Reducing catheter-associated urinary tract infections in a large health system: a quality improvement approach using a fractal management system by Elie A. Saade, Esther J. Thatcher, Tina Lewis, Susan Carr, Marcia Cornell, Rachel Arnold, Lisa Bushong, Zainab Albar, Peter Pronovost

“…Our goal was to improve the CAUTI rates through multiple hospitals through implementing sustainable practices, including enhancing communication, provider engagement, accountability, and transparency in reporting to achieve long-term improvements. Design: Quality improvement with multiple levels of interventions Setting: A health system in northern Ohio with 21 affiliated hospitals across 16 counties. …”
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TARGET Protein: the effect of augmented administration of enteral protein to critically ill adults on clinical outcomes—statistical analysis plan for a cluster randomized, cross-se... by Sophie Zaloumis, Matthew J. Summers, Jeffrey J. Presneill, Rinaldo Bellomo, Lee-anne S. Chapple, Marianne J. Chapman, Adam M. Deane, Suzie Ferrie, Craig French, Sally Hurford, Nima Kakho, Matthew J. Maiden, Stephanie N. O’Connor, Sandra L. Peake, Emma J. Ridley, An Tran-Duy, Patricia J. Williams, Paul J. Young, Amalia Karahalios, on behalf of the TARGET Protein Investigators, the Australian, New Zealand Intensive Care Society Clinical Trials Group

“…All statistical models will account for the cluster-randomized cross-over design to ensure correct estimation of the 95% confidence intervals. …”
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Analysis on characteristics and mechanism for rock fracture in deep rock with cracks under dynamic-static coupling effect by Jinjin Ge, Yongqi Jia, Wei Huang, Meilu Yu, Suqian Ni, Ying Xu, Leilei Yu, Keke Gu

“…The research provides valuable insights into the complex fracture behavior of fractured rocks under dynamic loads, which can inform the design of blasting parameters in deep engineering. …”
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Use of thymidine kinase 1 autoantibody, thymidine kinase antigen, extracellular protein kinase A autoantibody, and C‐reactive protein for early detection of malignant tumors in dog... by Yoonhee Kim, Wonhee Lee, Byunggak Kim, Bonghwan Jang, Kyung‐Rok Yu, Hong Sook Kim, Minok Ryu, Yein Oh, Kyoungwon Seo, Chul Park, Ulsoo Choi, Dongha Bhang, Hwayoung Youn

“…Methods TK1 autoantibody, ECPKA autoantibody, and CRP were measured using LFIA methods in serum samples of dog to design a new neoplastic index (NI) for early detection of malignant tumors in dogs. …”
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Ocular inoculation of toad venom: toxic cataract and proteomic profiling by Danni Lyu, Danni Lyu, Shuang Ni, Shuang Ni, Jia Xu, Jia Xu, Sha Zhu, Sha Zhu, Jing-Wei Xu, Jing-Wei Xu, Yixuan Feng, Yixuan Feng, Ce Shi, Ce Shi, Wen Xu, Wen Xu

“…Anterior capsule, nucleus, and cortex specimens from the patient (designated as PT_CAP, PT_PHACO, and PT_CTX, respectively) and age-related cataract controls (C_CAP, C_PHACO, and C_CTX, respectively) were collected and subjected to 4D label-free quantitative proteomics.ResultsA multitude of differentially expressed proteins (DEPs) were identified in the patient’s lens compared to those in the controls. …”
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Effects of plant- and animal-based-protein meals for a day on serum nitric oxide and peroxynitrite levels in healthy young men by Tomoko Kaneko, Masaki Yoshioka, Futo Kawahara, Natsumi Nishitani, Shoya Mori, Jiyeon Park, Takashi Tarumi, Keisei Kosaki, Seiji Maeda

“…The standard and test meals consisted of breakfast, lunch, and dinner and were designed to be isocaloric. Plant-based-protein meals contained no animal protein. …”
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Specific and sensitive detection of bovine coronavirus using CRISPR-Cas13a combined with RT-RAA technology by Zili Liang, Ruxing Luo, Qifu He, Cheng Tang, Zhidong Zhang, Yanmin Li, Zijing Guo

