Prevalence of potentially inappropriate prescribing in a subpopulation of older European clinical trial participants: a cross-sectional study by Manuel R Blum, Patricia M Kearney, Rose Galvin, Christine Baumgartner, Anette Van Dorland, Stephen Byrne, Nicolas Rodondi, Simon P Mooijaart, Carol Sinnott, Rosalinde K E Poortvliet, Jacobijn Gussekloo, David O Riordan, Carole Elodie Aubert, Kieran A Walsh, Robert S Du Puy, J Wouter Jukema, Vera McCarthy, Elaine K Walsh, Tinh-Hai Collet, Olaf M Dekkers

“…Objectives To estimate and compare the prevalence and type of potentially inappropriate prescribing (PIP) and potential prescribing omissions (PPOs) among community-dwelling older adults (≥65 years) enrolled to a clinical trial in three European countries.Design A secondary analysis of the Thyroid Hormone Replacement for Subclinical Hypothyroidism Trial dataset.Participants A subset of 48/80 PIP and 22/34 PPOs indicators from the Screening Tool of Older Persons Prescriptions/Screening Tool to Alert doctors to Right Treatment (STOPP/START) V2 criteria were applied to prescribed medication data for 532/737 trial participants in Ireland, Switzerland and the Netherlands.Results The overall prevalence of PIP was lower in the Irish participants (8.7%) compared with the Swiss (16.7%) and Dutch (12.5%) participants (P=0.15) and was not statistically significant. …”
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Determinants of Uterine Rupture and Its Management Outcomes among Mothers Who Gave Birth at Public Hospitals of Tigrai, North Ethiopia: An Unmatched Case Control Study by Meresa Berwo Mengesha, Desta Abraha Weldegeorges, Yared Hailesilassie, Weldu Mammo Werid, Mulu Gebretsadik Weldemariam, Fissaha Tekulu Welay, Senait Gebreslasie Gebremeskel, Berhanu Gebresilassie Gebrehiwot, Hagos Degefa Hidru, Hirut Teame, Haftay Gebremedhin, Natnael Etsay Assefa

“…A retrospective hospital-based unmatched case control study design was implemented with 135 cases of women with uterine rupture and 270 controls of women without uterine rupture. …”
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Optimizing fodder yield and quality through integrated organic nutrient amendments in multi-crop system by Santosh Onte, Santosh Onte, Vrushabh Vijay Fiskey, Manjunath S. Melavanki, Airadevi P. Angadi, Prasanna S. Pyati, Magan Singh, Dileep Kumar, Sanjivkumar Angadarao Kochewad, Sudhir Kumar, Hari Om, Vijendra Kumar Meena, Kamal Garg, Vetrivel Karunakaran, Manish Kanwat, Babu Lal Meena, Yogananda Shivalli Boregowda, Rahul Bellagi, K. Naveena, Sunil Chandersheker, Elisa Azura Azman, Sanjeev Kumar

“…Conducted during the period 2018 to 2021 using a randomized complete block design, the experiment encompassed seven treatments, each replicated three times. …”
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The role of OCO-3 XCO₂ retrievals in estimating global terrestrial net ecosystem exchanges by X. Wang, F. Jiang, F. Jiang, F. Jiang, H. Wang, Z. Zhang, M. Wu, J. Wang, W. He, W. Ju, W. Ju, J. M. Chen, J. M. Chen

“…The Orbiting Carbon Observatory 3 (OCO-3) satellite, launched in May 2019, was designed to address important questions about the distribution of carbon fluxes on Earth, but its role in estimating global terrestrial NEE remains unclear. …”
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Pathway Of Low Anterior Resection syndrome (LARS) relief after Surgery (POLARiS): protocol for an international, open-label, multi-arm, phase 3 randomised superiority trial within... by Deborah D Stocken, Charles H Knowles, Jared Torkington, David Jayne, Julie Hepburn, Laura Knight, Neil Corrigan, Julie Cornish, Katie Gordon, Ashley Douglas, Kate Wilson, Megan Dale, Julie Croft, Christina Lloydwin, Alexandra Harriet Coxon-Meggy, Judith White, Alun Meggy, Aaron Quyn, Emily Farrow, Kheng-Seong Ng, Hannah Mather, Huey Yi Chong, Betty Tan, Ralph Powell, Andrea Warwick

“…Despite this, little is known about the natural history and there is poor evidence to support current treatment options.Methods and analysis The objectives of POLARiS are to explore the natural history of LARS and to evaluate the clinical and cost-effectiveness of transanal irrigation (TAI) or sacral neuromodulation (SNM) compared with optimised conservative management (OCM) for people with major LARS.POLARiS is a prospective, international, open-label, multi-arm, phase 3 randomised superiority trial within a cohort design, with internal pilot phase, qualitative sub-study, process evaluation and economic evaluation. …”
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Micro-nano aerated subsurface drip irrigation and biochar promote photosynthesis, dry matter accumulation and yield of cucumbers in greenhouse by Zan Ouyang, Jie Zhang, Xueli Liang, Hui Wang, Zhenfeng Yang, Rong Tang, Qihua Yu, Yong Zhang

