Wii-Fit for Improving Gait and Balance in an Assisted Living Facility: A Pilot Study by Kalpana P. Padala, Prasad R. Padala, Timothy R. Malloy, Jenenne A. Geske, Patricia M. Dubbert, Richard A. Dennis, Kimberly K. Garner, Melinda M. Bopp, William J. Burke, Dennis H. Sullivan

“…To determine the effects on balance and gait of a Wii-Fit program compared to a walking program in subjects with mild Alzheimer’s dementia (AD). Methods. A prospective randomized (1 : 1) pilot study with two intervention arms was conducted in an assisted living facility with twenty-two mild AD subjects. …”
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A systematic review and meta-analysis assessing adverse event profile and tolerability of nicergoline by Amit Garg, Jun Xu, Mario Fioravanti, Taku Nakashima

“…The studies included in this review were majorly from European countries and mostly in cerebrovascular disease (n=15) and dementia (n=8).Results The treatment withdrawals were comparatively lower in the nicergoline group as compared with the placebo group (RR=0.92; 95% CI 0.7 to 1.21) and other active comparators (RR=0.45; 95% CI 0.10 to 1.95), but the difference was non-significant. …”
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Screening Mild and Major Neurocognitive Disorders in Parkinson’s Disease by Tivadar Lucza, Kázmér Karádi, János Kállai, Rita Weintraut, József Janszky, Attila Makkos, Sámuel Komoly, Norbert Kovács

“…Within the scope of our study we evaluated the sensitivity and specificity of different neuropsychological tests (Addenbrooke’s Cognitive Examination (ACE), Mattis Dementia Rating Scale (MDRS), Mini Mental State Examination (MMSE), and Montreal Cognitive Assessment (MoCA)) in 370 PD patients without depression. …”
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Improvement of Blood Plasmalogens and Clinical Symptoms in Parkinson’s Disease by Oral Administration of Ether Phospholipids: A Preliminary Report by Shiro Mawatari, Shinji Ohara, Yoshihide Taniwaki, Yoshio Tsuboi, Toru Maruyama, Takehiko Fujino

“…Nonmotor symptoms in PD include sleep problems, depression, and dementia, which are not adequately controlled with dopaminergic therapy. …”
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Water quality and neurodegenerative disease risk in the middle-aged and elderly population by Yujia Bao, Yongxuan Li, Yanqiu Zhou, Jingqi Zhou, Wei Mu, Xiaobei Deng, Chen Shen, Lefei Han, Jinjun Ran

“…We found water hardness in 0–120 mg/L elevated the incidence risks of Alzheimer’s disease and vascular dementia compared to that in 120–300 mg/L, with hazard ratios of 1.13 (1.01, 1.27) and 1.24 (1.05, 1.46), respectively. …”
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Explainable machine learning models for identifying mild cognitive impairment in older patients with chronic pain by Xiaoang Zhang, Yuping Liao, Daying Zhang, Weichen Liu, Zhijian Wang, Yaxin Jin, Shushu Chen, Jianmei Wei

“…Abstract Background Mild cognitive impairment (MCI) is prevalent in older adults with chronic pain, making early detection crucial for dementia prevention and healthy aging. This study aimed to determine MCI risk factors in older patients with chronic pain and to develop 9 machine learning models to identify MCI risk. …”
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A Novel Association of Polymorphism in the ITGA4 Gene Encoding the VLA-4 α4 Subunit with Increased Risk of Alzheimer’s Disease by Vladimira Durmanova, Zuzana Parnicka, Juraj Javor, Gabriel Minarik, Lubomir Vrazda, Barbora Vaseckova, Karin Gmitterova, Maria Kralova, Jan Pecenak, Peter Filipcik, Ivana Shawkatova

“…Alzheimer’s disease (AD) is the most prevalent cause of dementia in elderly people worldwide. Many studies support the hypothesis that the inflammation of the CNS contributes to the neurodegeneration and disease progression. …”
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Sicca Symptoms in Parkinson’s Disease: Association with Other Nonmotor Symptoms and Health-Related Quality of Life by Tino Prell, Denise Schaller, Caroline Perner, Otto W. Witte, Julian Grosskreutz

