Preliminary analysis of the role of small hepatitis B surface proteins mutations in the pathogenesis of occult hepatitis B infection via the endoplasmic reticulum stress-induced UP... by Huang Chengrong, Zhang Hao, Wang Jing, Li Jianfei, Liu Qian, Zong Qiyin, Zhang Yunyun, Wang Qin, Zhou Qiang

“…The mechanistic basis for these results, however, remains unclear. This study was designed to explore the potential impact and mechanisms of OBI-related SHBs mutations on serum HBsAg. …”
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Decomposing the Poor-Non-Poor Gap in the Prevalence of Undiagnosed and Untreated Hypertension Among Bangladeshi Population by Mosiur Rahman, Mahfuza Khatun, Asrafun Naher Pinkey, Syed Emdadul Haque, Farhana Akhter Liza, Md. Nuruzzaman Haque, Prosannajid Sarkar, Tapan Kumar Roy, G. M. Rabiul Islam, Md. Rashed Alam, Mahmudul Hasan, Izzeldin Fadl Adam, Nguyen Huu Chau Duc, Saber Al-Sobaihi, Abid Hasan

“…Objectives: Our objectives were to ascertain: the prevalence and socio-economic distribution of hypertension, as well as the rates of undiagnosed and untreated hypertension; the association between socioeconomic status (SES) and the occurrence of hypertension, as well as the rates of undiagnosed and untreated hypertension; and the factors influencing the poor-non-poor gap in terms of the prevalence, diagnosis, and treatment of hypertension. Design: Cross-sectional nationally representative study. …”
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Improving primary school children's motor skills: a physical education approach using circuit games with auditory sequencing by Hilmy Aliriad, Mohamad Da’i, Benny Widya Priadana, Moch Rimba Wigantara, Muchammad Ridwan Arifianto

“…Methods: In this research and development (RND) approach that involves several stages, namely game concept and design development, initial testing, and evaluation and revision based on test results. …”
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Work ability following breast cancer – the MyHealth randomized controlled trial by Trine A. Horsbøl, Lena Saltbæk, Caroline Urhammer, Randi V. Karlsen, Christoffer Johansen, Pernille E. Bidstrup, Beverley L. Høeg, Vibeke Zoffmann, Federica Belmonte, Ingelise Andersen, Anne S. Friberg, Mads N. Svendsen, Helle G. Christensen, Vesna Glavicic, Dorte L. Nielsen, Susanne O. Dalton

“…Future interventions should target patients with poor work ability and include components specifically designed to enhance work ability. …”
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Anticancer activity of Ilex khasiana, a rare and endemic species of holly in Northeast India, against murine lymphoma by Charles Lalnunfela, Pawi Bawitlung Lalthanpuii, Hmar Tlawmte Lalremsanga, Zothansiama, Chhaihlo Lalmuansangi, Mary Zosangzuali, Nachimuthu Senthil Kumar, Tochhawng Lalhriatpuii, Kholhring Lalchhandama

“…Ilex khasiana Purkay. is a lesser-known species of holly (family Aquifoliaceae) that is endemic to Northeast India. Designated as critically endangered, the plant is used in the treatments of bacterial infections, cancer, intestinal helminthiasis, tuberculosis, and viral infections. …”
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The Association between Resolvin D1 Levels and Gestational Diabetes Mellitus: Implications for Perinatal Outcomes by Zeynep Seyhanli, Burak Bayraktar, Mevlut Bucak, Gulsan Karabay, Betul Tokgoz Cakir, Can Ozan Ulusoy, Gizem Aktemur, Selver Ozge Sefik, Serap Topkara Sucu, Sevki Celen, Ali Turhan Caglar

“… OBJECTIVE: To evaluate maternal Resolvin D1 levels in women with gestational diabetes mellitus (GDM) and investigate the association between perinatal outcomes. STUDY DESIGN: This case-control study included 88 singleton pregnancies, conducted from August 2023 to January 2024, at a tertiary care center. …”
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From non-human to human primates: a translational approach to enhancing resection, safety, and indications in glioma surgery while preserving sensorimotor abilities by Matteo Gambaretti, Matteo Gambaretti, Luca Viganò, Luca Viganò, Matteo Gallo, Giovanni Pratelli, Tommaso Sciortino, Lorenzo Gay, Marco Conti Nibali, Alberto Luigi Gallotti, Alberto Luigi Gallotti, Leonardo Tariciotti, Luca Mattioli, Lorenzo Bello, Lorenzo Bello, Gabriella Cerri, Gabriella Cerri, Marco Rossi, Marco Rossi, Marco Rossi

“…We also detail how these techniques allowed the acquisition of new data on the properties of areas and tracts underlying sensorimotor control, in turn fostering the design of new tools to navigate within cortical and subcortical areas, that were before deemed to be “sacred and untouchable.”…”
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Reduced retinal microvascular density in women with coronary microvascular dysfunction: A pilot study by Sakshi Shiromani, Ahmed AlBadri, Aaron Lindeke-Myers, Arielle Schwartz, Nishant Vatsa, Esha Dave, Fauzia Rashid, Nieraj Jain, Puja K. Mehta

