Germline Mutation in KIF1Bβ Gene Associated with Loss of Heterozygosity: Usefulness of Next-Generation Sequencing in the Genetic Screening of Patients with Pheochromocytoma by Giuseppina De Filpo, Elisa Contini, Viola Serio, Andrea Valeri, Massimiliano Chetta, Daniele Guasti, Daniele Bani, Massimo Mannelli, Elena Rapizzi, Michaela Luconi, Mario Maggi, Tonino Ercolino, Letizia Canu

“…The genetic approach of pheochromocytomas and paragangliomas has changed in the last two decades. Nowadays, we know that more than 40% of patients have a germline mutation in one of the susceptibility genes identified to date. …”
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Recent advancements in the diverse roles of polymerase-associated proteins in the replication and pathogenesis of Newcastle disease virus by Jinghang Zhou, Yuqi Duan, Menglan Liu, Jinyang Liu, Zenglei Hu, Zhiqiang Duan

“…Among these, the polymerase-associated proteins (N, P, and L) and the viral RNA (vRNA) genome form the ribonucleoprotein complex, which plays a crucial role in the synthesis and transcription of NDV vRNA. In the last two decades, numerous studies have demonstrated that the polymerase-associated proteins are linked to the virulence, pathotype, and thermostability of NDV. …”
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Nonparametric analysis of inter‐individual relations using an attention‐based neural network by Takashi Morita, Aru Toyoda, Seitaro Aisu, Akihisa Kaneko, Naoko Suda‐Hashimoto, Ikuma Adachi, Ikki Matsuda, Hiroki Koda

“…Abstract Social network analysis, which has been widely adopted in animal studies over the past decade, enables the revelation of global characteristic patterns of animal social systems from pairwise inter‐individual relations. …”
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Molecular complexity of quantitative immunity in plants: from QTL mapping to functional and systems biology by Chauveau, Carine, Roby, Dominique

“…In nature, plants defend themselves against pathogen attack by activating an arsenal of defense mechanisms. During the last decades, work mainly focused on the understanding of qualitative disease resistance mediated by a few genes conferring an almost complete resistance, while quantitative disease resistance (QDR) remains poorly understood despite the fact that it represents the predominant and more durable form of resistance in natural populations and crops. …”
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Dental pulp stem cell-derived intracellular vesicles prevent orthodontic relapse by inhibiting PI3K/Akt/NF-κB-mediated osteoclast activity by Boyuan Peng, Ziwei Li, Yong Cheng, Henghua Jiang, Qingsong Ye, Guangli Han

“…Incomplete periodontal bone remodeling has been identified as a key factor in this process. Despite decades of research, currently there are no effective strategies to prevent relapse. …”
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An Overview of Hybrid DC–DC Converters: From Seeds to Leaves by Yan Lu, Junwei Huang, Zhiguo Tong, Tingxu Hu, Wen-Liang Zeng, Mo Huang, Xiangyu Mao, Guigang Cai

“…Meanwhile, battery-powered portable or wearable devices favor extremely high-power-density solutions, calling for novel power conversion topologies, which have been the hottest topic in the power management IC area in the past decade. This article reviews the switched-capacitor-inductor (SCI) hybrid dc–dc buck converters from the topology “seeds” to their “leaves.…”
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Convergent evidence for the temperature-dependent emergence of silicification in terrestrial plants by Zhihao Pang, Félix de Tombeur, Sue E. Hartley, Constantin M. Zohner, Miroslav Nikolic, Cyrille Violle, Lidong Mo, Thomas W. Crowther, Dong-Xing Guan, Zhongkui Luo, Yong-Guan Zhu, Yuxiao Wang, Ping Zhang, Hongyun Peng, Caroline A. E. Strömberg, Nina Nikolic, Yongchao Liang

