Glycerol Carbonate: A Novel Biosolvent with Strong Ionizing and Dissociating Powers by Guangnan Ou, Biyan He, Xuejing Li, Jianhui Lei

“…Due to the weak ionizing and dissociating powers of common organic solvents, the charge of the protein will change significantly when the protein is transferred from water to common organic solvents, resulting in protein denaturation. In this work, glycerol carbonate (GC) was synthesized, which ionizing and dissociating abilities were very close to those of water. …”
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In Vitro Antioxidative Evaluation of α- and β-Carotene, Isolated from Crude Palm Oil by Surashree Sen Gupta, Mahua Ghosh

“…In vitro antidenaturation test again specified the efficacy of low concentrations in preventing protein denaturation. Through this study a definite dosage formulation for consumption of carotenoids is being proposed which will enhance health promotion and prevent chronic diseases when taken as fortified foods or dietary supplements.…”
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The Effect of Divalent Metal Ions on the Temperature Stability of Poly(I:C) Duplex by Evgeniya Usenko, Vladimir Valeev, Alexander Glamazda, Victor Karachevtsev

“…The effect of divalent ions on the thermal stability of the double-stranded polynucleotide polyinosinic:polycytidylic acid (poly(I:C)) in a buffer solution (pH 7) was studied by UV absorption spectroscopy and thermal denaturation by measuring the absorbance at 260 nm. The concentration dependence of the polynucleotide melting temperature (Tm) in the presence of metal ions (2.5 × 10−6–10−2 M) was obtained. …”
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Adsorption Ability for Toxic Chromium (VI) Ions in Aqueous Solution of Some Modified Oyster Shell Types by Thuy Chinh Nguyen, Xuan Thai Nguyen, Do Mai Trang Tran, Quoc Trung Vu, Van Hai Nguyen, Duy Trinh Nguyen, Minh Thanh Do, Thi Len Nguyen, Thi Ngoc Lien Ly, Hoang Thai

“…The oyster shell samples were calcined at different temperatures and denatured by using ethylenediaminetetraacetic acid (EDTA). …”
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Divalent Metal- and High Mobility Group N Protein-Dependent Nucleosome Stability and Conformation by Michelle S. Ong, Dileep Vasudevan, Curt A. Davey

“…In addition, thermal denaturation assays show that the presence of 1 mM Mg2+> or Ca2+ gives a reduction in nucleosome core terminus stability, which is further substantially diminished by the binding of HMGN2 or truncated HMGN1. …”
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An Overview of the Intrinsic Role of Citrullination in Autoimmune Disorders by Mohammed Alghamdi, Doaa Alasmari, Amjad Assiri, Ehab Mattar, Abdullah A. Aljaddawi, Sana G. Alattas, Elrashdy M. Redwan

“…This modification leads to a charge shift, which affects the protein structure, protein-protein interactions, and hydrogen bond formation, and it may cause protein denaturation. The irreversible citrullination reaction is not limited to a specific protein, cell, or tissue. …”
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Phytochemical, Antioxidant, Anti-Inflammatory, and Thrombolytic Properties of Cleisomeria lanatum (Lindl.) Lindl. ex G. Don by Minhajur Rahman, Abu Taleb Surag, Roxy Begum, Md. Shakhuat Hossain Tusher, Mohammed Kamrul Huda

“…Antioxidant, anti-inflammatory, and thrombolytic properties were investigated using a free-radical scavenging assay, heat-induced albumin denaturation assay, and blood clotting inhibition assay. …”
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L-Proline-Catalyzed Synthesis of Phthalimide Derivatives and Evaluation of Their Antioxidant, Anti-Inflammatory, and Lipoxygenase Inhibition Activities by Shagufta Perveen, Raha Orfali

“…Compound 2 was found to be promising and about equal to the used standard aspirin in the inhibition of bovine serum albumin denaturation, while other compounds showed weak-to-moderate % inhibition.…”
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Microenvironmental modulation breaks intrinsic pH limitations of nanozymes to boost their activities by Tong Li, Xiaoyu Wang, Yuting Wang, Yihong Zhang, Sirong Li, Wanling Liu, Shujie Liu, Yufeng Liu, Hang Xing, Ken-ichi Otake, Susumu Kitagawa, Jiangjiexing Wu, Hao Dong, Hui Wei

“…The confinement of poly(acrylic acid) (PAA) into the channels of peroxidase-mimicking PCN-222-Fe (PCN = porous coordination network) nanozyme lowers its microenvironmental pH, enabling it to perform its best activity at pH 7.4 and to solve pH mismatch in cascade systems coupled with acid-denatured oxidases. Experimental investigations and molecular dynamics simulations reveal that PAA not only donates protons but also holds protons through the salt bridges between hydroniums and deprotonated carboxyl groups in neutral pH condition. …”
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Synthesis, Spectroscopic Characterisation, and Biopotential and DNA Cleavage Applications of Mixed Ligand 4-N,N-Dimethylaminopyridine Metal Complexes by C. Surendra Dilip, K. Manikandan, D. Rajalaxmi (a) Subahashini, R. Thiruneelakandan

“…The DNA interaction of the synthesized complexes on CT-DNA was investigated by UV-Vis spectroscopy, viscosity, thermal denaturation, and electroanalytical experiments and their binding constants () were also calculated.…”
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Effects of Hydrophobic Nanospaces on Structures of Lysozyme by Koki Takenaka, Tomonori Ohaba, Kazuo Takei, Kuniko Akama, Joaquin Silvestre-Albero, Hirofumi Kanoh

