Prognostic Value of Postpercutaneous Coronary Intervention Murray-Law-Based Quantitative Flow Ratio by Daixin Ding, PhD, Jinlong Zhang, MD, PhD, Peng Wu, PhD, Zhiqing Wang, MD, PhD, Huiping Shi, MSc, Wei Yu, PhD, Xinyang Hu, MD, PhD, Jeehoon Kang, MD, Joo-Yong Hahn, MD, Chang-Wook Nam, MD, Joon-Hyung Doh, MD, Bong-Ki Lee, MD, Weon Kim, MD, Jinyu Huang, MD, Fan Jiang, MD, Hao Zhou, MD, Peng Chen, MD, Lijiang Tang, MD, Wenbing Jiang, MD, Xiaomin Chen, MD, Wenming He, MD, Sung Gyun Ahn, MD, Myeong-Ho Yoon, MD, Ung Kim, MD, You-Jeong Ki, MD, Eun-Seok Shin, MD, Seung-Jea Tahk, MD, Jun Pu, MD, William Wijns, MD, PhD, Jian’an Wang, MD, PhD, Bon-Kwon Koo, MD, PhD, Shengxian Tu, PhD

“…The primary endpoint was 2-year target vessel failure, including cardiac death, target vessel myocardial infarction, and target vessel revascularization. …”
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Multimodal lung cancer theranostics via manganese phosphate/quercetin particle by Chong Qiu, Fei Xia, Qingchao Tu, Huan Tang, Yinan Liu, Hongda Liu, Chen Wang, HaiLu Yao, Linying Zhong, Yuanfeng Fu, Pengbo Guo, Weiqi Chen, Xinyu Zhou, Li Zou, Licheng Gan, Jiawei Yan, Yichong Hou, Junzhe Zhang, Huanhuan Pang, Yuqing Meng, Qiaoli Shi, Guang Han, Xijun Wang, Jigang Wang

“…Additionally, Mn2+ could activate the cGAS-STING signalling pathway and promote the maturation of dendritic cells and infiltration of activated T cells, thus inducing tumor immunogenic cell death (ICD). Furthermore, it exhibited effective T2-weighted MRI enhancement for tumor imaging, making them valuable for clinical diagnosis. …”
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Cancer cells avoid ferroptosis induced by immune cells via fatty acid binding proteins by Maria Angelica Freitas-Cortez, Fatemeh Masrorpour, Hong Jiang, Iqbal Mahmud, Yue Lu, Ailing Huang, Lisa K. Duong, Qi Wang, Tiffany A. Voss, Claudia S. Kettlun Leyton, Bo Wei, Wai-Kin Chan, Kevin Lin, Jie Zhang, Efrosini Tsouko, Shonik Ganjoo, Hampartsoum B. Barsoumian, Thomas S. Riad, Yun Hu, Carola Leuschner, Nahum Puebla-Osorio, Jing Wang, Jian Hu, Michael A. Davies, Vinay K. Puduvalli, Cyrielle Billon, Thomas P. Burris, Philip L. Lorenzi, Boyi Gan, James W. Welsh

“…One way the immune system fights back is by inducing ferroptosis, a type of cell death, in tumor cells through CD8 + T cells. This involves lipid peroxidation and enzymes like lysophosphatidylcholine acyltransferase 3 (Lpcat3), which makes cells more prone to ferroptosis. …”
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New Horizons In The Treatment Of Metastatic Castrate Resistant Prostate Cancer by Zein El Amir

“…Dissection provides solid, tangible scientific knowledge and teaches important skills like teamwork, professional development, empathy, and coming to terms with the prosaic reality of death.    However, due to the question of ethics and resources, dissection has been removed from many medical curricula. …”
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Anatomy In The Undergraduate Medical Curriculum; Blending The Old And New by Ayesha Yousaf

