Chronic Inflammation and Neutrophil Activation as Possible Causes of Joint Diseases in Ballet Dancers by Leandro da Silva Borges, José Ricardo Bortolon, Vinicius Coneglian Santos, Nivaldo Ribeiro de Moura, Alexandre Dermargos, Maria Fernanda Cury-Boaventura, Renata Gorjão, Tania Cristina Pithon-Curi, Elaine Hatanaka

“…We also verified neutrophil death and ROS release. Blood samples were taken from 13 dancers before, immediately after, and 18 hours after a ballet class. …”
Get full text

A multidimensional assessment of adverse events associated with paliperidone palmitate: a real-world pharmacovigilance study using the FAERS and JADER databases by Siyu Lou, Zhiwei Cui, Yingyong Ou, Junyou Chen, Linmei Zhou, Ruizhen Zhao, Chengyu Zhu, Li Wang, Zhu Wu, Fan Zou

“…Noteworthy, unexpected signals not listed in the drug label were also identified, such as psychosexual disorders, prolactin-producing pituitary tumors, suicide attempt, and sudden death. The median onset time for all ADEs was 40 days. …”
Get full text

Efficacy and safety of SHEN26, a novel oral small molecular RdRp inhibitor for COVID-19 treatment: a multicenter, randomized, double-blinded, placebo-controlled, phase II clinical... by Jiangtao Bai, Tetsuya Asakawa, Wenfang Yuan, Yuanlong Lin, Hao Ju, Dandan Xu, Mingming Yang, Shuo Li, Guanguan Li, Deyin Guo, Hongzhou Lu, Xumu Zhang

“…Administration of SHEN26 did not enhance drug-related ADEs and did not induce ADEs, and ADE inducing drug withdrawal, dose reduction, or death. Moreover, SHEN26 did not worsen the renal function. …”
Get full text

Periodontal Indices as Predictors of Cognitive Decline: Insights from the PerioMind Colombia Cohort by Catalina Arévalo-Caro, Diego López, Jose Antonio Sánchez Milán, Cristina Lorca, María Mulet, Humberto Arboleda, Sergio Losada Amaya, Aida Serra, Xavier Gallart-Palau

Get full text

Targeting sphingosine 1-phosphate receptor 3 inhibits T-cell exhaustion and regulates recruitment of proinflammatory macrophages to improve antitumor efficacy of CAR-T cells agains... by Weiting Liao, Ge Gao, Xia He, Pei Shu, Qizhi Ma, Benxia Zhang, Diyuan Qin, Yongsheng Wang

“…We have applied RNA sequencing, flow cytometry, ELISA, cellular/molecular immunological technology, and mouse models of solid cancers.Results Our study provided evidence that S1PR3 high expression is positively associated with resistance to programmed cell death protein-1 (PD-1)-based immunotherapy and increased T-cell exhaustion. …”
Get full text

Machine learning based on blood test biomarkers predicts fast progression in advanced NSCLC patients treated with immunotherapy by Jie Yang, Jian-Guo Zhou, Benjamin Frey, Hu Ma, Haitao Wang, Markus Hecht, Rainer Fietkau, Udo Gaipl, Xiaofei Chen, Ada Hang-Heng Wong, Fangya Tan, Si-Si He, Gang Shen, Yun-Jia Wang, Wenzhao Zhong

“…In addition, the absolute difference in median survival between the SVM-predicted FP and non-FP groups was significant in both progression-free survival and overall survival (p<0.001).Conclusion SVM trained using a 4-biomarker panel has good performance in predicting the occurrence of FP regardless of programmed cell death ligand 1 expression, hence providing evidence for decision-making in single-agent atezolizumab immunotherapy for patients with advanced NSCLC.…”
Get full text

Co-creation and application of a framework for the de-prioritization of urban communities during insecticide-treated bed net mass campaigns for malaria prevention and control in Kw... by Ifeoma D. Ozodiegwu, Laurette Mhlanga, Eniola A. Bamgboye, Adeniyi F. Fagbamigbe, Cyril Ademu, Chukwu Okoronkwo, Joshua O. Akinyemi, Akintayo O. Ogunwale, IkeOluwapo O. Ajayi, Beatriz Galatas

