MT1G promotes iron autophagy and inhibits the function of gastric cancer cell lines by intervening in GPX4/SQSTM1 by Kaiqiang Meng, Jian Song, Fan Qi, Jiamin Li, Zhichao Fang, Liang Song

“…Abstract Gastric cancer (GC) is the fifth most common cancer and the third most common cause of cancer death globally, with high invasiveness, high recurrence rate, and poor prognosis. …”
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The Immunohistochemical Prognostic Value of Nuclear and Cytoplasmic Silent Information Regulator 1 Protein Expression in Saudi Patients with Breast Cancer by Bayan Alharbi, Alia Aldahlawi, Mourad Assidi, Fatemah Basingab, Kawther Zaher, Jehan Alrahimi, Sara Mokhtar, Jaudah Al-Maghrabi, Abdelbaset Buhmeida, Kaltoom Al-Sakkaf

“…Background: The mammalian NAD-dependent deacetylase sirtuin-1 family (named also silent information regulator or SIRT family, where NAD stands for “nicotinamide adenine dinucleotide” (NAD)) appears to have a dual role in several human cancers by modulating cell proliferation and death. This study examines how SIRT1 protein levels correlate with clinicopathological characteristics and survival outcomes in patients with breast cancer. …”
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Trends and ethnic disparity in endometrial cancer mortality in South Africa (1999-2018): A population-based Age-period-cohort and Join point regression analyses. by Gbenga Olorunfemi, Elena Libhaber, Oliver Chukwujekwu Ezechi, Eustasius Musenge

“…The ASMR of endometrial cancer doubled from 0.76 deaths per 100,000 women in 1999 to 1.5 deaths per 100,000 women in 2018, with an average annual rise of 3.6% per annum. …”
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Free Fatty Acids in CSF and Neurological Clinical Scores: Prognostic Value for Stroke Severity in ICU by Sayed Gaber, Sherine Ibrahim ElGazzar, Mahmoud Qenawi, Nora Ismail Mohamed Abbas

“…Accumulation of FFA can lead to liberation of inflammatory byproducts that contribute to neuronal death. Increased risk of systemic thromboembolism was seen in animal models after FFA infusion possibly through activation of factor XII by stearic acids. …”
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Transcriptomic, histological and biochemical analyses of Macrobrachium nipponense response to acute heat stress by Xiao Wu, Yaoran Fan, Jianbin Feng, Keyi Ma, Jiale Li

“…Temperature changes could cause damages or even death. The oriental river prawn, Macrobrachium nipponense, is widely distributed in East Asian countries, and has been an important economical aquaculture species in China since 1990s. …”
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Metrics for Evaluating Telemedicine in Randomized Controlled Trials: Scoping Review by Yuka Sugawara, Yosuke Hirakawa, Masao Iwagami, Ryota Inokuchi, Rie Wakimizu, Masaomi Nangaku

“…The commonly used metrics that can be used across medical specialties were divided into the following 3 categories: (1) patient-centeredness (67/79, 85%), including patient satisfaction, workload, and quality of life; (2) patient outcomes (57/79, 72%), including general clinical parameters such as death, admission, and adverse events; and (3) cost-effectiveness (40/79, 51%), including cost assessment and quality-adjusted life year. …”
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E3 ubiquitin ligase SYVN1 as a promising therapeutic target for diverse human diseases by Li Zhu, Yong-Ping Liu, Yuan-Wang, Bo-Xuan Sun, Yu-Ting Huang, Ji-Kai Zhao, Jian-Feng Liu, Li-Ming Yu, Hui-Shan Wang

“…SYVN1, an E3 ubiquitin ligase, is characterized by its significant functions in regulating various biological processes, including molecular mechanisms related to gene expression, signaling pathways, and cell death, among others. Consequently, SYVN1 plays a crucial role in both normal human physiology and the pathogenesis of various diseases, such as oncogenesis, cardiovascular disorders, immune regulation, skeletal anomalies, and neurological diseases. …”
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Performance Evaluation of Large Language Models in Cervical Cancer Management Based on a Standardized Questionnaire: Comparative Study by Warisijiang Kuerbanjiang, Shengzhe Peng, Yiershatijiang Jiamaliding, Yuexiong Yi

