Dose Effect Evaluation and Therapeutic Window of the Neuro-EPO Nasal Application for the Treatment of the Focal Ischemia Model in the Mongolian Gerbil by Iliana Sosa Teste, Yuneidys Mengana Tamos, Yamila Rodríguez Cruz, Adriana Muñoz Cernada, Janette Cruz Rodríguez, Nelvis Subirós Martínez, Rosa Maria Coro Antich, Alina González-Quevedo, Julio Cesar García Rodríguez

“…Cerebrovascular disease is the third leading cause of death and the leading cause of disability in Cuba and in several developed countries. …”
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Evaluation of GABAergic Transmission Modulation as a Novel Functional Target for Management of Multiple Sclerosis: Exploring Inhibitory Effect of GABA on Glutamate-Mediated Excitot... by Ankit A. Gilani, Ranjeet Prasad Dash, Mehul N. Jivrajani, Sandeep Kumar Thakur, Manish Nivsarkar

“…An excess release of glutamate leads to the activation of ionotropic and metabotropic receptors, thus resulting in accumulation of toxic cytoplasmic Ca2+ and cell death. However, it has been observed that gamma-aminobutyric acid-A (GABAA) receptors located in the nerve terminals activate presynaptic Ca2+/calmodulin-dependent signaling to inhibit depolarization-evoked Ca2+ influx and glutamate release from isolated nerve terminals, which suggest a potential implication of GABAA receptor in management of MS. …”
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The long-term effects of cardiometabolic risk factors on mortality and life expectancy: evidence from a health check-up cohort study by Ping-Chen Chung, Tsuey-Hwa Hu, Chih-Hua Chiao, Jing-Shiang Hwang, Ta-Chien Chan

“…Methods Using data from the MJ Health Check-up Database (2002–2017), linked with the National Health Insurance Research Database (2000–2017) and the Death Registry (2002–2019), this study employed Cox proportional hazards models to determine mortality risk associated with various cardiometabolic risk factors. …”
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Liver cirrhosis epidemiology in Chelyabinsk region in 2006-2015 by A. I. Dolgushina, Ye. R. Olevskaya, A. N. Tarasov, M. S. Kazakova, A. Yu. Markina

“…The basic direct cause of death in LC patients is hepatocellular failure, in 12.84±0.6% of the cases patients died of gastro-intestinal bleeding. …”
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Factors associated with successful treatment outcomes among tuberculosis patients in a district municipality of Vhembe, Limpopo by Busisiwe Mkhavele, Slindile Zondi, Lindiwe Cele, Mabina Mogale, Margeret Mbelle

“…Contributions: This study highlight the need for heightened advocacy for supervised TB treatment and increased effort to combat the death of patients while on TB treatment.…”
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Astragaloside IV inhibits atherosclerosis caused by ferritin autophagy in a lipid deposition environment by activating Nrf2 by Dandan Liu, Hewei Qin, Guanghua Liu, Yang Gao, Yu Guo

“…Meanwhile, when ML385 inhibits Nrf2, astragaloside IV can diminish the expression of divalent iron, suppress iron death-related factors (FTH1, FTL, FPN, ACSL4), and alleviate disorders in iron metabolism and the overproduction of ROS. …”
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Efficacy and safety of immunotherapy in locally advanced or metastatic pulmonary lymphoepithelioma-like carcinoma: a multicenter retrospective study by Xiongwen Yang, Yi Xiao, Yubin Zhou, Hao Hu, Huiyin Deng, Jian Huang, Maoli Liang, Zihao Yuan, Longyan Dong, Shaohong Huang

“…High baseline EBV-DNA levels (>2000 copies/mL) and low programmed death ligand 1 (PD-L1) expression (<50%) were associated with poorer outcomes. …”
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Emodin Ameliorates Intestinal Dysfunction by Maintaining Intestinal Barrier Integrity and Modulating the Microbiota in Septic Mice by Mina Zhang, Bo Lian, Rui Zhang, Yuhong Guo, Jingxia Zhao, Shasha He, Yunjing Bai, Ning Wang, Yan Lin, Xuerui Wang, Qingquan Liu, Xiaolong Xu

“…Sepsis-induced inflammatory response leads to intestinal damage and secondary bacterial translocation, causing systemic infections and eventually death. Emodin is a natural anthraquinone derivative in many plants with promising bioactivities. …”
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Carbon Monoxide Poisoning with Neurological, Ocular, and Myocardial Damage: A Case Report by Duc Nguyen, Sinh Nguyen, Anh Lam

“…CO has a high affinity with hemoglobin because it reduces oxygen transport causing tissue hypoxia, lactic acidosis, and cell death.Case report: A 32-year-old female patient entered Poison Control Center of Bach Mai Hospital, Ha Noi, Vietnam, because of decreased consciousness, loss of vision in the right eye. …”
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Association of immunoglobulin G N-glycosylation with carotid atherosclerotic plaque phenotypes and actual clinical cardiovascular events: a study protocol for a longitudinal prospe... by Gehendra Mahara, Hongxia Zhang, Cuihong Tian, Xuerui Tan

