Thioredoxin‐interacting protein (TXNIP) is a substrate of the NEDD4‐like E3 ubiquitin‐protein ligase WWP1 in cellular redox state regulation of acute myeloid leukemia cells by Sara Giovannini, Yanan Li, Rosalba Pecorari, Claudia Fierro, Claudia Fiorilli, Federica Corigliano, Valeria Moriconi, Ji Zhou, Anna De Antoni, Artem Smirnov, Sara Rinalducci, Anna Maria Timperio, Massimiliano Agostini, Jinping Zhang, Yufang Shi, Eleonora Candi, Gerry Melino, Francesca Bernassola

“…Future studies are needed to establish whether TXNIP‐dependent deregulation of redox homeostasis in WWP1‐overexpressing blasts may affect the response of leukemic cells to chemotherapeutic drugs.…”
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Evidence of Inflammatory Network Disruption in Chronic Venous Disease: An Analysis of Circulating Cytokines and Chemokines by Oscar Fraile-Martinez, Cielo García-Montero, Ana María Gomez-Lahoz, Felipe Sainz, Julia Bujan, Silvestra Barrena-Blázquez, Laura López-González, Raul Díaz-Pedrero, Melchor Álvarez-Mon, Natalio García-Honduvilla, Miguel A. Saez, Jorge Monserrat, Miguel A. Ortega

“…A growing body of evidence displays the relationship between suffering from CVD and a marked deregulation of the immune inflammatory system. In this sense, the previous literature has reported some significant changes in the level of various circulating inflammatory parameters in these patients. …”
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Harnessing genomic and bioinformatic data to broaden understanding of leukaemia across continents by Gumelar Gugun, Ulfa Mia Maria, Amukti Danang Prasetyaning, Irham Lalu Muhammad, Yuliani Sapto, Adikusuma Wirawan, Khairi Sabiah, Darmawi Darmawi, Chong Rockie, Ates Ilker, Singh Dilpreet, Chavan Aditya Ashok

“…PATJ maintains brain cell integrity, MINDY1 regulates gene expression, CDKN1B controls the cell cycle and ABCC8 regulates glucose levels. Their deregulation is associated with neurological dysfunction and leukaemia. …”
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Analyzing the discourse of tourism development with a justice-oriented and moderate approach by Mostafa Ghodrati, Mehraban Hadipeykani, Reza Ebrahimzadeh

“…Also, the characteristics of modern public administration included: deregulation, privatization, adjustment of manpower, and market competition. …”
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Single-cell multiomics reveal divergent effects of DNMT3A- and TET2-mutant clonal hematopoiesis in inflammatory response by Wazim Mohammed Ismail, Jenna A. Fernandez, Moritz Binder, Terra L. Lasho, Minsuk Kim, Susan M. Geyer, Amelia Mazzone, Christy M. Finke, Abhishek A. Mangaonkar, Jeong-Heon Lee, Liguo Wang, Kwan Hyun Kim, Vernadette A. Simon, Fariborz Rakhshan Rohakthar, Amik Munankarmy, Seul Kee Byeon, Susan M. Schwager, Jonathan J. Harrington, Melissa R. Snyder, Keith D. Robertson, Akhilesh Pandey, Eric D. Wieben, Nicholas Chia, Alexandre Gaspar-Maia, Mrinal M. Patnaik

“…Using single-cell multiomics sequencing, we identify cell-specific gene expression changes associated with DNMT3A mutations, along with significant epigenomic deregulation affecting enhancer accessibility, resulting in overexpression of interleukin-32 (IL-32), a proinflammatory cytokine that can result in inflammasome activation in monocytes and macrophages. …”
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The Bioethics-CSR Divide by Caio Caesar Dib

“…But afterward, a joint trend emerged: on one side, the deregulation within the context of neoliberalism, and on the other, the operationalization of corporate social responsibility as a response to societal concerns.[14] The 1990s saw both opportunities and crises that derived from globalization. …”
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MicroRNAs Expression Profile in MN1-Altered Astroblastoma by Francesca Gianno, Evelina Miele, Claudia Sabato, Elisabetta Ferretti, Simone Minasi, Francesca Romana Buttarelli, Debora Salerno, Natalia Pediconi, Giuseppe Rubens Pascucci, Francesca Guerrieri, Andrea Ciolfi, Simone Pizzi, Maura Massimino, Veronica Biassoni, Elisabetta Schiavello, Marco Gessi, Sofia Asioli, Angela Mastronuzzi, Antonio d’Amati, Giuseppina Catanzaro, Elisabetta Viscardi, David Capper, Felice Giangaspero, Manila Antonelli

“…Thirty-nine miRNAs were deregulated in tumor samples compared to normal brain tissue. …”
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ANALYSIS OF FOREIGN EXPERIENCE OF DEVELOPMENT OF COMPETITION AT RETAIL ELECTRICITY MARKETS: UK AND NORTHERN EUROPE COUNTRIES EXPERIENCE by O. Mozgovaya

“…The rewarding experience of retail electricity markets performance demonstrates that the deregulated model of wholesale and retail electricity markets provides mostfavorite competitive mechanism. …”
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MicroRNAs in Human Pituitary Adenomas by Xu-Hui Li, Elaine Lu Wang, Hai-Meng Zhou, Katsuhiko Yoshimoto, Zhi Rong Qian

