Childhood neurodivergent traits, inflammation and chronic disabling fatigue in adolescence: a longitudinal case–control study by Neil A Harrison, Hugo D Critchley, Jessica Eccles, Kevin A Davies, Lisa Quadt, Rod Bond, Jenny Csecs

“…Objectives To test whether inflammatory processes link the expression of childhood neurodivergent traits to chronic disabling fatigue in adolescence.Design Longitudinal case–control study.Setting We analysed data from The Avon Longitudinal Study of Parents and Children (ALSPAC).Participants 8115 and 8036 children of the ALSPAC cohort at ages 7 and 9 years, respectively, 4563 of whom also completed self-report measures at age 18 years.Primary and secondary outcome measures We assessed if children scoring above screening threshold for autism/attention deficit hyperactivity disorder (ADHD) at ages 7 and 9 years had increased risk of chronic disabling fatigue at age 18 years, computing ORs and CIs for effects using binary logistic regression. …”
Get full text

A service ecosystems perspective to explore social prescribing value co-creation for vulnerable young people in NEET situation by Isabel Farina, Daniela Sangiorgi, Cristina Masella, Ilaria Simonelli, Regina Alves, Maria J. Marques, Sonia Dias, Carina Dantas, Sabrina Herzog, Sara Paternoster, Emanuele Torri, Marcello Bertotti

Get full text

Tibiofemoral Joint Contact Force Estimation Based on OpenSim Musculoskeletal Modeling by WANG Xiaoling, JIAN Jiawei, XIE Qiurong, LIAN Zhanghui, GUO Chunming, GUO Jiemei, LI Yurong

“…Compared with the imimplanted pressure testing equipment, the tibiofemoral joint contact force estimation method based on OpenSim muscle bone modeling could accurately predict the medical, lateral and total contact forces of the knee joint.ConclusionThe established full-body OpenSim musculoskeletal model of the knee joint with two contact points and three degrees of freedom can be used to generate muscle-driven gait simulation and obtain reliable contact forces of the tibiofemoral joint, which provides an important basis for accurate monitoring of tibiofemoral joint load, formulation of clinical rehabilitation programs and continuous improvement of prosthesis design.…”
Get full text

Isolation and Characterization of an Adult Stem Cell Population from Human Epidural Fat by Nedaa Al-Jezani, Roger Cho, Anand O. Masson, Brian Lenehan, Roman Krawetz, Frank G. Lyons

“…Study Design. Isolation and characterization of human epidural fat (HEF) stem/progenitor cells. …”
Get full text

A Speckle-Tracking Echocardiography Study: Cardiac Effect of Sleep Duration by Gülsüm Bingöl, Fulya Avcı Demir, Özge Özden, Emre Özmen, Serkan Ünlü

“…The patients who were eligible for the study design were called by the investigator to obtain information on average sleep duration, and two groups were defined by the self-reported sleep duration (≤7 hours, >7 hours per day) and were used in the statistical analyses. …”
Get full text

Life-history traits, pace of life and dispersal among and within five species of Trichogramma wasps: a comparative analysis by Guicharnaud, Chloé, Groussier, Géraldine, Beranger, Erwan, Lamy, Laurent, Vercken, Elodie, Dahirel, Maxime

“…We discuss how expanding our experimental design by accounting for the density-dependence of both the pace of life and dispersal might improve our understanding of those traits and how they interact with each other. …”
Get full text

Algorithm of Behaviour of Virtual Avatars During Public Speaking Training in a VR Environment by Karol Jędrasiak, Robert Robert Wolański, Damian Bereska

“…Project and methods: The project involved developing an innovative algorithm designed to control the behaviour of virtual avatars during public speaking training in a VR environment. …”
Get full text

Smartphone applications for physical activity and sedentary behaviour change in people with cardiovascular disease: A systematic review and meta-analysis. by Kacie Patterson, Rachel Davey, Richard Keegan, Nicole Freene

“…Study quality was assessed using validated tools appropriate for each study design. Random effects model was used and the pooled mean difference between post scores were calculated. …”
Get full text

Aetiological, seasonal and antibiotic susceptibility patterns of diarrhoeal diseases in Bhutan (2016–2022): a retrospective study of surveillance data by Sangay Dorji, Kinley Gyem, Sonam Pelden, Dorji Tshering, Kinley Penjor, Rinzin Wangchuk, Jigme Tenzin, Birdi Lal Phuyel

“…Objectives This study aimed to identify the aetiological spectrum, seasonal distribution and antimicrobial resistance patterns of diarrhoeal diseases in Bhutan.Study design and setting The study used a cross-sectional, retrospective analysis of secondary data gathered through a passive, hospital-based sentinel surveillance for diarrhoeal disease across 12 hospitals, representing Bhutan’s demographically diverse regions.Participants A total of 3429 participants’ data of all age groups who presented with diarrhoea at sentinel hospitals between 1 January 1 2016 and 31 December 2022 were analysed.Results Diarrhoeagenic Escherichia coli (DEC), Shigella, Salmonella and Aeromonas spp. were predominant bacterial pathogens, while Rotavirus, Astrovirus and Norovirus were the leading viral pathogens. …”
Get full text

Mesenchymal Stem Cell-Derived Neuron-Like Cell Transplantation Combined with Electroacupuncture Improves Synaptic Plasticity in Rats with Intracerebral Hemorrhage via mTOR/p70S6K S... by Guoqiang Yang, Jiayi Zhu, Guwen Zhan, Guangbi Fan, Li Deng, Huajun Tang, Xiaoqian Jiang, Bo Chen, Chaoxian Yang

