The genus Entomophthora: bringing the insect destroyers into the twenty-first century by Carolyn Elya, Henrik H. De Fine Licht

“…We briefly review the discovery of Entomophthora and provide a summary of the 21 recognized Entomophthora species, including their type hosts, methods of transmission (ejection of spores after or before host death), and for which molecular data are available. …”
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Genotoxic effects in island populations of Cartagena de Indias, Colombia due to environmental exposure to mercury and cadmium [version 3; peer review: 2 approved] by Doris Gómez-Camargo, Dacia Malambo-García, Eder Cano-Pérez

“…Moreover, the study group showed a higher incidence of DNA damage and cell death biomarkers (p < 0.05). Additionally, significant correlations were observed between total blood Hg levels and the frequencies of micronuclei, karyorrhexis, and karyolysis. …”
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Identification of Pseudoperonospora cubensis RxLR Effector Genes via Genome Sequencing by Rahel Dinsa Guta, Marc Semunyana, Saima Arif, Inyong Jeong, Sun Ha Kim, Jiyoung Min, Sang-Keun Oh

“…Furthermore, several effectors demonstrated the ability to suppress cell death induced by BAX and INF1. Subcellular localization analysis indicated that RxLR effectors exhibited fluorescence in the nucleus and plasma membrane of N. benthamiana cells, suggesting diverse roles in host-pathogen interactions. …”
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GLIM criteria for definition of malnutrition in peritoneal dialysis: a new aspect of nutritional assessment by Dao Wang, Jun Yin, Wen Liao, Xiaoran Feng, Fengping Zhang

“…The survival rate and hazard ratio (HR) of death between malnutrition and well-nourished were analyzed in all patients and various subgroups. …”
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Health Care Costs attributable to Hospital-diagnosed Back Pain: A Longitudinal Register-based Study of the Danish Population by Rikke Søgaard, Jan Sørensen

“…Data from other relevant health service use registries was appended along with data from the national cause of death registry in order to calculate cost rates per life year (2011 price year). …”
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A Novel Insight into Paraptosis-Related Classification and Signature in Lower-Grade Gliomas by Xi-Feng Qian, Jia-Hao Zhang, Yue-Xue Mai, Xin Yin, Yu-Bin Zheng, Zi-Yuan Yu, Guo-Dong Zhu, Xu-Guang Guo

“…Paraptosis is defined as a nonapoptotic form of programmed cell death, which is gradually focused on patients with gliomas to develop treatment options. …”
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Physicians’ moral distinctions between medical assistance in dying (MAiD) and withdrawing life-sustaining treatment in Canada: a qualitative descriptive study by Midori Matthew, Kieran Bonner, Andrew Stumpf

“…Theme 1 comprised of three sub-themes: (1.1) no moral difference between MAiD and WLT, (1.2) physician versus underlying medical condition as cause of death, and (1.3) relief of suffering. Conclusions In order to have practical utility for clinical practice, it is essential for bioethicists to engage in dialogue with patients and their medical providers pursuing MAiD or WLT. …”
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Synergistic potential of α-Phellandrene combined with conventional antifungal agents and its mechanism against antibiotic resistant Candida albicans by Riya Bhattacharya, Prashant Sharma, Debajyoti Bose, Manish Singh

“…Further, the synergistic potential was evaluated by employing a time kill assay and a checkerboard technique, respectively, which revealed after 16 h, the colony count of C. albicans cells ATCC90028 (2.56 ± 0.33) and MTCC277 (2.53 ± 0.33) dropped by a log10 when treated with a combination of α-Phellandrene and Fluconazole and α-Phellandrene and amphotericin B exhibited synergy against both C. albicans strains ATCC90028 and MTCC277 (2.42 ± 0.28 and 2.00 ± 0.21) log10 reduction in colony count, respectively, Additionally, 16–624-fold increase in the antifungal efficacy of clinical medicines, with total cell death occurring after 16 h. α-Phellandrene and antifungal drugs were tested in combination with the osmoprotectant test, ergosterol test and FESEM observations to determine their modes of action. …”
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Developing and Activated T Cell Survival Depends on Differential Signaling Pathways to Regulate Anti-Apoptotic Bcl-xL by Ruiqing Wang, Huimin Xie, Zhaofeng Huang, Weirong Shang, Zuoming Sun

“…However, the first round of rearrangement may fail, which triggers another round of α chain rearrangement until either successful positive selection or cell death occurs. Thus, the lifespan of double positive (CD4+CD8+; DP) thymocytes determines how many rounds of α chain rearrangement can be carried out and influences the likelihood of completing positive selection. …”
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Hydroxychloroquine Potentiates Apoptosis Induced by PPARα Antagonist in 786-O Clear Cell Renal Cell Carcinoma Cells Associated with Inhibiting Autophagy by Ruizhe Mao, Jian Shi, Xuyi Ma, Haiyan Xu

