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Elevated Serum Levels of the Antiapoptotic Protein Decoy-Receptor 3 Are Associated with Advanced Liver Disease
Published 2016-01-01“…Background. Decoy-receptor 3 (DcR3) exerts antiapoptotic and immunomodulatory function and is overexpressed in neoplastic and inflammatory conditions. …”
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The Antiangiogenic Effects of a Vascular Endothelial Growth Factor Decoy Receptor Can Be Monitored in Vivo Using Contrast-Enhanced Ultrasound Imaging
Published 2014-03-01“…We investigated whether the effects of a vascular endothelial growth factor decoy receptor (VEGF Trap, Regeneron Pharmaceuticals, Tarrytown, NY) could be monitored in vivo using contrast-enhanced ultrasonography (CEUS). …”
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Antiviral activity of an ACE2-Fc fusion protein against SARS-CoV-2 and its variants.
Published 2025-01-01“…SARS-CoV-2 and its mutants use the angiotensin-converting enzyme 2 (ACE2) as a cellular entry receptor, which has triggered several therapeutic strategies against COVID-19 relying on the use of ACE2 recombinant proteins as decoy receptors. In this work, we propose an ACE2 silent Fc fusion protein (ACE2-hFcLALA) as a candidate therapy against COVID-19. …”
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Follistatin Alleviates Synovitis and Articular Cartilage Degeneration Induced by Carrageenan
Published 2014-01-01“…Follistatin is an extracellular decoy receptor for activins. Since both activins and follistatin are expressed in articular cartilage, we hypothesized that activin-follistatin signaling participates in the process of joint inflammation and cartilage degeneration. …”
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Serum IL-33 Levels Are Associated with Liver Damage in Patients with Chronic Hepatitis C
Published 2012-01-01“…The levels of serum sST2, as a decoy receptor of IL-33, were significantly higher in CHC and SR-CHC patients than those in HC, and there was no correlation between the levels of serum sST2 and IL-33. …”
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Soluble RAGE Plasma Levels in Patients with Coronary Artery Disease and Peripheral Artery Disease
Published 2013-01-01“…CAD patients presenting with PAD have lower sRAGE levels than CAD patients without peripheral atherosclerosis showing that stable atherosclerotic lesions in different vascular districts are inversely related to soluble decoy receptor sRAGE.…”
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Oxymatrine inhibits the development of radioresistance in NSCLC cells by reversing EMT through the DcR3/AKT/GSK-3β pathway
Published 2023-01-01“…Plasmids were used to overexpress decoy receptor 3 (DcR3) in A549 cells. Xenograft models were established to measure the extent of NSCLC tumor growth in vivo. …”
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TNF Superfamily: A Growing Saga of Kidney Injury Modulators
Published 2010-01-01“…TNF-related apoptosis-inducing ligand (TRAIL and its potential decoy receptor osteoprotegerin are the two most upregulated death-related genes in human diabetic nephropathy. …”
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Modulatory Effect of 1,25-Dihydroxyvitamin D3 on IL1β-Induced RANKL, OPG, TNFα, and IL-6 Expression in Human Rheumatoid Synoviocyte MH7A
Published 2013-01-01“…Here, we investigated modulatory effect of 1,25(OH)2D3 on the expression of RANKL and its decoy receptor osteoprotegerin (OPG) in an inflammatory condition of human rheumatoid synoviocyte MH7A. …”
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Recombinant short TNF-BD protein from smallpox virus is pharmacologically active in an experimental septic shock model
Published 2020-05-01“…In particular, the G2R gene of VARV encodes the TNF decoy receptor, VARV-CrmB protein. This protein consists of N-ended TNF-biding (TNF-BD) and C-ended chemokine binding (Ch-BD) domains. …”
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Overexpression of DcR3 and Its Significance on Tumor Cell Differentiation and Proliferation in Glioma
Published 2014-01-01“…Overexpression of decoy receptor 3 (DcR3) have been reported in various classes of malignancies. …”
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