Long-term copper exposure induced pyroptosis and inflammation of rat spleen through intestinal-splenic axis by Jinwen Quan, Xiaoyue Chang, Siying Liu, Ting He, Gaolong Zhong, Zhonghua Liu, Wenlan Yu

“…Multiple studies have shown that excessive intake of copper can affect the immune function of animals and lead to disease or death. The intestine-spleen axis, which is the interaction between the spleen, intestines and gut microbiota, is closely linked to immune function in the body. …”
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Combined anti-leukemic effect of gilteritinib and GSK-J4 in FLT3-ITD+ acute myeloid leukemia by Qi Zhou, Yongyu Guan, Pingping Zhao, Huiyuan Chu, Yaming Xi

“…In addition, gilteritinib or GSK-J4 monotherapy increases reactive oxygen species (ROS) production, and the combination has a synergistic effect, accelerating leukemic cell death. Our study provides proof that the combined therapy of gilteritinib and GSK-J4 has a synergistic antileukemic effect on FLT3-ITD+ AML.…”
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Impact of Coronary Artery Disease and Diabetes Mellitus on the Long-Term Follow-Up in Patients after Retrograde Recanalization of the Femoropopliteal Arterial Region by Joanna Wojtasik-Bakalarz, Zoltan Ruzsa, Tomasz Rakowski, Andreas Nyerges, Krzysztof Bartuś, Agata Stanek, Dariusz Dudek, Andrzej Surdacki, Paweł Kleczyński, Stanisław Bartuś

“…However, there was a statistically significant difference in all-cause mortality: in the DM group, there were 6 deaths (12%) (P value = 0.038). To conclude, patients after retrograde recanalization, with coexisting CTO and DM, are at higher risk of death in long-term follow-up.…”
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Breathing time: a longue-durée multidisciplinary study of respiratory illnesses and airborne diseases in Switzerland (16th–21st century CE) by Tobias Hofstetter, Aude Fauvel, Silke Grabherr, Negahnaz Moghaddam

“…Indeed, this data compilation effort enabled to reconstruct crude birth and death rates for Switzerland from 1580 CE to the present day and to present the latter in graphical form. …”
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The effect of waiting time on ovarian cancer survival in oncology centres, Addis Ababa, Ethiopia: a retrospective cohort study by Abrham Tesfaye Habteyes, Jembere Tesfaye Deressa, Roza Teshome Kassa

“…The main outcome of interest for this study was death due to ovarian cancer. The authors compared the ovarian cancer patients with waiting times ≤ 10 weeks and waiting times > 10 weeks for overall survival rate using the log rank test. …”
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Virological Breakthrough: A Risk Factor for Loss to Followup in a Large Community-Based Cohort on Antiretroviral Therapy by Catherine Orrell, Richard Kaplan, Robin Wood, Linda-Gail Bekker

“…Their outcome (lost-to follow-up, death, in care on first-line therapy or in care on second-line therapy) was determined as of the 13th April 2010. …”
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Disability weights for environmental noise-related health states: results of a disability weights measurement study in Europe by Juanita A Haagsma, Periklis Charalampous, Carolien C H M Maas

“…We analysed paired comparison responses with probit regression analysis, and regression results were anchored on the disability weight scale between 0 (equivalent to full health) and 1 (equivalent to death).Results In total, 4056 respondents participated in the study. …”
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Increasing Donor Endothelial Cell Pool by Culturing Cells from Discarded Pieces of Human Donor Corneas for Regenerative Treatments by Mohit Parekh, Vito Romano, Alessandro Ruzza, Stephen B. Kaye, Diego Ponzin, Sajjad Ahmad, Stefano Ferrari

“…Donor corneas (n = 19) with a mean age of 72 years, male : female ratio of 15 : 4, and death-to-preservation time of 10 hours were assessed for endothelial cell density (ECD) and number of dead cells before isolation. …”
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Maternal Third Delay and Associated Factors among Women Admitted for Emergency Obstetric Care in Public Hospitals in Sidama Regional State, Ethiopia by Esuyawkal Mislu, Ali Seid, Nigus Bililign, Terefe Woyo, Dubale Dulla

“…Timing to get obstetric care is critical in preventing maternal death and disability. Maternal third delay, the delay in receiving care after reaching health facilities, involves factors related to organization, quality of care, patient referral, and availability of staff and equipment. …”
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Multimodal treatment with Neoadjuvant chemotherapy for eyelid and periocular sebaceous gland carcinoma: Long-term outcomes by Vijitha S. Vempuluru, Anshika Luthra, Vijay Anand Reddy Palkonda, Swathi Kaliki

“…No events of tumor recurrence, metastasis, or death were noted. Conclusions and importance: The long-term outcomes in patients with eyelid and periocular SGC who achieve tumor control with platinum-based NACT seem promising.…”
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Expansion of Circulating T Follicular Helper Cells in Children with Acute Henoch-Schönlein Purpura by Jue Xie, Yan Liu, Lei Wang, Guoxiang Ruan, Huiming Yuan, Hong Fang, Jianyong Wu, Dawei Cui