“…[xii] Not only does dissection provide solid, tangible scientific knowledge, it also teaches important skills like teamwork, professional development, empathy and coming to terms with the prosaic reality of death. [xiii]  However, due to the question of ethics and resources, dissection has been removed from many medical curricula. …”
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Clonal hematopoiesis of indeterminate potential and type 2 diabetes mellitus among patients with STEMI: from a prospective cohort study combing bidirectional Mendelian randomizatio... by Xiaoxiao Zhao, Jiannan Li, Shaodi Yan, Yu Tan, Runzhen Chen, Nan Li, Jinying Zhou, Chen Liu, Peng Zhou, Yi Chen, Hongbing Yan, Hanjun Zhao, Li Song

“…ASXL1 CHIP mutation which displayed a striking correlation with cardiac death (HR: 3.14; 95% CI 1.24–7.93; P < 0.05) with consistent associations observed among T2DM subgroup (HR: 4.51; 95% CI 1.30–15.6; P < 0.05). …”
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Effects of stress hyperglycemia ratio upon long-lasting prognosis in coronary artery disease patients with or lacking chronic renal impairment: findings from a Chinese multi-center... by Jielan Wu, Jin Liu, Ziyao Yuan, Shangyi Tang, Weipeng Zhang, Yulong Xiang, Jinming Chen, Qiqiang Lin, Wei Guo, Yibo He, Haozhang Huang, Xiaozhao Lu, Jingru Deng, Huangtao Ruan, Rengui Jiang, Shiqun Chen, Yong Liu

“…Results During a median follow-up of 5.2 years ( IQR 3.0–8.0), among 45,780 CAD patients (mean age [SD]: 62.8 ± 10.6 years; 23.9% female), the number of all-cause deaths was 7144(15.6%), and cardiovascular-related deaths was 3255 (7.1%). …”
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Engineered macrophage nanoparticles enhance microwave ablation efficacy in osteosarcoma via targeting the CD47-SIRPα Axis: A novel Biomimetic immunotherapeutic approach by Xiongfa Ji, Xin Qian, Guowen Luo, Wenjie Yang, Wenhan Huang, Zehua Lei, Jiaqi Zhou, Guoqing Zhong, Jielong Zhou, Nan Liu, Limin Ma, Mei Li, Xiangmei Liu, Shuilin Wu, Yu Zhang

“…These nanoparticles induce tumor cell death selectively through hyperthermia and microwave dynamic effects upon targeted microwave irradiation. …”
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Dicoumarol sensitizes hepatocellular carcinoma cells to ferroptosis induced by imidazole ketone erastin by Ziwei Yang, Ziwei Yang, Tixin Han, Ruibin Yang, Ruibin Yang, Yinuo Zhang, Yinuo Zhang, Yifei Qin, Yifei Qin, Yifei Qin, Jialu Hou, Jialu Hou, Fei Huo, Fei Huo, Zhuan Feng, Zhuan Feng, Yaxin Ding, Yaxin Ding, Jiali Yang, Jiali Yang, Gang Zhou, Gang Zhou, Shijie Wang, Shijie Wang, Xiaohang Xie, Xiaohang Xie, Peng Lin, Peng Lin, Zhi-Nan Chen, Zhi-Nan Chen, Jiao Wu, Jiao Wu

“…IntroductionFerroptosis, an iron-dependent form of regulated cell death, is characterized by the lethal accumulation of lipid peroxides on cellular membranes. …”
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The age-adjusted international prognostic index 2 (A-FLIPI2) for elderly patients with follicular lymphoma by Jiesong Wang, Junlei Jia, Jingwei Yu, Jing Liu, Meng Gao, Hengqi Liu, Lanfang Li, Lihua Qiu, Shiyong Zhou, Bin Meng, Wenchen Gong, Zhengzi Qian, Xianhuo Wang, Huilai Zhang

