Dual targeting of breast cancer by chitosan/poly lactic-co-glycolic acid nanodelivery systems: Surface activation with folic acid/aptamers, and co-encapsulated with Sorafenib and q... by Asghar Narmani, Saeid Ganji, Maryam Amirishoar, Fatemeh Hajikarimi, Aynaz Mazandarani, Mahya Karimi, Ali Mohammadinejad, Azin Azadpour, Roghayyeh Jahedi, Elham Assadpour, Seid Mahdi Jafari

“…Breast cancer has a high rate of incidence and is one of the leading causes of death worldwide. Therefore, a breakthrough aptamer (Apt)- and folic acid (FA)-targeted chitosan (CS)-poly lactic-co-glycolic acid (PLGA) nanocarrier was developed for co-delivery of sorafenib (So) and quercetin (Qu) to MCF-7 and MDA-MB-231 breast cancer cells. …”
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A Community-Based Intervention for Mental Health and Wellbeing in Pregnancy and Postpartum: One Healthy Start Site’s Story by Sampson M, Xu W, York FN, Roberson J

“…McClain Sampson,1 Wen Xu,2 Felicia N York,3 Jerry Roberson4 1Graduate College of Social Work, University of Houston, Houston, TX, USA; 2Department of Innovative Social Work, Faculty of Health and Wellbeing, City University of Macau, Macao, SAR, People’s Republic of China; 3Texas A&M University, College Station, TX, USA; 4United Associates, Dallas, TX, USACorrespondence: McClain Sampson, Graduate College of Social Work, University of Houston, Houston, TX, USA, Email mmsampson@uh.eduPurpose: Perinatal mood and anxiety disorders (PMADs) are the leading cause for maternal morbidity and are associated with underlying causes of pregnancy-related death. Healthy Start (HS) programs around the country seek to lower the risk of maternal mortality through services that screen for and address social determinants of health, including mental health. …”
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Interleukin 15‐Presenting Nanovesicles with Doxorubicin‐Loaded Ferritin Cores for Cancer Immunochemotherapy by Yihui Zhai, Wen Zhang, Jinming Wang, Ying Kong, Rong Rong, Tianqun Lang, Chao Zheng, Yanke Wang, Yang Yu, Helen He Zhu, Ying Cai, Pengcheng Zhang, Yaping Li

“…Dox‐Fn selectively target transferrin receptors on cancerous cells, facilitating intracellular Dox release and inducing immunogenic cell death. Concurrently, membrane‐bound IL15c recognizes and activates IL15 receptor β/γc heterodimers, leading to a remarkable increase in the proliferation and activation of CTLs (16‐fold and 28‐fold) and NK cells (37‐fold and 50‐fold). …”
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Peripheral versus central cannulation of VA-ECMO for primary graft dysfunction after heart transplantation: A systematic review and meta-analysis by Eduard Ródenas-Alesina, MD, Aleix Olivella, MD, Ani Orchanian-Cheff, MiST, Farid Foroutan, PhD, Yasbanoo Moayedi, MD, MSc, Vivek Rao, MD, PhD, Filio Billia, MD, PhD, Heather J. Ross, MD, MHSc, Ana Carolina Alba, MD, PhD, Natasha Aleksova, MD, MSc

“…Background: Severe primary graft dysfunction (PGD) after heart transplantation (HT) is a major cause of death and requires veno-arterial extracorporeal membrane oxygenation (VA-ECMO). …”
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Development and Validation of the Systemic Inflammatory Response Index-Based Nomogram for Predicting Short-Term Adverse Events in Patients With Acute Uncomplicated Type B Aortic In... by Wang Y, Wu X, Wang Y, Zhang Z, Liu X, Sun D, Liu X, Zhou T, Wang X

“…ARAEs were defined as death related to aortic disease, and the progression of IMH to aortic dissection or penetrating aortic ulcer. …”
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Diagnosis and management of type 2 diabetes mellitus in patients with ischaemic heart disease and acute coronary syndromes - a review of evidence and recommendations by Muhammad Usman Shah, Muhammad Usman Shah, Alun Roebuck, Bala Srinivasan, Joanna Kate Ward, Paul Edward Squires, Claire Elizabeth Hills, Kelvin Lee, Kelvin Lee

