Development of small molecule non-covalent coronavirus 3CL protease inhibitors from DNA-encoded chemical library screening by Hengrui Liu, Arie Zask, Farhad Forouhar, Sho Iketani, Alana Williams, Daniel R. Vaz, Dahlya Habashi, Karenna Choi, Samuel J. Resnick, Seo Jung Hong, David H. Lovett, Tian Bai, Alejandro Chavez, David D. Ho, Brent R. Stockwell

“…Abstract Variants of SARS-CoV-2 have continued to emerge across the world and cause hundreds of deaths each week. Due to the limited efficacy of vaccines against SARS-CoV-2 and resistance to current therapies, additional anti-viral therapeutics with pan-coronavirus activity are of high interest. …”
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Progesterone Increases Apoptosis and Inversely Decreases Autophagy in Human Hepatoma HA22T/VGH Cells Treated with Epirubicin by Wen-Tsan Chang, Hsiao-Ling Cheng, Bau-Shan Hsieh, Chien-Chih Chiu, King-Teh Lee, Kee-Lung Chang

“…Hepatocellular carcinoma (HCC) is the leading cause of cancer-related deaths worldwide. Epirubicin can induce intracellular reactive oxygen species and is widely used to treat unresectable HCC. …”
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Repeated Liver Resection for Colorectal Liver Metastases: A Comparison with Primary Liver Resections concerning Perioperative and Long-Term Outcome by Kristoffer Jönsson, Gerd Gröndahl, Martin Salö, Bobby Tingstedt, Roland Andersson

“…There was no 30-day postoperative mortality or postoperative hospital deaths. The median blood loss at repeat resection (1850 mL) was significantly (P=0.014) higher as compared to the primary liver resection (1000 mL). …”
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A Three-Echelon Healthcare Supply Chain Model for Blood Distribution During Crisis Times by Amir Khiabani, Alireza Rashidi Komijan, Amir Karbassi Yazdi, Yong Tan, Giuliani Coluccio Piñones, Alessio Ishizaka

“…Due to a lack of blood, the number of deaths related to this issue has significantly increased in recent years. …”
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Association between Interleukin-10-1082 G/A and Tumor Necrosis Factor-α 308 G/A Gene Polymorphisms and Respiratory Distress Syndrome in Iranian Preterm Infants by Abolfazl Khoshdel, Soleiman Kheiri, Peyman Omidvari, Fahimeh Moradi, Majid Hamidi, Hossein Teimori

“…The age of the mothers and gestational age ranged 17–45 (mean: 28.6±5.3) years and 24–34 (mean: 34.3±2.38) weeks, respectively. Totally, 23 deaths were recorded in the RDS group. Incidence of TNF-α-308 A/A and TNF-α-308 G/A was 84% and 16%, respectively. …”
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Changes in Proteinuria on the Risk of All-Cause Mortality in People with Diabetes or Prediabetes: A Prospective Cohort Study by Yang Sun, Anxin Wang, Xiaoxue Liu, Zhaoping Su, Junjuan Li, Yanxia Luo, Shuohua Chen, Jianli Wang, Xia Li, Zhan Zhao, Huiping Zhu, Shouling Wu, Xiuhua Guo

“…A total of 17,878 participants were finally included in this study. There were 1193 deaths after a median follow-up of 6.69 years. After adjusting for major covariates and proteinuria at baseline, mortality risk was significantly associated with elevated proteinuria (hazard ratio (HR): 1.54, 95% confidence interval (CI): 1.33–1.79) and reduced proteinuria (HR: 0.70, 95% CI: 0.55–0.89), compared to those with stable proteinuria. …”
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Mycobacteria Exploit Host GPR84 to Dampen Pro-Inflammatory Responses and Promote Infection in Macrophages by Reziya Wumaier, Ke Zhang, Jing Zhou, Zilu Wen, Zihan Chen, Geyang Luo, Hao Wang, Juliang Qin, Bing Du, Hua Ren, Yanzheng Song, Qian Gao, Bo Yan

