Infiltration of CD8+ cytotoxic T-cells and expression of PD-1 and PD-L1 in ovarian clear cell carcinoma by Mengdi Fu, Huimei Zhou, Jiaxin Yang, Dongyan Cao, Zhen Yuan

“…Assessing the expression of programmed cell death ligand 1 (PD-L1), PD-1, and CD8+T cell infiltration in OCCC is crucial, as their correlation with patient survival may provide valuable prognostic insights. …”
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Effect of Malaria and Schistosoma mansoni Coinfection on Selected Biochemical Profiles among Patients Attending Selected Health Institutions at Dembiya, Northwest Ethiopia by Wagaw Abebe, Wossenseged Lemma, Yalewayker Tegegne, Amare Mekuanint, Abebe Yenesew, Adane Derso

“…As a result, biochemical profile tests should be utilized to monitor and manage coinfection-related problems, as well as to reduce coinfection-related morbidity and death.…”
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Risk Estimation of Severe Primary Graft Dysfunction in Heart Transplant Recipients Using a Smartphone by Souhila Ait-Tigrine, Roger Hullin, Elsa Hoti, Matthias Kirsch, Piergiorgio Tozzi

“…Methods: Severe PGD was defined as the need for mechanical circulatory support and/or death from an unknown etiology within the first 24 hours following HTx. …”
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Global, regional, and national burdens of leukemia from 1990 to 2019: A systematic analysis of the global burden of disease in 2019 based on the APC model by Xiang Qu, Anjie Zheng, Jie Yang, Jinru Zhang, Hongmei Qiao, Fan Jiang, Jie Zhao, Chunping Wang, Peng Ning

“…Abstract Background Leukemia is the tenth most common cause of cancer death worldwide and one of the most important causes of disability. …”
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Clinicopathological Features of 166 Cases of Invasive Ductal Breast Carcinoma and Effect of Primary Tumor Location on Prognosis after Modified Radical Mastectomy by Shiman Chen, Liang Yang, Yaqiong Li

“…As of 31 May 2021, there were 11 patients with recurrence and metastasis and 20 patients with death. The median survival time in the outer upper quadrant group was 80 months, which was higher than that in the outer lower quadrant group by 72 months, the median survival time in the central region group by 71 months, the median survival time in the inner upper quadrant group by 67 months, and the median survival time in the inner lower quadrant group by 61 months. …”
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Addition of PARP1-inhibition enhances chemoradiotherapy and thermoradiotherapy when treating cervical cancer in an in vivo mouse model by Marloes IJff, Xionge Mei, Enzo M. Scutigliani, Hans M. Rodermond, Gregor G. W. van Bochove, Przemek M. Krawczyk, Nicolaas A. P. Franken, Lukas J. A. Stalpers, Johannes Crezee, Arlene L. Oei

“…Five cycles of treatment were applied with the following doses per cycle: irradiation 3 Gy, hyperthermia 1 h at 42 °C, cisplatin at 2 mg/kg, and twice PARP1-i at 50 mg/kg.Results: Quadruple treatment, combining radiotherapy, hyperthermia, cisplatin and PARP1-i, was very effective but also lead to severe side effects causing severe weight loss and death. In contrast, thermoradiotherapy or chemoradiotherapy with addition of PARP1-i, were effective without serious side effects.Conclusion: The triple combinations are promising options for potentially more effective treatment of locally advanced cervical cancer without more toxicity.…”
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Potential effects of induced focal ischemia in the motor cortex of rats undergoing experimental periodontitis by Victória dos Santos Chemelo, Marco Aurelio M. Freire, Leonardo Oliveira Bittencourt, Deborah Ribeiro Frazão, Deiweson Souza-Monteiro, Sabrina C. Cartagenes, Walace Gomes-Leal, Cristiane do Socorro Ferraz Maia, Gabriel S. Rocha, Daniel Falcao, Rafael Rodrigues Lima

