Economic evaluation of integrated services for non-communicable diseases and HIV: costs and client outcomes in rural Malawi by Luckson Dullie, Emily B Wroe, Elizabeth L Dunbar, Noel Kalanga, Lawrence Nazimera, Adarsh Shah, Bright Mailosi, Chiyembekezo Kachimanga, Ryan K McBain, Natalie Price, Mahlet Gizaw, Chantelle Boudreaux, Liberty Neba

“…Objective To evaluate the costs and client outcomes associated with integrating screening and treatment for non-communicable diseases (NCDs) into HIV services in a rural and remote part in southeastern Africa.Design Prospective cohort study.Setting Primary and secondary level health facilities in Neno District, Malawi.Participants New adult enrollees in Integrated Chronic Care Clinics (IC3) between July 2016 and June 2017.Main outcome measures We quantified the annualised total and per capita economic cost (US$2017) of integrated chronic care, using activity-based costing from a health system perspective. …”
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Analyzing sorbitol biosynthesis using a metabolic network flux model of a lichenized strain of the green microalga Diplosphaera chodatii by Hadi Nazem-Bokaee, Erik F. Y. Hom, Sarah Mathews, Cécile Gueidan

“…Moreover, the model predicts limits of the metabolic interplay between sorbitol biosynthesis and algal growth, which has potential applications in assisting the design of bio-based sorbitol production processes.…”
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Expression and Function of Synthetic Dimeric Exercise-Induced Cytokine Irisin-Irisin by LIU Fengying, HUANG Yide, LIN Jia, CHEN Xuequn, WANG Qingshui, LIN Yao

“…ObjectiveStudies have shown that the exercise-induced cytokine Irisin functions were as a dimer, so tandem Irisin-Irisin mock dimers were designed to explore the similarities and differences between recombinant Irisin-Irisin expressed by <italic>Escherichia coli </italic>and commercial Irisin in activity and function on tumor cells.Methods<italic>Escherichia coli</italic> strain BL21 (DE3) and pET-30a expression vectors were selected to obtain recombinant Irisin-Irisin by isopropyl β-D-1-thiogalactopyranoside (IPTG) induction. …”
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Latest Advancements in Transcutaneous Electrical Nerve Stimulation (TENS) and Electronic Muscle Stimulation (EMS): Revisiting an Established Therapy with New Possibilities by Patel P, Green M, Tram J, Wang E, Murphy M, Abd-Elsayed AA, Chakravarthy K

“…Future research must focus on rigorous study designs, standardized protocols, and meaningful patient-centered outcomes to fully realize the therapeutic potential of these modalities. …”
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Sick leave and disability pension in patients with chronic hepatitis C compared with a matched general population: a nationwide register study by Matti Sällberg, Katharina Büsch, Fredrik Hansson, Michelle Holton, Martin Lagging, Johan Westin, Jan Kövamees, Jonas Söderholm

“…Objective The objective of this study was to evaluate sick leave and disability pension in patients with chronic hepatitis C virus (HCV) infection as compared with a matched general population cohort.Design Retrospective register study.Setting Nationwide in Sweden.Participants This register-based study used the Swedish National Patient Register to identify working-age patients with HCV in 2012 (n=32 021) who were diagnosed between 1999 and 2007 (n=19 362). …”
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Clinical Efficacy of Three-Dimensional-Printed Pure Titanium Fracture Plates with Locking Screw Systems in Distal Tibia Fractures by Ji Hye Choi, Jun Hyoung Lee, Seung Hyeop Lee, Woo Young Jang

“…<i>Background and Objectives:</i> Distal tibia fractures are high-energy injuries characterized by a mismatch between standard plate designs and the patient’s specific anatomical bone structure, which can lead to severe soft tissue damage. …”
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Evaluation of Knowledge and Practice of Pharmacy Professionals regarding the Risk of Medication Use during Pregnancy in Dessie Town, Northeast Ethiopia: A Cross-Sectional Study by Abdu Tuha, Yilak Gurbie, Haftom Gebregergs Hailu

