Isolation and molecular detection of Peste des petits ruminants virus in an outbreak investigation in Benishangul Gumuz, Ethiopia by Mengesha Abebe, Yimer Lama, Aliy Abdi, Shegu Dereje, Abdeta Debela, Waktole Hika, Hirpa Tola Eyob

“…Its domino effects are economic losses through loss of production, deaths, abortions, and the cost of disease control. …”
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FadA antigen of Fusobacterium nucleatum: implications for ceRNA network in colorectal cancer and adenomatous polyps progression by Sama Rezasoltani, Elahe Shams, Moein Piroozkhah, Yaser Aidi, Mehdi Azizmohammad Looha, Parmida Bagheri, Roudabeh Behzadi Andouhjerdi, Amir Sadeghi, Leili Rejali, Ehsan Nazemalhosseini-Mojarad

“…Abstract Introduction Colorectal cancer (CRC) is the second most common cause of cancer-related deaths globally. The gut microbiota, along with adenomatous polyps (AP), has emerged as a plausible contributor to CRC progression. …”
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Assessment of risk communication and community engagement interventions during the Marburg virus disease outbreak in Kagera region, Northwestern Tanzania by Mololo Noah Mwanjala, Emmanuel Mnkeni, Mikidadi Issanudia Mtalika, Marcelina Mponela, Atuganile Musyani, George Mrema, Amour Seleman, Catherine Gitige, Kokuhabwa Mukurasi, Gloria Macha, Hussein Mohamed, Pius Horumpende, Leopord Sibomana Leonard, Jonathan Mcharo, Wangeci Gatei, Salum Manyatta

“…On March 21, 2023, Tanzania had its first MVD outbreak, resulting in nine cases and six deaths, leading to a fatality rate of 66.7%. Following that, the Risk Communication and Community Engagement (RCCE) approach was promptly initiated to create community awareness regarding the MVD. …”
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Retrospective analysis of disease characteristics and treatment patterns among patients with esophageal cancer across 14 surgically represented centers by Zhihao Lu, Mingfei Geng, Yongtao Han, Jianzhong Cao, Jun Wang, Tianshu Liu, Xianglin Yuan, Xue Meng, Yanqiao Zhang, Rong Zhao, Lixin Wan, Enxiao Li, Wenran Wang, Zhijie Li, Danfeng Shi, Jing Qian, Si Shi, Fengshi Dong, Lin Shen

“…Objective: Esophageal cancer (EC) ranks eighth among cancers in cancer-related deaths globally, and ~44% of new cases occur in China. …”
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Epidemiology of notifiable outbreaks in different hospital units in Saudi Arabia: A national descriptive study by Nawal M. Alanazi, Nasser H. Alshanbari, Hala M. Roushdy, Yahya I. Alnshbah, Eman Ali Barnawi, Nawaf M. Almatrafi, Rula Felemban, Zainah M. Al Shahrani, Nadeen Burhan, Aiman El-Saed, Khalid H. Alanazi

“…Results: A total of 1240 outbreaks were notified, including 2392 patients, 2703 infections, and 806 deaths. Males represented 62.3 % of the patients, and the average age was 51.2 ± 27.7 years. …”
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Diagnostic Challenges in Uncommon Firearm Injury Cases: A Multidisciplinary Approach by Andrea Vittorio Maria Failla, Gabriele Licciardello, Giuseppe Cocimano, Lucio Di Mauro, Mario Chisari, Francesco Sessa, Monica Salerno, Massimiliano Esposito

“…Among these, seventeen cases of firearm deaths were identified, with three atypical cases selected for detailed analysis. …”
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Current methods for detecting and assessing HIV-1 antibody resistance by Stanley Odidika, Stanley Odidika, Stanley Odidika, Martin Pirkl, Martin Pirkl, Thomas Lengauer, Thomas Lengauer, Thomas Lengauer, Philipp Schommers, Philipp Schommers, Philipp Schommers

“…Despite being available for decades, there are still 1.5 million new infections and 700,000 deaths each year, highlighting the need for better therapies. …”
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Early and Late Complications Associated with Penile Cancer Surgery and the Impact of Human Papillomavirus Status: Findings from a Retrospective Norwegian Cohort Study by Patrick Juliebø-Jones, Ida M. Nordanger, Christian Beisland, Tor K. Thorkelsen, Alfred Honoré, Christian A. Moen

