Physical activity and the outcome of cognitive trajectory: a machine learning approach by Bettina Barisch-Fritz, Jay Shah, Jelena Krafft, Yonas E. Geda, Teresa Wu, Alexander Woll, Janina Krell-Roesch

“…Machine learning (ML) techniques are increasingly used in dementia research, e.g., for diagnosis and risk stratification. …”
Get full text

Disturbances of visual perception in non-demented patients with Parkinson’s disease by R. Timofejavaitė, V. Vilda, A. Liveikienė, R. Kaladytė-Lokominienė

“…There is limited data on hallucinations in PD without dementia, considering them mostly iatrogenic. Materials and methods. …”
Get full text

Quantitative EEG and Cognitive Decline in Parkinson’s Disease by Vitalii V. Cozac, Ute Gschwandtner, Florian Hatz, Martin Hardmeier, Stephan Rüegg, Peter Fuhr

“…Different candidate biomarkers are currently studied for the risk of dementia in PD. Several studies have shown that quantitative EEG (QEEG) is a promising predictor of PD-related cognitive decline. …”
Get full text

How close is autophagy-targeting therapy for Alzheimer's disease to clinical use? A summary of autophagy modulators in clinical studies by Sofia Miranda Fernandes, Johanna Mayer, Per Nilsson, Makoto Shimozawa

“…Alzheimer’s disease (AD) is a neurodegenerative disorder clinically characterized by progressive decline of memory and cognitive functions, and it is the leading cause of dementia accounting for 60%–80% of dementia patients. …”
Get full text

Creutzfeldt-Jakob Disease as a Cause of Cognitive Decline and Seizures in the Elderly: Diagnostic Pointers and Strategy for Investigation by R. Williams, F. Cresswell, M. McClure, R. Lane

“…There is often a paucity of clues as to the underlying pathology, and while the diagnosis will usually prove to be either Alzheimer’s disease or vascular dementia, there may be clinical features suggesting rarer alternatives. …”
Get full text

Bidirectional Mendelian Randomization Analysis of the Association Between Mitochondrial Proteins and Neurodegenerative Diseases by Fangyuan Wang, Zhou Jing, Qingyi Wang, Minghe Li, Bingqi Lu, Ao Huo, Chenglin Zhao, Huanyu Zhou, Wulong Liang, Weihua Hu, Xudong Fu

“…Specifically, associations were found with Alzheimer's disease (AD) (three proteins), Parkinson's disease (PD) (four proteins), amyotrophic lateral sclerosis (ALS) (six proteins), multiple sclerosis (two proteins), and dementia with Lewy bodies (four proteins). Conversely, analyses indicated significant associations of neurodegenerative diseases with mitochondrial protein gene variants, notably with AD, dementia with Lewy bodies, and multiple sclerosis, affecting multiple mitochondrial protein levels. …”
Get full text

Isolation of Pleurotus florida derived acetylcholinesterase inhibitor for the treatment of cognitive dysfunction in mice by Kudrat Randhawa, Varinder Singh, Sanimardeep Kaur, Ravinder Kaur, Suresh Kumar, Richa Shri

“…It improved STZ induced dementia and neurodegeneration in mice by reducing brain acetylcholinesterase action and oxidative stress. …”
Get full text

Kleptomania Induced by Venlafaxine by Kumi Sakurada, Masashi Nibuya, Kazuo Yamada, Seishu Nakagawa, Eiji Suzuki

“…After the diagnostic exclusion of frontotemporal dementia, kleptomania induced by venlafaxine administration was suspected. …”
Get full text

Efficacy of Moxibustion in the Treatment of Parkinson’s Disease Based on Meta-Analysis under Intelligent Medical Treatment by Qianqian Niu, Weijie Xu

“…Dementia in Parkinson’s disease (PD) has become a major factor affecting the quality of life of patients with Parkinson’s disease. …”
Get full text

Barriers to self-management engagement among community-dwelling older adults with mild cognitive impairment: a qualitative study by Jingxian Sun, Yayi Zhao, Aihong Wang

“…IntroductionSelf-management is crucial for individuals with mild cognitive impairment (MCI) to enhance cognitive health and mitigate the potential risk of dementia. However, maintaining consistent engagement in self-management strategies seems a challenge for older adults with MCI. …”
Get full text