“…Abstract Research on silicon (Si) biogeochemistry and its beneficial effects for plants has received significant attention over several decades, but the reasons for the emergence of high-Si plants remain unclear. …”
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Cosmetic Outcome Assessment following Breast-Conserving Therapy: A Comparison between BCCT.core Software and Panel Evaluation by Max Hendrik Haloua, Nicole Marianna Alexandra Krekel, Gerrit Johannes Albertus Jacobs, Barbara Zonderhuis, Mark-Bram Bouman, Marlon Eugène Buncamper, Franciscus Bernardus Niessen, Henri Adolf Hubert Winters, Caroline Terwee, Sybren Meijer, Monique Petrousjka van den Tol

“…Purpose. Over recent decades, no consensus has yet been reached on the optimal approach to cosmetic evaluation following breast-conserving therapy (BCT). …”
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Sulforaphane as a promising anti-caries agents: inhibitory effects on Streptococcus mutans and caries control in a rat model by Meijiao Yu, Meijiao Yu, Yu Chen, Yu Chen, Sishi Dong, Sishi Dong, Zhongxin Chen, Zhongxin Chen, Xuelian Jiang, Xuelian Jiang, Yufei Wang, Yufei Wang, Linglin Zhang, Linglin Zhang

“…Dental caries has been one of the most prevalent diseases globally over the last few decades, threatening human oral and general health. …”
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Mass cytometry: exploring the immune landscape of systemic autoimmune and inflammatory diseases in the past fourteen years by Aïcha Kante, Aïcha Kante, Mathieu F. Chevalier, Damien Sène, Damien Sène, Jeanne Chauffier, Jeanne Chauffier, Stéphane Mouly, Stéphane Mouly, Benjamin Glenn Chousterman, Benjamin Glenn Chousterman, Fériel Azibani, Benjamin Terrier, Benjamin Terrier, Théo Pezel, Théo Pezel, Cloé Comarmond, Cloé Comarmond

“…In this comprehensive review, we explore how mass cytometry findings contributed in the past decade to a deeper understanding of the cellular actors involved in systemic auto-immune and auto-inflammatory diseases with their respective therapeutic and prognostic impact. …”
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Global burden of pneumoconiosis attributable to occupational particulate matter, gasses, and fumes from 1990~2021 and forecasting the future trends: a population-based study by Mao Qingsong, Ruijie Xiao, Wenqi Yang, Xinyi Wang, Yu-zhe Kong

“…Furthermore, an ARIMA model was employed to forecast future trends of pneumoconiosis up to 2050.ResultThe year 2021 saw pneumoconiosis from occupational particulate matter, gasses, and fumes account for roughly 4,775 deaths and 117.80 thousand disability-adjusted life years (DALYs). Over the past three decades, there was a notable decline in the disease’s burden. …”
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In Vivo Antimalarial Activity of 80% Methanol and Aqueous Bark Extracts of Terminalia brownii Fresen. (Combretaceae) against Plasmodium berghei in Mice by Hana Biruk, Biruk Sentayehu, Yonatan Alebachew, Wondmagegn Tamiru, Abebe Ejigu, Solomon Assefa

“…Despite a substantial scientific progress over the past two decades, malaria continues to be a worldwide burden. …”
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Proteomic Identification of Heat Shock-Induced Danger Signals in a Melanoma Cell Lysate Used in Dendritic Cell-Based Cancer Immunotherapy by Fermín E. González, Alexey Chernobrovkin, Cristián Pereda, Tamara García-Salum, Andrés Tittarelli, Mercedes N. López, Flavio Salazar-Onfray, Roman A. Zubarev

“…Autologous dendritic cells (DCs) loaded with cancer cell-derived lysates have become a promising tool in cancer immunotherapy. During the last decade, we demonstrated that vaccination of advanced melanoma patients with autologous tumor antigen presenting cells (TAPCells) loaded with an allogeneic heat shock- (HS-) conditioned melanoma cell-derived lysate (called TRIMEL) is able to induce an antitumor immune response associated with a prolonged patient survival. …”
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A first attempt to model global hydrology at hyper-resolution by B. van Jaarsveld, N. Wanders, E. H. Sutanudjaja, J. Hoch, J. Hoch, B. Droppers, J. Janzing, J. Janzing, J. Janzing, R. L. P. H. van Beek, M. F. P. Bierkens, M. F. P. Bierkens

