Phytocompounds from Indonesia Medicinal Herbs as Potential Apelin Receptor Agonist for Heart Failure Therapy: An In-silico Approach by Muhamad Rizqy Fadhillah, Wawaimuli Arozal, Muhammad Habiburrahman, Somasundaram Arumugam, Heri Wibowo, Suci Widya Primadhani, Aryo Tedjo, Surya Dwira, Nurul Gusti Khatimah

“… Heart failure is still a global health problem that demands new pharmacological treatments. The Apelin Receptor (APR), a class A (rhodopsin-like) G-Protein Coupled Receptor (GPCR), is one of the cell membrane receptors that potentially become a specific target of heart failure therapy when activated. …”
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Cross-agency working when conducting a pragmatic RCT for older victims of crime: our experiences and lessons learned by Marc Serfaty, Jessica Satchell, Gloria K. Laycock, Chris R. Brewin, Marta Buszewicz, Gerard Leavey, Vari M. Drennan, Jonathan Cooke, Anthony Kessel

“…Conclusion SNT screening was an effective way to identify distressed victims, but service demands question whether it is viable for working police staff and the delivery of the therapy proved challenging in the context of a traditional RCT. …”
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Unveiling the ultimate advantage: a meta-analysis of 3D visualization and problem-based learning in orthopedic education by Ting Li, Yidan Hu, Ruohong Song, Hangyu Liu, Xin Gao, Fei Wang, Chengwei Xiao, Xilin Liu

“…Conclusion Given the unique demands of orthopedic education, 3D + PBL emerges as a highly effective teaching method. …”
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Multi-Classification Using YOLOv11 and Hybrid YOLO11n-MobileNet Models: A Fire Classes Case Study by Eman H. Alkhammash

“…Recognizing fire classes is critical, since each kind demands a unique suppression approach. Proper fire classification helps to decrease the risk to both life and property. …”
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Modality in debate by Laurent Rouveyrol

“…Les gloses méta-énonciatives ayant pour fonction de demander la parole sont nombreuses. Par ailleurs, les notions d’argumentation, d’opposition et la valeur d’actualité  les caractérisent principalement.L’analyse qualitative montre que dans le cadre d’une argumentation, CAN permet de faire référence à un savoir implicite, présupposé, venant appuyer la thèse défendue. …”
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The impact of the COVID-19 pandemic on the research activity and working experience of clinical academics, with a focus on gender and ethnicity: a qualitative study in the UK by Carmen Soto, Jessica Elizabeth Morgan, Paul Crampton, Paul Alexander Tiffin, Gabrielle M Finn, Amelia Kehoe, Ellie Taylor, John AG Buchanan, Abisola Olatokunbo Balogun

“…Barriers included access to resources to conduct research and the increasing teaching demands. One of the most prominent subthemes within ‘personal characteristics’ was that of the perceived negative impact of the pandemic on the work of female clinical academics. …”
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Advancements, Trends and Future Prospects of Lower Limb Prosthesis by Muhammad Asif, Mohsin Islam Tiwana, Umar Shahbaz Khan, Waqar Shahid Qureshi, Javaid Iqbal, Nasir Rashid, Noman Naseer

“…A mutual observation demands the design of a bio-compatible, lightweight, and economic prosthesis to track the normal human gait by eliminating phantom limb pain. …”
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South African Open Distance Elearning Student: The Types, Effectiveness, and Preference of Feedback Support by Morakinyo Akintolu, Mohamed Ahmed Mitwally, Moeketsi Letseka

“…L’étude identifie également des formulaires de feedback spécifiques demandés par les étudiants pour améliorer leur expérience éducative. …”
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Biomass and Yield in Solanum lycopersicum Expressing a Synthetic Photorespiration Pathway by Laura Dougherty, Bret Cooper, James Bunce, Bryan Vinyard, John Stommel

“…The current study investigated whether a novel synthetic photorespiratory pathway demonstrated to reduce photorespiratory metabolic energy demands and increase plant vegetative biomass in model species could boost tomato crop yield, notably yield of marketable fruit. …”
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Reconstruction for Complex Oromandibular Facial Defects: The Fibula Free Flap and Pectoralis Major Flap Combination by Mohammed Qaisi, Ryan Dee, Issam Eid, James Murphy, Ignacio A. Velasco Martinez, Henry Fung

“…A simpler and less technically demanding way to deal with this may involve the use of a free flap in combination with a pedicled regional flap. …”
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No easy way out: towards a framework concept of long-term governance by Dirk Scheer, Sandra Venghaus, Stefania Sardo, Sascha Stark, Sophie Kuppler, Michael W. Schmidt, Carsten Hoyer-Klick