Sound Richness of Music Might Be Mediated by Color Perception: A PET Study by Masayuki Satoh, Ken Nagata, Hidekazu Tomimoto

Get full text

Intramuscular Olanzapine in the Management of Behavioral and Psychological Symptoms in Hospitalized Older Adults: A Retrospective Descriptive Study by Silvia Duong, Kam-Tong Yeung, Feng Chang

“…While behavioral and psychological symptoms are frequent in hospitalized older adults with dementia or delirium, data supporting the off-label use of intramuscular atypical antipsychotics remain scarce. …”
Get full text

Risk factors associated with mortality among vaccinated COVID-19 patients: A retrospective study by Hossein Lajmiri, Nioosha Ahmadi, Saeedeh Ebrahimi, Hadi Razavi Nikoo, Mehrdad Farrokhnia, Elham Heidari, Elham Mousavi

“…The median age of those who died was 69.9 years. Dementia and genitourinary system-related diseases was associated with an increased risk of death [6.00 (95% CI: 1.14-31.66) and 4.93 (95% CI: 1.80-13.52)]. …”
Get full text

Decision Making Cognition in Primary Progressive Aphasia by Ezequiel Gleichgerrcht, Teresa Torralva, María Roca, Daniela Szenkman, Agustin Ibanez, Pablo Richly, Mariángeles Pose, Facundo Manes

“…We sought to investigate the decision making profile of Primary Progressive Aphasia (PPA) by assessing patients diagnosed with this disease (n = 10), patients diagnosed with behavioral variant frontotemporal dementia (bvFTD, n = 35), and matched controls (n = 14) using the Iowa Gambling Task, a widely used test that mimics real-life decision making. …”
Get full text

ML-Based Quantitative Analysis of Linguistic and Speech Features Relevant in Predicting Alzheimer’s Disease by Tripti Tripathi, Rakesh Kumar

“…This study presents a novel approach for detecting and classifying six types of cognitive impairment using speech-based analysis, including probable AD, possible AD, mild cognitive impairment (MCI), memory impairments, vascular dementia, and control. The method employs speech data from DementiaBank’s Pitt Corpus, which is preprocessed and analyzed to extract pertinent acoustic features. …”
Get full text

Language assessment in primary progressive aphasia: Which components should be tested? by Andressa Aguiar da Silva, Marcela Lima Silagi, Karin Zazo Ortiz

“…<h4>Introduction</h4>Primary progressive aphasia (PPA) is a dementia syndrome whose onset and course manifests with language deficits. …”
Get full text

Sex Differences in Neuropsychiatric Symptoms of Alzheimer’s Disease: The Modifying Effect of Apolipoprotein E ε4 Status by Yi Xing, Yi Tang, Jianping Jia

“…In this study, sex differences in neuropsychiatric abnormalities were stratified and analyzed by ApoE ε4 status in mild AD and moderate to severe AD separately. The Clinical Dementia Rating (CDR) scale and the Neuropsychiatric Inventory (NPI) were used to assess dementia severity and neuropsychiatric symptoms. …”
Get full text

Metabolism: A Novel Shared Link between Diabetes Mellitus and Alzheimer’s Disease by Yanan Sun, Cao Ma, Hui Sun, Huan Wang, Wei Peng, Zibo Zhou, Hongwei Wang, Chenchen Pi, Yingai Shi, Xu He

“…Novel epidemiological studies demonstrate that some diabetic patients have an increased risk of developing dementia compared with healthy individuals. Alzheimer’s disease (AD) is the most frequent cause of dementia and leads to major progressive deficits in memory and cognitive function. …”
Get full text

Potential therapeutic effects of SIRT1 targeting APOE4-induced microvascular endothelial dysfunction by Yorito Hattori, Masafumi Ihara

Get full text

Visual Features in Alzheimer’s Disease: From Basic Mechanisms to Clinical Overview by María Alejandra Cerquera-Jaramillo, Mauricio O. Nava-Mesa, Rodrigo E. González-Reyes, Carlos Tellez-Conti, Alejandra de-la-Torre

“…Alzheimer’s disease (AD) is the leading cause of dementia worldwide. It compromises patients’ daily activities owing to progressive cognitive deterioration, which has elevated direct and indirect costs. …”
Get full text