Mutation-Specific Phenotypes in hiPSC-Derived Cardiomyocytes Carrying Either Myosin-Binding Protein C Or α-Tropomyosin Mutation for Hypertrophic Cardiomyopathy by Marisa Ojala, Chandra Prajapati, Risto-Pekka Pölönen, Kristiina Rajala, Mari Pekkanen-Mattila, Jyrki Rasku, Kim Larsson, Katriina Aalto-Setälä

“…The clinical symptoms include arrhythmias, progressive heart failure, and even sudden cardiac death but the mutation carrier can also be totally asymptomatic. …”
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Identification of cuproptosis and ferroptosis-related subtypes and development of a prognostic signature in colon cancer. by Yinghao He, Fuqiang Liu, Qingshu Li, Zheng Jiang

“…In recent years, ferroptosis and cuproptosis, as two novel forms of cell death, have attracted widespread attention for their potential roles in the development and treatment of colon cancer. …”
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Protease-activated receptor 1 in the pathogenesis of cystic fibrosis by Sarath Ranganathan, Philip Sutton, Sophie Day, Poshmaal Dhar, Kristy Azzopardi, Muhammad A Saeed, Sohinee Sarkar, Jia-Xi Han

“…Background The most common cause of death in those with cystic fibrosis (CF) is respiratory failure due to bronchiectasis resulting from repeated cycles of respiratory infection and inflammation. …”
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Recent advances of nanovaccines on cancer theranostics by Xiaobing Yuan, Xiaobing Yuan, Xiaobing Yuan, Tianyou Xu, Mubashir Hussain, Bin Liu, Jianwei Zhu, Jianwei Zhu

“…Cancer is a leading cause of death worldwide, with an estimated 20 million new cancer cases and 9.7 million cancer deaths worldwide in 2022. …”
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Impact of Renal Replacement Therapy on Outcomes of Living Donor Liver Transplantation for Acute Liver Failure: A Cohort Study by Abu Bakar Hafeez Bhatti, Nauman ul Haq, Nayyer Mehmood, Danyal Hassan, Arsalan Ahmed, Wasim Tariq Malik, Haseeb Haider Zia, Mohammad Salih, Nusrat Yar Khan, Abid Ilyas, Nasir Ayub Khan

“…Despite the promising role of renal replacement therapy (RRT) in acute liver failure (ALF), high-risk patients need liver transplantation and remain at risk for death due to cerebral complications. The objective of this study was to report outcomes of living donor liver transplantation (LDLT) for ALF with perioperative RRT. …”
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Methods Used in Urban Search and Rescue in Disasters and Evaluation of Current Approaches by Gürkan Yılmaz, Sevda Demiröz Yıldırım

“…Disaster is an event that results in serious physical and death of large number of people, because of earthquake, tsunami, flood, landslide, volcano eruption, hurricane, hose, airplane accidents, train accidents, nuclear power plant accidents, explosions and terrorist attacks. …”
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A multi-tissue longitudinal proteomics study to evaluate the suitability of post-mortem samples for pathophysiological research by Christian M. Beusch, Ken Braesch-Andersen, Ulrika Felldin, Pierre Sabatier, Anna Widgren, Jonas Bergquist, Karl-Henrik Grinnemo, Sergey Rodin

“…Here, we have revisited published data and conducted a clinically relevant time-course experiment in mice, revealing organ-specific proteome regulation after death, with only a fraction of these changes linked to protein autolysis. …”
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Daratumumab for autoimmune diseases: a systematic review by Martin Krusche, Ina Kötter, Lennard Ostendorf, Nikolas Ruffer, Marie-Therese Holzer, Tobias B. Huber

“…Autoantibody depletion or reduction was stated in 52% of patients. Death occurred in three patients (3%). Adverse events were reported in 45% of patients including application-associated reaction (20%), infection (19%) and hypogammaglobulinaemia (33%).Conclusion Targeting CD38 via daratumumab is a new promising therapeutic option in therapy refractory autoimmune diseases. …”
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Antioxidant activity of Micractinium sp. (Chlorophyta) extracts against H2O2 induced oxidative stress in human breast adenocarcinoma cells by Onur Bulut, Işkın Engin Köse, Çağla Sönmez, Hüseyin Avni Öktem

“…Moreover, extracts from Micractinium sp. exhibited remarkable cytoprotective activity by effectively inhibiting hydrogen peroxide-induced oxidative stress and cell death in human breast adenocarcinoma (MCF-7) cells. …”
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Impact of COPD and asthma on in-hospital mortality and management of patients with heart failure in England and Wales: an observational analysis by Claudia Gulea, Rosita Zakeri, Jennifer K Quint, Constantinos Kallis

“…Objective To evaluate the association between having concomitant chronic obstructive pulmonary disease (COPD) or asthma, and in-patient mortality and post-discharge management among patients hospitalised for acute heart failure (HF).Setting Data were obtained from patients enrolled in the National Heart Failure Audit.Participants 217 329 patients hospitalised for HF in England–Wales between March 2012 and 2018.Outcomes In-hospital mortality, referrals to cardiology follow-up and prescriptions for HF medications were compared between patients with comorbid COPD (COPD-HF) or asthma (asthma-HF) versus HF-alone using mixed-effects logistic regression.Results Patients with COPD-HF were more likely to die during hospitalisation, and those with asthma-HF had a reduced likelihood of death, compared with patients who had HF-alone ((adjusted)ORadj, 95% CI: 1.10, 1.06 to 1.14 and ORadj, 95% CI: 0.84, 0.79 to 0.88). …”
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Proton pump inhibitors enhance chemosensitivity, promote apoptosis, and suppress migration of breast cancer cells by Ihraiz Worood G., Ahram Mamoun, Bardaweel Sanaa K.