“…As medication knowledge of PPs is poor, a multitude of strategies (educational, economic, managerial, and regulatory) should be designed by the government, universities, and pharmaceutical associations to improve the pharmacy professionals’ role in the healthcare system by providing them with continuous and up-to-date medication knowledge.…”
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The Associations of Platelet Activation and Coagulation Parameters with Obstructive Sleep Apnoea: A Large-Scale Observational Study by Jundong Yang, Wenjun Xue, Zhicheng Wei, Caiqiong Hou, Huaming Zhu, Huajun Xu, Xiaolin Wu, Yunhai Feng, Xinyi Li

“…This study explored blood coagulability and breathing-related parameters during sleep in patients with OSA. Design. Cross-sectional observational study. Setting. …”
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Biventricular dysfunction predicts mortality in ST elevation myocardial infarction patients with cardiogenic shock by Angga Dwi Prasetyo, Hendry Purnasidha Bagaswoto, Firandi Saputra, Erika Maharani, Budi Yuli Setianto

“…Sardjito General Hospital in Yogyakarta, Indonesia, using the Sardjito Cardiovascular Intensive Care (SCIENCE) registry with a retrospective cohort design. Multivariate logistic regression analysis was used to assess predictors of in-hospital mortality. …”
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Risk prediction model for poor prognosis after intravenous thrombolysis among ischemic stroke patients aged ≥ 80 years and analysis of follow-up by Ying Wang, Dongwei Liu, Mokhtar Aldhabi, Zuolei Chen, Le Feng, Huanmin Gao, Lin Yin

“…R software was utilized to develop a clinical prediction model and perform internal validation. 2: Ninety days, 180 days, and one year were designated as follow-up time points for all patients. 1.Patients aged ≥ 80 years had higher 90-day poor outcome and mortality (P < 0.001).However, there was no significant difference in symptomatic intracranial hemorrhage between the two groups (P > 0.05).Baseline NIHSS score (OR, 1.15; 95% CI,1.07–1.23; P < 0.001) and admission blood glucose (OR, 1.36; 95% CI,1.11–1.74; P = 0.007) were identified as independent predictors of poor prognosis at 90 days.The area of the prediction model under the receiver operator characteristic curve was 0.77. …”
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The clinical efficacy of scalp acupuncture for tinnitus: A systematic review and meta-analysis by Jiadi Chen, Ruizhi Jing

“…Results: A total of 20 research studies,with 1430 participants,were included.The systematic review and meta-analysis revealed that the scalp acupuncture groups had a significantly higher clinical effective rate compared to the control groups (RR=1.25, 95 % CI 1.16–1.35, p < 0.00001),with low heterogeneity(p = 0.27,I2=20 %).The scalp acupuncture groups and scalp acupuncture plus auxiliary acupoints groups had greater reduction in tinnitus severity compared to the control groups(SMD=-0.76,95 %CI:-1.02,-0.51,p < 0.00001;SMD:-0.93,95 %CI:-1.52,-0.33,p = 0.002, respectively),with a moderate heterogeneity(p = 0.005,I2=62 %) and a significant heterogeneity (p < 0.00001,I2=86 %) observed due to differences in study design, sample characteristics, and intervention protocols.Sensitivity analysis confirmed the stability of the results.The summary table generated through GRADEpro indicated that the certainty of evidence ranged from moderate to low. …”
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Experimental and Numerical Simulation Study on the Mechanical Properties of Integrated Sleeve Mortise and Tenon Steel–Wood Composite Joints by Zhanguang Wang, Weihan Yang, Zhenyu Gao, Jianhua Shao, Dongmei Li