“…However, the underlying mechanisms by which the combined treatment promotes neuroprotection remain unclear. This study was designed to investigate the effects of the combined treatment on synaptic plasticity and elucidate their underlying mechanisms. …”
Get full text

The Influence of The Financial Sector on The Success of Micro Enterprises in Surabaya City by Sri Nathasya Br Sitepu, Andri Wijanarko, Florencia Gunawan

“…Objective: This research aims to analyze the influence of financial factors, consisting of financial literacy, financial attitude, financial inclusion, business capital, and digital financial systems on the success of micro enterprises. Design/methodology/approach: This study is quantitative research using secondary data. …”
Get full text

Development and validation of the Japanese version of the Public Attitudes Toward Epilepsy (PATE‐J) Scale by Junichi Hatakeda, Hiroumi Shimazaki, Izumi Kuramochi, Takayuki Iwayama, Sayaka Kobayashi, Hideyuki Matsuki, Haruo Yoshimasu, Kheng Seang Lim

“…Methods The study employed a cross‐sectional design using an online survey of 537 participants from the general public in Japan, with follow‐up surveys at 2 weeks and 3 months. …”
Get full text

Penggunaan Compressive Sensing pada Pengenalan Huruf dengan Tulisan Tangan Menggunakan Metode K-Nearest Neighbor by Zalfa Alif Muhammad, Gelar Budiman, Sofia Saidah

“…To find out, the data were collected and then processed using preprocessing, CS, reconstruction with Orthogonal Matching Pursuit, and the last detection process were using K- Nearest Neighbor in which there were feature extraction using Template Matching. After the design stage, several scenarios were tested to obtain the best detection accuracy by changing the size parameters of each block in an image, changing the compression line, and changing the image dimensions. …”
Get full text

The Role of Clinician-Developed Applications in Promoting Adherence to Evidence-Based Guidelines: Pilot Study by Madhu Prita Prakash, Aravinda Thiagalingam

“…The app utilizes a sequential design, requiring participants to input patient data in a step-wise fashion to reach the final patient risk stratification. …”
Get full text

Construction of machine learning-based models for screening the high-risk patients with gastric precancerous lesions by Shuxian Yu, Haiyang Jiang, Jing Xia, Jie Gu, Mengting Chen, Yan Wang, Xiaohong Zhao, Zehua Liao, Puhua Zeng, Tian Xie, Xinbing Sui

“…Methods In this study, a total of 2229 subjects were recruited from nine tertiary hospitals between October 2022 and November 2023. We designed a comprehensive questionnaire, identified statistically significant factors, and created a web-based column chart. …”
Get full text

Speed of urban public transport as criterion of the justification of spatial and time-based prioritization by Yurii Yevchuk

“…As a result, using the example of the road network of Lviv city, where urban public transport routes are designed, six types of segments were identified, which differ in the peculiarities of traffic flow and planning characteristics. …”
Get full text

Indigenous and non-Indigenous people experiencing homelessness and mental illness in two Canadian cities: A retrospective analysis and implications for culturally informed action by Brittany Bingham, Akm Moniruzzaman, Michelle Patterson, Jino Distasio, Jitender Sareen, John O’Neil, Julian M Somers

“…We hypothesised that compared with non-Indigenous people, those who are Indigenous would demonstrate histories of displacement earlier in life, higher rates of trauma and self-medication with alcohol and other substances.Design and setting Retrospective data were collected from a sample recruited through referral from diverse social and health agencies in Winnipeg and Vancouver.Participants Eligibility included being 19 years or older, current mental disorder and homelessness.Measures Data were collected via interviews, using questionnaires, on sociodemographics (eg, age, ethnicity, education), mental illness, substance use, physical health, service use and quality of life. …”
Get full text

Hubungan Perilaku Merokok dengan Ketahanan Kardiorespirasi (Ketahanan Jantung-Paru) Siswa SMKN I Padang by Amanda Besta Rizaldy, Afriwardi ., Yessy Susanty Sabri

“…This was an analytical research with cross-sectional study design. This study was done for the students of Vocational Senior High School 1 Padang with the total subjects were 111 peoples. …”
Get full text

Physicians’ knowledge, attitudes, and beliefs regarding practices of male and female surgical sterilization procedures in Lebanon by Jad Najdi, Alexandre Armache, Elia Abou Chawareb, Nassib Abou Heidar, Marwan Zein, Anthony Fadel, Jimmy Nehme, Bassel Bachir

“…Our survey aims to explore physicians’ knowledge, attitudes and beliefs about surgical sterilization techniques in Lebanon. Study design A web-based survey was sent to residents and attending physicians of different specialties in Lebanon between April 2022 and April 2023. …”
Get full text

Using Large Language Models to Detect and Understand Drug Discontinuation Events in Web-Based Forums: Development and Validation Study by William Trevena, Xiang Zhong, Michelle Alvarado, Alexander Semenov, Alp Oktay, Devin Devlin, Aarya Yogesh Gohil, Sai Harsha Chittimouju

“…MethodsWe used several LLMs, including GPT-4 Turbo, GPT-4o, DeBERTa (Decoding-Enhanced Bidirectional Encoder Representations from Transformer with Disentangled Attention), and BART, among others, to detect and determine the root causes of DDEs in user comments posted on MedHelp. Our study design included the use of zero-shot classification, which allows these models to make predictions without task-specific training. …”
Get full text