“…Tuberculosis (TB) remains the major cause of mortality and morbidity, causing approximately 1.3 million deaths annually. As a highly successful pathogen, <i>Mycobacterium tuberculosis</i> (<i>Mtb</i>) has evolved numerous strategies to evade host immune responses, making it essential to understand the interactions between <i>Mtb</i> and host cells. …”
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Effect of Stocking Density on Stress-Related Gene Expression of Pacific White Shrimp (Litopenaeus vannamei) Infected with Infectious Myonecrosis Virus (IMNV) by Moch. Nurhudah, Nur Komariah Baladrat, Sinung Rahardjo, Heny Budi Utari, Putu Angga Wiradana

“…The lowest cumulative number of shrimp deaths was at a density of 100 shrimp/m2 and was caused by the IMNV virus confirmed through RT-PCR. …”
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Insights into the molecular mechanisms and nanoparticle-based therapies for gastric cancer: A review by Smarika Chauhan, Eswar Marcharla, Sneha Hariharan, Saranya Vinayagam, Thanigaivel Sundaram, Priya SD, Swamynathan Ganesan, Maximilian Lackner

“…Gastric cancer is characterized by the abnormal development of cells in the intestinal lining and is listed as the third leading cause of cancer-related deaths globally. Accurate detection continues to be difficult and conventional therapies, such as radiation, surgery, and chemotherapy, frequently encounter problems with poor absorption, toxicity, and a lack of specificity. …”
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Global, regional, and national burden inequality of chronic kidney disease, 1990–2021: a systematic analysis for the global burden of disease study 2021 by Jingxun Guo, Jingxun Guo, Zhen Liu, Zhen Liu, Pengjun Wang, Heming Wu, Kai Fan, Kai Fan, Jianbo Jin, Jianbo Jin, Lan Zheng, Lan Zheng, Zeyu Liu, Zeyu Liu, Renyi Xie, Renyi Xie, Renyi Xie, Cheng Li, Cheng Li, Cheng Li, Cheng Li

“…Joinpoint regression was used to assess trends over the 30-year period.ResultsIn 2021, global CKD prevalence was 359 million, with 11.13 million new cases, 1.53 million deaths, and 44.45 million DALYs—up 92, 156, 176, and 114% since 1990. …”
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Integration of Microgrids and Electric Vehicle Technologies in the National Grid as the Key Enabler to the Sustainable Development for Rwanda by Samuel Bimenyimana, Chen Wang, Aphrodis Nduwamungu, Godwin Norense Osarumwense Asemota, Wellars Utetiwabo, Chun-Ling Ho, Jean De Dieu Niyonteze, Noel Hagumimana, Theobald Habineza, Waqar Bashir, Cicilia Kemunto Mesa, Yiyi Mo

“…In the transport sector, the concept of electric vehicles has been initiated and started in order to contribute to the UN Paris agreement and decrease the reliance of the transport sector on gaseous fuels which are one source of air pollutants leading to climate change, premature deaths, and morbidity associated with poor air quality. …”
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Research on Correlations of lncRNA ST7-AS1 with Progression and Therapeutic Targets of Esophageal Cancer by Xiao Lin, Sijia Sun, JiWen Zhang, Yan Cai, Quan Cheng

“…Background/Aims: Esophageal cancer is a highly prevalent gastrointestinal tumor in China, resulting in a significant number of deaths annually. In this paper, we investigated the regulatory role and therapeutic potential of aberrant ST7-AS1 expression in esophageal cancer. …”
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Optimal WSN Deployment to Measure Air Quality in Dynamic Multi-Source Dispersion Scenarios: A Case Study in Arequipa by Alexander Hilario-Tacuri, Alberth Tamo, Marco Pinares-Mamani, Walter Butron, Romel Jimenez

“…According to the World Health Organization, air pollution causes approximately 7 million premature deaths each year, with 99% of the global population exposed to air that fails to meet recommended quality standards. …”
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Examining priorities and investments made through the Global Financing Facility for maternal and newborn health: a sub-analysis on quality by Meghan Bruce Kumar, Mary Kinney, Joël Kiendrébéogo, Donat Shamba, Joy E. Lawn, Peter Waiswa