“…In view of the application status and technical challenges of steel–wood composite joints in architecture, this paper proposes an innovative connection technology to solve issues such as susceptibility to pry-out at beam–column joints and low load-bearing capacity and to provide various reinforcement methods in order to meet the different structural requirements and economic benefits. By designing and manufacturing four groups of beam–column joint specimens with different reinforcement methods, including no reinforcement, structural adhesive and angle steel reinforcement, 4 mm thick steel sleeve reinforcement, and 6 mm thick steel sleeve reinforcement, monotonic loading tests and finite element simulations were carried out, respectively. …”
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Investigating the Effect of Fasting on the Mental Health of Nursing Students by Mina Shirvani, Mostafa Roshanzadeh, Maryam Rabiey Faradonbeh, Razieh Mirzaeian

“…Materials and Methods: The present semi-experimental study with a pre-test-post-test design was conducted in 2022 at Shahrekord University of Medical Sciences. …”
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Five-year trajectories of symptom severity, physical and mental functioning in patients with persistent somatic symptoms: the PROSPECTS cohort study by Henriëtte E van der Horst, Johannes C van der Wouden, Hieke Barends, Nikki Claassen, Joost Dekker, Trynke Hoekstra

“…Therefore, we aimed to: (1) identify distinct 5-year trajectories of symptom severity, physical and mental functioning in adult patients with PSS and (2) explore patient characteristics associated with these trajectories.Design We used longitudinal data (seven measurements over a 5-year period) of the PROSPECTS study: a prospective cohort of adult patients with PSS. …”
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Expatriation-enhanced competencies: A multiple case study of technology-based entrepreneurs by Hilka Pelizza Vier Machado, Jörg Freiling

“…In the same vein, government can design policy to attract self-expatriate in innovations hubs, considering that local inhabitants can benefit from the cultural exchange. …”
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Research on the Status of KAP and Countermeasures of the Scientific Research Level of TCM Rehabilitation Practitioners by Jian SONG, Zhizhen LIU, Jingsong WU, Juan PENG, Bin CHEN, Jia HUANG

“…At the knowledge dimension, compare with non-tertiary hospital group, the ability of database literature retrieval, rehabilitation research and design of the tertiary hospital group were higher (<italic>P</italic>&lt;0.05), while there were no significant differences in rehabilitation literature reading and statistical analysis of scientific research (<italic>P</italic>&gt;0.05). …”
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The Gas-Sensing Properties of Ag-/Au-Modified Ti₃C₂T_x (T=O, F, OH) Monolayers for HCHO and C₆H₆ Gases by Xinghua Qi, Bahadar Nawab Khattak, Arif Alam, Wenfu Liu, Yingang Gui

“…The above results serve as a theoretical foundation for the design of new sensors for HCHO and C₆H₆.…”
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Exploring the purpose and stages of patient and public involvement and engagement (PPIE) in audiology research: a case study approach by Helen Pryce, Nisha Dhanda, Jean Straus

“…Building meaningful relationships with PPIE contributors ensures a wide range of perspectives, informing research design and conduct. The study highlights the challenges of traditional focus groups and the benefits of flexible, personalised engagement methods. …”
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Clinical Validation of the Defining Characteristics of the Nursing Diagnosis ‘Activity Intolerance’ in Patients With Acute Coronary Syndrome by Diana Isabel Cáceres Rivera, Luz Mileyde Jaimes Rojas, Luisa Yaneth Cristancho Zambrano, Jennifer Vanesa Acosta Barón, Diana Ivonne Cañon Gómez, Lyda Z. Rojas

“…ABSTRACT Aim To validate the defining characteristics (CDs) of the nursing diagnosis ‘Activity intolerance [00092]’ in patients with acute coronary syndrome (ACS). Design Cross‐sectional study. Patients over 18 years of age with a confirmed medical diagnosis of hospitalised ACS were included and those who were haemodynamically unstable, with alterations in the mental sphere or with communication limitations were excluded. …”
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The growth of red tilapia fed on organic-selenium supplemented diet by Muhammad Agus Suprayudi, Burhanudin Faisal, Mia Setiawati

“…This experiment were used randomized design with four treatments and two replications. …”
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