“…There was a 1% admission rate to the intensive care unit, but no deaths were recorded within 30 d. Body mass index (BMI)was a significant predictor of early complications (p = 0.01). …”
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MRTX1133 attenuates KRASG12D mutated-colorectal cancer progression through activating ferroptosis activity via METTL14/LINC02159/FOXC2 axis by Junwei Zou, Xiuhua Shi, Zhaoying Wu, Siyuan Zuo, Xiaolei Tang, Hailang Zhou, Yong Huang

“…Colorectal cancer (CRC) ranks as the third most commonly diagnosed cancer and the second leading cause of cancer-related deaths worldwide. Studies have shown that CRC patients with KRAS mutations, especially KRASG12D, have an increased risk of metastasis. …”
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Comparison of outcome and toxicity of postoperative intensity‐modulated radiation therapy with two‐dimensional radiotherapy in patients with soft tissue sarcoma of extremities and... by Jianyang Wang, Yongwen Song, Xinfan Liu, Jing Jin, Weihu Wang, Zihao Yu, Yueping Liu, Ning Li, Hui Fang, Hua Ren, Yuan Tang, Yu Tang, Bo Chen, Ningning Lu, Shunan Qi, Shulian Wang, Yexiong Li

“…Results With a median follow‐up time of 58.1 months, 30 local recurrences, 66 distant metastases, and 40 deaths occurred. Compared to 2D‐RT group, the IMRT group had higher 5‐year local recurrence‐free survival (LRFS) (91.1% vs 80.8%; P = 0.029), distant metastasis‐free survival (DMFS) (80.0% vs 69.7%; P = 0.048), disease‐free survival (DFS) (75.2% vs 59.2%; P = 0.021), and overall survival (OS) (90.2% vs 81.0%; P = 0.029). …”
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Motor Neuron Disease Systematic Multi-Arm Adaptive Randomised Trial (MND-SMART): a multi-arm, multi-stage, adaptive, platform, phase III randomised, double-blind, placebo-controlle... by Jeremy Chataway, Suvankar Pal, Charis Wong, Elizabeth Elliott, Jenna M Gregory, Siddharthan Chandran, Judith Newton, Shuna Colville, Maria Stavrou, Christopher J Weir, Nigel Stallard, Malcolm R Macleod, Michelle Steven, Richard Anthony Parker, Arpan R Mehta, Robert J Swingler, Mahesh K B Parmar, Rachel S Dakin, Jill Williamson

“…The primary analysis of ALSFRS-R will be conducted when 150 participants/arm, excluding long survivors, have completed 18 months of treatment; if positive the survival effect will be inferentially analysed when 113 deaths have been observed in the placebo group. The trial design ensures that other promising drugs can be added for evaluation in planned trial adaptations. …”
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The Tools for Integrated Management of Childhood Illness (TIMCI) study protocol: a multi-country mixed-method evaluation of pulse oximetry and clinical decision support algorithms by Fenella Beynon, Hélène Langet, Leah F. Bohle, Shally Awasthi, Ousmane Ndiaye, James Machoki M’Imunya, Honorati Masanja, Susan Horton, Maymouna Ba, Silvia Cicconi, Mira Emmanuel-Fabula, Papa Moctar Faye, Tracy R. Glass, Kristina Keitel, Divas Kumar, Gaurav Kumar, Gillian A. Levine, Lena Matata, Grace Mhalu, Andolo Miheso, Deusdedit Mjungu, Francis Njiri, Elisabeth Reus, Michael Ruffo, Fabian Schär, Kovid Sharma, Helen L. Storey, Irene Masanja, Kaspar Wyss, Valérie D’Acremont, TIMCI Collaborator Group

“…Effective and sustainable strategies are needed to address the burden of preventable deaths among children under-five in resource-constrained settings. …”
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Chronic fatigue and headache in post-COVID-19 syndrome: a radiological and clinical evaluation by Gonçalo G. Almeida, Gonçalo G. Almeida, Saide Alkan, Saide Alkan, Robert Hoepner, André Euler, André Euler, Lara Diem, Franca Wagner

“…IntroductionThe coronavirus disease 2019 (COVID-19) pandemic has caused millions of infections and deaths globally. Post-COVID-19 syndrome, or long COVID is characterized by lingering symptoms such as chronic fatigue, headaches, and sleep disturbances. …”
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Impact of enhanced chest CT with three-dimensional reconstruction combined with preoperative olive oil administration on the incidence of postoperative chylothorax: a retrospective... by Xindong Luo, Di Lu, Ziqiang Wang, Jingyi Wang, Ruozhu Dong, Yaping Wang, Wei Cao, Dacheng Jin, Zhaohao Lin, Haochi Li, Pengcheng Du, Yunjiu Gou, Pengcheng Dong, Yayuan Yang

