Genomic Profiling of Liver Cancer by Ju-Seog Lee

“…Development of liver cancers is driven largely by genomic alterations that deregulate signaling pathways, influencing growth and survival of cancer cells. …”
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Potential Role of Sugar Transporters in Cancer and Their Relationship with Anticancer Therapy by Moisés Blanco Calvo, Angélica Figueroa, Enrique Grande Pulido, Rosario García Campelo, Luís Antón Aparicio

“…In fact, sugar transporters are deregulated in cancer cells so they incorporate higher amounts of sugar than normal cells. …”
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Oxidative Stress, Tumor Microenvironment, and Metabolic Reprogramming: A Diabolic Liaison by Tania Fiaschi, Paola Chiarugi

“…Conversely to normal cells, where deregulated oxidative stress drives the activation of death pathways, malignant cells exploit oxidative milieu for its advantage. …”
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Exploring oncogenic roles and clinical significance of EZH2: focus on non-canonical activities by Michal Wozniak, Malgorzata Czyz

“…EZH2 is frequently mutated and/or its expression is deregulated in various cancer types. The cancer sensitivity to inhibitors of EZH2 enzymatic activity and state-of-the-art approaches to deplete EZH2 with chemical degraders are discussed. …”
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Thrombomodulin: A Bifunctional Modulator of Inflammation and Coagulation in Sepsis by Takayuki Okamoto, Hironobu Tanigami, Koji Suzuki, Motomu Shimaoka

“…Deregulated interplay between inflammation and coagulation plays a pivotal role in the pathogenesis of sepsis. …”
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Trajectories of Platform-mediated Gig Work in Nordic Taxi and Food Delivery Industries by Sigurd M. N. Oppegaard, Johan Alfonsson, Stine Rasmussen, Jere Immonen

“…It shows that gig platforms established themselves in the ‘fringes’ of the Nordic labor market model, evaded regulations by classifying workers as self-employed contractors, recruited workers from marginalized segments of the labor force, and provoked regulatory responses that deregulated markets to facilitate their business model. …”
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Aneuploidy Mechanisms in Human Colorectal Preneoplastic Lesions and Barrett’s Esophagus. Is There a Role for K-Ras and p53 Mutations? by Walter Giaretti

“…These data and data from experiments using in vitro and mouse models, suggest that chromosome instability, tetraploidization, and asymmetrical chromosome segregation during cell division are the result of deregulated cell cycle genes with multiple functions that normally exert active checks on the cell cycle processes including apoptosis and chromosome stability.…”
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The Ethnic Hierarchy of the Taxi Industry: Structural Changes and Social Mobility Among Migrant Drivers by Helga Hiim Stålhane

“…Building on these findings, I conjecture about how current deregulations can alter the ethnic hierarchy, but simultaneously limit paths to social mobility.…”
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Impaired GABA Neural Circuits Are Critical for Fragile X Syndrome by Fei Gao, Lijun Qi, Zhongzhen Yang, Tao Yang, Yan Zhang, Hui Xu, Huan Zhao

“…Here, we reviewed the changes of GABA neural circuits that were attributed to intellectual-deficient FXS, from several aspects including deregulated GABA metabolism, decreased expressions of GABA receptor subunits, and impaired GABAergic neural circuits. …”
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The Role of TGFβ Signaling in Squamous Cell Cancer: Lessons from Mouse Models by Adam B. Glick

“…TGFβ signaling is tightly regulated in normal tissues and becomes deregulated during cancer development in cutaneous SCC and many other solid tumors. …”
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Functional conservation and divergence of arabidopsis VENOSA4 and human SAMHD1 in DNA repair by Raquel Sarmiento-Mañús, Sara Fontcuberta-Cervera, Kensuke Kawade, Akira Oikawa, Hirokazu Tsukaya, Víctor Quesada, José Luis Micol, María Rosa Ponce

“…The ven4 loss-of-function mutants showed increased DNA ploidy and deregulated DNA repair genes, suggesting DNA damage accumulation. …”
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Targeting Apoptosis Pathways in Cancer with Alantolactone and Isoalantolactone by Azhar Rasul, Muhammad Khan, Muhammad Ali, Jiang Li, Xiaomeng Li