“…The primary outcome is the actual clinical CVD composite events, including non-fatal myocardial infarction, death due to coronary heart disease, and fatal or non-fatal stroke.Ethics and dissemination The Clinical Ethics Committee of the First Affiliated Hospital of Shantou University Medical College approved this study (number: B-2021-127). …”
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Image and Histologic Characterization of Intracranial Neoplasias by Martha Yudey Rodríguez Pino, Dianarelys Villafuerte Delgado, Thaimí Conde Cueto, Odalys Yanes Isray, Adelaida Martínez Godoy, Carlos Rafael Rivera Prieto

“…<strong>Background:</strong> In Cuba, as in all developed countries, cancer is the second cause of death and among it the different types of intracranial neoplasms present a morbidity of 2-3 %. …”
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Identifying Key Biomarkers Related to Immune Response in the Progression of Diabetic Kidney Disease: Mendelian Randomization Combined With Comprehensive Transcriptomics and Single-... by Hu M, Deng Y, Bai Y, Zhang J, Shen X, Shen L, Zhou L

“…Miao Hu, Yi Deng, Yujie Bai, Jiayan Zhang, Xiahong Shen, Lei Shen, Ling Zhou Department of Nephrology, The First Affiliated Hospital of Soochow University, Suzhou, People’s Republic of ChinaCorrespondence: Ling Zhou, Email zl66060@163.comBackground: Renal failure related death caused by diabetic kidney disease (DKD) is an inevitable outcome for most patients. …”
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Prenatal Diagnosis of Umbilical Cord Ulcer: A Report of Two Cases by Daisuke Katsura, Suzuko Moritani, Shunichiro Tsuji, Kaori Hayashi, Kazutaka Yamada, Shinsuke Tokoro, Kounosuke Suzuki, Fuminori Kimura, Takashi Murakami

“…Umbilical cord ulcer is related to fetal intestinal atresia or meconium; perforation of the ulcer causes fetal deterioration leading to fetal and neonatal death owing to fetal hemorrhage. However, to the best of our knowledge, a method to diagnose umbilical cord ulcer prenatally is not available. …”
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Canadian Thoracic Society Recommendations for Management of Chronic Obstructive Pulmonary Disease – 2003 by Denis E O’donnell, Shawn Aaron, Jean Bourbeau, Paul Hernandez, Darcy D Marciniuk, Meyer Balter, Gordon Ford, Andre Gervais, Roger Goldstein, Rick Hodder, Francois Maltais, Jeremy Road

“…Chronic obstructive pulmonary disease (COPD) is a common cause of disability and death in Canada. Moreover, morbidity and mortality from COPD continue to rise and the economic burden is enormous. …”
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Secondary Prevention Using Cholesterol-Lowering Medications in Patients with Prior Atherosclerotic Cardiovascular Disease Events: A Retrospective Cohort Analysis by Xue Han, Steven Fox, Michelle Chu, Jeff McCombs

“…**Background:** Secondary prevention with lipid-lowering medications in patients with atherosclerotic cardiovascular disease (ASCVD) is known to reduce the risk of clinical events and death. Current guidelines codify recommendations for implementing secondary prevention in appropriate patients. …”
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Type 2 Diabetes Mellitus Epidemiology of and its Complications by Julio Armando Sánchez Delgado, Nailé Edita Sánchez Lara

“…<strong>Background:</strong> the number of people with diabetes mellitus worldwide has quadrupled in the last three decades and is currently the ninth leading cause of death. <strong><br />Objective:</strong> to determine the epidemiology of type 2 diabetes mellitus. …”
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The Long Noncoding RNA Gm9866/Nuclear Factor-κB Axis Promotes Macrophage Polarization by Xiaomin Liao, Xianxian Ruan, Xiubing Chen, Biaolin Zheng, Xianbin Wu, Zhejun Deng, Zhe Yang, Feng Wang, Shanyu Qin, Haixing Jiang

“…Long noncoding RNAs (lncRNAs) play an important role in biological processes such as cell proliferation, death, and differentiation; however, how long noncoding RNAs affect the cellular functionality of macrophages remains to be studied. …”
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Causes of admissions and in-hospital mortality among patients admitted to critical care units in primary and secondary hospitals in Vietnam in 2018: a multicentre retrospective stu... by Vu Quoc Dat, Bui Thi Khanh Linh, Giang Bao Kim

“…Diseases of the respiratory system was the leading causes of death in term of number of deaths (21.8% or 367/1681 of all deaths). …”
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Risk assessment of look‒alike, sound‒alike (LASA) medication errors in an Italian hospital pharmacy: A model based on the ‘Failure Mode and Effect Analysis’ by Nestor Ciociano, Lucilla Grisi, Lucia Bagnasco, Maria Giovanna Elberti, Marcello Mazzarella

“…Introduction: Look alike/sound alike (LASA) drugs errors can take place in hospital wards, and they can place patients at risk for adverse events and death. This study was aimed to realize a risk assessment model for preventing LASA drugs distribution errors by the ‘S.Giovanni di Dio e Ruggi d’Aragona’ hospital pharmacy, in Salerno, Italy. …”
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Long-Term Follow-Up after Prostatectomy for Prostate Cancer and the Need for Active Monitoring by Gregory P. Swanson, Wencong Chen, Sean Trevathan, Michael Hermans

“…In patients with truly long-term follow-up after prostatectomy for prostate cancer, the risk of metastatic disease and cancer death is very low. Patients with the lower risk findings do not appear to benefit from routine follow-up after 10 years free of biochemical recurrence. …”
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