“…Improving quality of care could avert most of the 4.5 million maternal and neonatal deaths and stillbirths that occur each year. The Global Financing Facility (GFF) aims to catalyse the national scale-up of maternal and newborn health (MNH) interventions through focused investments. …”
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Case report: dysgeusia, strawberry tongue, and psoriatic eruptions after combination treatment with adalimumab, sulfasalazine, and etoricoxib for ankylosing spondylitis by Binglin Cui, Jing Lin, Yuanchun Huang, Huachen Zhu, Huachen Zhu, Huachen Zhu, Jinbo Zou, Jiesheng Qin, Hui Pan, Hui Pan, Jian Chen

“…BackgroundTumor necrosis factor blockers can suppress immune system and lead to various adverse drug reactions, including deaths. We present a rare case of dysgeusia, strawberry tongue, and psoriasis-like eruptions after simultaneous administration of adalimumab, sulfasalazine, and etoricoxib.Case descriptionA 36 year-old male with ankylosing spondylitis presented with progressive loss of taste for 3 months and rashes on his upper trunk for 5 days. …”
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Validation of the Model of End-Stage Liver Disease for Liver Transplant Allocation in Alberta: Implications for Future Directions in Canada by Kelly W. Burak, Glenda A. Meeberg, Robert P. Myers, Gordon H. Fick, Mark G. Swain, Vincent G. Bain, Norman M. Kneteman, Robert J. Hilsden

“…Within 1 year of listing, 47 patients were removed from the waiting list (29 deaths, 18 too ill for LT). Using logistic regression, the MELD and CP were better than the CanWAIT at predicting 3-month (AUROC: 0.79, 0.78, and 0.59; p=0.0002) and 1-year waitlist mortality (AUROC: 0.70, 0.70, and 0.55; p=0.0023). …”
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Hepatitis B Virus (HBV) Genotypes in an Ecuadorian Population: A Preliminary Study by Miguel Moncayo, Enrique Teran, Bernardo Gutierrez, Jorge Reyes, Johanna Cortez, Rodrigo Tobar, Gabriela Yerovi, Marcia Robalino, Ana Aguilar, Daniel Garzon-Chavez

“…The World Health Organization reported 890,000 HBV-related deaths in 2019, higher than reported previously. There are 10 HBV genotypes (A–J) subdivided into several subgenotypes that differ considerably by geography. …”
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The Science of Disaster Medicine: From Response to Risk Reduction by Hüseyin Koçak, Kerem Kınık, Cüneyt Çalışkan, Kurtuluş Açıksarı

“…Among the global goals of disaster medicine, are to reduce the number of deaths and injuries, reduce the number of affected people, strengthen critical facility infrastructure, and ensure functional sustainably of these facilities during disasters. …”
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Spatially mapping the tumour immune microenvironments of non-small cell lung cancer by Lysanne Desharnais, Mark Sorin, Morteza Rezanejad, Bridget Liu, Elham Karimi, Aline Atallah, Anikka M. Swaby, Miranda W. Yu, Samuel Doré, Saskia Hartner, Benoit Fiset, Yuhong Wei, Baharak Kadang, Roni Rayes, Philippe Joubert, Sophie Camilleri-Broët, Pierre-Olivier Fiset, Daniela F. Quail, Jonathan D. Spicer, Logan A. Walsh

“…Abstract Lung cancer is the leading cause of cancer-related deaths. An enhanced understanding of the immune microenvironments within these tumours may foster more precise and efficient treatment, particularly for immune-targeted therapies. …”
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A Review of Sulfate Removal from Water Using Polymeric Membranes by Jamal Al Mehrate, Sadek Shaban, Amr Henni

“…Sulfated waters represent a major challenge on the Canadian prairies, leading to many cattle deaths. While reverse osmosis (RO) membranes effectively remove sulfates, they are costly due to high-pressure requirements. …”
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