High HDL-C and high LDL-C are risk factors of pterygium in a population-based cross-sectional study in Southern China: the Dongguan Eye Study by Liang Zhang, Min Zhang, Ying Cui, Lixin Zhang, Guanrong Zhang, Qingyang Liu, Haike Guo, Qianli Meng, Siwen Zang, Chun-Han Lo, Yanlei Chen, Jin Zeng

“…Objectives To investigate the relationship between serum lipids and pterygium in a large-scale rural population aged 40 years or older from Southern China.Study design The Dongguan Eye Study was a cross-sectional population-based study from September 2011 to February 2012.Setting The area was set in the rural area of Dongguan, Southern China.Participants Adult rural population aged 40 or older.Methods Participants underwent physical, haematological and ophthalmic examinations.Primary and secondary outcome measures The frequency and risk factors of pterygium.Results A total of 11 357 participants were eligible for inclusion and 8952 (78.8%) participants were enrolled for the systemic and ophthalmic examinations. …”
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Thirty-six-year trends (1986–2022) in cigarette smoking and snus use in northern Sweden: a cross-sectional study by Stefan Söderberg, Maria Wennberg, Viktor Oskarsson, Jonas Andersson, Erica Sjödin, Maria Nordendahl, Lena Heldorsson Fjellström, Carolina Lundholm

“…Objectives To examine the 36-year trends in tobacco use in northern Sweden.Design and outcome measure Cross-sectional analysis of the eight population-based surveys that constitute the northern Sweden MONICA study (1986, 1990, 1994, 1999, 2004, 2009, 2014 and 2022). …”
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Navigating Patient Satisfaction: A Qualitative Insight into Healthcare Delivery during the COVID-19 Pandemic by Shazina Saeed, Manmohan Singhal, Mohd Shannawaz, Mandeep Kumar Arora

“…Materials and Methods: A qualitative research design was employed, utilising an in-depth interviews with patients who accessed healthcare services during the pandemic. …”
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NutriBase – management system for the integration and interoperability of food- and nutrition-related data and knowledge by Eva Valenčič, Eva Valenčič, Eva Valenčič, Eva Valenčič, Emma Beckett, Emma Beckett, Emma Beckett, Tamara Bucher, Tamara Bucher, Clare E. Collins, Clare E. Collins, Barbara Koroušić Seljak, Barbara Koroušić Seljak

“…Moreover, the traceability of the data and knowledge provenance allows the compilation of a trustworthy management system. The system is designed to allow easy integration of data from different sources, which enables data borrowing and reduction of missing data. …”
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Diagnostic Accuracy of Procalcitonin for Bacterial Infection in Liver Failure: A Meta-Analysis by Xinchun He, Liang Chen, Haiou Chen, Yuqing Feng, Baining Zhu, Caixia Yang

“…Furthermore, the metaregression analysis of PCT study design, bacterial infection site, and mean age displayed that the P values were >0.05. …”
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CD4 CAR-T cells targeting CD19 play a key role in exacerbating cytokine release syndrome, while maintaining long-term responses by Alice Bergamini, Barbara Camisa, Attilio Bondanza, Fabio Ciceri, Chiara Bonini, Monica Casucci, Beatrice Greco, Camilla Bove, Silvia Arcangeli, Laura Falcone, Rita El Khoury, Anna De Lucia

“…Interestingly, the combination of CD4.BBz with CD8.28z CAR-T cells resulted in the lowest toxicity, without impacting antitumor efficacy.Conclusions Taken together, these data point out that the rational design of improved adoptive T-cell therapies should consider the biological features of CD4 CAR-T cells, which emerged as crucial for maintaining long-term responses but also endowed by a higher toxic potential.…”
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Exploring urban-rural inequalities of maternal healthcare utilization in Bangladesh by A.T.M. Shariful Alam, Shorful Alam, Kashfia Mobasshira, S.M. Nuruzzaman Anik, Mohammad Nayeem Hasan, Muhammad Abdul Baker Chowdhury, Md Jamal Uddin

“…This study aims to assess the impact of different factors and describe the urban-rural inequalities in maternal healthcare service utilization. Methods & study design: This study's analysis is based on data extracted from the 2017-18 Bangladesh Demographic and Health Survey (BDHS), following STROBE guidelines. …”
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Patient participation in free cataract surgery: a cross-sectional study of the low-income elderly in urban China by Bo Qu, Hui Chen, Xuhua Tan, Xiaohang Wu, Haotian Lin, Zhenzhen Liu, Lixia Luo, Bo Zhang, Erping Long, Duoru Lin, Weirong Chen, Yizhi Liu, Haofeng Jiang, Jingjing Chen, Zhuoling Lin, Xiaoyan Li, Jinzhu Tang, Yingfen Lin