“…Based on the literature and also on our previous results, alantolactone and isoalantolactone induce apoptosis by targeting multiple cellular signaling pathways that are frequently deregulated in cancers and suggest that their simultaneous targeting by these compounds could result in efficacious and selective killing of cancer cells. …”
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Exosomal miRNAs involvement in pathogenesis, diagnosis, and treatment of rheumatoid arthritis by Mahvash Sadeghi, Jalil Tavakol Afshari, Afsane Fadaee, Mohammadreza Dashti, Fatemeh Kheradmand, Sajad Dehnavi, Mojgan Mohammadi

“…Exosomal miRNAs were shown to be involved in normal and pathological conditions. In RA, deregulated exosomal miRNA expression was observed to be involved in the intercellular communication between synovial cells, and inflammatory or regulatory immune cells. …”
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Mitochondrial quality control: a pathophysiological mechanism and potential therapeutic target for chronic obstructive pulmonary disease by Mengjiao Xu, Peng Feng, Peng Feng, Jun Yan, Lei Li

“…However, in COPD, due to the persistent stimulation of harmful factors such as smoking and air pollution, mitochondrial quality control mechanisms often become deregulated, leading to mitochondrial dysfunction. Mitochondrial dysfunction plays a pivotal role in the pathogenesis of COPD, contributing toinflammatory response, oxidative stress, cellular senescence. …”
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Cytokine Levels in the Serum of Healthy Subjects by Giulio Kleiner, Annalisa Marcuzzi, Valentina Zanin, Lorenzo Monasta, Giorgio Zauli

“…Indeed, when the cytokine production is deregulated, diseases often occur. The understanding of the physiological mechanism of the cytokine network would be useful to better comprehend pathological conditions. …”
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Plasma MicroRNA Expression Profiles in Psoriasis by Shiju Xiao, Xin Liu, Xiaoxu Wang, Hongpeng Lv, Junbo Zhao, Xinwei Guo, Fuyang Xian, Yunrun Ji, Guangzhong Zhang

“…Network analysis revealed pivotal deregulated plasma miRNAs and their relevant target genes and pathways regulating psoriasis pathogenesis. …”
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Liver-specific gene PGRMC1 blocks c-Myc-induced hepatocarcinogenesis through ER stress-independent PERK activation by Fubo Ji, Jianjuan Zhang, Liping Mao, Yaqi Tan, Meihua Ye, Xianglei He, Yongzhi Zhao, Jiaxin Liu, Yan Zhang, Nachuan Zhang, Jiong Shi, Jianing Yan, Xiujun Cai, Bin Zhao, Jianping Jin, Pinglong Xu, Stephanie Roessler, Xin Zheng, Junfang Ji

“…Patients with low-PGRMC1 in their tumors have poor prognosis. Collectively, deregulated LSGs in HCC are associated with the c-Myc pathway activation and PGRMC1 blocks c-Myc-induced hepatic carcinogenesis through promoting ER stress-independent PERK activation.…”
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The Role of Limbal Epithelial Stem Cells in Regulating Corneal (Lymph)angiogenic Privilege and the Micromilieu of the Limbal Niche following UV Exposure by M. Notara, A. Lentzsch, M. Coroneo, C. Cursiefen

“…This review focuses on the role of corneal and limbal epithelial cells and the stem cell niche in maintaining corneal avascularity and corneal immune privilege and how this may be deregulated following UV exposure. We present an overview of the PUBMED literature in the field as well as recent work from our laboratories.…”
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Notch/CXCR4 Partnership in Acute Lymphoblastic Leukemia Progression by Georgia Tsaouli, Elisabetta Ferretti, Diana Bellavia, Alessandra Vacca, Maria Pia Felli

“…Different genetic alterations characterize the two ALL forms. Deregulated Notch, either Notch1 or Notch3, and CXCR4 receptor signaling are involved in ALL disease development and progression. …”
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Brief review of pathophysiological disorders as consequence of psychological stress by Francisco López-Naranjo, Rebeca Córdova-Moreno, Ivo Heyerdahl-Viau

“…This is mainly due to the neurobiological and endocrine response because when faced with a stressful stimulus, a deregulated release of glucocorticoids and catecholamines is generated, altering the normal physiology of the organism. …”
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