Rational design of novel phenol ether derivatives as non-covalent proteasome inhibitors through 3D-QSAR, molecular docking and ADMET prediction by Miao Yuan, Hanwen Ji, Fengxin Sun, Qiang Chen, Ping Cheng

“…Aim: The purpose of this paper is to use different structures and ligand-based drug design methods properly to provide theoretical guidance for the design of novel non-covalent proteasome inhibitors, and conduct theoretical analysis of the binding interaction mode between receptors and ligands. …”
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Design of a public health emergency equipment system for bioterrorism events in public places based on literature review, scenario analysis and Delphi consultation by Xiaowen SUN, Yongzhong ZHANG, Chao ZHAO, Tianyang DENG, Song BAI

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New Evaluation Technique for WTG Design Wind Speed Using a CFD-Model-Based Unsteady Flow Simulation with Wind Direction Changes by Takanori Uchida, Takashi Maruyama, Yuji Ohya

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A Novel Design of Rescue Capsule considering the Pressure Characteristics and Thermal Dynamic Response with Thermomechanical Coupling Action Subjected to Gas Explosion Load by Xiaowei Zhai, Shibo Wu, Kai Wang, Xiaokun Chen, Haitao Li

“…Results show that the structural safety, tightness, and reliability of the capsule meet the requirements of the national safety regulations. The design method presented in this work provides a new thought for design of coal mine rescue capsule.…”
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Design and development of a portable resistive sensor based on α‐MnO2/GQD nanocomposites for trace quantification of Pb(II) in water by Amit K. Gupta, Mansi Khanna, Souradeep Roy, Pankaj, Shalini Nagabooshanam, Ranjit Kumar, Shikha Wadhwa, Ashish Mathur

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Biogas upgrading via CO2 absorption using monosodium glutamate-promoted potassium carbonate in packed absorption column: Design and performance assessment by Bambang Trisakti, Rivaldi Sidabutar, Irvan, Hani Suhastifa Rambe, Vikram Alexander, Andrew Moses Noverindo Simanjuntak, Joshua Syaloom Silalahi, Rafael Aginta Sitepu, Michael Michael, Juan Akmal Nasution, Yasmin Nabilah, Hiroyuki Daimon

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Design, synthesis and molecular modeling study of substituted indoline-2-ones and spiro[indole-heterocycles] with potential activity against Gram-positive bacteria by Radwan Awwad Abdoh, Aanazi Fares Kaed, Al-Agamy Mohammed, Mahrous Gamal Mohammad

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Design, Molecular Docking, Synthesis, Characterization and Preliminary Evaluation of Novel 1,3,4-Oxadiazole Derivatives as Cyclin-Dependent Kinase 2 Inhibitors by Yousef Sabah Ali, Monther Faisal Mahdi, Basma Monjid Abd Razik, Talal Aburjai

“… Novel 1,3,4-oxadiazole derivatives were designed, synthesized by reaction of semicarbazide hydrochloride with thiophene-2-carbaldehyde to form semicarbazone that undergo iodine-mediated cyclization to form 5-(thiophen-2-yl)-1,3,4-oxadiazol-2-amine which further reacted with different aldehydes to form Schiff base derivatives, and in-vitro tested for their cytotoxic activity. …”
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What Will the Architect Be Doing Next? How is the profession of the architect evolving as the focus of society shifts from sustainability to resilience or reactivist-driven design demands? by Alexander Mooi

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Rational emotive behavior therapy for reducing adolescent anxiety in post-covid-19 pandemic online learning: group approach and single case design by I Dewa Ayu Eka Purba Dharma Tari, I Made Mahaardhika

“…This study explores the prevalence of anxiety among students involved in distance learning and examines the effectiveness of REBT in alleviating this anxiety. A single case design was employed with 6 students, selected from an initial group of 121 participants from five junior high schools in Denpasar, Indonesia. …”
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How Influential Are Mental Models on Interaction Performance? Exploring the Gap between Users’ and Designers’ Mental Models through a New Quantitative Method by Bingjun Xie, Jia Zhou, Huilin Wang