“…Abstract Background Problems such as climate change, environmental pollution, nuclear disposal and unsustainable production and consumption share a common feature: they pose long-term challenges because of their complex nature, potentially severe consequences, and the demanding problem-solving paths. These challenges may have long-lasting impacts on both present and future generations and, therefore, require to be addressed through a long-term governance perspective, i.e., coherent and consistent policy-making across sectors, institutions, and temporal scales. …”
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Problematic Internet use among resident physicians at St. Paul’s Hospital Millennium Medical College in Addis Ababa, Ethiopia by Yiknashewa Solomon Mekonnen, Selamawit Alemayehu Tessema, Solomon Dhabi Bedane, Askalemariam Bikiss Ali

“…Resident physicians are at risk of exhibiting problematic internet use due to the high stress of academic demands, social isolation, long working hours, busy schedules, and internet access. …”
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REGENERATIVE MEDICINE IN BURN INJURY: A BIBLIOMETRIC ANALYSIS AND LITERATURE REVIEW by Naufal Aminur Rahman, Santi Devina, Muhammad Yusuf Billiant Pradana, Godwin Emeka Ozokolie, Lanre Peter Daodu, Shreya Pandey

“…Abstract: Introduction: Burn injuries represent a significant global health concern, demanding effective management strategies to mitigate their impact. …”
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Distinct dynamic regulation of pectoralis muscle metabolomics by insulin and the promotion of glucose-lipid metabolism with extended duration by Xiangli Zhang, Pengfei Du, Ziyang Wang, Yao Zhu, Xuemeng Si, Wen Chen, Yanqun Huang

“…Initially, chicken muscle tissues downregulate metabolic activities to accommodate the new signaling state, followed by significant upregulation to meet heightened metabolic demands. Extended insulin monitoring promotes glucose uptake and glycolysis, alongside enhanced fatty acid metabolism. …”
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Simplification and Electronisation of Administrative Procedure in the Visegrad Group Countries - a Sociological and Legal Approach by Beniamin Rozczynski

“… Purpose: The purpose of the research was to examine the sociological issues related to the biographical experience of a participant in the administrative procedure in the Visegrad Group countries (the perception of public administration bodies and their organisation, current demands of the public in the field of public administration activities, providing appropriate tangible and intangible tools for officials). …”
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InHeritage—A Gamified Mobile Application with AR and VR for Cultural Heritage Preservation in the Metaverse by Paula Srdanović, Tibor Skala, Marko Maričević

“…In an era increasingly shaped by digital innovation, preserving cultural heritage demands new strategies to sustain engagement with historical narratives and artifacts. …”
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Ecological validity and inclusivity in heritage bilingualism research: Examining objective and subjective Spanish proficiency assessments and language experience factors by Alicia Luque, Alicia Luque, Alicia Luque, Bryan Koronkiewicz, Bernard Issa, Mandy Faretta-Stutenberg, Harriet Wood Bowden

“…The multidimensional nature of bilingualism demands ecologically valid and inclusive research methods that can capture its dynamism and diversity. …”
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Optimal multiobjective design of an autonomous hybrid renewable energy system in the Adrar Region, Algeria by Abderrahmane Mehallou, Benalia M’hamdi, Abderrahmane Amari, Madjid Teguar, Abdelaziz Rabehi, Mawloud Guermoui, Amal H. Alharbi, El-Sayed M. El-kenawy, Doaa Sami Khafaga

“…Abstract Extended power outages are not only a nuisance but a critical problem in the modern world, which demands a continuous supply of decent quality electricity. …”
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Att bevisa målbildsuppsåt vid penningtvättsbrott – möjligheter och svårigheter by Jussi Karkkulainen

“…Proving target intent in particular demands details concerning the behaviour of the perpetrator at the time of the criminal act. …”
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Two-Dimensional Shear-Wave Elastography: Accuracy in Liver Fibrosis Staging Using Magnetic Resonance Elastography as the Reference Standard by Puwitch Charoenchue, Jiraporn Khorana, Taned Chitapanarux, Nakarin Inmutto, Wittanee Na Chiangmai, Amonlaya Amantakul, Suwalee Pojchamarnwiputh, Apichat Tantraworasin

“…Although magnetic resonance elastography (MRE) is the reference standard for noninvasive fibrosis assessment, its cost, specialized hardware, and operational demands restrict accessibility. In contrast, two-dimensional shear-wave elastography (2D-SWE) is more affordable, accessible, and widely integrated into routine ultrasound systems. …”
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