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The possible therapeutic role of advanced glycation end-product inhibitors in ischemic stroke
Published 2025-03-01“…AGEs-induced cellular aging is implicated in the development and progression of different neurological disorders such as dementia, neuropsychiatric disorders, and cerebrovascular diseases. …”
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542
Physical and cognitive-based training in healthy older adults: Evidence from a systematic review and meta-analysis
Published 2024-03-01“…Introduction: Several studies have shown that cognitive training interventions and regular physical activity are popular intervention in dementia prevention guidelines. The purpose of this study was to examine the effectiveness of physical and mental training on cognitive outcomes in, older adults. …”
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543
Effectiveness of befriending interventions: a systematic review and meta-analysis
Published 2017-04-01“…We aim to conduct a systematic review of the benefits of befriending.Design Systematic review.Methods A systematic search of electronic databases was conducted to identify randomised controlled trials and quasi-experimental trials of befriending for a range of physical and mental health indications including depression, anxiety, mental illness, cancer, physical illness and dementia. Main outcomes included patient-relevant and disease-specific outcomes, such as depression, loneliness, quality of life, self-esteem, social support and well-being.Results A total of 14 trials (2411 participants) were included; 7 were judged at low risk of bias. …”
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544
Effects of central administration of the human Tau proteinon the <i>Bdnf, Trkb, p75, Mapt, Bax</i> and <i>Bcl-2</i> genes expression in the mouse brain
Published 2023-07-01“…Alzheimer’s disease is the most common form of dementia, affecting millions of people worldwide. Despite intensive work by many researchers, the mechanisms underlying Alzheimer’s disease development have not yet been elucidated. …”
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545
Understanding retinal tau pathology through functional 2D and 3D iPSC-derived in vitro retinal models
Published 2025-01-01“…This study investigates the impact of the Frontotemporal Dementia-linked IVS 10 + 16 MAPT mutation on retinal development and function using 2D and 3D retinal models derived from human induced pluripotent stem cells. …”
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546
White Matter Lesion Assessment in Patients with Cognitive Impairment and Healthy Controls: Reliability Comparisons between Visual Rating, a Manual, and an Automatic Volumetrical MR...
Published 2013-01-01“…Age-related white matter lesions (WML) are a risk factor for stroke, cognitive decline, and dementia. Different requirements are imposed on methods for the assessment of WML in clinical settings and for research purposes, but reliability analysis is of major importance. …”
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547
Sex Modified the Association between Sleep Duration and worse Cognitive Performance in Chinese Hypertensive Population: Insight from the China H-Type Hypertension Registry Study
Published 2022-01-01“…Cognitive decline could be seen as the sign of preclinical phase of dementia, which was found to be sex differentiated. …”
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548
Gastric Dilation due to a Neuroleptic Agent in an Elderly Patient: A Case Report
Published 2014-01-01“…A 76-year-old man, living in a nursing home, was hospitalized for general weakness and abdominal pain. He had dementia with behavioral disorders treated with cyamemazine, a sedative and anxiolytic neuroleptic. …”
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549
Incidence and Prevalence of Alzheimer’s Disease in Medicare Beneficiaries
Published 2024-12-01“…Abstract Introduction The availability of anti-amyloid therapy for mild cognitive impairment (MCI) due to Alzheimer’s disease and mild Alzheimer’s dementia (AD) has underscored the need for realistic estimates of the population with AD/MCI within the healthcare system to assure adequate preparedness. …”
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550
Construction of a prediction and visualization system for cognitive impairment in elderly COPD patients based on self-assigning feature weights and residual evolution model
Published 2025-02-01“…BackgroundAssessing cognitive function in patients with chronic obstructive pulmonary disease (COPD) is crucial for ensuring treatment efficacy and avoiding moderate cognitive impairment (MCI) or dementia. We aimed to build better machine learning models and provide useful tools to provide better guidance and assistance for COPD patients' treatment and care.MethodsA total of 863 COPD patients from a local general hospital were collected and screened, and they were separated into two groups: cognitive impairment (356 patients) and cognitively normal (507 patients). …”
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551
The impact of nutritional status on centenarians’ physical, mental, and functional health
Published 2025-04-01“…Inadequate physical performance, frailty, sarcopenia, severe dementia, some degree of dependency, low PNI, and avoiding the use of dental prosthesis were significantly associated with nutritional vulnerability (P < 0.05). …”
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552
Therapeutic potential of phytocompounds of Bacopa monnieri (L.) Wettst (literature review)
Published 2024-10-01“…Numerous clinical trials show the effectiveness of the use of extracts in the treatment of anhedonia, depression, Alzheimer's disease, Parkinson's disease, dementia and hyperactivity. An analysis of clinical studies in Ukraine shows that drugs based on B. monnieri can be used in the complex treatment of cognitive impairment associated with dyscirculatory encephalopathy in adults and perinatal CNS damage in children. …”
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553
Clinical evaluation and management of a 45-year-old man with confusion, psychosis, agitation, stereotyped behavior, and impaired speech
Published 2022-01-01“…It is highly possible that an alcohol-related progressive dementia along with his chronic bipolar disorder played a key role in the progression of his brain neurodegeneration. …”
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554
The Microbiota–Gut–Brain Axis: Key Mechanisms Driving Glymphopathy and Cerebral Small Vessel Disease
Published 2024-12-01“…The recent explosion of microbiome research has begun to detail its important role in neurological health, particularly concerning cerebral small vessel disease (CSVD), a disorder associated with cognitive decline and vascular dementia. This narrative review represents state-of-the-art knowledge of the intimate, complex interplay between microbiota and brain health through the gut–brain axis (GBA) and the emerging role of glymphatic system dysfunction (glymphopathy) and circulating cell-derived microparticles (MPs) as mediators of these interactions. …”
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555
Cognitive-Enhancing Effect of a Hydroethanolic Extract of Crinum macowanii against Memory Impairment Induced by Aluminum Chloride in BALB/c Mice
Published 2018-01-01“…The results may support the usefulness of C. macowanii in the management of dementia and related illnesses.…”
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556
Autoimmune Polyglandular Syndrome Type 3 with Anorexia
Published 2012-01-01“…Extended periods of cobalamin deficiency can cause serious complications such as ataxia and dementia, and these complications may not be reversible if replacement therapy with cobalamin is delayed. …”
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557
Characterization of patients with ischemic cerebrovascular disease and cognitive impairment. Cienfuegos, 2018
Published 2020-05-01“…It constitutes the first cause of permanent disability in the adult and the second of dementia.<br /><strong>Objective:</strong> to characterize patients with cerebrovascular disease and cognitive disorder.…”
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558
Blinded by the Mind: Exploring the Hidden Psychiatric Burden in Glaucoma Patients
Published 2025-01-01“…Other less frequent but still significant conditions like sleep disorders, psychosis, dementia, and post-traumatic stress disorder were also observed. …”
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559
“We are Performance Philosophy Problems”
Published 2024-12-01“…Although we keep the offerings separate, both advance the idea that learning-disabled theatre and theatres where people show and share disability and diagnoses of dementia disturb some of the key assumptions of theatre and performance studies, notably ‘withness’ and ‘aboutness’. …”
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560
From Mild Ataxia to Huntington Disease Phenocopy: The Multiple Faces of Spinocerebellar Ataxia 17
Published 2014-01-01“…Among 3 affected members, one presented with HD phenocopy; one with progressive ataxia, dementia, chorea, dystonia, and seizures, and one with mild slowly progressive ataxia with minor cognitive and affective symptoms. …”
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