Vernolactone Promotes Apoptosis and Autophagy in Human Teratocarcinomal (NTERA-2) Cancer Stem-Like Cells by Nuwanka K. Abeysinghe, Ira Thabrew, Sameera R. Samarakoon, Meran K. Ediriweera, Kamani H. Tennekoon, Varuni P. C. Pathiranage, Anuka S. Mendis

“…The present study was designed to determine antiproliferative, apoptotic, autophagic, and antioxidant effects of vernolactone, isolated from V. zeylanica, in human embryonal carcinoma cells (NTERA-2, a cancer stem cell model). …”
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Functional gastrointestinal disorders predictors in neonates and toddlers: A machine learning approach to risk assessment by Flavia Indrio, Elio Masciari, Flavia Marchese, Matteo Rinaldi, Gianfranco Maffei, Ilaria Gangai, Assunta Grillo, Roberta De Benedetto, Enea Vincenzo Napolitano, Isadora Beghetti, Luigi Corvaglia, Antonio Di Mauro, Arianna Aceti

“…Based on these findings, an AI-based predictive model will be developed, along with a user-friendly, web-based interface designed for practical risk assessment. Results: 6060 infants were enrolled. 8.1 % were born preterm. …”
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Transitioning to a virtual post-intensive care rehabilitation service in response to the COVID-19 pandemic: results of multidisciplinary focus-groups by Fiona Howroyd, Fiona Howroyd, Natacha Earle, Jonathan Weblin, David McWilliams, Mark Raven, Niharika A. Duggal, Zubair Ahmed, Zubair Ahmed, Tonny Veenith

“…Although telerehabilitation is recommended across national guidelines, there is a lack of practical guidance to support clinicians with virtual adaptations.AimsThis study aimed to describe the key components of a safe and effective virtual post-intensive-care rehabilitation service, through qualitative exploration.MethodsThis is a qualitative study using a focus-group design based upon grounded theory. This study is nested within a service development project, taking place during the COVID-19 pandemic. …”
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mHealth Incentivized Adherence Plus Patient Navigation (MIAPP): protocol for a pilot randomized controlled trial to improve linkage and retention on buprenorphine for hospitalized... by Elenore P. Bhatraju, Devin N. Kennedy, Alexander J. Gojic, Matthew Iles-Shih, Joseph O. Merrill, Jeffrey H. Samet, Kevin A. Hallgren, Judith I. Tsui

“…We describe the intervention and design from a pilot randomized controlled trial of an intervention to increase linkage to and retention in outpatient buprenorphine services for patients with OUD and methamphetamine use who initiate buprenorphine in the hospital. …”
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LiDAR point cloud denoising for individual tree extraction based on the Noise4Denoise by Xiangfei Lu, Zongyu Ye, Liyong Fu, Huaiyi Wang, Kaiyu Wang, Yaquan Dou, Dongbo Xie, Xiaodi Zhao

“…The processing of LiDAR point cloud data is of critical importance in the context of forest resource surveys, as well as representing a pivotal element in the realm of forest physiological and ecological studies.Nonetheless, conventional denoising algorithms frequently exhibit deficiencies with regard to adaptability and denoising efficacy, particularly when employed in relation to disparate datasets.To address these issues, this study introduces DEN4, an unsupervised, deep learning-based point cloud denoising algorithm designed to improve the accuracy of single tree segmentation in LiDAR point clouds.DEN4 introduces a multilevel noise separation module that effectively distinguishes between signal and noise, thereby improving the signal-to-noise ratio (SNR) and reducing the error.The experimental results demonstrate that DEN4 significantly outperforms traditional denoising methods in several key metrics, including mean square error (MSE), SNR, Hausdorff distance, and structural similarity index (SSIM).In the 60 sample dataset, DEN4 achieved the best mean and standard deviation on all metrics: Specifically, the MSE mean was found to be 0.0094, with a standard deviation of 0.0008, the SNR mean was 149.1570, with a standard deviation of 0.5628, the Hausdorff mean was 0.8503, with a standard deviation of 0.0947, and the SSIM mean was 0.8399, with a standard deviation of 0.0054. …”
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Serological markers of exocrine pancreatic function are differentially informative for distinguishing individuals progressing to type 1 diabetes by Desmond Schatz, Laura Jacobsen, Todd M Brusko, Michael J Haller, Mark Atkinson, MacKenzie D Williams, Catherine Ramsey Grace, Amanda L Posgai, Kieran M McGrail, Maigan A Brusko, Rhonda Bacher, Clive H Wasserfall

“…We collectively evaluated seven such biomarkers, combined with islet autoantibodies (AAb) and genetic risk score (GRS2), for their utility in predicting AAb/T1D status.Research design and methods Cross-sectional serum samples (n=154 T1D, n=56 1AAb+, n=77 ≥2AAb+, n=256 AAb−) were assessed for IGF1, IGF2, adiponectin, leptin, amylase, lipase, and trypsinogen (n=543, age range 2.7–30.0 years) using random forest modeling.Results GRS2, age, lipase, trypsinogen, and AAb against ZnT8, GAD65, and insulin were the most informative markers. …”
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Aortic Stiffness, Left Ventricle Hypertrophy, and Homogeneity of Ventricle Repolarization in Adult Dialyzed Patients by Tomasz Zapolski, Andrzej Jaroszyński, Anna Drelich-Zbroja, Anna Wysocka, Jacek Furmaga, Andrzej Wysokiński, Andrzej Książek, Małgorzata Szczerbo-Trojanowska, Sławomir Rudzki

