Evaluation of current gene pool of Kholmogor and Black-and-white cattle breeds based on whole genome SNP analysis by A. V. Dotsev, A. A. Sermyagin, A. V. Shakhin, I. A.  Paronyan, K. V. Plemyashov, H. Reyer, K. Wimmers, G. Brem, N. A. Zinovieva

“…Conservation of local cattle genetic resources is an important strategy for achieving Russia’s food security. During last decades, in the Russian Federation, local livestock populations were either crossbred or replaced by highly productive imported breeds, which led to a loss of the major part of original breeds identities. …”
Get full text

Clinicopathological and Prognostic Significance of CD47 Expression in Lung Neuroendocrine Tumors by Mario Orozco-Morales, Alejandro Avilés-Salas, Norma Hernández-Pedro, Rodrigo Catalán, Graciela Cruz-Rico, Ana Laura Colín-González, Elsa Dosal-Mancilla, Pedro Barrios-Bernal, Oscar Arrieta

“…The Ki-67 index has been used for decades to evaluate mitotic counts however, the role of Ki-67 as a biomarker for assessing prognosis and guiding therapy in metastatic LNET still lacks feasible clinical validation. …”
Get full text

Current methods for detecting and assessing HIV-1 antibody resistance by Stanley Odidika, Stanley Odidika, Stanley Odidika, Martin Pirkl, Martin Pirkl, Thomas Lengauer, Thomas Lengauer, Thomas Lengauer, Philipp Schommers, Philipp Schommers, Philipp Schommers

“…Despite being available for decades, there are still 1.5 million new infections and 700,000 deaths each year, highlighting the need for better therapies. …”
Get full text

Distinctive dust weather intensities in North China resulted from two types of atmospheric circulation anomalies by Q. Huo, Q. Huo, Z. Yin, Z. Yin, Z. Yin, X. Ma, X. Ma, H. Wang, H. Wang, H. Wang

“…A super dust storm that occurred on 15 March 2021 raised Beijing's PM<span class="inline-formula">₁₀</span> (particulate matter with a diameter less than 10 <span class="inline-formula">µ</span>m) concentrations above 7000 <span class="inline-formula">µ</span>g m<span class="inline-formula">⁻³</span>, while 2023 witnessed the highest spring dust weather frequency in nearly a decade. Previous research has primarily focused on the role of the Mongolian cyclone in influencing dust weather in NC, with less attention given to other synoptic systems. …”
Get full text

Spatially explicit assessment of water stress and potential mitigating solutions in a large water-limited basin: the Yellow River basin in China by W. Zhang, W. Zhang, X. Zhao, X. Zhao, X. Gao, W. Liang, J. Li, B. Zhang

“…Compared to the period from 1965 to 1980, the regional water stress index (WSI) and the frequency and duration of water scarcity increased by 76 %, 100 %, and 92 %, respectively, over the most recent 2 decades. Water withdrawal was the primary driver of the increased WSI before 2000; however, it has since contributed as much as water availability. …”
Get full text

PROTON RADIATION THERAPY: CLINICAL APPLICATION OPPORTUNITIES AND RESEARCH PROSPECTS by M. V. Zabelin, V. A. Klimanov, J. J. Galyautdinova, A. S. Samoilov, A. O. Lebedev, E. V. Shelyhina

“…The experience of use of proton therapy of tumors of a skull base got for the last several decades, showed good results. Physical properties of a fascicle of protons allow to achieve the maximum dose conformality, having lowered, thereby, a radial load on the next crucial anatomical structures. …”
Get full text

The association between hair cortisol and burnout is moderated by age, psychosocial, and immunological markers by Patrick D. Gajewski, Peter Bröde, Maren Claus, Klaus Golka, Jan G. Hengstler, Carsten Watzl, Edmund Wascher, Stephan Getzmann

“…However, burnout is not an all-or-nothing phenomenon, but can occur in a milder to moderate form in otherwise healthy employees. In the last two decades hair cortisol concentrations (HCC) were increasingly related to the cumulative effect of psychosocial stress at work. …”
Get full text