“…Abstract Background Malaria continues to be a major cause of illness and death worldwide, particularly affecting children under the age of five and those living in high-burden countries like Nigeria. …”
Get full text

Ac2-26 Alleviates Brain Injury after Cardiac Arrest and Cardiopulmonary Resuscitation in Rats via the eNOS Pathway by Jing Gong, Qi-Hang Tai, Guang-Xiao Xu, Xue-Ting Wang, Jing-Li Zhu, Xiao-Qing Zhao, Hai-Bin Sun, Dan Zhu, Wei Gao

“…Brain injury is the leading cause of death following cardiac arrest (CA) and cardiopulmonary resuscitation (CPR). …”
Get full text

The relevance of a multidomain geriatric assessment in older patients with heart failure by Emma E.F. Kleipool, Julia H.I. Wiersinga, Marijke C. Trappenburg, Albert C. vanRossum, Carmen S. vanDam, Su‐San Liem, Mike J.L. Peters, M. Louis Handoko, Majon Muller

“…Logistic regression analyses adjusted for age, sex, diabetes and kidney function assessed 3 month risk of adverse health outcomes (emergency department visits, hospital admissions, and/or death) according to HF severity, physical frailty, and number of affected domains. …”
Get full text

The Explo’Santé mixed methods protocol: an interventional research school health promotion project in France by Matteo Olivo, Adeline Darlington-Bernard, Corélie Salque, Laurie Fraticelli, Emmanuel Ricard, Florence Carrouel, Emily Darlington

“…Abstract Background According to WHO, “noncommunicable diseases (NCDs) kill 41 million people” annually, as the primary cause of death globally. WHO’s Global Action Plan for the prevention and control of NCDs 2013–2020 (extended) tackles this issue and its implications regarding inequalities between countries and populations. …”
Get full text

Real-world outcomes in patients with melanoma brain metastasis: a US multisite retrospective chart review study of systemic treatments by Ning Ning, Sunandana Chandra, Andriy Moshyk, Divya Patel, Isabella C Glitza Oliva, Jennell Palaia, Leon A Sakkal, Natalia Han, Shardul Odak, Jordana K Schmier

“…Objective This study examined real-world treatment patterns and outcomes in patients with melanoma brain metastasis (MBM) treated with first-line immunotherapy consisting of nivolumab plus ipilimumab or anti-programmed death-1 (PD-1) monotherapy (nivolumab or pembrolizumab) or targeted therapy consisting of BRAF/MEK inhibitors.Design Retrospective chart review study.Setting Academic medical centres, community hospitals and private practice offices.Participants Included patients diagnosed with melanoma with brain metastasis in the USA.Outcome measures The statistical analysis was descriptive in nature. …”
Get full text

Mortality risk prediction model in AIDS patients with pneumocystis pneumonia in China by Xi Wang, Letian Liu, Wen Wang, Yang Zhang, Hui Chen, Zhangli Wang, Jianwei Li, Yue Gao, Yanqun Huang, Lijun Sun, Tong Zhang, Aixin Li

“…The patients were divided into death group and survival group according to clinical outcome during hospitalization. …”
Get full text

La transformation de l’ancien centre de détention secrète de Derb Moulay Cherif en musée des « années de plomb » (Casablanca, Maroc) by Anissa Habane

“…For several decades, this secret site, the centerpiece of the repressive system, held, tortured and killed political activists, union members and student activists, as well as random individuals. After the death of King Hassan II in 1999, an emerging body of prison literature in French and Arabic made it possible to expose and inform about the conditions of detention in these secret detention centers. …”
Get full text

Racial and ethnic differences in fatal child abuse and neglect and the intersection of community poverty: U.S., 2003 to 2022 by Rebecca F. Wilson, Xin Yue, Karen E. Thomas, Krishna Kiran Kota, Carter J. Betz

“…Participants and methods: This study integrated National Violent Death Reporting System (NVDRS) data, county poverty data, and population estimates data. …”
Get full text

Impact of healthcare-associated infections on in-hospital outcomes during the COVID-19 era: a multicenter comparative study of 20,942 isolated microorganisms from ICU patients by Armin Khavandegar, Zeinab Siami, Aziz Rasouli, Pershang Nazemi, Anoosha Gull