“…Objectives To explore the characteristics of the low-income elderly who underwent free cataract surgery and to determine the degree of patient satisfaction with the free cataract surgery programme in urban China.Methods A free cataract surgery management workflow was designed as a poverty relief project in Guangzhou. …”
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Sleep duration, chronotype, health and lifestyle factors affect cognition: a UK Biobank cross-sectional study by Daqing Ma, Raha West, Zhigang Liu, Ji-Eun Park, Ryan Tak Chun Wong, Si Woo Lee, Dinayinie Ekanayake Mudiyanselage

“…Objective To explore the nuanced relationship between sleep patterns, chronotype, quality and the influence of health and lifestyle factors on cognitive performance.Design, setting, participants This cross-sectional analysis used ordinary least squares regression within the UK Biobank database, assessing 26 820 participants aged 53–86 years, categorised into two cohorts: Cohort 1 (10 067 participants, 56% female; completed all four cognitive tests of Fluid Intelligence/reasoning, Pairs Matching, Reaction Time and Prospective Memory) and Cohort 2 (16 753 participants, 56% female; completed only two cognitive assessments of Pairs Matching and Reaction Time).Exposures Participant’s self-reported sleep duration, chronotype and quality. …”
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Preclinical study and parallel phase II trial evaluating antisense STAT3 oligonucleotide and checkpoint blockade for advanced pancreatic, non-small cell lung cancer and mismatch re... by Heather Lin, Vivek Subbiah, Siqing Fu, Aung Naing, Courtney Nicholas, Shubham Pant, Chad Tang, Michael A Curran, David S Hong, Ying Yuan, Sarina A Piha-Paul, Jordi Rodon Ahnert, Timonthy A Yap, Apostolia M Tsimberidou, Daniel D Karp, Anupallavi Srinivasamani, Coline Couillault, Genevieve P Hartley, James Dai, Ecaterina E Ileana Dumbrava, Paola Guerrero, Sarah Dhebat, Theresa Proia

“…In vitro experiments evaluated STAT3 inhibition in pancreatic stellate cells (PSCs) and myeloid-derived suppressor cells (MDSCs).A phase II trial employing a Simon II stage design tested the clinical efficacy of danvatirsen and durvalumab in non-small cell lung cancer (NSCLC), PDAC and mismatch repair-deficient colorectal cancer (MRD CRC). …”
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Disease-Related Knowledge, Stress, and Quality of Life of Parental Caregivers of Children with Cleft Lip and Palate in a Selected Hospital in Ho Chi Minh City, Vietnam by Phung Le Thi Kim, Leonora Collantes, Phuong Lam Hoai, An Phan Huynh, Nghia Le Trung, Tu Nguyen Thanh, Anh Nguyen Viet, Kieu Nguyen Thi Thanh, Truc Pham Thanh Luu, Phi Duong Nguyen

“…Materials and Methods: A descriptive-correlational design was used with a purposive sample of 235 parental caregivers from an Odonto-Stomatology Hospital in Ho Chi Minh City, Vietnam. …”
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Mobile application adjunct to the WHO basic emergency care course: a mixed methods study by Juma A Mfinanga, Hendry R Sawe, Anya L Greenberg, Andrea G Tenner, Alexandra Friedman, Paulina Nicholaus, Christian C Rose, Newton Addo, Catherine Reuben Shari, Upendo N George, Michael J Losak

“…We assessed whether a mobile application adjunct (BEC app) can have positive impact on knowledge acquisition and retention compared with the BEC course alone and evaluated perceptions, acceptability and barriers to adoption of such a tool.Design Mixed-methods prospective cohort study.Participants Adult healthcare workers in six health facilities in Tanzania who enrolled in the BEC course and were divided into the control arm (BEC course) or the intervention arm (BEC course plus BEC app).Main outcome measures Changes in knowledge assessment scores, self-efficacy and perceptions of BEC app.Results 92 enrolees, 46 (50%) in each arm, completed the BEC course. 71 (77%) returned for the 4-month follow-up. …”
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Identification of heat tolerant lentil genotypes through stress tolerance indices by Rohit Sarkar, Gyan Prakash Mishra, Premakumar, Ankita Singh, Jenia Roy, Kumbarahally Murthigowda Shivaprasad, Shashidhar B. Reddappa, Sudhir Kumar, Ruchi Bansal, Uttarayan Dasgupta, Soma Gupta, Susheel Kumar Sarkar, Sanjeev Gupta, Shiv Kumar, Harsh K. Dikshit, Prachi Sripathrao Yadav, Muraleedhar S. Aski

