Application of Flower Pollination Algorithm for Solving Complex Large-Scale Power System Restoration Problem Using PDFF Controllers by G. Ganesan Subramanian, Albert Alexander Stonier, Geno Peter, Vivekananda Ganji

“…This study also highlights the necessary ancillary service requirements for the system under a deregulated environment to cater to large-scale power failures and entire system outages. …”
Get full text

Mathematical Analysis Of A Modular Network Coordinating The Cell Cycle And Apoptosis by Gheorghe Craciun, Baltazar Aguda, Avner Friedman

“…The cell-division cycle and apoptosis are key cellular processes deregulated during carcinogenesis. Recent work of Aguda and Algar suggests a modular organization of regulatory molecular pathways linking the cellular processes of division and apoptosis. …”
Get full text

Faire tourner Paris : ethnogénétique et logogénétique de Nana de Zola by Sophie Ménard

“…Her textual destiny will be to upturn Paris by decaying and bloodying it with her deregulated sex. This embryonic story condenses a cultural microsystem which creates and structures one of the novel’s symbolic systems.…”
Get full text

Genomic Profiling of Liver Cancer by Ju-Seog Lee

“…Development of liver cancers is driven largely by genomic alterations that deregulate signaling pathways, influencing growth and survival of cancer cells. …”
Get full text

The Emerging Role of miRNAs and Their Clinical Implication in Biliary Tract Cancer by Nina Nayara Ferreira Martins, Kelly Cristina da Silva Oliveira, Amanda Braga Bona, Marília de Arruda Cardoso Smith, Geraldo Ishak, Paulo Pimentel Assumpção, Rommel Rodríguez Burbano, Danielle Queiroz Calcagno

“…Recently, a large number of studies have demonstrated that deregulated expression of microRNAs is closely associated with cancer development and progression. …”
Get full text

Oxidative Stress, Tumor Microenvironment, and Metabolic Reprogramming: A Diabolic Liaison by Tania Fiaschi, Paola Chiarugi

“…Conversely to normal cells, where deregulated oxidative stress drives the activation of death pathways, malignant cells exploit oxidative milieu for its advantage. …”
Get full text

Potential Role of Sugar Transporters in Cancer and Their Relationship with Anticancer Therapy by Moisés Blanco Calvo, Angélica Figueroa, Enrique Grande Pulido, Rosario García Campelo, Luís Antón Aparicio

“…In fact, sugar transporters are deregulated in cancer cells so they incorporate higher amounts of sugar than normal cells. …”
Get full text

Thrombomodulin: A Bifunctional Modulator of Inflammation and Coagulation in Sepsis by Takayuki Okamoto, Hironobu Tanigami, Koji Suzuki, Motomu Shimaoka

“…Deregulated interplay between inflammation and coagulation plays a pivotal role in the pathogenesis of sepsis. …”
Get full text

Trajectories of Platform-mediated Gig Work in Nordic Taxi and Food Delivery Industries by Sigurd M. N. Oppegaard, Johan Alfonsson, Stine Rasmussen, Jere Immonen

“…It shows that gig platforms established themselves in the ‘fringes’ of the Nordic labor market model, evaded regulations by classifying workers as self-employed contractors, recruited workers from marginalized segments of the labor force, and provoked regulatory responses that deregulated markets to facilitate their business model. …”
Get full text

Aneuploidy Mechanisms in Human Colorectal Preneoplastic Lesions and Barrett’s Esophagus. Is There a Role for K-Ras and p53 Mutations? by Walter Giaretti

“…These data and data from experiments using in vitro and mouse models, suggest that chromosome instability, tetraploidization, and asymmetrical chromosome segregation during cell division are the result of deregulated cell cycle genes with multiple functions that normally exert active checks on the cell cycle processes including apoptosis and chromosome stability.…”
Get full text

The Ethnic Hierarchy of the Taxi Industry: Structural Changes and Social Mobility Among Migrant Drivers by Helga Hiim Stålhane