“…The recovery of biological activity of lysozyme denatured by heating was promoted by CA. Thus, hydrophobic mesopores of CA influence the stability of the structure of lysozyme.…”
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Comparative In Vitro Binding Studies of TiCl2(dpme)2, Ti(ada)2(bzac)2, and TiCl2(bzac)(bpme) Titanium Complexes with Calf-Thymus DNA by Pamita Awasthi, Nitesh Kumar, Raj Kaushal, Mohan Kumar, Shrikant Kukreti

“…The binding of TiCl2(dpme)2 (1), (dpme = 6,6′-dimethyl-2,2′-bipyridine), Ti(ada)2(bzac)2 (2), (ada = adamantylamine; bzac = benzoylacetone), and TiCl2(bzac)(bpme) (3), (bpme = 4,4′-dimethyl-2,2′-bipyrdine) with calf thymus (ct) DNA has been studied by UV-visible spectroscopy, thermal denaturation, and circular dichroism spectroscopy. In UV-visible study complexes 1, 2, and 3 showed red, blue, and red shifts, respectively, upon the addition of ct-DNA along with a significant hyperchromism. …”
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Adrenal Hemangioma: A Case of Retroperitoneal Tumor by Genta Iwamoto, Kota Shimokihara, Takashi Kawahara, Daiji Takamoto, Masahiro Yao, Jun-ichi Teranishi, Masako Otani, Hiroji Uemura

“…Histopathologically, hyperplastic small vessels with hemorrhaging and denaturation were seen. The endothelial cells showed no variants or division of the nucleus. …”
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Hybrid Hydrogel Supplemented with Algal Polysaccharide for Potential Use in Biomedical Applications by Dana Stan, Andreea-Cristina Mirica, Sorin Mocanu, Diana Stan, Iunia Podolean, Natalia Candu, Magdi El Fergani, Laura Mihaela Stefan, Ana-Maria Seciu-Grama, Ludmila Aricov, Oana Brincoveanu, Carmen Moldovan, Lorena-Andreea Bocancia-Mateescu, Simona M. Coman

“…The characterization of the hydrogel membranes involved multiple methods to assess their structural, mechanical, and chemical properties, such as pH measurements, swelling, moisture content and uptake, gel fraction, hydrolytic degradation, protein adsorption and denaturation tests, rheological measurements, SEM, biocompatibility testing, and scratch wound assay. …”
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Multiple Adenomatous Duodenal Polyposis by Zdena Zádorová, Jan Hajer, Václav Mandys

“…Afterwards we screened the patient for germline MYH mutations using the denaturing high-performance liquid chromatography (DHPLC) in combination with sequencing. …”
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An artificial transcription factor that activates potent interferon-γ expression in human Jurkat T Cells by Ashley King, Davis Noblitt, Olivia Sherron, Olivia Sherron, Clara Kjerfve, Lydia Pless, Nicholas L. Truex

“…Biophysical characterization showed the recombinant ATF protein recognizes the human IFNG gene with nanomolar affinity (KD = 5.27 ± 0.3 nM), adopts a protein secondary structure associated with the ββα-fold of zinc finger domains, and is resistant to thermal denaturation. These studies demonstrate that transcriptional targeting of cytokine genes, rather than surface receptors, activates cytokine expression and shows significant potential for directing immune function.…”
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A novel isothermal whole genome sequencing approach for Monkeypox Virus by Matthias Licheri, Manon Flore Licheri, Lukas Probst, Cora Sägesser, Pascal Bittel, Franziska Suter-Riniker, Ronald Dijkman

“…This approach yielded from 88% up to 100% genome coverage using either alkaline denatured extracted DNA or clinical material as starting material, with the highest coverage generated by clinical material. …”
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La transparence du corps en médecine, obscur modèle de notre modernité by Alexandre Klein

“…Support d’un pouvoir sur la vie qui dénature la connaissance scientifique comme la démocratie, la translucidité se révèle, à l’aune d’une archéologie de notre rationalité moderne, comme un état limite des modalités de notre volonté de savoir. …”
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Design and Analysis of a Chamber for Thermal Sterilization of Irish Potatoes. by Igiraneza, Jackin

“…Thermal sterilization is a process that focuses on the destruction/denaturing of bacteria contained within food by the application of heat at given temperatures and for a given period of time. …”
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Anti-Inflammatory Potential and Synergic Activities of <i>Eclipta prostrata</i> (L.) L. Leaf-Derived Ointment Formulation in Combination with the Non-Steroidal Anti-Inflammatory Dr... by Muhammad M. Poyil, Mohammed H. Karrar Alsharif, Mahmoud H. El-Bidawy, Salman Bin Dayel, Mohammed Sarosh Khan, Zainab Mohammed M. Omar, Alaaeldin Ahmed Mohamed, Reda M. Fayyad, Tarig Gasim Mohamed Alarabi, Hesham A. Khairy, Nasraddin Othman Bahakim, Mohamed A. Samhan, Abd El-Lateef Saeed Abd El-Lateef

“…Using an egg albumin denaturation inhibition assay, the anti-inflammatory activities of <i>E. prostrata</i> alone and in combination with diclofenac were investigated, and they showed 93% and 99% denaturation inhibition at 5 mg concentration of <i>E. prostrata</i> in alone and combination with diclofenac, respectively. …”
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