“…Objective: To compare retinal microvascular density among women with ischemia with no obstructive coronary artery disease (INOCA) with and without coronary microvascular dysfunction (CMD). Design: Cross-sectional study. Setting: Patients with myocardial INOCA often have CMD, possibly indicating systemic vascular dysfunction. …”
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Surface Modification of TFC-PA RO Membrane by Grafting Hydrophilic pH Switchable Poly(Acrylic Acid) Brushes by Muhammad Asad Abbas, Shehla Mushtaq, Waqas A. Cheema, Hazim Qiblawey, Shenmin Zhu, Yao Li, Runnan Zhang, Hong Wu, Zhongyi Jiang, Rehan Sadiq, Nasir M. Ahmad

“…These experimental results are significant and have immediate implication for advances in polymer technology to design and modify the “switchable membrane surfaces” with controllable charge distribution and surface wettability, as well as regulation of water flux and salt.…”
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MnS/MnO heterostructures with dual ion defects for high-performance aqueous magnesium ion capacitors by Minghui Liu, Mudi Li, Siwen Zhang, Yaxi Ding, Ying Sun, Jiazhuo Li, Haixi Gu, Bosi Yin, Hui Li, Tianyi Ma

“…Hence, DID-MnS/MnO offers insightful perspectives for designing alternative clean energy sources and is expected to contribute significantly to the advancement of the clean energy sector.…”
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Serial Paediatrics Omics Tracking in Myalgic Encephalomyelitis (SPOT-ME): protocol paper for a multidisciplinary, observational study of clinical and biological markers of paediatr... by Adam Scheinberg, Natalie Thomas, Katherine Huang, Paul R Gooley, Elisha K Josev, Tracey Chau, Darcy Tantanis, Sarah J Knight, Christopher W Armstrong

“…The longitudinal repeated-measures study design is optimal for studying heterogeneous chronic diseases like ME/CFS as it can detect subtle changes, control for individual differences, enhance precision and boost statistical power. …”
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Daratumumab followed by tocilizumab for treatment of late antibody-mediated rejection in renal transplant recipients with high or moderate levels of de novo donor-specific antibodi... by Zhiliang Guo, Rula Sa, Daqiang Zhao, Songxia Li, Hui Guo, Lan Zhu, Gang Chen

“…Conclusions This new therapy combining Dara and TCZ achieved a good desensitization effect, providing an important reference point for designing better-optimized treatment of late or chronic active AMR in the future. …”
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Dietary Magnesium Intake and Leukocyte Telomere Attrition in Adults: The Regulatory Role of Serum Tumor Necrosis Factor α by Jie Yu, Haibin Liu, Shuli He, Pingping Li, Chunxiao Ma, Minglei Ma, Yiwen Liu, Lu Lv, Fan Ping, Huabing Zhang, Wei Li, Qi Sun, Lingling Xu, Yuxiu Li

“…In this study, we assessed the effects of dietary magnesium on leukocyte telomere length (LTL). Designs. The current cross-sectional analysis was based on data collected within a type 2 diabetes project. …”
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Intravenous liposomal irinotecan in metastatic triple-negative breast cancer after ≥ 2 prior lines of chemotherapy: a phase Ib study by Ying Fan, Qingyuan Zhang, Min Yan, Xiujuan Qu, Yongmei Yin, Tao Sun, Jin Yang, Ying Wang, Xu Wang, Zhaofeng Niu, Xinshuai Wang, Sanyuan Sun, Weihong Zhao, Yanping Liu, Miao Niu, Xuemin Zhao, Binghe Xu

“…In part 1, the 3 + 3 design was used to investigate three dose levels of HE072 (50, 70 and 90 mg/m2). …”
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Does the CDC Surgical Wound Classification adequately predict postoperative infection in lower extremity fracture surgery? by Elizabeth Cho, MD, Hanna House, MD, Andrew Marten, BS, Marina Feffer, MPH, Julie Agel, MA, John Scolaro, MD, Meir Marmor, MD, Ashley E. Levack, MD, MAS, OTA Classification & Outcomes Committee, James Kellam, MD, Gillian Soles, MD, Jarrod Dumpe, MD, Kyle Schweser, MD, Geoffrey Maracek, MD

“…The purpose of this investigation was to evaluate the utility of the Centers for Disease Control (CDC) Surgical Wound Classification (SWC) in predicting surgical site infection (SSI) after orthopaedic trauma procedures. Design:. Retrospective cohort study. Setting:. Level I academic trauma center. …”
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Latent class cluster analysis of knowledge on acute myocardial infarction in community residents: a cross-sectional study in Tianjin, China by Jing Wang, Xu Zhang, Yan Zhang, Jing Ma, Nan Zhang, Yuan Wang, Jing Gao, Jian-yong Xiao, Yin Liu, Ji-xiang Wang, Xiao-wei Li, Ming-dong Gao, Jing-xian Wang, Shi-bo Xu