“…Building on these findings, I conjecture about how current deregulations can alter the ethnic hierarchy, but simultaneously limit paths to social mobility.…”
Get full text

Impaired GABA Neural Circuits Are Critical for Fragile X Syndrome by Fei Gao, Lijun Qi, Zhongzhen Yang, Tao Yang, Yan Zhang, Hui Xu, Huan Zhao

“…Here, we reviewed the changes of GABA neural circuits that were attributed to intellectual-deficient FXS, from several aspects including deregulated GABA metabolism, decreased expressions of GABA receptor subunits, and impaired GABAergic neural circuits. …”
Get full text

The Role of TGFβ Signaling in Squamous Cell Cancer: Lessons from Mouse Models by Adam B. Glick

“…TGFβ signaling is tightly regulated in normal tissues and becomes deregulated during cancer development in cutaneous SCC and many other solid tumors. …”
Get full text

Targeting Apoptosis Pathways in Cancer with Alantolactone and Isoalantolactone by Azhar Rasul, Muhammad Khan, Muhammad Ali, Jiang Li, Xiaomeng Li

“…Based on the literature and also on our previous results, alantolactone and isoalantolactone induce apoptosis by targeting multiple cellular signaling pathways that are frequently deregulated in cancers and suggest that their simultaneous targeting by these compounds could result in efficacious and selective killing of cancer cells. …”
Get full text

Exosomal miRNAs involvement in pathogenesis, diagnosis, and treatment of rheumatoid arthritis by Mahvash Sadeghi, Jalil Tavakol Afshari, Afsane Fadaee, Mohammadreza Dashti, Fatemeh Kheradmand, Sajad Dehnavi, Mojgan Mohammadi

“…Exosomal miRNAs were shown to be involved in normal and pathological conditions. In RA, deregulated exosomal miRNA expression was observed to be involved in the intercellular communication between synovial cells, and inflammatory or regulatory immune cells. …”
Get full text

Cytokine Levels in the Serum of Healthy Subjects by Giulio Kleiner, Annalisa Marcuzzi, Valentina Zanin, Lorenzo Monasta, Giorgio Zauli

“…Indeed, when the cytokine production is deregulated, diseases often occur. The understanding of the physiological mechanism of the cytokine network would be useful to better comprehend pathological conditions. …”
Get full text

Plasma MicroRNA Expression Profiles in Psoriasis by Shiju Xiao, Xin Liu, Xiaoxu Wang, Hongpeng Lv, Junbo Zhao, Xinwei Guo, Fuyang Xian, Yunrun Ji, Guangzhong Zhang

“…Network analysis revealed pivotal deregulated plasma miRNAs and their relevant target genes and pathways regulating psoriasis pathogenesis. …”
Get full text

The Role of Limbal Epithelial Stem Cells in Regulating Corneal (Lymph)angiogenic Privilege and the Micromilieu of the Limbal Niche following UV Exposure by M. Notara, A. Lentzsch, M. Coroneo, C. Cursiefen

“…This review focuses on the role of corneal and limbal epithelial cells and the stem cell niche in maintaining corneal avascularity and corneal immune privilege and how this may be deregulated following UV exposure. We present an overview of the PUBMED literature in the field as well as recent work from our laboratories.…”
Get full text

Notch/CXCR4 Partnership in Acute Lymphoblastic Leukemia Progression by Georgia Tsaouli, Elisabetta Ferretti, Diana Bellavia, Alessandra Vacca, Maria Pia Felli

“…Different genetic alterations characterize the two ALL forms. Deregulated Notch, either Notch1 or Notch3, and CXCR4 receptor signaling are involved in ALL disease development and progression. …”
Get full text

Brief review of pathophysiological disorders as consequence of psychological stress by Francisco López-Naranjo, Rebeca Córdova-Moreno, Ivo Heyerdahl-Viau

“…This is mainly due to the neurobiological and endocrine response because when faced with a stressful stimulus, a deregulated release of glucocorticoids and catecholamines is generated, altering the normal physiology of the organism. …”
Get full text