“…Currently, stroke stands as the second leading cause of death worldwide and the third leading cause when considering both mortality and disability together. …”
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Peroxiredoxin 6 Attenuates Alloxan-Induced Type 1 Diabetes Mellitus in Mice and Cytokine-Induced Cytotoxicity in RIN-m5F Beta Cells by Elena G. Novoselova, Olga V. Glushkova, Sergey M. Lunin, Maxim O. Khrenov, Svetlana B. Parfenyuk, Tatyana V. Novoselova, Mars G. Sharapov, Vladimir I. Novoselov, Evgeny E. Fesenko

“…In addition, PRDX6 protected rat insulinoma RIN-m5F β cells, cultured with TNF-α and IL-1β, against the cytokine-induced cytotoxicity and reduced the apoptotic cell death and production of ROS. Signal transduction studies showed that PRDX6 prevented the activation of NF-κB and c-Jun N-terminal kinase signaling cascades in RIN-m5F β cells cultured with cytokines. …”
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Prognostic Factors for COVID-19 Hospitalized Patients with Preexisting Type 2 Diabetes by Yuanyuan Fu, Ling Hu, Hong-Wei Ren, Yi Zuo, Shaoqiu Chen, Qiu-Shi Zhang, Chen Shao, Yao Ma, Lin Wu, Jun-Jie Hao, Chuan-Zhen Wang, Zhanwei Wang, Richard Yanagihara, Youping Deng

“…Type 2 diabetes (T2D) as a worldwide chronic disease combined with the COVID-19 pandemic prompts the need for improving the management of hospitalized COVID-19 patients with preexisting T2D to reduce complications and the risk of death. This study aimed to identify clinical factors associated with COVID-19 outcomes specifically targeted at T2D patients and build an individualized risk prediction nomogram for risk stratification and early clinical intervention to reduce mortality. …”
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Association of Side-Branch Treatment and Patient Factors in Left Anterior Descending Artery True Bifurcation Lesions: Analysis from the GRAND-DES Pooled Registry by Gyu Chul Oh, Kyung Woo Park, Jeehoon Kang, Jung-Kyu Han, Han-Mo Yang, Hyun-Jae Kang, Bon Kwon Koo, Hyo-Soo Kim

“…Target lesion failure (TLF), a composite of cardiac death, target vessel myocardial infarction, and target lesion revascularization, was assessed at 3 years. …”
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Cardiac Tamponade as an Initial Manifestation of Cervical Cancer by Yuridia Evangelina Rodríguez-Rosales, Carlos Eduardo Salazar-Mejía, Blanca Angélica Soto-Martínez, David Hernández-Barajas, Oscar Vidal-Gutiérrez, Gabriela Sofia Gómez-Macías

“…Cervical cancer is the second most common malignancy worldwide in women and the third most common cause of cancer death in developing countries. This type of cancer spreads mainly to the lung, the bone, and the brain; however, the pericardium is an unusual site of invasion, which is associated with a poor prognosis. …”
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Pancreatic cancer mortality in South Africa: A case-control study by M L Nhleko, I Edoka, E Musenge

“…There are variations in the numbers of pancreatic cancer deaths reported annually in South Africa (SA). Since pancreatic cancer deaths occurred in SA from 1997 to 2016, the number of cases has hugely increased, and reached 23 581 in both sexes. …”
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Mapping Drug-Resistant Tuberculosis Treatment Outcomes in Hunan Province, China by Temesgen Yihunie Akalu, Archie C. A. Clements, Zuhui Xu, Liqiong Bai, Kefyalew Addis Alene

“…An overall upward trend in poor DR-TB treatment outcomes was observed, peaking at 14.75% in 2018. Deaths and treatment failures fluctuated over the years, with a notable increase in deaths from 2016 to 2018, while the proportion of patients lost to follow-up significantly declined from 2014 to 2018. …”
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Association of Serum Gamma-Glutamyltransferase with In-hospital Heart Failure in Patients with ST-segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary I... by An-Cheng Hou, Jian-Tong Hou, Wei-Ning Zhou, Yan-Jin Wei, Zhi-Hong Ou, Cun-Fei Liu

