TROPION-Breast04: a randomized phase III study of neoadjuvant datopotamab deruxtecan (Dato-DXd) plus durvalumab followed by adjuvant durvalumab versus standard of care in patients... by Heather L. McArthur, Sara M. Tolaney, Rebecca Dent, Peter Schmid, Jamil Asselah, Qiang Liu, Jane Lowe Meisel, Naoki Niikura, Yeon Hee Park, Gustavo Werutsky, Giampaolo Bianchini, Jay C. Andersen, Robert Kozarski, Nana Rokutanda, Barbara Pistilli, Sibylle Loibl

“…Objectives: The primary objective of TROPION-Breast04 is to evaluate the efficacy and safety of neoadjuvant Dato-DXd plus durvalumab followed by adjuvant durvalumab with or without chemotherapy versus standard of care in patients with previously untreated early-stage TNBC or HR-low/HER2− breast cancer. Design: This is an ongoing, international, phase III, open-label, randomized controlled study. …”
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Impacts of Dryopteris serrato-dentata (Beddome) Hayata (Dhekishak) and Blumealacera DC. (Shialmutra) on rice and weed as growth inhibitor: an evaluation through the use of manure a... by Md. Tutul Hossen, Md. Liton Mia, Uttam Kumer Sarker, Ahmed Khairul Hasan, Md. Abdus Salam, Md. Shafiqul Islam

“…., manures and fertilizers (t ha−1): Control (R1), Residues1.5 + Cowdung 5 (R2), Residues1.5 + Cowdung 2.5 + 50% of recommended dose Fertilizer (R3), Residues 1.5 + Vermicompost 5 (R4), Residues 1.5 + Vermicompost 2.5 + 50% of recommended dose Fertilizer (R5), Residues 1.5 + Trichocompost 10 (R6) and Residues 1.5 + Trichocompost 5 + 50% of recommended dose Fertilizer (R7) and was laid out in a randomized complete block design (RCBD) with three replications. Eleven weed species from seven families were found in this study. …”
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Candida Bloodstream Infection: Changing Pattern of Occurrence and Antifungal Susceptibility over 10 Years in a Tertiary Care Saudi Hospital by Nawaf Alkharashi, Sameera Aljohani, Laila Layqah, Emad Masuadi, Waleed Baharoon, Hamdan AL-Jahdali, Salim Baharoon

“…To study the epidemiology and to evaluate the risk factors, prognostic factors, and mortality associated with candidemia and to compare these findings with previously published studies from Saudi Arabia. Design. A retrospective medical record review. Setting. …”
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Synthesis, Antibacterial, Antioxidant, and Molecular Modeling Studies of Novel [2,3′-Biquinoline]-4-Carboxylic Acid and Quinoline-3-Carbaldehyde Analogs by Zeleke Digafie, Yadessa Melaku, Zerihun Belay, Rajalakshmanan Eswaramoorthy

“…Hence, this project aims to design, synthesize, and evaluate their antibacterial and antioxidant activities of new series of [2,3′-biquinoline]-4-carboxylic acid and quinoline-3-carbaldehyde analogs. …”
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Clinical outcomes of a digital musculoskeletal women’s pelvic health program: an observational, longitudinal study with comparison group by Mindy Hong, Rachel Foster Kirk, Bijal Toprani, Cynthia Castro Sweet, Clare Pan, Jeffrey Krauss, Tamara Grisales

“…Digital exercise therapy designed to target pelvic pain can improve symptomology while reducing time and cost-related barriers to in-person clinical care. …”
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A Deep Learning Framework for the Classification of Brazilian Coins by Debabrata Swain, Viral Rupapara, Amro Nour, Santosh Satapathy, Biswaranjan Acharya, Shakti Mishra, Ali Bostani

“…However, the distinctive visual characteristics of Brazilian coins, including variations in size, color, and design, pose significant challenges for automated classification. …”
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Psychosocial determinants of the willingness to pay for social health insurance among workers at a commercial bank in Dessie, Ethiopia: a multi-setting study by Alemayehu Mebratu Abate, Asnakew Molla Mekonen, Abebe Kibret Assfaw, Husien Nurahmed Toleha, Ewunetie Mekashaw Bayked