“…These account accounting for 50% of deaths in patients with T2DM. Cardiovascular diseases in the context of diabetes particular represent a significant cause of morbidity and mortality with a two to three times higher risk of cardiovascular disease in individuals with T2DM than in those without the condition normo-glycaemia. …”
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Electrochemotherapy with bleomycin, oxaliplatin, or cisplatin in mouse tumor models, from tumor ablation to in situ vaccination by Katja Uršič Valentinuzzi, Katja Uršič Valentinuzzi, Urška Kamenšek, Urška Kamenšek, Simona Kranjc Brezar, Chloe Heranney, Chloe Heranney, Tilen Komel, Tilen Komel, Simon Buček, Simon Buček, Maja Čemažar, Maja Čemažar, Gregor Serša, Gregor Serša

“…Through histological analyses and the use of immunodeficient and metastatic (for abscopal effect) mouse models, we identified and compared both the cytotoxic and immunological components of ECT’s antitumor efficiency, such as immunologically recognizable cell deaths (immunogenic cell death and necrosis) and immune infiltrate (CD11+, CD4+, CD8+, GrB+).ResultsDifferences in immunological involvement after equieffective intratumoral ECT were highlighted by variable kinetics of immunologically recognizable cell deaths and immune infiltrate across the studied tumor models. …”
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Integrating Bulk and Single-Cell Transcriptomic Data to Identify Ferroptosis-Associated Inflammatory Gene in Alzheimer’s Disease by Zhou H, Peng Y, Huo X, Li B, Liu H, Wang J, Zhang G

“…FuRong Laboratory, Changsha, Hunan, 410078, People’s Republic of China, Email ghzhang@hunnu.edu.cn Jian Wang, The Institute of Reproduction and Stem Cell Engineering, School of Basic Medical Sciences, Central South University, Changsha, 410006, People’s Republic of China, Email 205106@csu.edu.cnBackground: Ferroptosis is a form of programmed cell death triggered by iron-dependent lipid peroxidation, characterized by iron accumulation and elevated reactive oxygen species (ROS), leading to cell membrane damage. …”
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Identification of novel clinical subtypes in patients with microscopic polyangiitis using cluster analysis: multicenter REVEAL cohort study by Ayana Okazaki, Shogo Matsuda, Takuya Kotani, Keisuke Fukui, Keisuke Fukui, Takaho Gon, Ryu Watanabe, Atsushi Manabe, Mikihito Shoji, Keiichiro Kadoba, Ryosuke Hiwa, Wataru Yamamoto, Motomu Hashimoto, Tohru Takeuchi

“…Cluster 1 showed the worst ESRD-free survival and relapse rates, whereas Cluster 2 showed the worst overall survival and respiratory-related death-free survival rates among the four groups.ConclusionsOur study identified four unique subgroups with different MPA outcomes. …”
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Changes in Phenylacetylglutamine Levels Provide Add-On Value in Risk Stratification of Hypertensive Patients: A Longitudinal Cohort Study by Xuan Xu, Lixin Jia, Bokang Qiao, Yanyan Gong, Shan Gao, Yuan Wang, Jie Du

“…After follow-up, the Kaplan–Meier curve and the Cox regression model were utilized to determine the correlation between PAGln and MACEs (death, non-fatal ischemic stroke and hemorrhagic stroke, non-fatal acute coronary syndrome and unplanned revascularization). …”
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USP35 promotes the growth of ER positive breast cancer by inhibiting ferroptosis via BRD4-SLC7A11 axis by Jiawei Cao, Tao Wu, Tong Zhou, Zewei Jiang, Yinrui Ren, Jiawei Yu, Jiayi Wang, Changrui Qian, Guang Wu, Licai He, Hongzhi Li, Rixu Lin, Min Liu, Haihua Gu

“…We previously showed that deubiquitinase USP35 and ERα act in a positive feedback loop to promote the carcinogenesis of ER+ breast cancer although it is unclear whether USP35 regulates cell death in ER+ breast cancer. In this study, we uncovered that USP35 inhibited ferroptosis of ER+ breast cancer cells. …”
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Sistem Identifikasi Penyakit Paru Obstruktif Kronik (PPOK) Berdasarkan Suara Paru-Paru Menggunakan Jaringan Saraf Tiruan Berbasis Raspberry Pi by Lindhu Parang Kusuma, Barlian Henryranu Prasetio, Eko Setiawan

“…Abstract According to the World Health Organization (WHO), Chronic Obstructive Pulmonary Disease (COPD) is the third-largest disease that causes death worldwide, with 3.23 million deaths in 2019. …”
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Exploring the experiences of healthcare professionals in South Africa and Uganda around communicating with children about life-threatening conditions: a workshop-based qualitative... by Sue Ziebland, Julia Ambler, Julia Downing, Alan Stein, Elizabeth Namukwaya, Elizabeth Nabirye, Louise Walker, Elizabeth Rapa, Jeffrey R Hanna, Louise J Dalton, Teresa Pollard, Stephanie Santos-Paulo, Yasmin Gogay, David Kavuma, Ruth Mary Kemigisha, Juliet Namyeso, Tracey Brand, Beverley G Neethling

