Pyrogallol acts as a novel anticancer factor to enhance the sensitivity to cisplatin in ovarian cancer cells through inducing miR-15a upregulation by Azin Shirani, Razieh Mirabbasi, Leila Shabani, Somayeh Reiisi

“…Conclusion This study suggests that the combination treatment of pyrogallol and cisplatin significantly increases the death of ovarian cancer cells by inducing apoptosis. …”
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Mesenchymal stem cells enchanced by salidroside to inhibit ferroptosis and improve premature ovarian insufficiency via Keap1/Nrf2/GPX4 signaling by Lixuan Chen, Yingnan Wu, Tiying Lv, Rui Tuo, Yang Xiao

“…The genes and proteins of Keap1/Nrf2/GPX4 signaling were examined.Results Salidroside and MSCs were found to inhibit cell death of GCs by reducing peroxidation and intracellular ferrous. …”
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INFLUENCE OF EXO- AND ENDOGENOUS FACTORS ON THE MORPHOLOGICAL AND FUNCTIONAL STATE OF THE SPLEEN AS AN IMPORTANT MEDICAL AND SOCIAL PROBLEM OF THE HEALTH CARE SYSTEM by O.V. Mamai, S.M. Bilash, R.M. Grinko

“…Changes in the spleen are also known to occur in the setting of death from anaphylaxis, drowning, and sepsis. Autopsy of the spleen plays an important role in toxicological research. …”
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The role of inflammasomes in hepatocellular carcinoma: Mechanisms and therapeutic insights by Valentina Arrè, Roberto Negro, Gianluigi Giannelli

“…It has been reported that they can exert oncosuppressive functions by triggering the inflammatory death of cancer cells. Vice versa, chronic activation contributes to the development of a pro-tumorigenic environment, thus supporting tumor growth. …”
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Aloe-Emodin-Mediated Photodynamic Therapy Induces Apoptosis in Basal Cell Carcinoma Cells via Activation of ERK/JNK Signaling Pathway by Woodvine Otieno Odhiambo, Songmei Geng, Xiaopeng Wang, Xiaodong Chen, Mengting Qin, Meng Yuan, Yang Wang, Farooq Riaz, Chengcheng Liu, Yanhong Ji

“…CCK-8 assay was used to analyse cell viability following AE-mediated PDT. The cell death rate and reactive oxygen species (ROS) were assessed by flow cytometry. …”
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Gender Differences in Ghrelin Association with Cardiometabolic Risk Factors in Arab Population by Mohamed Abu-Farha, Mohammed Dehbi, Fiona Noronha, Ali Tiss, Monira Alarouj, Kazem Behbehani, Abdullah Bennakhi, Naser Elkum

“…Ghrelin is a stomach produced hormone that has been shown to have protective role against development of CVD which is a leading cause of death in the Arab world. The objective of this study is to examine the gender difference in association between traditional CVD risk factors and plasma ghrelin among Arabs. 359 Arab residents in Kuwait participated in a cross-sectional survey (≥20 years old): 191 were females and 168 were males. …”
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Expression Levels of IL-17A, IL-17F, IL-17RA, and IL-17RC in Prostate Cancer with Taking into Account the Histological Grade according to Gleason Scale in Comparison to Benign Pros... by Marlena Janiczek, Łukasz Szylberg, Paulina Antosik, Anna Kasperska, Andrzej Marszałek

“…Prostate cancer (PCa) is the second most commonly diagnosed malignant tumor and the fifth leading cause of cancer death in men in the world. The most common types of tumors are adenocarcinomas. …”
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Inhibition of hippocampal interleukin-6 receptor-evoked signalling normalises long-term potentiation in dystrophin-deficient mdx mice by Kimberley A. Stephenson, Aaron Barron, Mark G. Rae, Dervla O'Malley

“…Duchenne muscular dystrophy (DMD), an X-linked neuromuscular disorder, characterised by progressive immobility, chronic inflammation and premature death, is caused by the loss of the mechano-transducing signalling molecule, dystrophin. …”
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Detection of the I172N Mutation in Cuban Patients with Congenital Adrenal Hyperplasia due to 21 Hydroxylase Insufficiency by Taimí Barrueta Ordóñez, Teresa Collazo Mesa, Paulina Lantigua Cruz, Adrián de Jesús González Navarro, Tania Espinosa Reyes

“…The variables analyzed were: age, social sex, age at diagnosis, clinical form of hyperplasia, diagnosis by screening program, family history, consanguinity, nonspecific neonatal death, genital crisis of the newborn, previous molecular diagnosis, mutations studied previously, mutation I172N gene CYP21A. …”
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Immunological Evaluation for Personalized Interventions in Children with Tuberculosis: Should It Be Routinely Performed? by Laura E. Carreto-Binaghi, Esmeralda Juárez, Silvia Guzmán-Beltrán, María Teresa Herrera, Martha Torres, Alejandro Alejandre, José Arturo Martínez-Orozco, Eduardo Becerril-Vargas, Yolanda Gonzalez

