HDAC1-3 inhibition triggers NEDD4-mediated CCR2 downregulation and attenuates immunosuppression in myeloid-derived suppressor cells by Zhiqi Xie, Jinjin Shao, Zeren Shen, Zhichao Ye, Yoshiaki Okada, Daisuke Okuzaki, Naoki Okada, Masashi Tachibana

“…Our results also suggest that HDAC1-3 inhibitors potentiate the antitumor effects of anti-programmed cell death protein 1 antibodies. ATAC-seq and RNA-seq analyses revealed 115 genes epigenetically upregulated by HDAC1-3 inhibitors, primarily linked to transcriptional regulation and ubiquitination. …”
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How does news coverage of suicide affect suicidal behaviour at a high-frequency location? A 7-year time series analysis by Lisa Marzano, Ruth Spence, Ian Kruger, Ian Marsh, Arianna Barbin

“…Introduction News reporting of suicide can have a significant influence on suicidal behaviour in the general population, especially following the death of a well-known individual. By comparison, the impact of reporting on suicides at well-known, ‘high-frequency’ locations is less well understood. …”
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Examining anti-inflammatory therapies in the prevention of cardiovascular events: protocol for a systematic review and network meta-analysis of randomised controlled trials by George A Wells, Kevin Emery Boczar, Sheojung Shin, Kathryn A Bezzina, Aishwarya Geejo, Alexander Liam Pearson, Saba Shahab, Christophe A Fehlmann, Sarah Visintini, Rob Beanlands

“…The primary outcomes will include major adverse cardiac events (MACE), and each individual component of MACE (myocardial infarction, stroke and cardiovascular death). Key secondary outcomes will include unstable angina, heart failure, all-cause mortality, cardiac arrest and revascularisation. …”
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lnc-MRGPRF-6:1 Promotes ox-LDL-Induced Macrophage Ferroptosis via Suppressing GPX4 by Zhihuan You, Xiaotian Ye, Meihua Jiang, Ning Gu, Caihong Liang

“…Ferroptosis, a newly discovered mode of cell death, emerges as a new target for atherosclerosis (AS). …”
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Feasibility of Endobronchial Ultrasound Guided Miniforceps Biopsy for PD‐L1 Expression and Quantitative Tissue Analysis by Max T. Wayne, Nathaniel G. Moulton, Cody Weimholt, Praveen Chenna, Alexander C. Chen

“…ABSTRACT Background Testing for targeting programmed death ligand 1 (PD‐L1) is standard of care for patients with newly diagnosed non‐small cell lung cancer (NSCLC) but is only approved for use with core biopsy specimens. …”
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The Impact of Smoking on Clinical Outcomes after Percutaneous Coronary Intervention in Women Compared to Men by Seyyed Saeed Mohammadi, Mohammad Javad Zibaeenezhad, Mehrab Sayadi, Soorena Khorshidi, Ehsan Hadiyan, Iman Razeghian-Jahromi

“…Participants were followed up seeking for major adverse cardiac events (MACE) including revascularization (PCI or coronary artery bypass grafting), myocardial infarction, and coronary death in three time intervals according to the time of index PCI (short term: up to 24 hours, mid-term: 24 hours to less than 6 months, and long term: more than 6 months). …”
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Massive Blood Transfusion for Trauma Score to Predict Massive Blood Transfusion in Trauma by Osaree Akaraborworn, Boonying Siribumrungwong, Burapat Sangthong, Komet Thongkhao

“…Massive blood loss is the most common cause of immediate death in trauma. A massive blood transfusion (MBT) score is a prediction tool to activate blood banks to prepare blood products. …”
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Survival status and determinants of under-five mortality in Sudan: Evidence from the Multiple Indicator Cluster Survey 2014 by Huda Mohamed Mukhtar AHMED, Hiba Abbas Omer ELKARIB, Mutaz Fikri Mohamed Osman DIGNA

“…Results: Our research showed that the risk of death among under-five children vary by states in Sudan. …”
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Anxiety disorder, depression and coronary artery disease: associations and modification by genetic susceptibility by Shinya Nakada, Joey Ward, Rona J. Strawbridge, Paul Welsh, Carlos Celis-Morales, Frederick K. Ho, Jill P. Pell

“…Incident CAD was ascertained through hospital admission and death certificate data after baseline. CAD polygenic risk score (PRSCAD) was obtained from CARDIoGRAMplus4 and categorised into low, intermediate, and high. …”
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Potentials of Presepsin as a Novel Sepsis Biomarker in Critically Ill Adults: Correlation Analysis with the Current Diagnostic Markers by Mai S. Sater, Nourah Almansour, Zainab Hasan Abdulla Malalla, Salim Fredericks, Muhalab E. Ali, Hayder A. Giha

“…<b>Background:</b> Sepsis is a major cause of patient death in intensive care units (ICUs). Rapid diagnosis of sepsis assists in optimizing treatments and improves outcomes. …”
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Real-world cost-effectiveness of nirmatrelvir-ritonavir as treatment for SARS-CoV-2 infection in the Belgian setting with omicron variant by Sophie Marbaix, Sophie Marbaix, Steven Simoens, Philippe Clevenbergh, Pascal Van Bleyenbergh, Keliane Liberman, Dimitri Dehenau