“…The specific primers for RT-RAA and CRISPR RNA (crRNA) were designed in the conserved region of the BCoV nucleocapsid (N) gene.ResultsThe detection limit of the RT-RAA CRISPR/Cas13a assays for BCoV detection was 1.72 copies/μl, and there were no cross-reactions with the other 10 common bovine enteric and respiratory disease-associated pathogens. …”
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Image-based anomaly detection in low-light industrial environments with feature enhancement by Dinh-Cuong Hoang, Phan Xuan Tan, Anh-Nhat Nguyen, Son-Anh Bui, Ta Huu Anh Duong, Tuan-Minh Huynh, Duc-Manh Nguyen, Viet-Anh Trinh, Quang-Huy Ha, Nguyen Dinh Bao Long, Duc-Thanh Tran, Xuan-Tung Dinh, Van-Hiep Duong, Tran Thi Thuy Trang

“…In this paper, we present DarkAD, a novel end-to-end approach specifically designed to address the difficulties of anomaly detection under low-light conditions. …”
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Longitudinal association of thyroid-stimulating immunoglobulin levels with clinical characteristics in thyroid eye disease by Kyung In Woo, Suk-Woo Yang, Jeong Kyu Lee, Sang In Khwarg, Jin Sook Yoon, Sehyun Baek, Jae Wook Yang, JaeSang Ko, Koung Hoon Kook, Sang Duck Kim, Jun Hyuk Son, Helen Lew, Sung Bok Lee, Jae Woo Jang, Hee Young Choi, Mi Jung Chi

“…In this study, we evaluated the longitudinal association between changes in serum thyroid-stimulating hormone (TSH) receptor antibody (TRAb) levels and course of disease activity and severity over time.Design This was a multicentre, prospective, observational study.Setting Fifteen tertiary care oculoplastic service centres in Korea.Participants Seventy-six patients with newly diagnosed TED were included and followed up for 12 months.Methods We evaluated clinical characteristics and serum TRAb levels at baseline, 6 and 12 months of TED diagnosis. …”
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ConvXGB: A novel deep learning model to predict recurrence risk of early-stage cervical cancer following surgery using multiparametric MRI images by Ji Wu, Jian Li, Bo Huang, Sunbin Dong, Luyang Wu, Xiping Shen, Zhigang Zheng

“…Methods: The clinicopathologic data and multiparametric MRI images of 406 cervical cancer patients from three institutions were collected. We designed a novel deep learning model called “ConvXGB” for predicting recurrence risk by combining the convolutional neural network (CNN) and eXtreme Gradient Boost (XGBoost). …”
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Impact of empiric antibiotics on risk of Clostridioides difficile—a causal inference observational analysis by Matthew A. Pappas, Shoshana J. Herzig, Andrew D. Auerbach, Abhishek Deshpande, Eunice Blanchard, Michael B. Rothberg

“…Causal inference observational study designs can be used to estimate patient-level harms of interventions such as empiric antimicrobials. …”
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Evaluation of a PCR-based lateral flow device for detecting Aspergillus and Candida species from clinical specimens by Ariff Khalid, Jacinta Santhanam, Mohd Nizam Tzar, Ang-Lim Chua, Sharifah Fadilah Abdul Wahid, Wan Rahiza Wan Mat, Raha Abd Rahman, Petrick Periyasamy

“…Methods: Three separate multiplexed PCR reactions were designed together with a testing algorithm, using biotin, digoxigenin and Tamra fluorophore-labelled fungal internal transcribed spacer universal fungal primers, fungal genera-specific primers, and species-specific primers to produce labelled PCR products that were detected on the LFA dipstick. …”
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Neonatal BCG vaccination and child survival in TB-exposed and TB-unexposed children: a prospective cohort study by Peter Aaby, Per Kallestrup, Christine Stabell Benn, Sanne M Thysen, Ane Fisker, Victor Francisco Gomes, Frauke Rudolf, Christian Wejse, Adam Roth

“…Objectives To assess the association between neonatal BCG vaccination and mortality between 28 days and 3 years of age among tuberculosis (TB)-exposed and TB-unexposed children.Design Prospective cohort study.Setting Bandim Health Project runs an urban Health and Demographic Surveillance site in Guinea-Bissau with registration of mortality, vaccination status and TB cases.Participants Children entered the analysis when their vaccination card was inspected after 28 days of age and remained under surveillance to 3 years of age. …”
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Chitosan oligosaccharides maintained postharvest quality and increased shelf life of mango by Nishat Nitu, Md. Sefat Ullah, Prianka Howlader, Md. Nazmul Mehedi, Habiba Meem, Santosh Bose