“…Moreover, the incidence of HF significantly increased in-hospital death risk (OR, 7.75; 95% CI, 1.87–32.12; p = 0.005). …”
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Association of vascular endothelial growth factor B (VEGFВ) gene polymorphisms with intracranial aneurysms by R. I. Sultanova, R. I. Khusainova, E. R. Lebedeva, M. A. Yankina, D. V. Gilev, E. K. Khusnutdinova

“…The average worldwide prevalence of this disease is about 2–5 %, with 50 % of them ending in death or neurological disorders of varying severity, with a high probability of recurrence of hemorrhage during the frst half of the year after rupture. …”
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The Hydroalcoholic Extract Obtained from Mentha piperita L. Leaves Attenuates Oxidative Stress and Improves Survival in Lipopolysaccharide-Treated Macrophages by Mariana Oliveira Arruda, Saulo José Figueiredo Mendes, Simone Aparecida Teixeira, Ludmilla Santos Silva de Mesquita, Maria Nilce de Sousa Ribeiro, Stanley de Sousa Lima Galvão, Marcelo Nicolás Muscará, Elizabeth Soares Fernandes, Valério Monteiro-Neto

“…LPS-induced macrophage death was reversed by incubation with LHAE (1–30 μg/ml). …”
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β-Nicotinamide Mononucleotide Reduces Oxidative Stress and Improves Steroidogenesis in Granulosa Cells Associated with Sheep Prolificacy via Activating AMPK Pathway by Yu Cai, Hua Yang, Hui Xu, Shanglai Li, Bingru Zhao, Zhibo Wang, Xiaolei Yao, Feng Wang, Yanli Zhang

“…Oxidative stress is a significant factor in the death of granulosa cells (GCs), leading to follicular atresia and consequently limiting the number of dominant follicles that can mature and ovulate within each follicular wave. …”
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Improving diagnostics and surveillance of malaria among displaced people in Africa by Toufik Abdul-Rahman, Oyinbolaji Akinwande Ajetunmobi, Gafar Babatunde Bamigbade, Innocent Ayesiga, Muhammad Hamza Shah, Tolulope Sharon Rumide, Abdurahman Babatunde Adesina, Ganiyat Adekemi Adeshina, Oluwabusola Elizabeth Oni, Bet-ini Nsikak Christian, Abdullahi Tunde Aborode, Andrew Awuah Wireko, Hala Ibrahim Thaalibi, Iman Mustafa Abdalla, Sewar Basheer Banimusa, Justice Ndubuisi Jonathan, Isreal Ayobami Onifade, Md Ariful Haque

“…This leads to greater rates of illness and death, especially among young people. Insufficient monitoring worsens the condition, leading to delayed identification and medical intervention, and contributing to a higher incidence of severe malaria and deaths. …”
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Familial Hypercholesterolemia: Genetics, Symptoms, Diagnosis and Treatment - A Literature Overview by Maciej Rutkiewicz, Sabina Przygodzka, Katarzyna Gadżała, Karolina Garbino, Katarzyna Brudniak, Antoni Szuścik, Magdalena Czyczerska

“…People who are affected by mutation have around thirteen times higher risk of coronary artery disease (CAD) and, in order to that, premature death. Identifying sickness includes a physical examination, when we can observe xanthomas, corneal arcus, or xanthomata, and scales that focus on the patient's as well as his family's past. …”
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Ambient PM2.5 Temporal Variation and Source Apportionment in Mbarara, Uganda by Silver Onyango, Crystal M. North, Hatem A. Ellaithy, Paul Tumwesigye, Choong-Min Kang, Vasileios Matthaios, Martin Mukama, Nuriat Nambogo, J. Mikhail Wolfson, Stephen Ferguson, Stephen Asiimwe, Lynn Atuyambe, Data Santorino, David C. Christiani, Petros Koutrakis

“…Abstract Air pollution is the leading environmental cause of death globally, and most mortality occurs in resource-limited settings such as sub-Saharan Africa. …”
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