“…Aim. Study was designed to assess relationship between aortic compliance and homogeneity of heart electrical activity in dialysis patients. …”
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Narrative Review of Free Radicals and Reactive Oxygen Species in Otitis Media by Jeongmin Lee, Seok Min Hong, Yong Sung Choi, Jinseok Lee, Joon Hyung Yeo, Sung Soo Kim, Jae Min Lee, Dong Keon Yon, Seung Geun Yeo

“…Although the levels of free radicals and ROS varied by type of OM, study design, control group selection, sample type, ROS and free radical markers, and antioxidant types, most studies showed increased ROS and decreased antioxidants in OM patients. …”
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The Effect of Knowledge, Education, Income, and Marriage Age on Iron Deficiency Anemia in Pregnant Women in Taiz City-Yemen by Lamia A. S. Ali, Hermanto Tri Joewono, Widati Fatmaningrum, Riyadh A. S. Thabit, Hebah H. M. Almothana, Fardous G. Alsoufi, Aya Ali Abdullah, Tasnim Mohammed Al-Qadhi, Suha Ali Al Hajj, Samar A. A. Ahmed, Sarah A. D. Alselwi, Habib Thabet, Haitham T. S. Mohammed, Linda Andriani

“…Methods: The study was carried out utilizing a quantitative design (Descriptive study). From 3rd November 2023, until 30th January 2024. …”
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An interlaboratory comparison to quantify oxidative potential measurement in aerosol particles: challenges and recommendations for harmonisation by P. A. Dominutti, J.-L. Jaffrezo, A. Marsal, T. Mhadhbi, R. Elazzouzi, C. Rak, F. Cavalli, J.-P. Putaud, A. Bougiatioti, N. Mihalopoulos, N. Mihalopoulos, D. Paraskevopoulou, I. Mudway, I. Mudway, A. Nenes, A. Nenes, K. R. Daellenbach, C. Banach, S. J. Campbell, H. Cigánková, D. Contini, G. Evans, M. Georgopoulou, M. Ghanem, D. A. Glencross, D. A. Glencross, M. R. Guascito, M. R. Guascito, H. Herrmann, S. Iram, M. Jovanović, M. Jovašević-Stojanović, M. Kalberer, I. M. Kooter, S. E. Paulson, A. Patel, A. Patel, A. Patel, E. Perdrix, M. C. Pietrogrande, P. Mikuška, J.-J. Sauvain, K. Seitanidi, P. Shahpoury, E. J. d. S. Souza, S. Steimer, S. Steimer, S. Stevanovic, G. Suarez, P. S. G. Subramanian, B. Utinger, M. F. van Os, V. Verma, X. Wang, R. J. Weber, Y. Yang, X. Querol, G. Hoek, R. M. Harrison, R. M. Harrison, G. Uzu

“…<p>This paper presents the findings from a collaborative interlaboratory comparison exercise designed to assess oxidative potential (OP) measurements conducted by 20 laboratories worldwide. …”
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The effects of weather on physical activity and sedentary behaviour in older adults by Kathryn M. Crosby, Kathryn M. Crosby, Kathryn M. Crosby, Brittany Adams, Elizabeth Zambrano Garza, Mathieu L. Bourbonnais, Melanie Fenton, Christiane Hoppmann, Christiane Hoppmann, Christiane Hoppmann, Jennifer M. Jakobi, Jennifer M. Jakobi, Jennifer M. Jakobi

“…Females tend to participate in indoor LPA, and as age increases the time spent in outdoor LPA decreases.ImplicationsConsideration needs to be given to designing indoor PA interventions, with a focus on increasing MVPA for older adults.…”
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Acute Bronchiolitis To Pediatric Inpatient Clinic In Patients Under 2 Years Old, Installed with Diagnosis Investigation of the Relationship of Bronchiolitis and Asthma by Selin Kuzucu, İpek Türktaş, Tuğba Bedir Demirdağ, Meltem Polat, Hasan Tezer, Anıl Tapısız, Nazmi Mutlu Karakaş, Ayşe Tana Aslan, Hakan Tüzün

“…The asthma risk was evaluated using the modified Asthma Predictive Index (mAPI) designed for predicting future asthma in bronchiolitis cases. …”
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Soap and water cleaning versus bleach-based cleaners for eliminating SARS-CoV-2 infection by Ekong E. Udoh, Ubong A. Udoh, Abiodun Egwuenu, Ekpereonne B. Esu, Aruk Eteng, Faithman E. Ovat, Uduak Okomo, Olabisi Oduwole, Joseph Okebe, Martin Meremikwu