“…Three levels concentrations of dissolved oxygen (DO) in MNBW: O1 (4–5 mg/L), O2 (9–10 mg/L), and O3 (14–15 mg/L), as well as three levels amount of biochar application (BA): B1 (20 t/hm2), B2 (40 t/hm2), and B3 (60 t/hm2), and one control group (CK, O: 4–5 mg/L, B: 0 t/hm2) were the subjects of this study, followed by a two-factor randomized block design. The study examined the aeration practices of the red soil (clay) and the responses of greenhouse-grown cucumbers to SDI over the first and second growing seasons. …”
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HELLO: a protocol for a cluster randomized controlled trial to enhance interpersonal relationships and team cohesion among ICU healthcare professionals by Elie Azoulay, Nancy Kentish Barnes, Sheila Nainan Myatra, Maria-Cruz Martin Delgado, Yaseen Arabi, Carole Boulanger, Giovanni Mistraletti, Maria Theodorakopoulou, Vernon Van Heerden, José-Artur Paiva, Oktay Demirkýran, Gabriel Heras La Calle, Abdulrahman Al Fares, Gaston Burghi, Guy Francois, Anita Barth, Jan De Waele, Samir Jaber, Michael Darmon, Maurizio Cecconi

“…Determinants of burnout include communication, team cohesion, psychological support, and well-being promotion. We designed the 'Hello Bundle' intervention to mitigate burnout among ICU-HCPs by fostering positive social interactions and a supportive work environment. …”
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Towards person-centred maternal and newborn care in Ethiopia: a mixed method study of satisfaction and experiences of care by Tigist Eshetu, Eshcolewyine Fekadu, Ahmed Abdella, Adiyam Mulushoa, Girmay Medhin, Merga Belina, Atalay Alem, Roxanne Keynejad, Tanya Robbins, Nadine Seward, Andrew Shennan, Louise M. Howard, Martin Prince, Jane Sandall, Charlotte Hanlon

“…We aimed to explore women’s experiences of care and investigate satisfaction with antenatal care (ANC) in relation to person-centred care and unmet psychosocial needs in rural Ethiopia. Methods Design: facility-based, convergent mixed-method study. …”
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Cardio-metabolic-related plasma proteins reveal biological links between cardiovascular diseases and fragility fractures: a cohort and Mendelian randomisation investigationResearch... by Karl Michaëlsson, Rui Zheng, John A. Baron, Tove Fall, Alicja Wolk, Lars Lind, Jonas Höijer, Carl Brunius, Eva Warensjö Lemming, Olga E. Titova, Bodil Svennblad, Susanna C. Larsson, Shuai Yuan, Håkan Melhus, Liisa Byberg, Hannah L. Brooke

“…Methods: We used proteomics and a cohort design combined with Mendelian randomisation analysis to understand shared mechanisms for developing CVD and fragility fractures, two significant sources of disease burden and health expenditure. …”
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Spatial and temporal changes of breast-conserving surgery rates and its influential factors among Chinese patients with breast cancer from 2013 to 2019: a registry-based study by Pengpeng Ye, Yuan Yang, Wei Hu, Lingyan Dai, Erwei Song, Shunrong Li, Liling Zhu, Kai Chen, Yanjie Xu, Xiaoyu Wang, Jianli Zhao, Jianrong He, Queran Lin, Tongrui Shang, Xiujuan Gui, Ziliang Zhong, Qianru Chen, Qing Yan, Xiaoliang Huang, Zijian Liang

“…Objective Our study aims to evaluate the spatial and temporal changes of breast-conserving surgery (BCS) rates and influential factors of BCS in Guangdong Province, China.Design, setting and participants This registry-based cohort study analysed the data of patients of all age groups, from the medical record cover page, which was mandatorily collected for inpatients by the Health Administrative Department of Guangdong Province, China. …”
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Contextual Vulnerability Should Guide Fair Subject Selection in Xenotransplantation Clinical Trials by Gianna Strand

“…[xxiv] This process begins with physician-investigators designing research trials and IRB review of proposed trials in which some or all potential subjects are vulnerable.…”
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Durvalumab and tremelimumab in patients with advanced rare cancer: a multi-centre, non-blinded, open-label phase II basket trialResearch in context by Abha A. Gupta, Anna Tinker, Derek Jonker, Rahma Jamal, Hal Hirte, Eric W. Winquist, Quincy Chu, Christian Kollmannsberger, Ralph Wong, Thierry Alcindor, Torsten O. Nielsen, Ming Tsao, Tricia R. Cottrell, Diane Provencher, John Hilton, Monika K. Krzyżanowska, Christine Elser, Sebastien Hotte, Joana Sederias, Siwei Zhang, Wei Tu, Janet Dancey

