Lessons from a Mouse Model Characterizing Features of Vascular Cognitive Impairment with White Matter Changes by Masafumi Ihara, Hidekazu Tomimoto

“…With the demographic shift in age in advanced countries inexorably set to progress in the 21st century, dementia will become one of the most important health problems worldwide. …”
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White Matter Lesions and Cognitive Impairment as Silent Cerebral Disease in Hypertension by Cristina Sierra, Antonio Coca

“…Hypertension is known to be the most important factor for developing stroke and vascular dementia. In addition, the presence of cerebral white matter lesions is an important prognostic factor for the development of stroke, and also for cognitive impairment and dementia. …”
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Syntactic Comprehension in Patients with Amyotrophic Lateral Sclerosis by Kentarou Yoshizawa, Nao Yasuda, Michinari Fukuda, Yumi Yukimoto, Mieko Ogino, Wakana Hata, Ikuyo Ishizaka, Mari Higashikawa

“…In this study, we evaluated syntactic comprehension using the Syntax Test for Aphasia (STA) auditory comprehension task, frontal executive function using the Frontal Assessment Battery (FAB), visuospatial function using Raven’s Coloured Progressive Matrices (RCPM), and dementia using the Hasegawa Dementia Scale-Revised (HDS-R) in 25 patients with ALS. …”
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CASE REPORT by Oana Hănuţ

“…Challenges in the differential diagnosis of dementia in young adults Neurocognitive disorders in patients with alcoholic dependence …”
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Disturbances of visual perception in non-demented patients with Parkinson’s disease by R. Timofejavaitė, V. Vilda, A. Liveikienė, R. Kaladytė-Lokominienė

“…There is limited data on hallucinations in PD without dementia, considering them mostly iatrogenic. Materials and methods. …”
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Quantitative EEG and Cognitive Decline in Parkinson’s Disease by Vitalii V. Cozac, Ute Gschwandtner, Florian Hatz, Martin Hardmeier, Stephan Rüegg, Peter Fuhr

“…Different candidate biomarkers are currently studied for the risk of dementia in PD. Several studies have shown that quantitative EEG (QEEG) is a promising predictor of PD-related cognitive decline. …”
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Creutzfeldt-Jakob Disease as a Cause of Cognitive Decline and Seizures in the Elderly: Diagnostic Pointers and Strategy for Investigation by R. Williams, F. Cresswell, M. McClure, R. Lane

“…There is often a paucity of clues as to the underlying pathology, and while the diagnosis will usually prove to be either Alzheimer’s disease or vascular dementia, there may be clinical features suggesting rarer alternatives. …”
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Bidirectional Mendelian Randomization Analysis of the Association Between Mitochondrial Proteins and Neurodegenerative Diseases by Fangyuan Wang, Zhou Jing, Qingyi Wang, Minghe Li, Bingqi Lu, Ao Huo, Chenglin Zhao, Huanyu Zhou, Wulong Liang, Weihua Hu, Xudong Fu

“…Specifically, associations were found with Alzheimer's disease (AD) (three proteins), Parkinson's disease (PD) (four proteins), amyotrophic lateral sclerosis (ALS) (six proteins), multiple sclerosis (two proteins), and dementia with Lewy bodies (four proteins). Conversely, analyses indicated significant associations of neurodegenerative diseases with mitochondrial protein gene variants, notably with AD, dementia with Lewy bodies, and multiple sclerosis, affecting multiple mitochondrial protein levels. …”
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Isolation of Pleurotus florida derived acetylcholinesterase inhibitor for the treatment of cognitive dysfunction in mice by Kudrat Randhawa, Varinder Singh, Sanimardeep Kaur, Ravinder Kaur, Suresh Kumar, Richa Shri

“…It improved STZ induced dementia and neurodegeneration in mice by reducing brain acetylcholinesterase action and oxidative stress. …”
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Efficacy of Moxibustion in the Treatment of Parkinson’s Disease Based on Meta-Analysis under Intelligent Medical Treatment by Qianqian Niu, Weijie Xu