“…The objective of this study was to look into the psychosocial determinants of the willingness to pay (WTP) for SHI among employees at a commercial bank in Dessie, Ethiopia.MethodsWe employed a cross-sectional study (October to December 2023) design. A self-administered questionnaire was used to collect the data. …”
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Affordability of Essential Medicines and Associated Factors in Public Health Facilities of Jimma Zone, Southwest Ethiopia by Eyassu Mathewos Oridanigo, Waju Beyene Salgedo, Feyera Gebissa Kebene

“…A facility-based cross-sectional study design was employed. The study was conducted from March 28 to April 30, 2018, in the public health facilities of Jimma Zone, Southwest Ethiopia. …”
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Elexacaftor/tezacaftor/ivacaftor and inflammation in children and adolescents with cystic fibrosis: a retrospective dual-center cohort study by Angela Pepe, Cristina Fevola, Daniela Dolce, Silvia Campana, Novella Ravenni, Giovanni Taccetti, Donatello Salvatore, Vito Terlizzi

“…Objective: To evaluate the impact of ETI on systemic inflammation in children and adolescents with CF. Design: Retrospective, dual-center observational, propensity score-matching study of pediatric pwCF on ETI. …”
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The Effects Of Differing Density Of Swim-Training Sessions On Shoulder Range Of Motion and Isometric Force Production In National and University Level Swimmers by Matias Yoma, Lee Herrington, Tanya Mackenzie

“…To compare the post-swim changes of these physical qualities between groups. # Study design Cross-sectional. # Methods Ten male swimmers (age= 18.7 ± 1.2 years) were divided into high-load (N= 5 national-level, weekly swim-volume= 37.0 ± 2.7 km) and low-load groups (N= 5 university-level, weekly swim-volume= 6.8 ± 1.8 km). …”
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THE PLACE OF PROFESSIONAL EDUCATION SYSTEM IN FORMATION OF GRADUATES’ COMPETITIVENESS by G. F. Shafranov-Kutsev, G. Z. Efimova

“…The materials of the research can be applied in the system of education to design the recommendations on formation and development of necessary qualities in the studying youth. …”
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Impact of gas composition, pressure, and temperature on interfacial Tension dynamics in CO₂-Enhanced oil recovery by Rahul Gajbhiye

“…This knowledge is instrumental in designing processes such as CO2-EOR and condensate banking, incorporating the effects of pressure, temperature, and gas composition at the reservoir scale.…”
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Socio-Demographic and Lifestyle Factors Influencing Adherence to AntiHypertensive Treatment in a Rural Area of Ludhiana, India by Sangeeta Girdhar, ,Mahesh Satija, Daljit Kaur, .Anurag Chaudhary

“…Hence, this study was done in a rural area of Ludhiana to determine adherence to anti-hypertensive treatment among hypertensive patients and explore various socio-demographic and lifestyle factors associated with adherence Methodology A cross-sectional study was conducted among clinically diagnosed cases of hypertension attending OPD at Rural health Training centre, Pohir over 3-month period, aged above 18 years of age and were on treatment for at least 6 months. A pre-designed semi-structured questionnaire was used to assess the patient’s socio-demographic profile, treatment seeking behaviour, duration and type of treatment and presence of any complication of hypertension. …”
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Adult dietary patterns and their association with iodine nutrition levels and thyroid function: a cross-sectional study by Gulinaizeer Abuduwaili, Jia Huang, Yan Ma, Hongguang Sun

“… Abstract Objective: To understand the dietary patterns of adults and explore their association with iodine nutritional levels and thyroid function in adults. Design: We randomly collected 5 ml of adult urine samples and measured urinary iodine concentration (UIC) by cerium arsenate-catalysed spectrophotometry. …”
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A novel consensus bacterial 6-phytase variant supplemented to an all-vegetable broiler diet totally replaced added trace minerals including zinc, iron, copper and manganese in two... by Yueming Dersjant-Li, Cees Kwakernaak, Abiodun Bello, Leon Marchal