“…Among the four scoring systems evaluated, A-FLIPI2 showed the highest AUC for predicting risk of death (0.793) and disease progression (0.678). And the performance of A-FLIPI2 is validated in an external validation cohort. …”
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Comparison of autologous hematopoietic cell transplantation, matched sibling donor hematopoietic cell transplantation, and chemotherapy in patients with favorable- and intermediate... by Mingyang Wang, Shulian Chen, Qiuqiu Zhang, Linyu Yuan, Xue Wang, Junshi Zhang, Xiaoyu Zhang, Yigeng Cao, Dongmei Li, Xinxiao Lu, Meijiao Wang, Xiaosi Jiang, Rongli Zhang, Xin Chen, Qiaoling Ma, Jialin Wei, Donglin Yang, Yi He, Aiming Pang, Sizhou Feng, Mingzhe Han, Weihua Zhai, Xingli Zhao, Erlie Jiang

“…Additionally, 27 cases in the chemotherapy group, excluding patients with early relapse or death, were included for comparison.ResultsIn the overall population, the 3-year overall survival (OS) rates were 85.7%, 83.1%, and 70.4% (p = 0.043), while the disease-free survival (DFS) rates were 78.6%, 83.2%, and 57.1% (p = 0.002) in the auto-HSCT, MSD-HSCT, and chemotherapy groups, respectively. …”
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Dramatic and Cinematic Potentials of the Fifth Dome in Nizami's Haft Peykar by Heydar Ali Dahmarde, Hojat Raeisi

“…The first section encompasses the beginning and ending of the book, detailing the life of Bahram V, a Sassanid emperor, from his birth to his death. This part employs a historical narrative style. …”
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Plasma IL-17A is increased in patients with critical MIS-C and associated to in-hospital mortality by Emmerson C. F. de Farias, Luciana M. P. P. do Nascimento, Manoel J. C. Pavão Junior, Dalila C. A. Pavão, Ana P. S. Pinheiro, Andreza H. O. Pinheiro, Marília C. B. Alves, Kíssila M. M. M. Ferraro, Larisse F. Q. Aires, Luana G. Dias, Mayara M. M. Machado, Michaelle J. D. Serrão, Raphaella R. Gomes, Sara M. P. de Moraes, Gabriela C. L. Pontes, Railana D. F. P. Carvalho, Cristiane T. C. Silva, Carla M. A. das Neves, Joyce C. L. dos Santos, Adriana M. B. de Sousa, Leda L. da Silva, Mary L. F. M. F. de Mello, Patricia B. Carvalho, Renata de B. Braga, Kathia de O. Harada, Maria C. A. Justino, Iran B. Costa, Igor Brasil-Costa, Marta C. Monteiro, Gleice Clemente, Maria Teresa Terreri

“…Our findings suggest that patients with high levels of IL-17A are at greater risk for death.…”
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Clinical and genetic drivers of oligo-metastatic disease in colon cancer by Alessandro Ottaiano, Mariachiara Santorsola, Roberto Sirica, Annabella Di Mauro, Antonella Di Carlo, Monica Ianniello, Francesco Sabbatino, Rosa Castiello, Francesca Del Peschio, Marco Cascella, Francesco Perri, Maurizio Capuozzo, Nicola Martucci, Edoardo Mercadante, Valentina Borzillo, Rossella Di Franco, Francesco Izzo, Vincenza Granata, Carmine Picone, Antonella Petrillo, Massimiliano Berretta, Salvatore Stilo, Luca Tarotto, Anna Chiara Carratù, Gerardo Ferrara, Madhura Tathode, Alessia Maria Cossu, Marco Bocchetti, Michele Caraglia, Guglielmo Nasti, Giovanni Savarese

“…Overall survival (OS) was determined from metastasis diagnosis until death using Kaplan–Meier analysis. Multivariate Cox regression examined prognostic links between clinicopathological and genetic factors. …”
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Inhibition of S100A8/A9 ameliorates neuroinflammation by blocking NET formation following traumatic brain injury by Guihong Shi, Yiyao Cao, Jianye Xu, Bo Chen, Xu Zhang, Yanlin Zhu, Liang Liu, Xilei Liu, Luyuan Zhang, Yuan Zhou, Shenghui Li, Guili Yang, Xiao Liu, Fanglian Chen, Xin Chen, Jianning Zhang, Shu Zhang

