Optimizing longifolene production in Yarrowia lipolytica via metabolic and protein engineering by Yi-Tong Yao, Xiao Zhang, Chen-Yu Wang, Yu-He Zhang, Da-Wei Li, Wei-Dong Yang, Hong-Ye Li, Li-Gong Zou

“…This study not only demonstrates the feasibility of enhancing sesquiterpene production in Y. lipolytica but also highlights the potential of microbial platforms in meeting industrial demands for complex natural products.…”
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A wicked problem: Systemic issues surrounding Canadian equestrian dressage and dressage horse welfare by Megan Ross, Kathryn Proudfoot, Katrina Merkies, Charlotte Lundgren, Caroline Ritter

“…Interviews and field notes were analysed using reflexive thematic analysis leading to the development of three themes: (1) the systems that participants operate within; (2) how these systems foster a culture of contradiction in the industry; and (3) the ‘equestrian dilemma’ highlighting how participants navigate their love for horses with their horses’ well-being amid the sport’s demands. The three themes portray that the issues faced by the dressage industry may be rooted in systemic problems and could be described as a ‘wicked problem’. …”
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Versatility of the Anterolateral Thigh Flap for Abdominal Wall Reconstruction by Nadine E. Pedrazzi, MD, Riccardo Schweizer, MD, Holger J. Klein, MD, Stephan Steiner, MD, René Vonlanthen, MD, Thomas Hermanns, MD, Didier Schneiter, MD, Pietro Giovanoli, MD, Jan A. Plock, MD

“…Abdominal wall reconstruction represents an ambitious and demanding challenge. This study aimed to illustrate the versatility of the anterolateral thigh (ALT) flap in its different designs for the reconstruction of complex defects of the abdominal wall. …”
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Social control: knowledge and attitude of professionals in the Academia da Cidade Program by Cícero Adriano Melo Figueirêdo, Bruno César Rodrigues da Silva, Amanda Emmanuelly de Melo Tavares Albuquerque, Mateus Gustavo Brainer, Sulamita Emy Tavares de Oliveira Mendonça Soares, Emmanuelly Correia de Lemos

“…Moreover, the great majority (81.7%) encouraged users to participate in social control spaces, as well as, valued and reflected (93.3%) on the demands indicated by them. However, more than 90.0% did not participate in health councils and territorial meetings. …”
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Cascaded neural network surrogate modeling for real-time decision-making in long-distance water supply distribution by Lin Shi, Jian Zhang, Sheng Chen, Yi Liu, Wenlong Zhao

“…In the proposed CNN model, the classification component identifies the number of pumps needed to meet system flow demands, while the regression component predicts target values for pump speeds and valve openings. …”
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Effects of shrinkage, temperature and the degree of connection (N/N f) on the behavior of steel-concrete composite beams by Halima Aouad, Nacer Rahal, Houda Beghdad, Mohamed Sadoun, Abdelaziz Souici, Sara Zatir, Khaled Benmahdi

“…Hence, taking into account the demands brought by these additional effects is necessary. …”
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An optimized method for AUV trajectory model in benthonic hydrothermal area based on improved slime mold algorithm by Chunmeng Jiang, Yiming Tang, Jianguo Wang, Wenchao Zhang, Min Zhou, Jiaying Niu, Lei Wan, Guofang Chen, Gongxing Wu, Xide Cheng

“…Although the spline interpolation method was an ideal option for smooth curves, a great number of points were needed for a complex desired trajectory mode. In response to the demanding requirements of AUV trajectory tracking control in the benthonic hydrothermal area, an under-actuated test platform was first established, and the cubic spline interpolation was adopted to process the preset path points for a smooth desired trajectory. …”
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Legionella pneumophila response to shifts in biofilm structure mediated by hydrodynamics by Ana Rosa Silva, C. William Keevil, Ana Pereira

“…Preventing legionellosis in water systems demands effective hydrodynamic management and biofilm mitigation. …”
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Relationship of Knowledge with the Implementation of OHS Management System in Regional General Hospital North Konawe District by Laode Muhammad Yasmin, Erwin Azizi Jayadipraja, Nunung Nunung, La Ode Saafi, Adnin Alista