“…We prioritised systematic reviews and randomised studies and only included other study designs, such as laboratory studies, which had interventions of relevant interest. …”
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A Complementary Low Schottky Barrier Nonvolatile Bidirectional Reconfigurable Field Effect Transistor Based on Dual Metal Silicide S/D Contacts by Liu Xi, Ya Wang, Meile Wu, Lin Qi, Mengmeng Li, Shouqiang Zhang, Xiaoshi Jin

“…In this work, a high-performance nanoscale complementary low Schottky barrier (CLSB) nonvolatile bidirectional reconfigurable field effect transistor (NBRFET) based on dual metal silicide source/drain (S/D) contacts (CLSB-NBRFET) is proposed. It is designed with Source floating gate (SFG) and drain floating gate (DFG) and adopts two kinds of metal silicide contacts to form complementary low Schottky barrier both between the S/D electrodes and the conduction band of silicon and between the S/D electrodes and the valence band of silicon at the same time. …”
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Health systems efficiency in China and ASEAN, 2015–2020: a DEA-Tobit and SFA analysis application by Jing Kang, Rong Peng, Zhen Li, Fen Huang, Yujun Chen, Jun Feng, Junyuan Wei, Fu Yu, Xiaorong Su, Xianjing Qin, Qiming Feng

“…Objective To evaluate the health systems efficiency in China and Association of Southeast Asian Nations (ASEAN) countries from 2015 to 2020.Design Health efficiency analysis using data envelopment analysis (DEA) and stochastic frontier approach analysis.Setting Health systems in China and ASEAN countries.Methods DEA-Malmquist model and SFA model were used to analyse the health system efficiency among China and ASEAN countries, and the Tobit regression model was employed to analyse the factors affecting the efficiency of health system among these countries.Results In 2020, the average technical efficiency, pure technical efficiency and scale efficiency of China and 10 ASEAN countries’ health systems were 0.700, 1 and 0.701, respectively. …”
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Improved Outcomes following the Establishment of a Neurocritical Care Unit in Saudi Arabia by Ibrahim Soliman, Waleed Tharwat Aletreby, Fahad Faqihi, Nasir Nasim Mahmood, Omar E. Ramadan, Ahmad Fouad Mady, Babar Kahlon, Abdulrahman Alharthy, Peter Brindley, Dimitrios Karakitsos

“…This is the first study in the Middle East to evaluate the clinical impact of a neurocritical care unit (NCCU) launched within the diverse clinical setting of a polyvalent intensive care unit (ICU). Design and Methods. A retrospective before and after cohort study comparing the outcomes of neurologically injured patients. …”
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Sustainable Asphalt Mixtures Reinforced with Basic Oxygen Furnace Steel Slag: Multi-Scale Analysis of Enhanced Interfacial Bonding by Bin Lei, Linjie Yu, Jiawu Chen, Yuan Meng, Dong Lu, Ning Li, Fulin Qu

“…Moreover, the study further revealed that the width and nanomechanical properties of the ITZ are closely associated with the surface roughness and chemical affinity of the aggregates, which holds significant implications for the design and application of sustainable pavement materials.…”
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Integrating hepatitis B care and treatment with existing HIV services is possible: cost of integrated HIV and hepatitis B treatment in a low-resource setting: a cross-sectional hos... by Andrew Kambugu, Philippa Easterbrook, Jacinto Amandua, David Livingstone Ejalu, Joan N Mutyoba, Claude Wandera, Emmanuel Seremba, Alex Muganzi, Racheal Beyagira, Kaggwa Mugagga, Ponsiano Ocama

“…Background Hepatitis B and HIV care share health system challenges in the implementation of primary prevention, screening, early linkage to care, monitoring of therapeutic success and long-term medication adherence.Setting Arua regional referral hospital (RRH) and Koboko district hospital (DH), the West Nile region of Uganda.Design A cross-sectional hospital-based cost minimisation study from the providers’ perspective considers financial costs to measure the amount of money spent on resources used in the stand-alone and integrated pathways.Data sources Clinic inputs and procurement invoices, budgetary documents, open market information and expert opinion. …”
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Phenolic and amino acid profiles, and antioxidant properties of third generation snack foods adding Citrus mitis by-products and milk powder: impact of extrusion processing and mic... by Xóchitl Ariadna Ruiz-Armenta, Carlos Iván Delgado-Nieblas, José de Jesús Zazueta-Morales, Ernesto Aguilar-Palazuelos, Perla Rosa Fitch-Vargas, José Alberto Gallegos-Infante, José Ángel López-Valenzuela, María Fernanda Quintero-Soto

“…The statistical analysis was performed using an unifactorial design with three levels (PS1, PS2, and PS3), evaluating four formulations (F1&amp;ndash;F4) and a commercial product (COM). …”
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Amplitude Modulation Depth Coding Method for SSVEP-Based Brain&#x2013;Computer Interfaces by Ruxue Li, Zhenyu Wang, Xi Zhao, Guiying Xu, Honglin Hu, Ting Zhou, Tianheng Xu

“…A 36-target paradigm based on AMDC strategy was designed and evaluated in terms of user experience and classification performance in Experiment 2. …”
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