Lipid Nanoparticles With Fine‐Tuned Composition Show Enhanced Colon Targeting as a Platform for mRNA Therapeutics by Riccardo Rampado, Gonna Somu Naidu, Olga Karpov, Meir Goldsmith, Preeti Sharma, Assaf Ezra, Lior Stotsky, Dor Breier, Dan Peer

“…Nevertheless, investigating the effects of LNPs composition on their biodistribution can expand the toolbox for particle design, leading to improved delivery strategies. Herein, a new LNPs (30‐n‐LNPs) formulation with increasing amounts of phospholipids is investigated as a possible mRNA delivery system for treating Inflammatory Bowel Diseases. …”
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Evaluating the effects of seed oils on lipid profile, inflammatory and oxidative markers, and glycemic control of diabetic and dyslipidemic patients: a systematic review of clinica... by Lucas Fornari Laurindo, Lucas Fornari Laurindo, Lucas Fornari Laurindo, Lívia Fornari Laurindo, Victória Dogani Rodrigues, Jéssica da Silva Camarinha Oliveira, Beatriz Leme Boaro, Adriano Cressoni Araújo, Adriano Cressoni Araújo, Elen Landgraf Guiguer, Elen Landgraf Guiguer, Elen Landgraf Guiguer, Claudia Rucco Penteado Detregiachi, Claudia Rucco Penteado Detregiachi, Virgínia Maria Cavallari Strozze Catharin, Virgínia Maria Cavallari Strozze Catharin, Eduardo Federighi Baisi Chagas, Eduardo Federighi Baisi Chagas, Vitor Cavallari Strozze Catharin, Vitor Cavallari Strozze Catharin, Rosa Direito, Sandra Maria Barbalho, Sandra Maria Barbalho, Sandra Maria Barbalho, Sandra Maria Barbalho

“…The studies include randomized controlled, parallel-design, double-blind, placebo-controlled, and open-label studies published in English. …”
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Detector development for spin-echo SANS techniques using ZnS:Ag/6LiF and 6Li glass scintillators by Giacomo Mauri, G. Jeff Sykora, Gregory N. Smith, Steven R. Parnell, Robert M. Dalgliesh, Dirk Honecker, Sarah E. Mann, Erik M. Schooneveld, Nigel J. Rhodes

“…A detector prototype using GS20 glass scintillator directly coupled to a multi-anode photomultiplier was developed as an alternative for SESANS measurements at higher incident neutron fluxes. The designs and results obtained with the two detectors are presented together with future improvements to both technologies. …”
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Effects of mosquito-proofing storm drains on adult and larvae mosquito abundance: Protocol of the IDAlErt storm drAin randomiSed controlled trial (IDEAS) by Marina Treskova, Tomás Montalvo, Joacim Rocklöv, Charles Hatfield, Frederic Bartumeus, Shouro Dasgupta, João Encarnação, Rachel Lowe, Jan C. Semenza, Pascale Stiles, Jordi Noya, Andrea Valsecchi, Till Bärnighausen, John R.B. Palmer, Aditi Bunker

“…Together with the Agency, we designed a randomised controlled trial (RCT) to experimentally assess the effectiveness of these modifications on adult Aedes albopictus and Culex pipiens populations. …”
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Rockburst in Sandstone Containing Elliptic Holes with Varying Axial Ratios by Yang Wang, Manchao He, Dongqiao Liu, Yubing Gao

“…This paper has some reference value for practical engineering design and prevention of rockburst.…”
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An esophageal stent integrated with wireless battery-free movable photodynamic-therapy unit for targeted tumor treatment by Qian Han, Pingjin Zou, Xianhao Wei, Junyang Chen, Xiaojiao Li, Li Quan, Ranlin Wang, Lili Xing, Xinyu Xue, Yi Zhou, Meihua Chen