“…This study aimed to identify clusters of knowledge on symptoms and RFs of AMI, compare characteristics and the awareness of the need for prompt treatment.Design Multistage stratified sampling was used in this cross-sectional study. …”
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Prebiotics as an adjunct therapy for posttraumatic stress disorder: a pilot randomized controlled trial by Robin M. Voigt, Robin M. Voigt, Robin M. Voigt, Phillip A. Engen, Michelle Villanueva, Simona A. Bambi, Stefan J. Green, Stefan J. Green, Ankur Naqib, Ankur Naqib, Shohreh Raeisi, Maliha Shaikh, Bruce R. Hamaker, Bruce R. Hamaker, Thaisa M. Cantu-Jungles, Thaisa M. Cantu-Jungles, Sarah A. Pridgen, Philip Held, Ali Keshavarzian, Ali Keshavarzian, Ali Keshavarzian, Ali Keshavarzian

“…This proof-of-concept, pilot trial was designed to assess: (1) the relationship between severity of PTSD symptoms and microbiota composition and SCFA levels (i.e., acetate, propionate, butyrate), (2) if CBT treatment with a concomitant prebiotic fiber intervention would beneficially impact clinical outcomes in veterans with PTSD, (3) evaluate the feasibility and acceptability of a prebiotic intervention as an adjunct treatment to CBT, and (4) assess the impact of treatment on the intestinal microbiota and stool SCFA (i.e., mechanism).ResultsThis study found that PTSD severity may be associated with reduced abundance of taxa capable of producing the SCFA propionate, and that a subset of individuals with PTSD may benefit from a microbiota-modifying prebiotic intervention.ConclusionThis study suggests that targeting the intestinal microbiome through prebiotic supplementation could represent a promising avenue for enhancing treatment outcomes in some individuals with PTSD.Clinical trial registrationhttps://clinicaltrials.gov/, identifier NCT05424146.…”
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Carbapenem resistance in the Dominican Republic: clinical characteristics, genotypic profiles, and risk factors by Ricardo Ernesto Hernández-Landa, Rita Rojas-Fermín, Anel Guzman-Marte, Katherine Peralta Agramonte, Missel María Jiménez Cedano, Surelly Alexandra Mora-Peralta, Patricia Sanrregré-Oven, Alfredo J. Mena Lora

“… Abstract Objective: To characterize the clinical and microbiological features of carbapenem-resistant Enterobacterales (CRE) compared to carbapenem-susceptible Enterobacterales (CSE) in the Dominican Republic (DR), and to assess risk factors associated with CRE. Design: Retrospective case-control study. Setting: Hospital General Plaza de la Salud, a tertiary teaching hospital in Santo Domingo, DR, from January 2015 to June 2024. …”
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Potential epidemiological impact of the 2017 American College of Cardiology/American Heart Association high blood pressure guideline on the Chinese population: a cross-sectional st... by Zhao Li, Guozhe Sun, Yingxian Sun, Zhaoqing Sun, Yue Dai, Jia Zheng, Yuanyuan Dong, Xiaofan Guo, Yanxia Xie, Yali Wang, Rongrong Guo, Liqiang Zheng

“…Objectives The present study estimated the percentage of rural Chinese adults with hypertension and recommended pharmacological antihypertensive treatment according to the 2017 American College of Cardiology/American Heart Association (ACC/AHA) guideline compared with the 2010 Chinese Guideline for the Management of Hypertension.Design Cross-sectional study.Setting Three counties in rural areas of northeastern China.Participants A total of 11 747 eligible individuals aged ≥35 years from rural areas of northeastern China were selected for the present analysis.Main outcome measures The percentage of rural Chinese adults with hypertension and recommended pharmacological antihypertensive treatment according to the 2017 ACC/AHA guideline and the 2010 Chinese Guideline for the Management of Hypertension, and the proportion of rural Chinese adults taking antihypertensive medication with blood pressure (BP) above the 2017 ACC/AHA guideline and the 2010 Chinese guideline treatment goal.Results The mean age of the study population was 53.9±10.8 years and 53.7% of the participants were women. …”
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Evidence-based exercise recommendations to improve functional mobility in older adults - A study protocol for living systematic review and meta-analysis [version 2; peer review: 2... by Claudia Volecker-Rehage, Uros Marusic, Bettina Wollesen, Antoine Langeard, Tamar Yellon, Anna Wunderlich, Vera Belkin, Guoping Qian, Eleftheria Giannouli, Zbigniew Ossowski, Rafael A. Bernades, Yael Netz, Rajesh Sighdel

“…This review will assess the effects of state-of-the-art exercise interventions designed to promote functional mobility. Therefore, after identifying all potential interventions, we will use the F.I.T.T. principles (frequency, intensity, time, type) as well as the physical and health status of the participants as moderators to analyse the mechanisms for the positive benefits of exercise interventions. …”
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