“…Furthermore, using a TBI mouse model, we demonstrated that treatment with the selective S100A8/A9 inhibitor Paquinimod significantly mitigated neuroinflammation and neuronal death, thereby improving the prognosis of TBI mice. …”
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Blood and Iron: The Rise and Fall of the German Empire 1871 – 1918 by Arzu Melek Ozgumus

“…The chapter succinctly outlines key events such as the death of Kaiser Wilhelm, the brief reign of his son Freidrich III, wo passed away in just 99 days after his coronation, and the ascension of son Wilhelm II as the last Kaiser. …”
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Deciphering the effect of exercise timing on glucose metabolism: a randomised controlled trial by Fabienne Bruggisser, Denis Infanger, Henner Hanssen, Raphael Knaier

“… Introduction Impaired glycaemic control is a major risk factor for cardiovascular disease, the leading cause of death worldwide (Roth et al., 2020). Reducing sedentary behaviour and increasing physical activity are key strategies for improving glycaemic control (Sparks et al., 2021). …”
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E4F1 coordinates pyruvate metabolism and the activity of the elongator complex to ensure translation fidelity during brain development by Michela Di Michele, Aurore Attina, Pierre-François Roux, Imène Tabet, Sophie Laguesse, Javier Florido, Morane Houdeville, Armelle Choquet, Betty Encislai, Giuseppe Arena, Carlo De Blasio, Olivia Wendling, François-Xavier Frenois, Laura Papon, Lucille Stuani, Maryse Fuentes, Céline Jahannault Talignani, Mélanie Rousseau, Justine Guégan, Yoan Buscail, Pierrick Dupré, Henri-Alexandre Michaud, Geneviève Rodier, Floriant Bellvert, Hanna Kulyk, Carole Ferraro Peyret, Hugo Mathieu, Pierre Close, Francesca Rapino, Cédric Chaveroux, Nelly Pirot, Lucie Rubio, Adeline Torro, Tania Sorg, Fabrice Ango, Christophe Hirtz, Vincent Compan, Elise Lebigot, Andrea Legati, Daniele Ghezzi, Laurent Nguyen, Alexandre David, Claude Sardet, Matthieu Lacroix, Laurent Le Cam

“…Abstract Pyruvate metabolism defects lead to severe neuropathies such as the Leigh syndrome (LS) but the molecular mechanisms underlying neuronal cell death remain poorly understood. Here, we unravel a connection between pyruvate metabolism and the regulation of the epitranscriptome that plays an essential role during brain development. …”
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Integrative analysis of cuproptosis-related lncRNAs: Unveiling prognostic significance, immune microenvironment, and copper-induced mechanisms in prostate cancer by Haitao Zhong, Yiming Lai, Wenhao Ouyang, Yunfang Yu, Yongxin Wu, Xinxin He, Lexiang Zeng, Xueen Qiu, Peixian Chen, Lingfeng Li, Jie Zhou, Tianlong Luo, Hai Huang

“…Cuproptosis, a newly discovered form of cell death, plays an important role in cancer. Nonetheless, additional research investigating the association between cuproptosis-related lncRNAs and prostate cancer (PCa) prognosis is required. …”
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Èdè Àyàn: The Language of Àyàn in Yorùbá Art and Ritual of Egúngún by Oláwọlé Fámúlẹ̀

“…  Kò séní m’èdè Àyàn   Bí ení mú kò ̣ ̣ǹgó ̣ è ̣ lówọ́  No one understands the language of Àyàn Better than the drummer who holds the gong in his hand Yorùbá maxim From the Yorùbá oral historical, mythological, and ontological, abstract lines of reasoning, Àyàn is believed to be the first Yorùbá drum maker and drummer, who, after his death, was deified as the god of Drumming (Òrìsà ̣ Àyàn, or simply Àyàn). …”
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