“…In this study, we propose a novel esophageal stent equipped with a wireless, battery-free, and movable photodynamic therapy (PDT) unit designed to treat esophageal tumors with flexibility, precision, and real-time control. …”
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Bioinformatics Analysis, Prokaryotic Expression and Biological Activity of Lysin from Vibrio parahaemolyticus Phage vB_VpP_1 by ZHANG Defu, YANG Wenjing, LIU Ke, LIU Qingqing, BAI Wutong, LI Fan, LÜ Xinran, BAI Xue, TAN Xiqian, LI Xuepeng, LI Jianrong

“…The amino acid sequence and structure of gp32 were analyzed by various tools such as Expasy. Primers were designed using Primer 5.0 software and cloned into the pET-28a(+) vector for prokaryotic expression. …”
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FutureMS cohort profile: a Scottish multicentre inception cohort study of relapsing-remitting multiple sclerosis by David Hunt, Siddharthan Chandran, Peter Connick, Peter Foley, Patrick K A Kearns, Sergio E Baranzini, Adam D Waldman, Sarah J Martin, Elizabeth Freyer, F J Carod-Artal, Lee Murphy, Amy Stenson, Jessie Chang, Rozanna Meijboom, Elizabeth N York, Yingdi Chen, Christine Weaver, Katarzyna Hafezi, Stacey Thomson, Adil Harroud, Margaret McLeod, Jonathon O'Riordan, Niall J J MacDougall

“…Here, we describe the cohort design and present a profile of the participants at baseline and 1 year of follow-up.Future plans A third follow-up wave for the cohort has recently begun at 5 years after first visit and a further wave of follow-up is funded for year 10. …”
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Lifestyle Interventions Targeting Body Weight Changes during the Menopause Transition: A Systematic Review by Janet Jull, Dawn Stacey, Sarah Beach, Alex Dumas, Irene Strychar, Lee-Anne Ufholz, Stephanie Prince, Joseph Abdulnour, Denis Prud’homme

“…Two independent researchers screened for studies using experimental designs to evaluate the impact of exercise and/or nutrition interventions on body weight and/or central weight gain performed during the menopausal transition. …”
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Mobile Applications in Breast Cancer Postoperative Care: A Scoping Review by Maryam Alidadi, Reza Rabiei, Atieh Akbari, Hassan Emami, Seyed Mohsen Laal Mousavi

“…Conclusions Mobile applications for postoperative breast cancer care encompass a range of features. In a co‐design approach, understanding patients' required features could help to develop usable applications to improve the postoperative care for breast cancer patients.…”
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Negative symptoms in schizophrenia: a study in a large clinical sample of patients using a novel automated method by Robert Stewart, Hitesh Shetty, Matthew Broadbent, Angus Roberts, Rashmi Patel, Philip McGuire, Richard D Hayes, Nishamali Jayatilleke, Genevieve Gorrell, Chin-Kuo Chang, Richard Jackson, Nadia Foskett, Caroline Johnston

“…Objectives To identify negative symptoms in the clinical records of a large sample of patients with schizophrenia using natural language processing and assess their relationship with clinical outcomes.Design Observational study using an anonymised electronic health record case register.Setting South London and Maudsley NHS Trust (SLaM), a large provider of inpatient and community mental healthcare in the UK.Participants 7678 patients with schizophrenia receiving care during 2011.Main outcome measures Hospital admission, readmission and duration of admission.Results 10 different negative symptoms were ascertained with precision statistics above 0.80. 41% of patients had 2 or more negative symptoms. …”
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High-Fidelity Depth Map Reconstruction System With RGB-Guided Super Resolution CNN and Cross-Calibrated Chaos LiDAR by Yu-Chun Ding, Chia-Yu Chang, Pei-Rong Li, Chao-Tsung Huang, Yung-Chen Lin, Tsung Chen, Wei-Lun Lin, Cheng-Ting Lee, Fan-Yi Lin, Yuan-Hao Huang