“…Autonomic symptoms (Survey of Autonomic Symptoms, SASs), motor function (Movement Disorder Society-sponsored revision of the Unified Parkinson’s Disease Rating Scale III, MDS-UPDRS III), nonmotor symptoms (nonmotor symptoms questionnaire, NMS-Quest), and QoL (PD Questionnaire-39, PDQ-39) were analysed in 93 PD patients without dementia. Multivariable and multivariate analyses were performed to study the association between clinical parameters and PDQ-39 domains. …”
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Subthalamic Nucleus Deep Brain Stimulation in Early Stage Parkinson’s Disease Is Not Associated with Increased Body Mass Index by Sarah H. Millan, Mallory L. Hacker, Maxim Turchan, Anna L. Molinari, Amanda D. Currie, David Charles

“…This study analyzes changes in body mass index (BMI) in 29 subjects from a prospective, single-blind trial of DBS in early stage PD (age 50–75, Hoehn & Yahr stage II off medication, treated with antiparkinsonian medications for ≥6 months but <4 years, and without a history of motor fluctuations, dyskinesias, or dementia). Subjects were randomized to DBS plus optimal drug therapy (DBS+ODT; n=15) or ODT (n=14) and followed for 24 months. …”
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Respiratory syncytial virus vaccination in older adults and patients with chronic disorders: A position paper from the Portuguese Society of Pulmonology, the Portuguese Association... by Tiago Alfaro, Filipe Froes, Cláudia Vicente, Rui Costa, Cristina Gavina, Rui Baptista, António Maio, Saraiva da Cunha, João Sérgio Neves, Pedro Leuschner, Sofia Duque, Paula Pinto

“…Background Respiratory syncytial virus (RSV) is an important cause of lower respiratory tract infection, hospitalisation and death in adults.Methods Based on evidence regarding the impact of RSV on adult populations at risk for severe infection and the efficacy and safety of RSV vaccines, the Portuguese Society of Pulmonology, the Portuguese Association of General and Family Medicine, the Portuguese Society of Cardiology, the Portuguese Society of Infectious Diseases and Clinical Microbiology, the Portuguese Society of Endocrinology, Diabetes and Metabolism, and the Portuguese Society of Internal Medicine endorses this position paper with recommendations to prevent RSV-associated disease and its complications in adults through vaccination.Conclusion The RSV vaccine is recommended for people aged ≥50 years with risk factors (chronic obstructive pulmonary disease, asthma, heart failure, coronary artery disease, diabetes, chronic kidney disease, chronic liver disease, immunocompromise, frailty, dementia, and residence in a nursing home) and all persons aged ≥60 years. …”
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Glymphatic system: a self-purification circulation in brain by Siying Chen, Siying Chen, Huijing Wang, Lini Zhang, Yingying Xi, Yiying Lu, Kailin Yu, Yujie Zhu, Izmailova Regina, Yong Bi, Fang Tong, Fang Tong

“…Damage to the glymphatic system will give rise to the development and progression of many brain diseases, such as Alzheimer’s disease (AD), Parkinson’s disease (PD), chronic traumatic encephalopathy (CTE), and vascular dementia (VaD). Here, we reviewed previous research associated with the glymphatic system, including its concepts, principles, and influencing factors. …”
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Research Progress and Trends in Exercise Interventions for Mild Cognitive Impairment: A Bibliometric Visualization Analysis Using CiteSpace by Han Q, Kim SM

“…High co-occurrence keywords include “mild cognitive impairment”, “dementia”, and “Alzheimer’s disease”. The primary keyword clusters are &num;0 Cognitive training, &num;1 Cognitive impairment, and &num;2 Mild Cognitive impairment, while newly burst keywords “systematic review”, “recommendations”, and “depression”.Conclusion: Research on exercise interventions for MCI has been steadily gaining attention, becoming an interdisciplinary research area in fields such as geriatrics and neuroscience, with relevant findings concentrated in specific journals. …”
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Nonfluent/Agrammatic PPA with In-Vivo Cortical Amyloidosis and Pick’s Disease Pathology by Francesca Caso, Benno Gesierich, Maya Henry, Manu Sidhu, Amanda LaMarre, Miranda Babiak, Bruce L. Miller, Gil D. Rabinovici, Eric J. Huang, Giuseppe Magnani, Massimo Filippi, Giancarlo Comi, William W. Seeley, Maria Luisa Gorno-Tempini

