Comparative Evaluation of Emergency Medical Service Trauma Patient Transportation Patterns Before and After Level 1 Regional Trauma Center Establishment: A Retrospective Single-Cen... by Hyeong Seok Lee, Won Young Sung, Jang Young Lee, Won Suk Lee, Sang Won Seo

“…Yearly comparisons revealed a gradually increasing trend in the hospital death rate (ptrend=0.031). Conclusions After establishing a level 1 RTC, the EMS transportation of severe trauma patients increased gradually along with the long-distance transportation of minor trauma patients. …”
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ImmunoglobuliN in the Treatment of Encephalitis (IgNiTE): protocol for a multicentre randomised controlled trial by R Kneen, M Lim, A Vincent, A J Pollard, W K Chong, L-M Yu, M A Iro, M Sadarangani, M Absoud, C A Clark, A Easton, V Gray, M Pike, T Solomon, L Willis

“…Introduction Infectious and immune-mediated encephalitides are important but under-recognised causes of morbidity and mortality in childhood, with a 7% death rate and up to 50% morbidity after prolonged follow-up. …”
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Levofloxacin prophylaxis omission in acute myeloid leukemia during post induction aplasia: a single center study by Irene Urbino, Chiara Frairia, Alessandro Busca, Silvia Corcione, Stefano D'Ardia, Chiara Maria Dellacasa, Valentina Giai, Carolina Secreto, Roberto Freilone, Francesco Giuseppe De Rosa, Semra Aydin, Giovannino Ciccone, Rosalba Rosato, Marco Cerrano, Ernesta Audisio

“…Results: neutropenic fever was observed in 91% of patients in gA and 97% in gB (OR 0.35, IC95% 0.08 – 1.52, p=0162).The rate of BSIs was 27% in gA compared to 34% in gB (OR 0.69, 0.38 – 1.25, p=0.222). Induction death rate was 5% in gA and 3% in gB (OR 1.50, 0.34 – 6.70, p=0.284). …”
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Global burden of breast cancer and attributable risk factors in 204 countries and territories, from 1990 to 2021: results from the Global Burden of Disease Study 2021 by Rui Sha, Xiang-meng Kong, Xin-yu Li, Ya-bing Wang

“…We obtained and analyzed the age-standardized incidence rate (ASIR), age-standardized death rate (ASDR), and age-standardized DALYs rate from 1990 to 2021. …”
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Burden of esophageal cancer in global, regional and national regions from 1990 to 2021 and its projection until 2050: results from the GBD study 2021 by Chengcheng Zhang, Linzhi Chen, Yuqi Xiu, Hongling Zhang, Yuejuan Zhang, Wenjuan Ying

“…The global number of deaths reached 538,602, with an age-standardized death rate (ASDR) of 6.25 per 100,000, representing a 30.67% decline. …”
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SRT3025-loaded cell membrane hybrid liposomes (3025@ML) enhanced anti-tumor activity of Oxaliplatin via inhibiting pyruvate kinase M2 and fatty acid synthase by Xiaobin Wang, Shulin Li, Zichen Li, Zhuona Lin, Zhifeng Wang

“…Results The present study demonstrated that 3025@ML enhances the chemotherapeutic effect of OXA. 3025@ML + OXA treated T24 and 5637 cells showed that combination therapy significantly reduced cell viability and increased cell death rate. Flow cytometry analysis showed that the combination of 3025@ML and OXA significantly increased the percentage of apoptotic cells in T24 cells. 3025@ML and compound 3 K reduced the levels of FASN in T24 and 5637 cells and increased the anti-tumor activity of OXA. …”
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Pathological and radiological assessment of benign breast lesions with BIRADS IVc/V subtypes. should we repeat the biopsy? by Wesam Rjoop, Anwar Rjoop, Alia Almohtaseb, Lama Bataineh, Zeina Nser Joubi, Maha Gharaibeh, Abdalrahman Al-Qwabah, Yousef Alasheh, Ismail Matalka

“…Abstract Background Timely diagnosis is a crucial factor in decreasing the death rate of patients with breast cancer. BI-RADS categories IVc and V indicate a strong suspicion of cancer. …”
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Early-life famine exposure and subsequent risk of chronic diseases in later adulthood: a population-based retrospective cohort study by Rui Zhao, Qi Zheng, Le-qin Chen

“…Considering that climate conditions and population density can influence the intensity of famine, we characterize its severity by establishing a threshold of 50% excess death rate. The 14 chronic diseases assessed by CHARLS were used as the main outcome indicator, with multimorbidity as a secondary outcome indicator. …”
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How long does it take to start minimal enteral feeding in preterm Neonates admitted to NICUs in Southern Oromia, Ethiopia? by Anteneh Fikrie, Terefu Yambo, Alo Edin, Miesa Gelchu, Dejene Hailu, Mark Spigt

“…Conclusion We observed a significant low rate of early TF initiation and higher death rate of preterm newborn in our study as compared to the global. …”
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Global burden, trends, and disparities in kidney cancer attributable to smoking from 1990 to 2021 by Siyu Han, Shiyu Zhao, Ran Zhong, Peizhe Li, Yuewen Pang, Shuang He, Junyao Duan, Huijie Gong, Jing Shi, Li Liu, Yongji Yan

“…Despite this increase, the age-standardized death rate (ASDR) dropped from 0.25 to 0.19 per 100,000 (EAPC: −0.93). …”
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Global assessment of leukemia care quality: insights from the quality of care index (QCI) from 1990 to 2021Research in context by Yuzhe Pan, Qian Liu, Nan Zhang, Shuang Peng, Xinqi Li, Fuling Zhou

“…Findings: Between 1990 and 2021, both the age-standardized incidence rate (ASIR) and age-standardized death rate (ASDR) for leukemia exhibited a consistent decline. …”
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COVID-19 – if the cure is worse than the disease. The Italian chaos by Giuseppe FERRARI

“…Why in this region number of deceased and infected people are not even comparable with those in other parts of the world? Why the death rate is not showing significant evidence of a slow down despite Lombardy has been put in lockdown for a very prolonged amount of time now? …”