“… Background:The high incidence of accidents at the North Konawe District Hospital, coupled with the increasing demands for accreditation concerning employee protection, underscores the necessity for implementing an Occupational Health and Safety (OHS) management system at the hospital. …”
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An Overview of Complications and Treatment Strategies in Periocular Dermal Fillers: A Literature Review by Aleksandra Ciesielska, Aleksandra Sieradzka, Krzysztof Szerej, Alicja Kot, Marta Wojtczak, Natalia Myśliwiec, Adrian Różycki, Michał Pniak, Paweł Miklis, Maciej Mawlichanów

“…Conclusions: The periocular region is exceptionally demanding, requiring excellent anatomical awareness and proper administration techniques for uneventful procedures. …”
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Exploring the Potential of Selenium-Containing Amine (Se-AMA) to Enhance Photosynthesis and Leaf Water Content: New Avenues for Carbonic Anhydrase Modulation in <i>Arabidopsis thal... by Sara Beltrami, Francesca Alderotti, Antonella Capperucci, Damiano Tanini, Cecilia Brunetti, Francesco Ferrini, Ermes Lo Piccolo, Antonella Gori

“…Global changes and growing demands have led to the development of new molecular approaches to improve crop physiological performances. …”
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Large-Scale MIMO Transmitters for CR-NOMA in Fixed Physical Space: The Effect of Realistic System Impairments Using Stochastic Geometry by Emmanuel Ampoma Affum, Samuel Tweneboah-Koduah, Owusu Agyeman Antwi, Benjamin Asubam Weyori, Willie Ofosu

“…In this study, the LAT is considered a cylindrical array, and parameters such as delay spread, angle of arrival, and departure are incorporated to achieve a CR-NOMA-GBSM system with amplify-and-forward (AF) or decode-and-forward (DF) relaying schemes. To reduce computing demands, we offer a novel concept of using the physical dimensions of the array to derive the location vector of the antenna element. …”
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Hyperadaptor; Temperature-insensitive tensile properties of Ni-based high-entropy alloy a wide temperature range by Hyojin Park, Sujung Son, Soung Yeoul Ahn, Hyojeong Ha, Rae Eon Kim, Jae Heung Lee, Hyo Moon Joo, Jung Gi Kim, Hyoung Seop Kim

“…Our findings highlight the potential of Ni-based HEA for demanding applications in aerospace, automotive, and energy sectors, establishing them as pioneering materials in alloy development.HIGHLIGHTS Introduces the concept of ‘Hyperadaptor’ materials, which exhibits minimal environmental sensitivity, and demonstrates Ni-based high-entropy alloys (HEAs) as prime examples, showing consistent mechanical properties across a wide temperature range from 77 K to 873 K.Demonstrates minimal temperature sensitivity of Ni-based HEA through analyses of nano-sized L12 precipitates and high stacking fault energy, enhancing strength and ductility.Employs various characterization techniques, including EBSD, ECCI, and TEM, to illustrate the dislocation slip-induced plasticity and precipitation hardening, achieving temperature-independent mechanical performance.Validates the potential of Ni-based HEAs for critical applications in the aerospace, automotive, and energy sectors, emphasizing their consistent mechanical properties under extreme temperature fluctuations.…”
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Occupational Risks in Occupational Therapy Service Learning: A Single-Site “Fear Factor” Study in South Africa by Deshini Naidoo, Pragashnie Govender, Stephanie Nicole Naidoo, Naledi Ngubane, Zamankosi Nkosi, Aziza Mulla

“…These insights into the perceived occupational risk factors can be translated into actionable strategies to improve the preparation of health science students for service-learning, including coping skills to deal with the demands of service-learning.…”
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Biogenic silver nanoparticles produced by Trichoderma reesei inhibit SARS-CoV-2 infection, reduce lung viral load and ameliorate acute pulmonary inflammation by Marcus V.M.V. Amaral, Cláudia B. Carraro, Amanda C.C. Antoniêto, Mariana N. Costa, Thais F.C. Fraga-Silva, Ualter G. Cipriano, Rodrigo P.F. Abuná, Tamara S. Rodrigues, Ronaldo B. Martins, Andreia M. Luzenti, Glaucia R. Caruso, Priscyla D. Marcato, Vania L.D. Bonato, Dario S. Zamboni, Bergman M. Ribeiro, Sônia N. Báo, Joao S. da Silva, Flávio P. Veras, Roberto N. Silva