“…This antiviral has proven to significantly reduce the risk of hospitalization and death compared to no anti-SARS-CoV-2 treatment in this target population. …”
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With big data comes big responsibility: Strategies for utilizing aggregated, standardized, de‐identified electronic health record data for research by Veronica R. Olaker, Sarah Fry, Pauline Terebuh, Pamela B. Davis, Daniel J. Tisch, Rong Xu, Margaret G. Miller, Ian Dorney, Matvey B. Palchuk, David C. Kaelber

“…Their use, however, is fraught with hazards, including introduction or reinforcement of biases, clarity of disease definitions, protection of patient privacy, definitions of covariates or confounders, accuracy of medication usage compared with prescriptions, the need to introduce other data sources such as vaccination or death records and the ensuing potential for inaccuracy, duplicative records, and understanding and interpreting the outcomes of data queries. …”
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Multi-stage structure-based virtual screening approach combining 3D pharmacophore, docking and molecular dynamic simulation towards the identification of potential selective PARP-1... by Mahmoud A. El Hassab, Wagdy M. Eldehna, Ghaneya S. Hassan, Sahar M. Abou-Seri

“…Abstract Presently, humanity is confronted with a range of diseases that have high death rates, especially those linked to cancerous growths. …”
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Overview of Recent Advances in Canine Parvovirus Research: Current Status and Future Perspectives by Hongzhuan Zhou, Kaidi Cui, Xia Su, Huanhuan Zhang, Bing Xiao, Songping Li, Bing Yang

“…Despite widespread vaccination efforts, CPV remains one of the primary causes of acute gastroenteritis and death in young and juvenile dogs. Furthermore, the detection of CPV in swine populations has introduced additional challenges to its control. …”
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Plasma YKL-40 Elevation on Admission and Follow-Up Is Associated with Diastolic Dysfunction and Mortality in Patients with Acute Myocardial Infarction by Selcuk Pala, Munevver Sari, Gokhan Kahveci, Elnur Alizade, Ugur Arslantas, Abdulkadir Uslu

“…The levels of YKL-40 on admission were correlated with log BNP on admission (r=0.41,p=0.004), Tei index (r=0.44,p=0.002), left atrium volume index (r=0.32,p=0.02), and mitral septal annular E/e′ (r=0.44,p=0.003). Death was more frequently observed in patients with plasma YKL-40 above the median value than in those with plasma YKL-40 below the median value (p=0.001; OR = 13.6 (2.5–72.3)). …”
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Exploration of analgesic and anthelmintic activities of Artocarpus chaplasha ROXB. leaves supported by in silico molecular docking by S M Sohag, Sharmin Nur Toma, Md. Niaj Morshed, Md. Al Imran Imon, Md. Monirul Islam, Md. Ibnul Piash, Naznin Shahria, Imran Mahmud

“…In the anthelmintic tests, a 100 mg/mL concentration resulted in the lowest paralysis and death times of 14.03 and 18.03 mins, respectively. …”
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Pregnant Women's Knowledge and Attitudes About Pregnancy Care: The Effect of Using the Ebumil Android Application by Kartini, Farming, Fitriati Sabur

“…Lack of knowledge and attitude, makes pregnant women less aware of the emergence of symptoms of certain dangerous diseases, either indirectly causing maternal death. Objective: The purpose of the study was to determine the knowledge and attitudes of pregnant women after being given education through the Ebumil android application. …”
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The effects of co-designed physical activity interventions in older adults: A systematic review and meta-analysis. by Amanda Zacharuk, Alison Ferguson, Chelsea Komar, Nicole Bentley, Alexandra Dempsey, Michelle Louwagie, Sachi O'Hoski, Cassandra D'Amore, Marla Beauchamp

“…<h4>Background</h4>Physical activity (PA) declines with age despite the knowledge that physical inactivity is a leading cause of disease, death, and disability worldwide. To better tailor PA interventions to older adults, researchers are turning to the collaborative principles of co-design. …”
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Minimally Invasive Fetoscopic Resection of Life-Threatening Amniotic Band Constrictions in a Human Fetus at 22 + 2 Weeks of Gestation Complicated by Subtotal Chorioamniotic Separat... by Nadja Riehle, Oliver Nowak, Leila Messroghli, Samantha Wakerlin, Thomas Schaible, Thomas Kohl

“…If detected early enough, select cases may benefit from prenatal resection of the amniotic bands, thus preventing amputation and fetal death. Yet, especially in the presence of complete chorioamniotic separation, these procedures are rare, technically difficult, and not without significant risk. …”
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Tailoring lipid management interventions to reduce inequalities in cardiovascular disease risk management in primary care for deprived communities in Northern England: a mixed-meth... by Julia L Newton, Yu Fu, Sarah Sowden, Paula Whitty, Eugene YH Tang

“…Introduction Hyperlipidaemia contributes a significant proportion of modifiable cardiovascular disease (CVD) risk, which is a condition that disproportionally affects disadvantaged socioeconomic communities, with death rates in the most deprived areas being four times higher than those in the least deprived. …”
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