“…The primary objective of this paper is therefore to establish a first-of-its-kind, truly global hyper-resolution hydrological model that spans a multiple-decade period (1985–2019). To achieve this, two key limitations are addressed, namely the lack of high-resolution meteorological data and insufficient representation of lateral movement of snow and ice. …”
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Estimating the contribution of Arctic sea-ice loss to central Asia temperature anomalies: the case of winter 2020/2021 by Lara R Cosford, Rohit Ghosh, Marlene Kretschmer, Clare Oatley, Theodore G Shepherd

“…Arctic sea-ice cover has declined drastically in recent decades, notably in the Barents-Kara Seas (BKS). Previous research has linked low autumn BKS-ice cover to subsequent cold Eurasian winters. …”
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Changes in the standard freezing depth of seasonally frozen ground in China over the last 50 years by Shuo Wang, Zuo-Jun Ning, You-Hua Ran, Wei Cao, Er-Xing Peng, Chen-Yang Peng, Ji-Chun Wu, Bing-Quan Wang, Yu Sheng

“…From the overall performance of the SFD in different decadal periods, the SFD in central and northeast China changed sharply within the range of 35° N to 50° N in SFG regions. …”
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Influenza A virus hemagglutinin: from classical fusion inhibitors to proteolysis targeting chimera-based strategies in antiviral drug discovery by Francisco Javier Hermoso-Pinilla, Aitor Valdivia, María-José Camarasa, Tiziana Ginex, Francisco Javier Luque

“…Given its pivotal role in the early stages of influenza A infections, intense drug discovery efforts have been undertaken to target HA in the past decades. Drug discovery studies mainly rely on preventing the recognition of sialic acid units by the receptor binding site in the globular head (GH) domain, or the conformational rearrangement required for the fusion of viral and cell membranes. …”
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Diabetes and gut microbiome by Kateřina Olša Fliegerová, Tiziana Maria Mahayri, Tiziana Maria Mahayri, Hana Sechovcová, Hana Sechovcová, Chahrazed Mekadim, Jakub Mrázek, Radka Jarošíková, Radka Jarošíková, Michal Dubský, Vladimíra Fejfarová, Vladimíra Fejfarová

“…The pathogenesis of the two most common subtypes of diabetes mellitus, type 1 (T1DM) and type 2 (T2DM), is substantially different, so each form is characterized by a different causation, etiology, pathophysiology, presentation, and treatment. Research in recent decades increasingly indicates the potential role of the gut microbiome in the initiation, development, and progression of this disease. …”
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Case report: JAK inhibitor treatment of immune dysregulation symptoms in a patient with PTPN2 deficiency by Anna Roppelt, Ulyana Markina, Irina Beloglazova, Irina Beloglazova, Vasily Parshin, Dmitry Kanner, Dmitry Pershin, Mariia Fadeeva, Elena Raykina, Maxim Aleksenko, Alexander Karaulov, Mariana Lysenko, Mariana Lysenko, Daria Fomina, Daria Fomina, Daria Fomina

“…The patient has been receiving systemic steroid treatment for decades, which has resulted in hormone dependence as well as therapy-related adverse side effects. …”
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Reversed link between central pacific ENSO and Greenland–Barents sea ice by Yuxin Xie, Anmin Duan, Chao Zhang, Chuangzhi He, Qi Mao, Bingxian Liu

“…Abstract Winter Arctic sea ice is a crucial climate indicator, declining at an accelerated rate compared to the past and playing a significant role in Arctic amplification over recent decades. The sea-ice concentration (SIC) in the Greenland–Barents Sea (GBS) shows considerable interannual variability, yet the link between this variability and the El Niño–Southern Oscillation (ENSO) remains uncertain. …”
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