HIV-1 drug resistance and genetic transmission networks among patients with sexually transmitted HIV in Ningxia, China by Jianxin Pei, Zhonglan Wu, Zhonglan Wu, Bingqian Si, Chunhua Ma, Yichang Liu, Xiaofa Ma, Wenhe Kuai, Yinhao Zhang, Yong Li

“…BackgroundOver the past decade, sexual transmission has become a dominant source of new HIV-1 infection in China. …”
Get full text

Policy and practice implication of - and tools to address - mental health and psychosocial support needs in Sierra Leone by Alastair Ager, Rebecca Horn, Abdulai Bah, Abdulai Bah, Haja Wurie, Mohamed Samai, Mohamed Samai

“…The last two decades have seen increased awareness of the impact of mental health issues on the population of Sierra Leone. …”
Get full text

Understanding the educational inequalities in suicide attempts and their mediators: a Mendelian randomisation study by Jing Wang, Ye Yang, Rui Gao, Lilu Ding, Jiahao Zhu, Dan Zhou, Yingjun Li, Houpu Liu

“…Background Educational inequalities in suicide have become increasingly prominent over the past decade. Elucidating modifiable risk factors that serve as intermediaries in the impact of low educational attainment on suicide has the potential to reduce health disparities.Aims To examine the risk factors that mediate the relationship between educational attainment and suicide attempts and quantify their contributions to the mediation effect.Methods We conducted a two-sample Mendelian randomisation (MR) analysis to estimate the causal effect of educational attainment on suicide attempts, utilising genome-wide association study summary statistics from the Integrative Psychiatric Research (iPSYCH; 6024 cases and 44 240 controls) and FinnGen (8978 cases and 368 299 controls). …”
Get full text

High speciation in the cryptic Pristimantis celator clade (Anura: Strabomantidae) of the Mira river basin, Ecuador-Colombia by Mario H. Yánez-Muñoz, Juan P. Reyes-Puig, Carolina Reyes-Puig, Gabriela Lagla-Chimba, Christian Paucar-Veintimilla, Miguel A. Urgiles-Merchán, Julio C. Carrión-Olmedo

“…Over the past decade, research in the montane forests of the Mira River basin, spanning Ecuador and Colombia, has identified it as crucial for the adaptive radiation of flora and fauna, shaped by its complex geological and climatic history. …”
Get full text

Recent Developments to the ANSWERS® Monte Carlo Codes MONK® and MCBEND® by Fildes Jessica, Richards Simon, Bird Adam, Cox Andrew, Fry Timothy, Hanlon David, Jones Brian, Long David, Tantillo Francesco, Wright George, Hiles Richard

“…MONK® and MCBEND® are two advanced Monte Carlo codes developed by the ANSWERS® Software Service, which have been used in over 30 countries worldwide for a range of applications, and have been well-established in the UK criticality and shielding communities respectively over the course of several decades. These codes continue to be actively developed to meet the needs of their users. …”
Get full text

Global, regional and national burdens of bipolar disorders in adolescents and young adults: a trend analysis from 1990 to 2019 by Yifan Chen, Long Sun, Meiqi Wang, Yunxi Zhong, Xiaoying Su, Qixiu Li, Ziming Shao

“…Global trends by age, sex and Social Development Index (SDI) were further analysed.Results Globally, the incidence of bipolar disorder among adolescents and young adults increased from 79.21 per 100 000 population (95% uncertainty interval (UI): 58.13 to 105.15) in 1990 to 84.97 per 100 000 population (95% UI: 61.73 to 113.46) in 2019, AAPC 0.24 (95% confidence interval (CI): 0.22 to 0.26). In the past three decades, there has been an increase in incidence, prevalence and YLDs in both males and females. …”
Get full text

Analysis of ecological network evolution in an ecological restoration area with the MSPA-MCR model: A case study from Ningwu County, China by Ziyan Guo, Chuxin Zhu, Xiang Fan, Muye Li, Nuo Xu, Yuan Yuan, Yanjun Guan, Chunjuan Lyu, Zhongke Bai