“…The mechanism of cell death was assessed using annexin V-FITC/propidium iodide staining flow cytometry method. …”
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Sirolimus-Eluting Balloon for the Treatment of Coronary Lesions in Complex ACS Patients: The SELFIE Registry by Gianluca Caiazzo, Mario De Michele, Luca Golino, Vincenzo Manganiello, Luciano Fattore

“…At the 11 ± 7 months follow-up, major adverse cardiovascular events (MACEs) were 3 (4.8%). Cardiovascular death (CD) occurred in 1 (1.6%) patient and myocardial infarction (MI) in 2 patients (3.2%) as well as ischemia-driven target lesion revascularization (TLR). …”
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Predicting the Clinical Outcome of Triple-Negative Breast Cancer Based on the Gene Expression Characteristics of Necroptosis and Different Molecular Subtypes by Peng Luo, Zhaoqi Shi, Changshou He, Guojun Chen, Ji Feng, Linghua Zhu, Xiangyang Song

“…Nevertheless, studies that determine the impact of death on triple-negative breast cancer (TNBC) are scarce. …”
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Prospective Study of Antibiotic Prophylaxis for Prostate Biopsy Involving >1100 Men by Rustom P. Manecksha, Gregory J. Nason, Ivor M. Cullen, Jérôme P. Fennell, Elizabeth McEvoy, Ted McDermott, Robert J. Flynn, Ronald Grainger, John A. Thornhill

“…All patients were sensitive to Meropenem. There was 1 (0.2%) death with regimen 1. Commencing Ofloxacin 24 hours before TRUSgpb reduced the incidence of febrile episodes significantly. …”
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Recognition and Management of Postpartum Hemorrhage by Tasabih Ali EL Hassan Mohamed, Edwin Chandraharan, Yang Pan

“…PPH is a major contributor to maternal deaths worldwide, and it is estimated that a person dies because of PPH approximately every 5 minutes. …”
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Deficiency of Interleukin-1 Receptor Antagonist: A Case with Late Onset Severe Inflammatory Arthritis, Nail Psoriasis with Onychomycosis and Well Responsive to Adalimumab Therapy by Necil Kutukculer, Anne Puel, Sanem Eren Akarcan, Kunihiko Moriya, Neslihan Edeer Karaca, Melanie Migaud, Jean-Laurent Casanova, Guzide Aksu

“…The DIRA disease can lead to death from multiple organ failures and if recognized early, the treatment with replacement of the deficient protein with biologic agents induces rapid and complete remission. …”
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Chemical Composition and In Vitro Evaluation of the Mosquito (Anopheles) Repellent Property of Neem (Azadirachta indica) Seed Oil by Olive Aidoo, Noble Kuntworbe, Fredrick William Akuffo Owusu, Deryl Nii Okantey Kuevi

“…As one of the killer diseases in the world, malaria contributes to child mortality and global death annually. As a result, many reactive mechanisms have evolved to control and repel mosquitoes. …”
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Synthesis, Characterization, and Biological Evaluation of Gabapentinoid Hybrids with Isoindole-1,3(2H)-Dione Moiety as Potential Antioxidant, Antimicrobial, and Anticancer Agents by Mirna Jabbour, Mohammad Ammar Al-Khayat, Mahmoud Al-Ktaifani

“…Furthermore, we have studied the effect of compounds on proliferation, cell cycle, and cell death in two human cancer cell lines (Caco-2 and HCT-116). …”
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Therapeutic Adherence in Patients with Arterial Hypertension by Liens Hernández Quintero, Diana Amelia Crespo Fernández, Liliet Trujillo Cruz, Liliana María Hernández Quintero, Marcia Azcuy Pérez

“…<strong>Background:</strong> arterial hypertension is presented worldwide as one of the main causes of death and disability. Lack of adherence to treatment is one of this disease great problems. …”
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The Regional Centralization of Electronic Fetal Heart Rate Monitoring and Its Impact on Neonatal Acidemia and the Cesarean Birth Rate by Kaori Michikata, Hiroshi Sameshima, Hirotoshi Urabe, Syuichi Tokunaga, Yuki Kodama, Tsuyomu Ikenoue

“…The before-and-after study showed no difference in the rates of acidemia, cesarean births, or perinatal death in the whole population. A subgroup analysis using the 4 hospitals in which an FHR centralization system was continuously connected (compliant group) and 3 hospitals in which the FHR centralization system was connected on demand (noncompliant group) showed that the incidence acidemia was significantly decreased (from 0.47% to 0.11%) without a corresponding increase in the cesarean birth rate due to nonreassuring FHR patterns in the compliant group. …”
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