“…We sought to determine the objective response rate of combination durvalumab (D) plus tremelimumab (TM) in parallel cohorts of patients with carefully selected rare cancer types in which these agents had not previously been evaluated in phase II trials and for which there was clinical or biological rationale for dual immune checkpoint inhibitor therapy to be active. Methods: We designed a multi-centre, non-blinded, open-label phase II basket trial with each of the following 8 rare cancers considered a separate phase II trial: salivary carcinoma, carcinoma of unknown primary (CUP) with tumour infiltrating lymphocytes and/or expressing PD-L1, mucosal melanoma, acral melanoma, osteosarcoma, undifferentiated pleomorphic sarcoma, clear cell carcinoma of the ovary (CCCO) or squamous cell carcinoma of the anal canal (SCCA). …”
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Dietary ambon lumut banana stem extract Musa cavendishii var. dwarf Paxton as an immunostimulant for white spot disease prevention in Pacific white shrimp Litopenaeus vannamei by Afriani Ramadhan, Sri Nuryati, Nur Bambang Priyoutomo, Alimuddin Alimuddin

“…The shrimps fed by pellet containing ambon banana stem extracts with different dosages for 29 days, i.e designated as 0.1 (A); 0.3 (B), and 0.5 (C) g/kg, the diet treatment without ambon banana stem extract without challenged test (K-), and diet treatment without ambon banana stem extract with challenged test (K+). …”
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Usefulness of a personalized algorithm‐based discharge checklist in patients hospitalized for acute heart failure by Florent Allain, Virginie Loizeau, Laure Chaufourier, Maya Hallouche, Laurence Herrou, Amir Hodzic, Katrien Blanchart, Annette Belin, Alain Manrique, Paul Milliez, Rémi Sabatier, Damien Legallois

“…Methods and results We designed an algorithm to generate PCL, based on 2016 HF European Society of Cardiology Guidelines and the screening of common comorbidities in elderly HF patients. …”
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Optimizing Muscle Performance in Young Soccer Players: Exploring the Impact of Resisted Sprint Training and Its Relationship with Distance Covered by Felipe Hermosilla-Palma, Juan Francisco Loro-Ferrer, Pablo Merino-Muñoz, Nicolás Gómez-Álvarez, Rodrigo Zacca, Hugo Cerda-Kohler, Ciro Brito, Jorge Pérez-Contreras, Moacyr Portes-Junior, Esteban Aedo-Muñoz

“…This quantitative study utilized a pre-post experimental design. The sample consisted of 24 young soccer players (15.3 ± 0.68 years; 61.4 ± 7.08 kg; 1.60 ± 0.06 m) randomized into three groups (10, 20, and 30 m) and subjected to 12 sessions of resisted sprint training over six weeks. …”
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Utilization of fish bone charcoal in feed on growth and physiological responses of catfish fry Clarias gariepinus by Rizqiyatul Fardila Putri, Mia Setiawati, Dedi Jusadi, Julie Ekasari

“…The experiment employed a completely randomized design (CRD) with five treatments and four replicates. …”
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Reducing dietary crude protein levels while meeting metabolizable protein requirements: Performance of dairy cows over a full lactation period by A. Lavery, A. Craig, A.W. Gordon, A. White, N. Barkley, C.P. Ferris

“…ABSTRACT: A total of 90 Holstein dairy cows (24 primiparous, 66 multiparous, mean parity = 3.0) were fed diets containing either 150, 160, or 170 g CP/kg DM from 8 to 180 DIM, with all diets designed to supply at least 100% MP requirements. On d 181, half of the cows in each treatment changed to a diet containing 140 g CP/kg DM (supplying 100% MP requirements), with the remaining cows continuing to be offered their original treatment diets. …”
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Evaluation of Yield and Yield Components of Different Ecotypes of Black Cumin (Nigella sativa L.) to Planting Date in Gorgan by Mohammad Sadeq Ashrafi, Farshid Ghaderi-Far, Elias Soltani, Ebrahim Zeinali, Asieh Siahmarguee

“…The experiment was carried out in the form of split plots based on completely randomized block statistical design with three replication, in which four planting dates were 18th December, 17th January, 16th February and 18th March as the main plot and thirteen ecotypes (Such as Tafaresh, Gardmiran, Razan, Hamedan, Arak, Esfahan, Semirom, Eqlid, Ashkazar, Zabol, Bajestan, Sarayan and Khaf) with 3 replication were considered as sub-plot. …”
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Evaluation of a peer support group programme for vulnerable host population and refugees living with diabetes and/or hypertension in Lebanon: a before-after study by Leah Anku Sanga, Carla Njeim, Éimhín Ansbro, Rima Kighsro Naimi, Ali Ibrahim, Benjamin Schmid, Jasmin Lilian Diab, Jytte Roswall, Tim Clayton, Lars Bruun Larsen, Pablo Perel

“…We used a before-after study design and included a control group for clinical outcomes. …”
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A Study on the Yield Stability of Oilseed Sunflower Genotypes under Drought Stress by Nasrin Akbari, Reza Darvishzadeh

“…Methods: One hundred oilseed sunflower genotypes were evaluated in a 10 × 10 simple lattice design under two normal and drought stress (irrigation limitation) conditions during 2012 and 2013 (four environments) in terms of seed yield in Qezeljeh village in West Azerbaijan, Iran. …”
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