“…Our findings provide practitioners with a new perspective of bridging the gap between users’ and designers’ mental models.…”
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Reliability-Based Design of Solid and Nail-jointed I-Section of Nigerian-Grown African Birch (<i>Anogeissus leiocarpus</i>) Timber Column by U.N. Wilson, A.A. Adedeji, F.O.P. Oriola, J.A. Alomaja, J.E. Sani

“…The ‘I’- section was found unsafe to bear the design load unlike its corresponding solid section. …”
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Design, theoretical approaches and new framework of pyrazolo[3,4-d]pyrimidine as potent anticancer agents: Efficient synthesis, ADME-T and molecular docking by Peduri Suresh Reddy, Thuraka Sekhar, Pinnu Thriveni, Gandla Mahesh Kumar, Allaka Tejeswara Rao, Mohammad Raish, Tota Giridhar, Gudipati Srinivasulu

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Designing Channel Attention Fully Convolutional Networks with Neural Architecture Search for Customer Socio-Demographic Information Identification Using Smart Meter Data by Zhirui Luo, Qingqing Li, Ruobin Qi, Jun Zheng

“…We designed a search space based on a novel channel attention fully convolutional network architecture. …”
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Development and evaluation of a novel E7 multi-epitopic vaccine for human papillomavirus type 16: design, expression, purification, and immunological characterization by Bahareh Bahmani, Zahra Amini-bayat, Mohammad Mehdi Ranjbar, Masoud Hassanzadeh Makoui, Amir-Hassan Zarnani

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Hepatitis B care cascade among people with HIV/HBV coinfection in the North American AIDS Cohort Collaboration on Research and Design, 2012-2016. by Jessica Kim, Craig W Newcomb, Dean Carbonari, Jessie Torgersen, Keri N Althoff, Mari M Kitahata, Marina B Klein, Richard D Moore, K Rajender Reddy, Michael J Silverberg, Angel M Mayor, Michael A Horberg, Edward R Cachay, Joseph K Lim, M John Gill, Kara Chew, Timothy R Sterling, Mark Hull, Eric C Seaberg, Gregory D Kirk, Sally B Coburn, Raynell Lang, Kathleen A McGinnis, Kelly A Gebo, Sonia Napravnik, H Nina Kim, Vincent Lo Re, North American AIDS Cohort Collaboration on Research and Design of IeDEA

“…We conducted a cross-sectional study among people living with HIV and HBV coinfection receiving care between January 1, 2012 and December 31, 2016 within 13 United States and Canadian clinical cohorts contributing data to the North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD). We evaluated each of the steps in this cascade, including: 1) laboratory-confirmed HBV infection, 2) tenofovir-based or entecavir-based HBV therapy prescribed, 3) HBV DNA measured during treatment, and 4) viral suppression achieved via undetectable HBV DNA. …”
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Novel Xanthene-1,8-dione Derivatives Containing the Benzylic Ether Tail as Potent Cytotoxic Agents: Design, Synthesis, In Vitro, and In Silico Studies by Ahmad Ebadi, Aref Karimi, Asrin Bahmani, Zahra Najafi, Gholamabbas Chehardoli

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Esmiuçando os arquivos de processos de quatro designers editoriais: generalizações e particularidades na criação de projetos de livro by Amanda Monteiro Gonçalves, Sérgio Antônio Silva

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Designing a Digital Flash Reading Test for Data-Based Decisions in Inclusive Classrooms: Duration and Word Length as Difficulty-Generating-Item Characteristics by Judith Zellner, Nikola Ebenbeck, Markus Gebhardt

“…We provide information for test developers interested in designing similar assessments and teachers who can use this instrument to make informed decisions in the classroom.…”
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Intergranular creep resistance affected by grain boundary carbides to suppress lamellae γʹ precipitation in a specially designed inconel 740H variant by Cheol-Hyeok Yang, Chiwon Kim, Siyeon Kim, Hi-Won Jeong, Hyungsoo Lee, Dae Won Yun, Hyun-Uk Hong

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