“…The COVID-19 pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), posed a significant global health challenge and still demands efforts to develop new therapies. In this study, we investigated the potential of biogenic silver nanoparticles (AgNPs) synthesized by the fungus Trichoderma reesei to combat SARS-CoV-2 infection. …”
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Reimagining Global Health: Accelerating Change for a Sustainable Future by Melissa Salm, Ala Alwan, Maureen Lichtveld, Patricia J. García, Peter H. Kilmarx, Nelson K. Sewankambo, Rebecca Martin, Tahmeed Ahmed, Judith N. Wasserheit

“…At the heart of this viewpoint article lies a fundamental question: How can we reimagine global health to best confront existing challenges and meet the demands of the future? To fully assess the scope of global health challenges and identify sustainable solutions, a clear definition of the aims and strategic approaches is needed. …”
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Unraveling the power of sense of coherence: a key predictor of symptom severity among depressive disorders clients by Samah Mohamed Taha, Mona Metwally El-Sayed, Mahmoud Abdelwahab Khedr, Ayman Mohamed El-Ashry, Azza Ibrahim Abdelraof, Hassan Mohammed Sonbol, Manal Mohammed Hawash, Eman Sameh Abd Elhay

“…The severity of depression showed a significant negative correlation with difficulties in understanding and finding meaning in life and challenges in effectively coping with life’s demands (r = -0.626, p < 0.001). The regression analysis revealed that for every one-unit increase in SOC, there was a corresponding decrease of 0.5 units in depressive symptoms. …”
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Simple and Fail-safe Method to Transform Miniprep Escherichia coli Strain K12 Plasmid DNA Into Viable Agrobacterium tumefaciens EHA105 Cells for Plant Genetic Transformation by Beenzu Siamalube, Emmanuel Ehinmitan, Maina Ngotho, Justus Onguso, Steven Runo

“…Conventionally, plant genetic transformation has relied on time-consuming, costly, and technically demanding procedures, such as electroporation and chimeric viruses or biolistic methods, which usually yield variable transformation efficiencies. …”
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Training for Sustainable and Healthy Building for 2050: New Methodologies for an Integrated and Transnational Education Approach Targeting Skills Development for the Transition Tow... by Maria K. Koukou, Susana Lucas, Julia Justino, Silviano Rafael, Antonios D. Livieratos, Nelson Carriço, John Konstantaras, Michail Gr. Vrachopoulos, Anna Chiara Benedetti, Cecilia Mazzoli, Annarita Ferrante, Mohammad Abdollah Fadel Abdollah, Rossano Scoccia, Jacopo Famiglietti, Tomasz Bakoń, Joanna Aleksiejuk-Gawron

“…The development of existing technologies and the emergence of new technologies aiming at the total decarbonization of the buildings sector by 2050 requires and encourages upskilling and reskilling of existing professionals as well as the development of new subjects from higher education courses to be able to respond to the demands of these challenges. In responding to those challenges, the main objective of the research is to design, implement, and evaluate a novel, integrated, and transnational educational approach aimed at equipping professionals and students in the construction sector with the necessary skills to achieve sustainable and energy-efficient buildings. …”
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Optimizing Lightweight Recurrent Networks for Solar Forecasting in TinyML: Modified Metaheuristics and Legal Implications by Gradimirka Popovic , Zaklina Spalevic , Luka Jovanovic , Miodrag Zivkovic , Lazar Stosic , Nebojsa Bacanin 

“…Additionally, a modified metaheuristic optimizer is introduced to meet the demanding requirements of optimization. Simulations, along with a rigid comparative analysis with other contemporary metaheuristics, are also conducted on a real-world dataset, with the best models achieving a mean squared error (MSE) of just 0.000935 volts and 0.007011 volts on the two datasets, suggesting viability for real-world usage. …”
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