“…The role of biomarkers in predicting pathological findings in the frontotemporal dementia (FTD) clinical spectrum disorders is still being explored. …”
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Addenbrooke’s Cognitive Examination and Individual Domain Cut-Off Scores for Discriminating between Different Cognitive Subtypes of Parkinson’s Disease by Dagmar Berankova, Eva Janousova, Martina Mrackova, Ilona Eliasova, Milena Kostalova, Svetlana Skutilova, Irena Rektorova

“…The main aim of this study was to verify the sensitivity and specificity of Addenbrooke’s Cognitive Examination-Revised (ACE-R) in discriminating between Parkinson’s disease (PD) with normal cognition (PD-NC) and PD with mild cognitive impairment (PD-MCI) and between PD-MCI and PD with dementia (PD-D). We also evaluated how ACE-R correlates with neuropsychological cognitive tests in PD. …”
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Molecular Mechanisms of Neurodegeneration Related to C9orf72 Hexanucleotide Repeat Expansion by Mirjana Babić Leko, Vera Župunski, Jason Kirincich, Dinko Smilović, Tibor Hortobágyi, Patrick R. Hof, Goran Šimić

“…Two clinically distinct diseases, amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), have recently been classified as two extremes of the FTD/ALS spectrum. …”
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Recent advances in the managements of type 2 diabetes mellitus and natural hypoglycemic substances by Chong Ning, Yuhan Jiao, Jiaqi Wang, Weiwei Li, Jingqiu Zhou, Yi-Chieh Lee, Dik-Lung Ma, Chung-Hang Leung, Rugang Zhu, Hui-Min David Wang

“…Patients with T2DM suffer from complications such as the development of a chronic hyperglycemic condition and even serious metabolic disorders and organ damage in the body and depression and dementia, in addition to other chronic complications. …”
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Prevalence and associated factors of healthy aging among community-dwelling older adults in Lishui city, China: a cross-sectional study by Jian-Hua Chen, Norhasmah Mohd Zain, Azlina Yusuf, Bi-He Ying

“…A validated questionnaire of Healthy Aging Instruments (HAI), Basic Psychological Needs Satisfaction (BPNS), Patient Health Questionnaire (PHQ-9), Ascertain Dementia 8 questionnaire (AD8), Family Adaption Scale (FAS), Community-Based Health Promotion Activity Questionnaires (HPAQ), Social Function Questionnaire for Chinese Older Adults (SFQCOA), Adult Health Self-Management Skills (ability) Rating Scale (AHSMSRS) was incorporated. …”
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Research hotspots and trends in the antioxidant effects of acupuncture: A bibliometric analysis from 2003 to 2024 by Zhilin Huang, Song Li, YiHao Zhou, Anhong Dai, Yi Zhang, Meifang Liu, Mengqi Le, Jing Shi

“…Neurological disorders such as Parkinson's disease, vascular dementia, and stroke are major research areas in this field. …”
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Assessment of the Impact of Different Types and Intensities of Physical Exercise on the Quality of Life of Patients with Alzheimer’s Disease: A Literature Review by Katarzyna Barabasz, Paulina Więcławek, Piotr Juda, Patrycja Kłaptocz, Katarzyna Łukoś-Karcz, Dominik Bańkowski, Gabriela Pabian, Karol Musiał, Kamil Bielak

“… Objective Alzheimer’s Disease (AD) is the most common form of dementia, representing a global health challenge. The aim of this review is to assess the impact of different types and intensities of physical exercise on cognitive functions, biomarkers, and the quality of life of AD patients.   …”
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Inflammatory biomarkers profiles and cognition among older adults by Aline Thomas, Jing Guo, Dolly Reyes-Dumeyer, Danurys Sanchez, Nikolaos Scarmeas, Jennifer J. Manly, Adam M. Brickman, Rafael A. Lantigua, Richard Mayeux, Yian Gu

“…We explored 23 circulating inflammatory biomarkers using data from 1,743 participants without dementia (≥ 65 years-old) from the community-based, multiethnic Washington Heights Inwood Columbia Aging Project. …”
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