“…Results All patients in both groups underwent surgeries successfully without any perioperative deaths. Compared to the control group, the 3D reconstruction group exhibited a significant decrease in the incidence of postoperative chylothorax (0% versus 8.2%, P < 0.001). …”
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Assessing cross-country inequalities in global burden of gastrointestinal cancers: slope and concentration index approach by Haoyun Zhou, Yongbo Wang, Fang Wang, Runtang Meng, Yong Yu, Su Han, Yu Zhang, Yu Wu, Xiaoxue Liu

“…Abstract Purpose New cases and deaths of gastrointestinal cancers are predicted to increase significantly by 2040. …”
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Predictive accuracy of lactate albumin ratio for mortality in intensive care units: a nationwide cohort study by Yohei Okada, Yoshitaka Aoki, Mikio Nakajima, Yasuhito Suzuki, Mikihiro Shimizu, Ryo Imai, Soichiro Mimuro, Yoshiki Nakajima

“…Subgroup analysis was used to evaluate the predictive accuracy of the LAR across different patient attributes and clinical scenarios.Results Of 2 34 774 cases analysed, in-hospital mortality was 8.8% (20 723 deaths). The LAR had an area under the curve of 0.761 (95%CI 0.757 to 0.765), indicating a fair predictive performance for in-hospital mortality. …”
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Cancer Burden Disease Attributable to PM2.5 and Health Risk by PM2.5-bound Toxic Species in Two Urban Chilean Municipalities by Ye Li, Franz Muñoz-lbañéz, Ana Maldonado-Alcaíno, Darby Jack, Beizhan Yan, Li Xu, Marco Acuña, Manuel Leiva-Guzman, Ana Valdés, Dante D. Cáceres

“…The attributable fraction (AF) of deaths due to lung cancer from long-term exposure to PM2.5 reached 54% (95% CI: 25–72) in Coyhaique vs. 43% (95% CI: 19–46) in Independencia. …”
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Comprehensive health risk assessment of urban ambient air pollution (PM2.5, NO2 and O3) in Ghana by Boansi Adu Ababio, Gerheart Winfred Ashong, Thomas Peprah Agyekum, Blessed Adjei Yeboah, Marian Asantewah Nkansah, Jonathan Nartey Hogarh, Michael Kweku Commeh, Edward Ebow Kwaansa-Ansah, Kwabena Dabie, Felix Adulley, Eldad Boansi, Lorenda Sarbeng, Birago Adu Ababio, Maame Serwaa Boapea, Nana Kwabena Oduro Darko, Meshach Kojo Appiah

“…Air pollution in Ghana causes approximately 28,000 premature deaths and disabilities annually, ranking as a leading cause of mortality and disability-adjusted life years. …”
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Adjuvant endocrine therapy with cyclin-dependent kinase 4/6 inhibitor, ribociclib, for localized hormone receptor-positive/HER2– breast cancer (LEADER) by Laura M. Spring, Lauren Scarpetti, Arielle J. Medford, Andrzej Niemierko, Amy Comander, Therese Mulvey, Lowell Schnipper, Steven J. Isakoff, Beverly Moy, Seth A. Wander, Jennifer Shin, Zanta Ephrem, Anneke R. Laposta, Elyssa Denault, Elizabeth Abraham, Gayle Calistro, Ekaterina Kalashnikova, Angel Rodriguez, Minetta C. Liu, Alexey Aleshin, Jeffrey Peppercorn, Leif W. Ellisen, Aditya Bardia

“…Only six serious adverse events occurred, with no significant difference between treatment arms and no subject deaths. Twenty-five patients (31%) discontinued ribociclib before completion of 12 months, with no significant difference between treatment arms. …”
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Venetoclax plus low-intensity chemotherapy for adults with acute lymphoblastic leukemia by Marlise R. Luskin, Shai Shimony, Julia Keating, Eric S. Winer, Jacqueline S. Garcia, Richard M. Stone, Elias Jabbour, Yael Flamand, Kristen Stevenson, Jeremy Ryan, Zhihong Zeng, Anthony Letai, Marina Konopleva, Nitin Jain, Daniel J. DeAngelo

“…The most common nonhematologic adverse events were grade ≥3 infections. There were no deaths within 60 days. There was no tumor lysis syndrome, hepatotoxicity, prolonged cytopenias, or early discontinuation for toxicity. …”
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