Harnessing the power of structure‐based design: A new lease on life for cardiovascular drug development with apelin receptor modulators by Junxia Zhang, Erdan Dong, Yan Zhang, Yan Zhang

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Designing of an innovative conserved multiepitope subunit vaccine targeting SARS-CoV-2 glycoprotein and nucleoprotein through immunoinformatic by Temitope Isaac Adelusi, Abdeen Tunde Ogunlana, Moyosoluwa Precious Oyewole, Taiwo Ooreoluwa Ojo, Olamide Tosin Olaoba, Elijah Kolawole Oladipo, Shopnil Akash, Samir Ibenmoussa, Mohammed Bourhia, Yousef A. Bin Jardan, Baye Sitotaw

“…This demonstrates the potentiality of the vaccine design to trigger an immunological response. Furthermore, the vaccine-ACE-2 receptor complex was tested, confirming its ability to interact with ACE-2’s core pocket and induce an immunological response. …”
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An X-Band Class-J GaN MMIC Power Amplifier with Well-Designed In-Band Output Power Flatness by Bangjie Zheng, Zhiqun Cheng, Zhiwei Zhang, Ruizhe Zhang, Tingwei Gong, Chao Le

“…An L-C impedance matching network is used to match the amplifier’s output impedance to the overlapping region of the 0.5 dB constant power contour and the CCBJ impedance space, significantly improving the in-band power flatness of the PA based on the CCBJ design approach. Additionally, an RC parallel structure is integrated into the interstage matching network to maximize gain while ensuring stability. …”
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Optimization Design of Wind Turbine Blade Based on an Improved Particle Swarm Optimization Algorithm Combined with Non-Gaussian Distribution by Fangjin Sun, Zhonghao Xu, Daming Zhang

“…The non-Gaussian distribution combined with PSO provides a more reliable theoretical basis for the design of wind turbine blades.…”
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A Research on a Temporary Shelter Design to be Used After Natural Disasters: A Case Study of Indonesia – Sinabung by Irham Walad Nasution

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Compact inverse designed vertical coupler with bottom reflector for sub-decibel fiber-to-chip coupling on silicon on insulator platform by Shiang-Yu Huang, Stefanie Barz

“…Abstract Inverse design via topology optimization has led to innovations in integrated photonics and offers a promising way for designing high-efficiency on-chip couplers with a minimal footprint. …”
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Co-Optimization of Power Delivery Network Design for 3-D Heterogeneous Integration of RRAM-Based Compute In-Memory Accelerators by Madison Manley, James Read, Ankit Kaul, Shimeng Yu, Muhannad Bakir

“…We analyze the impact of through-silicon via (TSV) design and placement to optimize the IR-drop and classification accuracy. …”
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A novel imatinib analogue inhibitor of chronic myeloid leukaemia: design, synthesis and characterization—explanation of its folded conformation by Rodolfo Moreno-Fuquen, Juan F. Avellaneda-Tamayo, Kevin Arango-Daraviña, Javier Ellena, Alan R. Kennedy

“…These findings suggest that PAPP could be a promising scaffold for future CML drug design, offering a potential alternative to existing TKIs, and PAPP1 is a promising lead susceptible to optimization.…”
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Mass transfer approach and the designing of horizontal subsurface flow constructed wetland systems treating waste stabilisation pond effluent by Anita M., Rugaika, Damian, Kajunguri, Rob, Van Deun, Bart Van der, Bruggen, Karoli N., Njau

“…Since CW design considers temperature which is irrelevant in tropics, mass transfer approach could improve the design. …”
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Fragmenstein: predicting protein–ligand structures of compounds derived from known crystallographic fragment hits using a strict conserved-binding–based methodology by Matteo P. Ferla, Rubén Sánchez-García, Rachael E. Skyner, Stefan Gahbauer, Jenny C. Taylor, Frank von Delft, Brian D. Marsden, Charlotte M. Deane

Subjects: “…Fragment-based drug design…”
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Codesigning More-than-Human Ecosystems with Social and Environmental Systems: The Gamification of NetWall and BioDiveIn by Marie Davidová, María Claudia Valverde Rojas, Hanane Behnam

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Experimental analysis on fiber diameter of spunbond nonwoven fabrics through Plackett–Burman and Box–Behnken designs and its impact on mechanical properties by Kaoutar Abdel‐Mouttalib, Ayoub Nadi, Samir Tetouani, Abdelowahed Hajjaji, Omar Cherkaoui, Samira Touhtouh

Subjects: “…Box–Behnken design…”
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A Simple Machine Learning-Based Quantitative Structure–Activity Relationship Model for Predicting pIC₅₀ Inhibition Values of FLT3 Tyrosine Kinase by Jackson J. Alcázar, Ignacio Sánchez, Cristian Merino, Bruno Monasterio, Gaspar Sajuria, Diego Miranda, Felipe Díaz, Paola R. Campodónico

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TAD-SIE: sample size estimation for clinical randomized controlled trials using a Trend-Adaptive Design with a Synthetic-Intervention-Based Estimator by Sayeri Lala, Niraj K. Jha

Subjects: “…Adaptive design…”
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Possibility-Based Sizing Method for Hybrid Electric Aircraft by Zin Win Thu, Maxim Tyan, Yong-Hyeon Choi, Mohammad Irfan Alam, Jae-Woo Lee

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Pre-Occupancy Evaluation of Affective Experiences in Building Information Modeling Through SLR and an e-Delphi Survey by Balamaheshwaran Renganathan, Radhakrishnan Shanthi Priya, Ramalingam Senthil

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