“… BackgroundCervical cancer remains the fourth leading cause of death among women globally, with a particularly severe burden in low-resource settings. …”
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Retinal Protection of New Nutraceutical Formulation by Luca Rosario La Rosa, Veronica Pepe, Francesca Lazzara, Giovanni Luca Romano, Federica Conti, Erika Giuffrida, Claudio Bucolo, Santa Viola, Giuseppe De Pasquale, Maria Cristina Curatolo, Cristina Zappulla

“…Finally, Epicolin treatment on DBA/2J mice protected the RGCs from loss of function, as demonstrated by PERG analysis, and attenuated their death by enhancing brain-derived neurotrophic factor (<i>BDNF</i>) and reducing interleukin-1 beta (<i>IL-1β</i>) and tumor necrosis factor-alpha (<i>TNF-α</i>) expression. …”
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Clinical Implications of Bifurcation Angles in Left Main Bifurcation Intervention Using a Two-Stent Technique by You-Jeong Ki, Ji Hyun Jung, Jung-Kyu Han, Sukkeun Hong, Jang Hyun Cho, Hyeon-Cheol Gwon, Sung Yun Lee, Jay Young Rhew, Jei Keon Chae, In-Ho Chae, Han-Mo Yang, Kyung Woo Park, Hyun-Jae Kang, Bon-Kwon Koo, Hyo-Soo Kim

“…The primary outcome was target lesion failure (TLF), a composite of cardiac death, myocardial infarction, and target lesion revascularization (TLR). …”
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Hubungan Tindakan Pemberantasan Sarang Nyamuk dengan Keberadaan Larva Vektor DBD di Kelurahan Lubuk Buaya by Ayu Azlina, Adrial ., Eliza Anas Anas

“…</p><p><strong>Kata kunci</strong><strong>:</strong> PSN, larva, vektor DBD</p><p> </p><p><strong><em>Abstract</em></strong></p><p><em>Kelurahan Lubuk Buaya is a </em><em>Dengue Hemorhagic Fever </em><em>(</em><em>DHF) endemic area with the highest death case in 2012. The spreading of DHF influenced by environmental factor and practice of mosquito breading place eradication. …”
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Long-term results of antiviral therapy in patients with chronic hepatitis C with sustained virologic response by T. M. Ignatova, T. N. Lopatkina, V. P. Chulanov, Ye. V. Gaydasheva, S. N. Batskikh, G. V. Mikhaylovskaya, D. T. Abdurakhmanov, S. Yu. Karpov, Ye. N. Nikulkina, O. A. Chernova

“…There were no cases of decompensation of LC, hepatocellular carcinoma and death due to liver disease.Conclusion. At patients who have achieved SVO as a result of AVT, late relapses of HCV-infection are rare and in the majority no disease progression was found. …”
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Clinical burden of obstructive hypertrophic cardiomyopathy in France by Philippe Charron, Carla Zema, François-Emery Cotté, Eléonore Herquelot, Taryn Krause, Florent Daydé, Jean-Noël Trochu

“…The incidence of cardiovascular-related hospitalization was high (35,436 hospitalizations; 117,229 per 100,000 patient-years) and this risk increased with NYHA class (from 81,247 per 100,000 patient-years for NYHA class I/II patients to 140,790 per 100,000 patient-years for NYHA class III/IV patients, p &lt; 0.0001).ConclusionsPatients with obstructive HCM are at high risk of death and cardiovascular outcomes, especially those in higher NYHA classes. …”
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Tissue Doppler echocardiography predicts long-term cardiovascular mortality: the Anglo-Scandinavian Cardiac Outcomes Trial (ASCOT) legacy 20-year follow-up study by Simon Thom, Alice Stanton, Jamil Mayet, Amit Kaura, Darrel Francis, Anoop SV Shah, Andrew Sharp, Alun D Hughes, Neil R Poulter, Anenta Ratneswaren, Tong Wu, Somayeh Rostamian, Devan Wasan, PS Sever