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Do you think medicines can be prescribed in a more eco-directed, greener way? A qualitative study based on public and prescriber focus groups on the impact of pharmaceuticals in Sc... by Claire Anderson, Lydia Niemi, Naoko Arakawa, Mark Taggart, Stuart Gibb, Sharon Pfleger

“…Objectives This qualitative study explored public and prescriber awareness of pharmaceutical pollution in the water environment and eco-directed sustainable prescribing (EDSP) as a mitigation strategy to reduce the environmental impact of prescribing in Scotland.Design Focus groups explored prescriber and public perceptions of the topic. …”
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Correlation between Neutrophil Gelatinase Associated with Lipocaline and Beta-2 Microglobulin with Other Renal Markers in Iraqi Patients with Multiple Myeloma by Inas Nazeeh Abed, Usama Salman Al-timari, Hiba Abid Al-Hussein hassan, Abbas Thamer Dwayyikh

“…The current study is designed to find the correlation between Neutrophil gelatinase-associated lipocalin and ß2-Microglobulin with other renal markers among patients with multiple myeloma and healthy people. …”
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Comparison of fracture risk calculators in elderly fallers: a hospital-based cross-sectional study by Sophia von Widekind, Georgi Todorov, Susan Brook, Nicole Quah Qin Xian, Bernard Freudenthal, Alexander N Comninos

“…In this study, we compare these risk calculators in a high-risk cohort of elderly patients admitted to hospital with falls.Design Hospital-based cross-sectional study.Setting Secondary care, London, UK.Participants Data from 120 consecutive elderly patients who had falls presenting to a single hospital over 4 months were collected. 10-year major and hip fracture risks were calculated using FRAX, QFracture and Garvan. 1-year major and hip fracture risks from QFracture were assessed against prospective incidence of fracture.Results Median 10-year major fracture risk was: FRAX 19.5%, QFracture 26.0%, Garvan 32.5%. …”
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Association of outpatient use of renin–angiotensin–aldosterone system blockers on outcomes of acute respiratory illness during the COVID-19 pandemic: a cohort study by Molly Moore Jeffery, Lucas Oliveira J e Silva, Fernanda Bellolio, Nathan W Cummins, Timothy M Dempsey, Vesna D Garovic, Andrew Limper

“…Objectives Evaluate the associations between patients taking ACE inhibitors and angiotensin receptor blockers (ARBs) and their clinical outcomes after an acute viral respiratory illness (AVRI) due to COVID-19.Design Retrospective cohort.Setting The USA; 2017–2018 influenza season, 2018–2019 influenza season, and 2019–2020 influenza/COVID-19 season.Participants People with hypertension (HTN) taking an ACEi, ARB or other HTN medications, and experiencing AVRI.Main outcome measures Change in hospital admission, intensive care unit (ICU) or coronary care unit (CCU), acute respiratory distress (ARD), ARD syndrome (ARDS) and all-cause mortality, comparing COVID-19 to pre-COVID-19 influenza seasons.Results The cohort included 1 059 474 episodes of AVRI (653 797 filled an ACEi or ARB, and 405 677 other HTN medications). 58.6% were women and 72.9% with age ≥65. …”
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Situational analysis of the quality of maternal, child, and adolescent health data in the health districts of Thiès, Mbour, Kédougou, and Saraya in Senegal by Fatoumata Binetou Diongue, Adama Faye, Cheikh Loucoubar, Ndèye Marème Sougou, Ibrahima Sy, Adama Tall, Youssoupha Ndiaye, Samba Cor Sarr

“…Materials and methods A mixed quantitative and qualitative design was chosen in four health districts, including Thiès, Mbour, Kédougou, and Saraya. …”
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Analysis of Metabolic Risk Factors for Microcirculation Disorders Post-Percutaneous Coronary Intervention and Predictive Model Construction: A Study on Patients with Unstable Angin... by Kangming Li, Shuang Liu, Jing Wang, Zhen Liu, Chunmei Qi

“…Methods: A single-center retrospective study design was used, which included 553 patients with UA who underwent PCI. …”
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Association between chiropractic spinal manipulative therapy and benzodiazepine prescription in patients with radicular low back pain: a retrospective cohort study using real-world... by Jeffery A Dusek, Robert James Trager, Zachary A Cupler, Kayla J DeLano, Jaime A Perez

“…We hypothesise that utilisation of CSMT for newly diagnosed rLBP is associated with reduced odds of benzodiazepine prescription through 12 months’ follow-up.Design Retrospective cohort study.Setting National, multicentre 73-million-patient electronic health records-based network (TriNetX) in the USA, queried on 30 July 2021, yielding data from 2003 to the date of query.Participants Adults aged 18–49 with an index diagnosis of rLBP were included. …”
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