“…The odds of in-hospital mortality in all six main infection categories have significantly increased in the COVID-19 era when compared to the pre-COVID-19 era. The odds of death were increased in the SSI group more than the rest (OR:2.65, CI 95%: 2.13–3.29).ConclusionCOVID-19 changed the pattern of HAIs and also increased their mortality. …”
Get full text

Calidad del cuidado de enfermería en la unidad de cuidados intensivos durante la COVID-19: estudio cualitativo by John Camilo Garcia Uribe, Susana Vallejo, Yuliana Cardenas Jaramillo

“…The experiences and meanings of the nursing professionals in this study were framed by difficult working conditions, encounter with death, work overload, decrease in the quality of care, increase in adverse events, and tensions between positive and negative emotions. …”
Get full text

Study protocol: multi-centre, randomised controlled clinical trial exploring stromal targeting in locally advanced pancreatic cancer; STARPAC2 by Hemant M. Kocher, BCI-STARPAC2 team, BPTB team, Precision-Panc team, Peter Sasieni, Pippa Corrie, Mairéad G. McNamara, Debashis Sarker, Fieke E. M. Froeling, Alan Christie, Roopinder Gillmore, Khurum Khan, David Propper

“…Primary endpoint is progression free survival (PFS) defined as the time from the date of randomisation to the date of first documented tumour progression (response evaluation criteria in solid tumours [RECIST] v1.1) or death from any cause, whichever occurs first. Secondary endpoints include objective response rate (ORR), overall survival (OS), safety and tolerability, surgical resection rate, R0 surgical resection rate and patient reported outcome measures (PROMS) as measured by questionnaire EQ-5D-5L. …”
Get full text

CDK9 Expression Shows Role as a Potential Prognostic Biomarker in Breast Cancer Patients Who Fail to Achieve Pathologic Complete Response after Neoadjuvant Chemotherapy by Ashley J. Schlafstein, Allison E. Withers, Soumon Rudra, Diana Danelia, Jeffrey M. Switchenko, Donna Mister, Saul Harari, Hui Zhang, Waaqo Daddacha, Shahrzad Ehdaivand, Xiaoxian Li, Mylin A. Torres, David S. Yu

“…In a Cox proportional hazards model, using a time-dependent covariate to evaluate the risk of death between groups beyond 3 years, high CDK9 expression was significantly associated with an increase in OS (HR: 0.26, 95% CI: 0.07-0.98, p=0.046). …”
Get full text

Hubungan Lingkungan Fisik dan Tindakan Penduduk dengan Kejadian ISPA pada Balita di Wilayah Kerja Puskesmas Lubuk by Irma Suryani, Edison ., Julizar Nazar

“…<br />Kata kunci: ISPA balita, lingkungan fisik, tindakan penduduk</p><p>Abstract<br />The mortality rate due to Acute Respiratory Infections (ARI) in developing countries is about 20% which is 1/3-1/2 is the death of the children under five years old. The objective of this research was to determined the correlation between the physical environment which include the ventilation, the natural lighting, the house humidity, the density of residential house, and community behavior which include the habitual of smoking at house, the habitual of window open and household fuel use with the incidence of ARI on children under five years old. …”
Get full text

Admission outcomes and their associated factors among children admitted to the paediatric emergency unit within 24 hours of Dilla University Referral Hospital, Ethiopia, 2023: a cr... by Binyam Tariku Seboka, Tomas Yeheyis, Yihenew Ayehu Dessie, Samuel Jigso Dube, Abel Desalegn Demeke, Mekdes Mekonnen Feleke, Abdo Hajo Jarso, Asresu Feleke Bati, Etaferaw Udo, Selam Tadele Markos, Chalachew Kassaw, Amdehiwot Aynalem Debebe, Ephrem Geja Gechere

“…Background Children in paediatric emergency units are those who need special attention, and unless treated early, they are a vulnerable population to unwanted outcomes like death, discharge against medical advice or referral to other institutions within 24 hours.Objectives To assess admission outcomes and their associated factors among children admitted to the paediatric emergency unit of Dilla University Referral Hospital, Ethiopia, 2023.Methods An institution-based cross-sectional study design was employed among children admitted to the paediatric emergency unit at Dilla University Referral Hospital from 8 May 2023 to 8 June 2023. …”
Get full text