“…In this study, the frequency of circulating CXCR5+CD4+TFH cells with inducible costimulator (ICOS) expression in the children with acute HSP was significantly higher than that in healthy controls (HCs) but not CXCR5+CD4+TFH cells with programmed death-1 (PD-1) expression. Moreover, serum levels of IL-21 and IL-6 cytokines, IgA, and C3 in HSP children were also significantly higher than those in HCs. …”
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Paramètres socio-spatiaux, réseaux sociaux et budget d'activité chez un groupe de mâles chimpanzés : stabilité dans le temps et effet de la réduction spatiale by Nerea Amezcua‑Valmala, Daniel Vázquez, Álvaro Ballesteros, Marcos Bella, Catarina Casanova, Fernando Colmenares

“…Across time, changes in maturity and the death of a member did not affect proximity patterns in this colony. …”
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Combination of potassium oxonate with anti-PD-1 for the treatment of colorectal cancer by Yuanyuan Wang, Chenxi Hu, Tianpeng Du, Jiawen Li, Kaiyuan Hui, Xiaodong Jiang

“…In our previous study, potassium oxonate (PO), a uricase inhibitor commonly used for elevating uric acid in mice, unexpectedly showed remarkable inhibition of tumor growth when combined with anti-programmed death-1 (PD-1). Further research demonstrated that the combination of potassium oxonate and anti-PD-1 could reprogram the immune microenvironment. …”
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Navigating the Risk Landscape in ST-Elevation Myocardial Infarction Patients Postpercutaneous Coronary Intervention: A Narrative Review by Utkarsh Gaur, Charuta Gadkari, Aditya Pundkar

“…The ST-Elevation Myocardial Infarction (STEMI) remains one of the major contributors to death and disability worldwide. The primary Percutaneous Coronary Intervention (pPCI) has gained wide adoption as the preferred reperfusion strategy over time. …”
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PARP inhibitors as therapy for small cell lung carcinoma: A systematic review and meta-analysis of clinical trials by Samuel Pratama, Lowilius Wiyono, Martien Silviandy Setiawan, Brigitta Cindy Lauren

“…Poly ADP-Ribose Polymerase inhibitors (PARPi) are novel anti-cancer agents that induce DNA damages and cause cell death in tumor cells with impaired DNA repair, known as the synthetic lethality concept. …”
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Equine Herpesvirus-1 Induced Respiratory Disease in Dezhou Donkey Foals: Case Study from China, 2024 by Lian Ruan, Liangliang Li, Rongze Yang, Anrong You, Muhammad Zahoor Khan, Yue Yu, Li Chen, Yubao Li, Guiqin Liu, Changfa Wang, Tongtong Wang

“…Overall, our study revealed that EHV-1 can cause respiratory distress as well as death in donkeys. The study underscores the emerging threat of EHV-1 in donkeys and highlights the need for veterinarians and breeders to give proper attention to the potential threat of EHV-1 outbreaks.…”
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J Point and ST Elevation Resembling Brugada: A Marker of Mortality in Methanol Toxicity by Mohammad Hossein Nikoo, Alireza Estedal, Kiana Khatami, Maryam Pakfetrat, Alireza Arjangzadeh, Shahrokh Sadeghi Boogar, Sina Danesh, Seyed Taghi Heydari

“…This clinical entity, among asymptomatic individuals with no family history of sudden cardiac death, would be reported in some severely ill patients before ventricular fibrillation. …”
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Chinese expert consensus on vaginal self-sampling with high-risk human papillomavirus testing for cervical cancer screening by Linhong Wang, Yun Zhao, Beihua Kong, Ding Ma, Ruifang Wu, Hui Du, Xinfeng Qu, Lihui Wei, Long Sui, Mingzhu Li, Fanghui Zhao, Jingran Li

“…Cervical cancer is one of the most common cancers in women globally and remains the leading cause of cancer-related death among women in low- and middle-income countries. …”
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卒中防治科学传播发展现状与对策建议的研究进展 Research Progress on the Development Status and Countermeasures of Scientific Communication in Stroke Prevention and Treatment... by 张熙1，李杨1，张鹏骞2，3 (ZHANG Xi1, LI Yang1, ZHANG Pengqian2,3 )

“…Abstract: Stroke has become the first cause of death in our country, and it is one of the major diseases threatening our national health. …”
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Pancreatic Cancer: Molecular, Biochemical, Chemopreventive, and Therapeutic Aspects by Juan Iovanna, José Luis Neira

“…Pancreatic cancer (PC) is the fourth leading cause of cancer death, with a median survival of 6 months and a dismal 5-year survival rate of 35%, a figure which has remained relatively unchanged over the past 25 years. …”
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