“…Dementia in Parkinson’s disease (PD) has become a major factor affecting the quality of life of patients with Parkinson’s disease. …”
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Sound Richness of Music Might Be Mediated by Color Perception: A PET Study by Masayuki Satoh, Ken Nagata, Hidekazu Tomimoto

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Intramuscular Olanzapine in the Management of Behavioral and Psychological Symptoms in Hospitalized Older Adults: A Retrospective Descriptive Study by Silvia Duong, Kam-Tong Yeung, Feng Chang

“…While behavioral and psychological symptoms are frequent in hospitalized older adults with dementia or delirium, data supporting the off-label use of intramuscular atypical antipsychotics remain scarce. …”
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Risk factors associated with mortality among vaccinated COVID-19 patients: A retrospective study by Hossein Lajmiri, Nioosha Ahmadi, Saeedeh Ebrahimi, Hadi Razavi Nikoo, Mehrdad Farrokhnia, Elham Heidari, Elham Mousavi

“…The median age of those who died was 69.9 years. Dementia and genitourinary system-related diseases was associated with an increased risk of death [6.00 (95% CI: 1.14-31.66) and 4.93 (95% CI: 1.80-13.52)]. …”
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Decision Making Cognition in Primary Progressive Aphasia by Ezequiel Gleichgerrcht, Teresa Torralva, María Roca, Daniela Szenkman, Agustin Ibanez, Pablo Richly, Mariángeles Pose, Facundo Manes

“…We sought to investigate the decision making profile of Primary Progressive Aphasia (PPA) by assessing patients diagnosed with this disease (n = 10), patients diagnosed with behavioral variant frontotemporal dementia (bvFTD, n = 35), and matched controls (n = 14) using the Iowa Gambling Task, a widely used test that mimics real-life decision making. …”
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ML-Based Quantitative Analysis of Linguistic and Speech Features Relevant in Predicting Alzheimer’s Disease by Tripti Tripathi, Rakesh Kumar

“…This study presents a novel approach for detecting and classifying six types of cognitive impairment using speech-based analysis, including probable AD, possible AD, mild cognitive impairment (MCI), memory impairments, vascular dementia, and control. The method employs speech data from DementiaBank’s Pitt Corpus, which is preprocessed and analyzed to extract pertinent acoustic features. …”
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Language assessment in primary progressive aphasia: Which components should be tested? by Andressa Aguiar da Silva, Marcela Lima Silagi, Karin Zazo Ortiz

“…<h4>Introduction</h4>Primary progressive aphasia (PPA) is a dementia syndrome whose onset and course manifests with language deficits. …”
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Metabolism: A Novel Shared Link between Diabetes Mellitus and Alzheimer’s Disease by Yanan Sun, Cao Ma, Hui Sun, Huan Wang, Wei Peng, Zibo Zhou, Hongwei Wang, Chenchen Pi, Yingai Shi, Xu He

“…Novel epidemiological studies demonstrate that some diabetic patients have an increased risk of developing dementia compared with healthy individuals. Alzheimer’s disease (AD) is the most frequent cause of dementia and leads to major progressive deficits in memory and cognitive function. …”
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Potential therapeutic effects of SIRT1 targeting APOE4-induced microvascular endothelial dysfunction by Yorito Hattori, Masafumi Ihara

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Visual Features in Alzheimer’s Disease: From Basic Mechanisms to Clinical Overview by María Alejandra Cerquera-Jaramillo, Mauricio O. Nava-Mesa, Rodrigo E. González-Reyes, Carlos Tellez-Conti, Alejandra de-la-Torre

“…Alzheimer’s disease (AD) is the leading cause of dementia worldwide. It compromises patients’ daily activities owing to progressive cognitive deterioration, which has elevated direct and indirect costs. …”
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Miglustat Reverts the Impairment of Synaptic Plasticity in a Mouse Model of NPC Disease by G. D’Arcangelo, D. Grossi, M. Racaniello, A. Cardinale, A. Zaratti, S. Rufini, A. Cutarelli, V. Tancredi, D. Merlo, C. Frank

“…Progressive neurological deterioration and insurgence of symptoms like ataxia, seizure, and cognitive decline until severe dementia are pathognomonic features of the disease. …”
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