“…This system provides highly accurate depth estimates in various scenarios, particularly for indoor scenes with dim lighting or long distances ranging from 4 m to 6 m. We address two design challenges to maximize the quality of the reconstructed depth map of the system. …”
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Effect of BMP-2 Delivery Mode on Osteogenic Differentiation of Stem Cells by Taekhee Jung, John Hwan Lee, Soonjung Park, Yong-Jin Kim, Joseph Seo, Hye-Eun Shim, Ki-Suk Kim, Hyon-Seok Jang, Hyung-Min Chung, Seong-Geun Oh, Sung-Hwan Moon, Sun-Woong Kang

“…Previously, BMP delivery has been designed and evaluated for osteogenic differentiation, focusing on carriers and sustained release system for delivery of BMPs. …”
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Growth and Fruit Yield of Okro as Influenced by Genotypes and Mulch in the Guinea Savannah Conditions of Ghana by Richard Yaw Agyare, Mashark Seidu Abdulai, Samuel Saaka Buah, Emmanuel Ayipio, Samuel Kwame Bonsu, Regine Tchientche Kamga

“…Ten okro genotypes were evaluated in a split plot design with 3 replications. Three treatments of mulch (black plastic, grass, and no mulch) represented the main plots with the genotypes as the subplots. …”
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Solo Sonographically Guided PCNL under Spinal Anesthesia: Defining Predictors of Success by Akbar Nouralizadeh, Hamid Pakmanesh, Abbas Basiri, Mohammad Aayanifard, Mohammad Hossein Soltani, Ali Tabibi, Farzaneh Sharifiaghdas, Seyed Amir Mohsen Ziaee, Naser Shakhssalim, Reza Valipour, Behzad Narouie, Mohammad Hadi Radfar

“…Sonography has been brought in percutaneous nephrolithotripsy (PCNL) as an adjunct to or substitute for X-ray to restrict radiation exposure. This study was designed to investigate the possible predictors for the success of the solo sonographically guided PCNL. …”
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Engaging Students in Audiovisual Coding Through Interactive MATLAB GUIs by Carlos Cuevas, Carlos Cortes, Narciso Garcia

“…This study introduces three novel graphical user interface applications designed to strengthen foundational knowledge in audio, image, and video signal coding. …”
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Recovery of the valuable metals from complex converter slag at elevated temperature with sulfuric acid solution by Liao Y.-L., Shi G.-C., Huang F.-R., Zhang Y.

“…The central composite design of response surface methodology was employed to optimize controlling conditions for the leaching of more valuable metals such as nickel, cobalt, and copper, while dissolution of iron was curbed. …”
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Communal-based domestic rainwater harvesting system: A novel approach to alternative solutions for increasing water supply and recharging groundwater in Jagakarsa urban area, South... by Suprapti Suprapti, Muhammad Syahril Badri Kusuma, Hadi Kardhana, Muhammad Cahyono, Imroatul Chalimah Juliana

“…This allows centralized rainwater management in communal tanks, thereby reducing groundwater usage. The design of this model is simple. Therefore it can be easily duplicated for application in other locations.…”
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The challenge of using date branch waste as a peat substitute in container nursery production of lettuce (Lactuca sativa L.) by Najla Dhen, Safa ben Abed, Amin Zouba, Faouzi Haouala, Bouthaina AlMohandes Dridi

“…Methods The research was conducted in a completely block randomized design with a linear substitution (0, 25, 50, 75 and 100%) of peat with date-palm waste peat for transplant production of lettuce (Lactuca sativa L.). …”
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Psychometric comparison of two short versions of the Perceived Stress Scale (PSS-4) in a representative sample of the German population by Bjarne Schmalbach, Mareike Ernst, Mareike Ernst, Elmar Brähler, Elmar Brähler, Katja Petrowski

“…In sum, both versions can be recommended for research designs in need of a brief measure of stress and offer unique contributions.…”
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