“…The ecological corridors increased from 8 in 2000 to 9 in 2010, and 20 in 2020; and the total length increased from 70.23 km in 2000 to 144.23 km in 2010, and 170.21 km in 2020. (4) The ecological network topological structure indices showed that the ecological network structure improved over the two decades. These results indicate that the series of ecological restoration programs effectively enhanced the ecosystem integrity and connectivity. …”
Get full text

Motor Neuron Disease Systematic Multi-Arm Adaptive Randomised Trial (MND-SMART): a multi-arm, multi-stage, adaptive, platform, phase III randomised, double-blind, placebo-controlle... by Jeremy Chataway, Suvankar Pal, Charis Wong, Elizabeth Elliott, Jenna M Gregory, Siddharthan Chandran, Judith Newton, Shuna Colville, Maria Stavrou, Christopher J Weir, Nigel Stallard, Malcolm R Macleod, Michelle Steven, Richard Anthony Parker, Arpan R Mehta, Robert J Swingler, Mahesh K B Parmar, Rachel S Dakin, Jill Williamson

“…Introduction Motor neuron disease (MND) is a rapidly fatal neurodegenerative disease. Despite decades of research and clinical trials there remains no cure and only one globally approved drug, riluzole, which prolongs survival by 2–3 months. …”
Get full text

Increase in disturbance-induced canopy gaps leads to reorganization of Central European bird communities by Anne Graser, Claudia Frank, Friederike Kunz, Andreas Schuldt, Cornelius Senf, Christoph Sudfeldt, Sven Trautmann, Johannes Kamp

“…Due to climate change and land-use legacies, natural disturbances in Central European forests – such as windthrow and insect outbreaks – have increased in recent decades. How those changes affect biodiversity has, however, rarely been quantified over larger spatial and longer temporal scales, mostly because concurrent datasets on biodiversity trends and forest disturbances are rare. …”
Get full text

People’s knowledge, attitudes, and conflicts with carnivores in central hills, Sri Lanka by Ashan Thudugala, Hem Bahadur Katuwal, Nalindra Laxman, Vishwa Dushmantha, Ravindi Menikrama, Harsha Dissanayake, Chameera Dilshan, Ru-Chuan He, Rui-Chang Quan

“…Despite these challenges, 68 % of respondents believed conflicts had decreased over the last two decades. However, 73 % of respondents had no clear idea about conflict mitigation measures, while 17 % advocated relocating problematic animals as a primary solution for conflicts. …”
Get full text

Predicting the impact of missense mutations on an unresolved protein’s stability, structure, and function: A case study of Alzheimer’s disease-associated TREM2 R47H variant by Joshua Pillai, Kijung Sung, Chengbiao Wu

“…However, AF2 falls short of predicting the effects of missense mutations on unresolved protein structures that may be informative to efforts in personalized medicine. Over the last decade, countless in-silico methods have been developed to predict the pathogenicity of point mutations on resolved structures, but no studies have evaluated their capabilities on unresolved protein structures predicted by AF2. …”
Get full text

Enhanced Recovery after Intensive Care (ERIC): study protocol for a German stepped wedge cluster randomised controlled trial to evaluate the effectiveness of a critical care telehe... by Ulrich Mansmann, Claudia Spies, Ursula Marschall, Reinhard Busse, Christine Adrion, Bjoern Weiss, Nicolas Paul, Elke Berger, Jörg Caumanns, Simone Rosseau

“…Introduction Survival after critical illness has noticeably improved over the last decades due to advances in critical care medicine. …”
Get full text

Mesenchymal Stem Cell Therapy for Diabetic Kidney Disease: A Review of the Studies Using Syngeneic, Autologous, Allogeneic, and Xenogeneic Cells by Christian Sávio-Silva, Stephany Beyerstedt, Poliana E. Soinski-Sousa, Expedito B. Casaro, Maria Theresa A. Balby-Rocha, Antônio Simplício-Filho, Jamille Alves-Silva, Érika B. Rangel

“…Importantly, the bench to bedside pathway has been constructed in the last decade for assessing the therapeutic potential of MSCs in the DM setting. …”
Get full text