“…Childhood tuberculosis (TB) is a significant public health problem and the ninth leading cause of death worldwide. Progression of Mycobacterium tuberculosis infection to active disease depends on mycobacterial virulence, environmental diversity, and host susceptibility and immune response. …”
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High mortality rates and long-term complications in children with infectious brainstem encephalitis: A study of sixteen cases. by Yuanyuan Zhou, Yi Zhu, Lingfeng Cao, Yingyan Shi, Jun Shen

“…<h4>Objective</h4>Brainstem encephalitis (BE) can cause sudden death in children. Fewer studies have been conducted on the incidence, clinical manifestations, pathogens and post-infectious sequelae of pediatric infectious BE.…”
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Management Outcome of Burn Injury and Associated Factors among Hospitalized Children at Ayder Referral Hospital, Tigray, Ethiopia by Sielu Alemayehu, Bhafta Afera, Kalayou Kidanu, Tilahun Belete

“…In Ethiopia, burn was the second leading cause of death among children from the unintentional injuries. …”
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Definition of a Novel Cuproptosis-Relevant lncRNA Signature for Uncovering Distinct Survival, Genomic Alterations, and Treatment Implications in Lung Adenocarcinoma by Zhuning Wang, Junqiao Yao, Tengyu Dong, Xing Niu

“…Cuproptosis is a newly discovered copper-independent cell death modality, and limited evidence suggests the critical implications in human cancers. …”
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New trends in AA amyloidosis with renal involvement: a single-center experience by Nídia Marques, Catarina Oliveira-Silva, Ana Pinho, Ana Teresa Nunes, Susana Sampaio, Ana Oliveira, Isabel Tavares

“…Overall, infections were the leading cause of death, with a significant rise over time (9.1% in CA to 76.9% at CC, p = 0.002). …”
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Tumor Necrosis Factor Alpha Mediates GABAA Receptor Trafficking to the Plasma Membrane of Spinal Cord Neurons In Vivo by Ellen D. Stück, Randolph N. Christensen, J. Russell Huie, C. Amy Tovar, Brandon A. Miller, Yvette S. Nout, Jacqueline C. Bresnahan, Michael S. Beattie, Adam R. Ferguson

“…The proinflammatory cytokine TNFα contributes to cell death in central nervous system (CNS) disorders by altering synaptic neurotransmission. …”
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Complications and Mortality Characterization in Acute Ischemic Cerebrovascular Disease by Ricardo Leyva Tornés, Lázaro Ibrahim Romero García, Esther Mayor Guerra, Yordanis Páez Candelaria, Karima Gondres Legró, Pedro Alexei Bacardí Zapata

“…The variables selected were: sex, type of complications, topography of the lesion by neuroimaging, state at discharge, and direct cause of death. 95 % confidence intervals were computed. The non-parametric Chi squared test of independence was applied and a significance level α = 0.05 was selected. …”
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Isosteviol Sodium Promotes Neurological Function Recovery in a Model of Spinal Cord Injury in Rats by Tongxia Zhang, Tao Zhang, Han Yu, Lingyi Chi

“…Results We found that STVNa improved spinal cord functional recovery in rats, as evidenced by enhanced BBB locomotor rating scale, angle of inclination, decreased cavity of spinal cord damage, and neuron death in vivo. In addition, STVNa reduced inflammation in rats following SCI, as demonstrated by a reduction in proinflammatory cytokines such as tumor necrosis factor (TNF)‐α, interleukin (IL)‐6, and interleukin (IL)‐1β. …”
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Reducing Hospital Readmissions in Chronic Obstructive Pulmonary Disease Patients: Current Treatments and Preventive Strategies by Claudia Di Chiara, Giulia Sartori, Alberto Fantin, Nadia Castaldo, Ernesto Crisafulli

“…COPD is one of the leading causes of death worldwide, so it represents a significant public health challenge. …”
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Immunotherapy-associated autoimmune hemolytic anemia by Uqba Khan, Tarik Hadid, Farman Ali, Muhammad Siddique Khurram, Awais Zaka

“…Cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and programmed cell death 1 (PD-1) pathway are the prototypic checkpoint targets for immunotherapy. …”
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Osteoprotegerin as an Emerging Biomarker of Carotid Artery Stenosis? A Scoping Review with Meta-Analysis by Jerzy Chudek, Marta Pośpiech, Anna Chudek, Michał Holecki, Monika Puzianowska-Kuźnicka

“…<b>Objective</b>: In developed countries, stroke is the fifth cause of death, with a high mortality rate, and with recovery to normal neurological function in one-third of survivors. …”
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