“…Cardiovascular mortality was defined as death from coronary heart disease, stroke and other cardiovascular aetiology such as heart failure or peripheral vascular disease. …”
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The endoplasmic reticulum degradation-enhancing α-mannosidase-like protein 3 attenuates the unfolded protein response and has pro-survival and pro-viral roles in hepatoma cells and... by Alina-Veronica Ghionescu, Mihaela Uta, Andrei Sorop, Catalin Lazar, Petruta R. Flintoaca-Alexandru, Gabriela Chiritoiu, Livia Sima, Stefana-Maria Petrescu, Simona Olimpia Dima, Norica Branza-Nichita

“…Conversely, cell depletion of EDEM3 resulted in significant ER stress inducing pro-apoptotic mechanisms and cell death. Conclusions We provide evidence of major implications of the ERAD pathway in HBV infection and HCC development and progression. …”
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Diversity in mitotic DNA repair efficiencies between commercial inbred maize lines and native Central American purple landraces by Carlos Víquez-Zamora, Sergio Castro-Pacheco, María Viñas, Pablo Bolaños-Villegas

“…Abstract Background Homologous recombination allows plants to repair double strand breaks in DNA, which if unrepaired may lead to cell death. In this project, we determined the relative DNA repair efficiency of the US inbred lines B73 and Mo17 and Central American purple landraces from Guatemala and Costa Rica with the purpose to uncover genetic differences that may allow for the breeding of new lines better adapted to tolerate DNA damage caused by environmental factors. …”
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Antiviral Activity and Underlying Mechanism of <i>Moslae herba</i> Aqueous Extract for Treating SARS-CoV-2 by Yan Feng, Qiong Ge, Jian Gao, Zhuoying Wu, Yunyi Zhang, Haiyan Mao, Beibei Wu, Changping Xu

“…AEMH exerted anti-SARS-CoV-2 effects by inhibiting viral replication and reducing cell death caused by infection (IC₅₀ is 170 μg/mL for omicron strain). …”
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Modulation of Innate Immunity by G-CSF and Inflammatory Response by LBPK95A Improves the Outcome of Sepsis in a Rat Model by Haoshu Fang, Chuanfeng Hua, Stefanie Weiss, Anding Liu, Wenhui Cheng, Ralf Claus, Jürgen Rödel, Olaf Dirsch, Uta Dahmen

“…Sepsis is the primary cause of death from infection. We wanted to improve the outcome of sepsis by stimulating innate immunity in combination with modulating the severity of inflammatory responses in rats. …”
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Multimorbidity is associated with risk of incident venous thromboembolism – A nationwide proof-of-concept study by Jonatan Ahrén, MirNabi Pirouzifard, Björn Holmquist, Jan Sundquist, Kristina Sundquist, Bengt Zöller

“…A hazard ratio (HR) with 95 % confidence interval (CI) for VTE was calculated and adjusted for sex, education and year of birth. Death and emigration were treated as competing events. …”
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Six MicroRNA Prognostic Models for Overall Survival of Lung Adenocarcinoma by Juan Li, Xuyu Gu, Chanchan Gao, Jun Zhang

“…Finally, after sorting the risk scores calculated from low to high using the prognostic model, the patients with higher scores had shorter survival time and higher frequency of death, and there were significant differences in the immersion levels of 21 immune cells in the high- and low-risk groups. ceRNA network analysis found that TM9SF3 was regulated by miR-195-3p and was highly expressed in the tissues of LUAD patients, and the prognosis of the patients was poor. …”
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