“…To provide an overview of miRNAs dysregulation and functions of these miRNAs in pituitary adenoma progression, we summarize the deregulated miRNAs and their targets to shed more light on their potential as therapeutic targets and novel biomarkers.…”
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Analysis of Argonaute Complex Bound mRNAs in DU145 Prostate Carcinoma Cells Reveals New miRNA Target Genes by Jaroslaw Szczyrba, Volker Jung, Michaela Beitzinger, Elke Nolte, Sven Wach, Martin Hart, Sandra Sapich, Marc Wiesehöfer, Helge Taubert, Gunther Wennemuth, Norbert Eichner, Thomas Stempfl, Bernd Wullich, Gunter Meister, Friedrich A. Grässer

“…The analysis of Ago complexes derived from PNFs or DU145 confirmed the enrichment or depletion of a variety of mRNAs already known from the literature to be deregulated. Novel potential targets were analyzed by luciferase assays with miRNAs known to be deregulated in PCa. …”
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“Omics” Signatures in Peripheral Monocytes from Women with Low BMD Condition by Bhavna Daswani, M. Ikram Khatkhatay

“…The molecules in monocytes that are deregulated in low BMD condition may contribute to processes such as monocyte survival, migration/chemotaxis, adhesion, transendothelial migration, and differentiation into the osteoclast lineage. …”
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An Update on Blood Pressure Short-Term Variability by Nina Japundžić-Žigon

“…It emphasizes the contribution of spectral methodologies in early diagnosis of blood pressure deregulations. Moreover, the effects of antihypertensive drugs, as well as of new, nonpeptide vasopressin antagonists on short-term blood pressure variability, are briefly described.…”
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MAM‐STAT3‐Driven Mitochondrial Ca+2 Upregulation Contributes to Immunosenescence in Type A Mandibuloacral Dysplasia Patients by Arshad Ahmed Padhiar, Xiaohong Yang, Syed Aqib Ali Zaidi, Zhu Li, Jinqi Liao, Wei Shu, Arif Ali Chishti, Liangge He, Gulzar Alam, Abdullah Faqeer, Ilyas Ali, Shuai Zhang, Ting Wang, Tao Liu, Meiling Zhou, Gang Wang, Yan Zhou, Guangqian Zhou

“…Characterization of MAD iPSC‐derived Mesenchymal stem cells (MAD‐iMSC) uncovers deregulated mitochondrial Ca+2 as the primary cause of inflammaging, mediated through inflammasome formation rather than the cGAS‐STING pathway. …”
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Bem mais que pós-moderno: poder, sociedade civil e democracia na modernidade periférica radicalizada by Marco Aurélio Nogueira

“…Starting from the hypothesis that radicalized peripheral modernity lives with a dynamic of institutional difficulties and of an organizational suffering that deregulates social practices and blocks the actions of civil society, the text investigates the chances of democratic power in a historical and social situation that seems to be not only breaking apart, but also losing the typical centers of reference, authority and order…”
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The Clinical and Prognostic Significance of Activated AKT-mTOR Pathway in Human Astrocytomas by Elias A. El Habr, Christos Adamopoulos, Georgia Levidou, Aggeliki A. Saetta, Penelope Korkolopoulou, Christina Piperi

“…This paper is focused on the impact of deregulated AKT-mTOR signaling components in the clinical outcome and prognosis of human astrocytomas. …”
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Targeting protein synthesis pathways in MYC-amplified medulloblastoma by Devendra Kumar, Ranjana Kanchan, Nagendra K. Chaturvedi

“…Abstract MYC is one of the most deregulated oncogenic transcription factors in human cancers. …”
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Application of Flower Pollination Algorithm for Solving Complex Large-Scale Power System Restoration Problem Using PDFF Controllers by G. Ganesan Subramanian, Albert Alexander Stonier, Geno Peter, Vivekananda Ganji

“…This study also highlights the necessary ancillary service requirements for the system under a deregulated environment to cater to large-scale power failures and entire system outages. …”
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Mathematical Analysis Of A Modular Network Coordinating The Cell Cycle And Apoptosis by Gheorghe Craciun, Baltazar Aguda, Avner Friedman

“…The cell-division cycle and apoptosis are key cellular processes deregulated during carcinogenesis. Recent work of Aguda and Algar suggests a modular organization of regulatory molecular pathways linking the cellular processes of division and apoptosis. …”
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Faire tourner Paris : ethnogénétique et logogénétique de Nana de Zola by Sophie Ménard

“…Her textual destiny will be to upturn Paris by decaying and bloodying it with her deregulated sex. This embryonic story condenses a cultural microsystem which creates and structures one of the novel’s symbolic systems.…”
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The Emerging Role of miRNAs and Their Clinical Implication in Biliary Tract Cancer by Nina Nayara Ferreira Martins, Kelly Cristina da Silva Oliveira, Amanda Braga Bona, Marília de Arruda Cardoso Smith, Geraldo Ishak, Paulo Pimentel Assumpção, Rommel Rodríguez Burbano, Danielle Queiroz Calcagno

“…Recently, a large number of studies have demonstrated that deregulated expression of microRNAs is closely associated with cancer development and progression. …”
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