency department (ED).Design The TrIAGE project (TRiage Improvements Across General Emergency departments), a prospective observational study based on curated electronic health record data.Setting Five diverse European hospitals in four countries (Austria, The Netherlands, Portugal, UK).Participants All consecutive paediatric ED visits of children under the age of 16 during the study period (8–36 months between 2012 and 2015).Main outcome measures The association between sex (male of female) and diagnostic tests and disease management in general paediatric ED visits and in subgroups presenting with trauma or musculoskeletal, gastrointestinal and respiratory problems and fever. …”
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Assessment of the general population knowledge about the emergence of Nipah virus outbreak in Bangladesh: A nationwide cross-sectional study by Mobin Ibne Mokbul, Shuvajit Saha, Samiha Nahar Tuli, Fatema Binte Nur, A.M. Khairul Islam, Tariful Islam, Shirsho Shreyan, Alok Bijoy Bhadra, Golam Dastageer Prince, Irfath Sharmin Eva, Mustari Nailah Tabassum, Ferdous Wahid, Md Irfan Bin Kayes, Nazim Hassan Ziad, Mohammad Delwer Hossain Hawlader

“…The current study underscores the importance of evidence-based educational strategies, and may guide government and policymakers to design future targeted interventions to enhance public health literacy and mitigate the spread of NiV in Bangladesh as well as in its neighbouring countries.…”
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Substantia nigra alterations in mice modeling Parkinson’s disease by I. N. Rozhkova, S. V. Okotrub, E. Yu. Brusentsev, T. A. Rakhmanova, D. A. Lebedeva, V. S. Kozeneva, N. A. Shavshaeva, N. V. Khotskin, S. Ya. Amstislavsky

“…To study the mechanisms of this pathology, genetic models in mice have been designed. Transgenic mice of the B6.Cg-Tg(Prnp-SNCA*A53T)23Mkle/J strain (referred to as B6.Cg-Tg further in the text) possess the A53T mutation in the human alpha-synuclein SNCA gene. …”
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The Eczema Bathing Study: Weekly versus daily bathing for people with eczema? Protocol of an online, randomised controlled trial [version 2; peer review: 1 approved, 2 approved wit... by Paul Leighton, Wei Chern Gavin Fong, Ingrid Muller, Laura Howells, Arabella Baker, Eleanor J Mitchell, Eleanor Harrison, Leila Thuma, Yimin Jiang, Lucy Bradshaw, Alan Montgomery, Fiona Cowdel, Matthew J Ridd, Jane Ravenscroft, Reiko J Tanaka, Miriam Santer, Richard Swinden, Nicholas Hilken, Carron Layfield, Richard Dooley, Sophia Collins, Clare Upton, Tracy Owen, Firoza Davies, Devin Patel, Mars Eddis-Finbow, Hywel C Williams, Goldie Putrym, Kim S Thomas, Amanda Roberts

“…This project involves working with members of the public to co-design and conduct studies that answer questions of importance to them. …”
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Role of bilevel erector spinae with high thoracic block vs conventional unilevel block in analgesia and reduction of pain in axilla in breast cancer surgeries: a randomized control... by Walaa Y. Elsabeeny, Reham M. Fahmy, Fatma H. Elshamy, Nahla N. Shehab, Sayed M. Abed, Walid S. Taha, Mostafa A. Ibrahim, Ahmed F. Gad

“…Objective:. This study was designed to investigate the effect of bilevel erector spinae plane block (ESPB) with high thoracic block vs the conventional unilevel ESPB vs opioids in patients with cancer undergoing modified radical mastectomy regarding pain control and reducing pain in axilla. …”
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Admission outcomes and their associated factors among children admitted to the paediatric emergency unit within 24 hours of Dilla University Referral Hospital, Ethiopia, 2023: a cr... by Binyam Tariku Seboka, Tomas Yeheyis, Yihenew Ayehu Dessie, Samuel Jigso Dube, Abel Desalegn Demeke, Mekdes Mekonnen Feleke, Abdo Hajo Jarso, Asresu Feleke Bati, Etaferaw Udo, Selam Tadele Markos, Chalachew Kassaw, Amdehiwot Aynalem Debebe, Ephrem Geja Gechere

“…Background Children in paediatric emergency units are those who need special attention, and unless treated early, they are a vulnerable population to unwanted outcomes like death, discharge against medical advice or referral to other institutions within 24 hours.Objectives To assess admission outcomes and their associated factors among children admitted to the paediatric emergency unit of Dilla University Referral Hospital, Ethiopia, 2023.Methods An institution-based cross-sectional study design was employed among children admitted to the paediatric emergency unit at Dilla University Referral Hospital from 8 May 2023 to 8 June 2023. …”
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