“…Each tested 12 treatments in a 2 × 6 factorial arrangement with 3,360 Ross 308 males (35 birds/pen, 8 pens/treatment) in a randomized complete block design. Phytase levels comprised no PhyG or PhyG at 2,000, 1,500 and 1,000 FTU/kg during 0 to 10, 10 to 20 and (Experiment 2) 20 to 35 d of age, respectively; TM diets comprised: no added TM (diet 1); 10, 15, 3 and 10, or 20, 30, 6 and 20 mg/kg of Zn, Fe, Cu and Mn as sulphate (diets 2 and 3); 15, 3 and 10 mg/kg of Zn, Cu and Mn as oxide and 15 mg/kg Fe as sulphate, or 30, 6 and 20 mg/kg of Zn, Cu and Mn as oxide and 30 mg/kg Fe as sulphate (diets 4 and 5), and; 10, 3, 15 and 10 mg/kg of organic Zn, Cu, Fe and Mn (diet 6). …”
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Evaluation of vegetable pigeonpea [Cajanus cajan (L.) Millsp] genotypes for yield stability by J. D. Ojwang, R. Nyankanga, N. V. P. R. G. Ganga Rao, J. Imungi

“…The genotypes were planted in a Randomized Complete Block design (RCBD), replicated three times at all sites. …”
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EFFECT OF DIFFERENT SEED PRIMING METHODS ON PERFORMANCE OF DIRECT BROADCAST SEEDED RICE (DBSR) IN CHITWAN, NEPAL by Raj Narayan Chaudhary, Surya Bahadur Thapa

“…The treatments consisted of four priming methods {Control (no-priming), Hydro-priming (24 hrs tap water soaking + 12 hrs shade drying), KCl priming (24 hrs solution soaking, @ 20.74 g/ltr + 12 hrs shade drying), CaCl2 priming (24 hrs solution soaking , @ 22.2 g/ltr + 12 hrs shade drying) } which were tested on two different seed rates (60 kg ha-1 and 30 kg ha-1) of two rice varieties { Hybrid (Gorakhnath-509) and Inbred (Sabitri)} in split-split plot design with four replications. The research results showed that priming resulted uniform plant population, faster crop establishment and better crop productivity. …”
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Inhibition of triple-negative breast cancer growth via delphinidin-mediated suppression of the JAK2/STAT3/PD-L1 pathway by Xiaoping Yu, Xiaolong Song, Jiali Yan, Ziting Xiong, Lujie Zheng, Yan Luo, Fengcheng Deng, Yanfeng Zhu

“…Objective: This study investigates the effects of Dp on TNBC and aims to elucidate its specific mechanisms of action. Design: We utilized cell counting kit-8 (CCK-8) assays, colony formation assays, and scratch assays to evaluate the influence of Dp on the proliferation and migration of TNBC cells. …”
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Shaping Treatment Expectation to Optimize Efficacy of Interleukin 17A Antagonist Secukinumab in Psoriasis Patients by Hölsken S, Krefting F, Mühlhaus S, Bese D, Schedlowski M, Sondermann W

“…This clinical proof-of-concept study aimed to enhance treatment outcomes by targeting positive treatment expectations of psoriasis patients beginning systemic anti-psoriatic therapy with secukinumab, an interleukin (IL)-17A antagonist.Patients and Methods: We randomly assigned patients to three groups: a treatment as usual (TAU) group receiving the standard 300mg dose of secukinumab, a dose-control (DC) group with 75% dose reduction and an experimental (EXP) group receiving the same reduced dose along with a “cover story” designed to positively influence treatment expectations. …”
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Seasonal activity patterns of Ixodes scapularis and Ixodes pacificus in the United States by Lars Eisen

“…Discrepancies between seasonal patterns for peak tick questing activity and peak human infestation appear to occur primarily for the adult stages of I. scapularis and I. pacificus. Study design and data presentation limitations of the published literature are discussed. …”
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