“…The two factor-experiments were laid out in a completely randomized design with three replications. Findings: Results demonstrated that COS had a positive effect on retaining higher amount of anthocyanin content, total sugar and total soluble solid content. …”
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What should be publicly funded in the Colombian health system? A mixed methods study of citizens’ perceptions by Juan Carlos Velasquez, Claudia Marcela Vélez, Diana Patricia Díaz-Hernández, Pamela Velázquez-Salazar, Gilma Hernández-Herrera, Daniel Felipe Patiño-Lugo, Olga Francisca Salazar-Blanco, Leydi Camila Rodríguez-Corredor, Viviana María Vélez-Marín, Anny Julieth Jaramillo-García

“…Prioritising which health technologies should be publicly funded is one decision that requires prudence and consideration of the values and expectations of the people who will be affected by it.Objective To identify and understand the citizens’ perceptions about which health technologies should be publicly funded in Colombia.Design Sequential exploratory mixed methods study; the first was a qualitative embedded case study, and the second was a Q methodology study.Participants 46 citizens were interviewed, and 30 citizens ordered a Q-sample of 45 statements.Analysis Interviews were content analysed. …”
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The adolescent Internet Adaptability Scale: Development and psychometric properties by Weijun Wang, Jianmei Ye, Rouchun Dong, Shihao Ma, Dawei Huang, Xin Zhao

“… This study presents the development and validation of the Adolescent Internet Adaptability Scale (AIAS), designed to assess adolescents’ adaptive capacities in Internet use. …”
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Clinical Features and Genetic Characteristics of XLID Patients With KDM5C Gene Mutations: Insights on Phenotype–Genotype Correlations From 175 Previous Cases and Identification of... by Mohammad‐Reza Ghasemi, Zahra Esmaeilizadeh, Sahand Tehrani Fateh, Hossein Sadeghi, Saman Bagheri, Farzad Hashemi‐Gorji, Morteza Sheikhi Nooshabadi, Rasoul Madannezhad, Toktam Sadat Tavabe Ghavami, Reza Mirfakhraie, Mohammad Miryounesi

“…This study also conducted a narrative review of the literature to identify key clinical and genetic characteristics of XLID caused by mutations in the KDM5C gene. Study Design Whole‐exome sequencing was performed on the proband's DNA, and Sanger sequencing was used to confirm and analyze the identified variant in a 20‐month‐old male patient with motor and speech delays. …”
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Demographic and motivational factors affecting the whole-body donation programme in Nanjing, China: a cross-sectional survey by Li Yuan, Jiayi Jiang, Mingyi Zhang, Haojie Meng, Xiang Cui, Yuxin Yang, Chuan Su, Jinfan Wang, Luqing Zhang

“…Objectives To investigate the demographics and motivations of whole-body donors in China, and help suggest a solution to the problem of low body donation numbers.Design A cross-sectional study on body donors in China. …”
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Nurses' Sleep Quality and Its Influencing Factors During the First Explosive COVID‐19 Outbreak in Zhejiang, China, After the Relaxation of Epidemic Prevention and Control Measures:... by Lifen Lu, Di Sheng, Yaling Zhu, Xiaowei Xia, Guanghui Chen, Jiali Liang, Xiulan Shen, Gui Zheng

“…ABSTRACT Aim To investigate the sleep quality and its influencing factors among nurses in hospitals in Zhejiang, China, during the first explosive COVID‐19 outbreak following the relaxation of prevention and control measures. Design A multicentre cross‐sectional study. Methods Between 10 January and 20 January 2023—approximately 1 month after the policy was loosened—a total of 573 nurses from tertiary and community hospitals in Zhejiang participated in an online, self‐administered survey. …”
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Corticosteroid Pulses for Hospitalized Patients with COVID-19: Effects on Mortality by Ivan Cusacovich, Álvaro Aparisi, Miguel Marcos, Cristina Ybarra-Falcón, Carolina Iglesias-Echevarria, Maria Lopez-Veloso, Julio Barraza-Vengoechea, Carlos Dueñas, Santiago Antonio Juarros Martínez, Beatriz Rodríguez-Alonso, José-Ángel Martín-Oterino, Miguel Montero-Baladia, Leticia Moralejo, David Andaluz-Ojeda, Roberto Gonzalez-Fuentes

“…To assess the influence of corticosteroid pulses on 60-day mortality in hospitalized patients with severe COVID-19. Methods. We designed a multicenter retrospective cohort study in three teaching hospitals of Castilla y León, Spain (865,096 people). …”
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