Physicochemical properties, structure, growth-promoting and antioxidant activities of Glycyrrhiza leaf polysaccharides modified by fermentation by Juan Du, Yuan Wang, Xia Li, Zhalaga, Na Liu, Wenwen Wang, Jingwei Qi, Xiaoli Fan, Xiaoping An

“…FGLP exhibited superior protective effects against lipid peroxidation and cell death induced by AAPH. Graphical Abstract…”
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Enhancing magnetic hyperthermia: Investigating iron oxide nanoparticle coating and stability by Joana Santos, Jorge Carvalho Silva, Manuel A. Valente, Tânia Vieira, Paula I.P. Soares

“…Further research is essential for a better understanding of the cell death mechanism induced by MH and for its clinical translation.…”
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Performance of digital early warning score (NEWS2) in a cardiac specialist setting: retrospective cohort study by Amitava Banerjee, Riyaz Patel, Baneen Alhmoud, Daniel Melley, Tim Bonnici

“…We used logistic regression analysis with the area under the receiver operating characteristic curve (AUC) to measure discrimination.Results In 6143 patients admitted under cardiac specialties, NEWS2 showed moderate to low predictive accuracy of traditionally examined outcomes: death, ICU admission, cardiac arrest and medical emergency (AUC: 0.63, 0.56, 0.70 and 0.63, respectively). …”
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Biomarkers of residual risk and all-cause mortality after acute coronary syndrome. by Anna Toso, Mario Leoncini, Mauro Maioli, Simona Villani, Francesco Bellandi

“…The association between the four biomarkers and all-cause death within 3 years was evaluated with Cox proportional analysis. …”
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Assessing the effects of therapeutic combinations on SARS-CoV-2 infected patient outcomes: A big data approach. by Hamidreza Moradi, H Timothy Bunnell, Bradley S Price, Maryam Khodaverdi, Michael T Vest, James Z Porterfield, Alfred J Anzalone, Susan L Santangelo, Wesley Kimble, Jeremy Harper, William B Hillegass, Sally L Hodder, National COVID Cohort Collaborative (N3C) Consortium

“…<h4>Results</h4>Gradient Boosted Decision Tree classifiers present the highest prediction accuracy in identifying patient outcomes with area under the receiver operator characteristic curve of 0.90 and accuracy of 0.81 for the outcomes of death or sufficient improvement to be discharged. …”
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Methylcobalamin protects against liver failure via engaging gasdermin E by Wanfeng Xu, Yun Wang, Shuang Cui, Qiuling Zheng, Yanghao Lin, Qingqing Cui, Yuxin Xie, Yuming Zeng, Chuan Zhang, Yujie Li, Xin Jin, Minna Qin, Huiyong Sun, Haiping Hao, Lijuan Cao

“…Abstract Gasdermin E (GSDME) is a pyroptotic cell death effector and a promising target for pyroptotic tissue injury. …”
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Proportional mortality and years of potential life lost due to liver diseases among agricultural workers, Brazil, 2017 to 2022 by Jailma dos Santos Silva, Soraia Arruda, Thayane Silva Nunes, Wiler de Paula Dias, Adedayo Michael Awoniyi, Armando Meyer, Cleber Cremonese

“…In the studied period, 15,362 deaths due to liver diseases occurred in Brazilian agricultural workers, with an average age at death of 51.3 years (±10.7), concentrated in K70 − alcoholic liver disease (53.8%). …”
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Metabolic consequences of erastin-induced ferroptosis in human ovarian cancer cells: an untargeted metabolomics study by Kaylie I. Kirkwood-Donelson, Alan K. Jarmusch, Carl D. Bortner, Bruce Alex Merrick, Birandra K. Sinha

“…Additionally, we found that ER treatment decreased cellular levels of NAD+/NADP+, carnitines and glutamine/glutamate in both cells, suggesting significant oxidative stress, decrease in energy production, and cellular and mitochondrial disfunctions, leading to cell death.ConclusionOur studies identified several potential biomarkers of ER-induced ferroptosis including OPH, taurine, NAD+, NADP+ and glutamate in ovarian cancer cells. …”
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Impaired Fasting Glucose and Diabetes as Predictors for Radial Artery Calcification in End Stage Renal Disease Patients by Katarzyna Janda, Marcin Krzanowski, Mariusz Gajda, Paulina Dumnicka, Danuta Fedak, Grzegorz J. Lis, Piotr Jaśkowski, Jan A. Litwin, Władysław Sułowicz

“…Combination of renal insufficiency and hyperglycemic conditions exerts a synergistic effect on vascular calcification and increases the risk of death.…”
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Pharmacological Inhibition of Caspase-1 Ameliorates Cisplatin-Induced Nephrotoxicity through Suppression of Apoptosis, Oxidative Stress, and Inflammation in Mice by Jung-Yeon Kim, Jae-Hyung Park, Kiryeong Kim, Jungmin Jo, Jaechan Leem, Kwan-Kyu Park