“…Autophagy, which can be induced by stress in eukaryotic cells, plays a complex role in the proliferation, survival, and death of tumor cells. In our study, we found that the expression of PPARα was low in highly differentiated ccRCC tissues and 786-O cell line but high in poorly differentiated ccRCC tissues. …”
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Damage control resuscitation: how it’s done and where we can improve. A view of the Brazilian reality according to trauma professionals by MARCELO AUGUSTO FONTENELLE RIBEIRO JUNIOR, LETICIA STEFANI PACHECO, JUAN CARLOS DUCHESNE, JOSE GUSTAVO PARREIRA, SHAHIN MOHSENI

“…ABSTRACT Introduction: Hemorrhage is the leading cause of preventable deaths in trauma patients, resulting in 1.5 million deaths annually worldwide. …”
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Results of a modified Delphi consensus on the optimal testing pathway for oesophago-gastric cancer care in the UK by Philippe Taniere, Manuel Rodriguez-Justo, Naureen Starling, Wasat Mansoor, Thomas Bird, Martin Eatock

“…Given the level of agreement and that the stopping criteria were met, it was decided not to undertake further Delphi rounds.Conclusion The recommendations support the use of a reflex testing approach for human epidermal growth factor receptor 2, programmed death ligand 1 and microsatellite instability high/mismatch repair deficiency in patients diagnosed with OG cancer who are suitable for treatment with targeted therapy.…”
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A Mathematical Model for the Growth Dynamics of Demand in the Fashion Industry within the Era of the COVID-19 Pandemic by John Awuah Addor, Anthony Joe Turkson, Douglas Yenwon Kparib

“…The fourth variant has just announced its appearance with its high death toll and impact on economic activities. The basic reproductive number R0, which measures the transmission potential of an infectious disease, is extremely important in the study of epidemiology. …”
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The role of pharmacists in mitigating medication errors in the perioperative setting: a systematic review by Lina Naseralallah, Somaya Koraysh, May Alasmar, Bodoor Aboujabal

“…Abstract Introduction Medication errors occur at any point of the medication management process and are a major cause of death and harm globally. The perioperative environment introduces challenges in identifying medication errors due to the frequent use of time-sensitive, high-alert medications in a dynamic and intricate setting. …”
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Tannic acid elicits differential gene regulation in prostate cancer apoptosis by Kandir Sinan, Karakurt Sevtap, Gökçek-Saraç Çiğdem, Karakurt Serdar

“…Cell proliferation, cytotoxicity, and effects of tannic acid on the cell death mechanism were evaluated. mRNA expression levels of 84 genes were explored in cells following tannic acid treatment. …”
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Loxoscelism: Cutaneous and Hematologic Manifestations by Ngan Nguyen, Manjari Pandey

“…Brown recluse spider (BRS) envenomation can lead to significant morbidity through severe local reaction and systemic illness including acute hemolytic anemia, rhabdomyolysis, disseminated intravascular coagulopathy (DIC), and even death. We aim to describe the clinical features and the roles of antibiotics and steroids in the treatment of loxoscelism. …”
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Using the ADAPT guidance to culturally adapt a brief intervention to reduce alcohol use among injury patients in Tanzania. by Catherine A Staton, Armand Zimmerman, Msafiri Pesambili, Ashley J Phillips, Anna Tupetz, Joao Vitor Perez de Souza, Judith Boshe, Michael H Pantalon, Monica Swahn, Blandina T Mmbaga, Joao Ricardo Nickenig Vissoci

“…Harmful alcohol use is a leading risk factor for injury-related death and disability in low- and middle-income countries (LMICs). …”
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Operative versus Nonoperative Treatment in Patients with Advanced Non-Small-Cell Lung Cancer: Recommended for Surgery by Hui Wang, Di Yang, Yan Lv, Jing Lin, Haibin Wang

“…The cumulative rates of death were compared between patients with and without recommended operations using the Kaplan−Meier curves. …”
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Effect of beetroot or beetroot plus vitamin C supplementation on cardiovascular function in patients with coronary artery disease: protocol for a double-blind, placebo-controlled,... by Hamed Tabesh, Mohsen Nematy, Leila Sadat Bahrami, Mohsen Mohebaty, Seyyed Mostafa Arabi, Reza Rezvani

“…Introduction Coronary artery disease (CAD), classified into the atherosclerosis category, is a prevalent cardiovascular disease worldwide that is associated with serious comorbidities and death. The purpose of this study was to evaluate the effect of beetroot/beetroot plus vitamin C on cardiovascular health status and function in patients with CAD.Method and analysis A randomised, placebo-controlled, double-blind clinical trial to recruit 90 patients with CAD at the cardiac outpatient clinic and Imam Reza Hospital, Mashhad, Iran. …”
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N-Alkyl-Substituted Isatins Enhance P2X7 Receptor-Induced Interleukin-1β Release from Murine Macrophages by Ronald Sluyter, Kara L. Vine

“…In contrast, 24-hour incubation with NAI and NAI-imine (in the absence of exogenous ATP) induced macrophage death in a concentration-dependent manner. In conclusion, this study demonstrates that N-alkyl-substituted isatins enhance P2X7 receptor-induced IL-1β release from murine macrophages. …”
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