“…These included patients’ beliefs about illness, medicine and death, language barriers between families and the healthcare team, and emotional and practical challenges for professionals in having these conversations. …”
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Ferroptosis Transcriptional Regulation and Prognostic Impact in Medulloblastoma Subtypes Revealed by RNA-Seq by Christophe Desterke, Yuanji Fu, Jenny Bonifacio-Mundaca, Claudia Monge, Pascal Pineau, Jorge Mata-Garrido, Raquel Francés

“…Ferroptosis, a form of regulated cell death, can be induced in medulloblastoma cells in vitro using erastin or RSL3. …”
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An online emergency medical management information system using mobile computing by Sarandis Mitropoulos, Christos Mitsis, Petros Valacheas, Christos Douligeris

“…Social implications – Providing emergency care before the hospital is of great importance for upgrading the quality of health services provided at the accident site, thus significantly reducing the risk of premature death of patients. This in itself has a significant social implication. …”
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Surgical treatment of anomalous aortic origin of the coronary artery in paediatric patients: a Chinese single-center experience by Kai Luo, Bin Ji, Qi-Liang Zhang, Xiao-Yang Zhang, Yan-Jun Pan, Zhong-Qun Zhu, Qiang Chen, Xiao-Min He, Jing-Hao Zheng

“…Some high-risk anatomical structures are at risk of inducing cardiogenic shock or even sudden death. This article summarizes our surgical experience with AAOCA in paediatric patients. …”
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Biochanin A Reduces Inflammatory Injury and Neuronal Apoptosis following Subarachnoid Hemorrhage via Suppression of the TLRs/TIRAP/MyD88/NF-κB Pathway by Ling-yun Wu, Zhen-nan Ye, Zong Zhuang, Yongyue Gao, Chao Tang, Chen-hui Zhou, Chun-xi Wang, Xiang-sheng Zhang, Guang-bin Xie, Jing-peng Liu, Meng-liang Zhou, Chun-hua Hang, Ji-xin Shi

“…Suppression of inflammation has recently been shown to reduce neuronal death and neurobehavioral dysfunction post SAH. Biochanin A (BCA), a natural bioactive isoflavonoid, has been confirmed to emerge the anti-inflammatory pharmacological function. …”
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A randomized controlled, trial on effects of mobile phone text messaging in combination with motivational interviewing versus standard infant feeding counselling on breastfeeding a... by Moleen Zunza, Lehana Thabane, Louise Kuhn, Christine Els, Carl Lombard, Mark F. Cotton, Taryn Young

“…We also found that early breastfeeding cessation increased risk of child hospitalization or death compared to any form of breastfeeding to week 24, 10% (5/48) versus 3% (5/158), p = 0.055. …”
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Understanding secondary hypogammaglobulinemia and its implications for cancer prognosis in children: A retrospective cohort study by Ana Lucía Guzmán, Isabella Villamil, Sofía Martínez-Betancur, Oriana Arias-Valderrama, Jacobo Triviño-Arias, Jessica Largo, Viviana Lotero, Alexis Franco, Ximena Castro, Pamela Rodríguez, Luz Angela Urcuqui, Diego Medina, Manuela Olaya

“…In the follow-up, the most significant reduction among all ages was for IgA and was related to infections and death. Conclusions. Our findings highlight the importance of measuring immunoglobulin levels at the time of the cancer diagnosis, as hypogammaglobulinemia may be linked to a poorer prognosis. …”
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Computational pathology assessments of cardiac stromal remodeling: Clinical correlates and prognostic implications in heart transplantation by Eliot G. Peyster, MD, MSc, Cai Yuan, PhD, Sara Arabyarmohammadi, PhD, Priti Lal, MD, Michael D. Feldman, MD, PhD, Pingfu Fu, PhD, Kenneth B. Margulies, MD, MS, Anant Madabhushi, PhD, FAIMBE, FIEEE, FNAI

“…Methods: This retrospective cohort consisted of n = 2,167 digitized heart transplant biopsy slides along with records of prior inflammatory events and future allograft outcomes (cardiac death or allograft vasculopathy). Utilizing computational pathology analysis, biopsy images were analyzed to identify the pathologic stromal changes associated with future allograft loss or vasculopathy. …”
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