“…We found that administration of Ac-YVAD-cmk effectively attenuated cisplatin-induced renal dysfunction, as evidenced by reduced plasma levels of blood urea nitrogen and creatinine, and histological abnormalities, such as tubular cell death, dilatation, and cast formation. Administration of Ac-YVAD-cmk inhibited caspase-3 activation as well as caspase-1 activation and attenuated apoptotic cell death, as assessed by terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling, in the kidneys of cisplatin-treated mice. …”
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Joint and independent associations of dietary antioxidant intakes with all-cause and cardiovascular mortality among patients with hypertension: a population-based cohort study by Songfeng Zhao, Yangbin Cao, Hongyi Liu, Aihua Liu

“…Methods and results This study included 16,190 adults with hypertension from the National Health and Nutrition Examination Survey (NHANES) 1999–2018. Death outcomes were ascertained by linkage to National Death Index records through December 31, 2019. …”
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Tanshinlactone triggers methuosis in breast cancer cells via NRF2 activation by Wanjun Lin, Zifeng Huang, Xuening Zhang, Dayuan Zheng, Yanchao Yang, Meina Shi, Dongfang Yang, Tong Chu, Wenzhe Ma

“…Catastrophic macropinocytosis, also called methuosis, as a nonapoptotic cell death associated with cytoplasmic vacuolization, has gained increasing attention, largely because of its potential importance in cancer therapy.MethodsThe effect of tanshinlactone on the growth of human cancer cells was evaluated using sulforhodamine B and colony formation assay. …”
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Healthcare Worker Attitudes to Living Donation Prior to Planned Withdrawal of Care by Smruti Rath, MD, Claire Luo, MD, Laura Washburn, MD, Matthew Brent Price, MD, Matthew Goss, MD, Priyanka Moolchandani, MD, Sandra Parsons, PhD, Abbas Rana, MD, FACS, John Goss, MD, FACS, Nhu Thao Nguyen Galván, MD, MPH, FACS

“…This study assesses the attitudes of healthcare practitioners toward Living Donation Prior to Planned Withdrawal of Care (LD-PPW): the recovery of a living donor organ before withdrawal of life-sustaining measures in a patient who does not meet criteria for brain death, but for whom medical care toward meaningful recovery is deemed futile. …”
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Clinical and Prognostic Significance of Idiopathic Left Bundle-Branch Block in Young Adults by Pietro Delise, Luigi Rivetti, Giuseppe Poletti, Monica Centa, Giuseppe Allocca, Nadir Sitta, Arianna Cati, Giovanni Turiano, Emanuela Lanari, Paolo Zeppilli, Luigi Sciarra

“…During follow-up (12+/10 years, median 10 years) no sudden death occurred. At the end of follow-up, all patients were alive, except for one who suffered accidental death. …”
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Implementation of stroke protocol: Insights from a tertiary care facility in urban India by Neha Sharma, Shweta Tyagi, Nitin Jain, Rajnish Kumar, Govind Prakas, Nitisha Goyal

“…Background: Stroke is the second leading cause of death globally and ranks third for combined death and disability. …”
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Characterization of Stroke Patients in an Intensive Care Unit by Marianela Planes Fajardo, Georgia Díaz-Perera Fernández, Maylín Isabel Alonso Martínez, Aurora Calzada Fajardo

“…Stroke is the main neurological cause of death and the third most common cause of death in the world. …”
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The role of isoniazid dosage and NAT2 gene polymorphism in the treatment of tuberculous meningitis by Yi Jian, Yuhang Bao, Fashuang Yang, Mei Zhu

“…By month 12, 25 patients (21.0%) experienced disability or death, with 22 cases (18.5%) occurring by the end of the 3rd month. …”
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One-year Prevalence, Comorbidities, and Cost of Hospitalizations for Alpha-1 Antitrypsin Deficiency among Patients with Chronic Obstructive Pulmonary Disease in the United States by Christopher M. Blanchette, Emily Zacherle, Joshua M. Noone, Bryce A. Van Doren, Debosree Roy, Reuben Howden

“…We compared patient demographics and healthcare outcomes (eg, length of stay, inpatient death, type and number of procedures, and cost of care) between COPD patients with and without alpha-1 antitrypsin deficiency. …”
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PD-L1 Blockade Attenuated Sepsis-Induced Liver Injury in a Mouse Cecal Ligation and Puncture Model by Weimin Zhu, Rui Bao, Xiaohua Fan, Tianzhu Tao, Jiali Zhu, Jiafeng Wang, Jinbao Li, Lulong Bo, Xiaoming Deng

“…Our previous studies indicated that programmed death-1 (PD-1) and its ligand programmed death ligand-1 (PD-L1) are crucial modulators of host immune responses during sepsis. …”
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The All-Cause Mortality and a Screening Tool to Determine High-Risk Patients among Prevalent Type 2 Diabetes Mellitus Patients by Mohamad Adam Bujang, Pei Xuan Kuan, Xun Ting Tiong, Fatin Ellisya Saperi, Mastura Ismail, Feisul Idzwan Mustafa, Abd Muneer Abd Hamid

“…Their records were matched with the national death record at the end of year 2013 to determine the status after five years. …”
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